Clinical trials: Sodium Alendronate
Post-menopausal Osteoporosis
Bisphosphonate Action on the Appendicular Skeleton: Evidence for Differential Effects
A study to determine if the three licensed bisphosphonates (alendronate, ibandronate and risedronate):a) affect the peripheral skeleton differently, as assessed by quantitative ultrasound of bone (QUS), peripheral quantitative…
- Trial name
- NCT00666627
- Testing
- Ibandronate, Risedronate, Alendronate
- Where
- United Kingdom
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Osteoporosis
Treatment of Childhood Osteoporosis With Alendronate (Fosamax)
Bones grow and stay strong through a continuous process of formation (building) and resorption (break down). When more bone is formed than resorbed, the density (level of calcium) in bone increases and the bones become stronger.
- Trial name
- NCT00001720
- Testing
- Alendronate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Osteonecrosis, Osteonecrosis of the Femoral Head
A Phase II Trial of RAB001 (LLP2A-Alendronate) for Steroid-Induced Early-Stage Osteonecrosis of the Femoral Head
This is a multicenter, randomized (similar to drawing lots, where the treatment you receive is not chosen by you or the researchers), controlled, blinded (the three dose groups of the investigational drug are blinded, meaning…
- Trial name
- LLP2A-Ale (NCT07471880)
- Testing
- RAB001 high dose, RAB001 medium dose, RAB001 low dose
- Where
- China
- Volunteers
- 161 people
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Cystic Fibrosis, Osteoporosis
Study of Alendronate to Prevent and Treat Osteoporosis in Cystic Fibrosis Patients
The primary objective of this study is to determine efficacy of 70 mg alendronate once weekly compared to placebo. This will be measured by percent changes in lumbar spine(LS) bone mineral density(BMD) in adult cystic…
- Conditions
- Cystic Fibrosis, Osteoporosis, Bone Diseases, Metabolic
- Trial name
- NCT00157690
- Testing
- Alendronate
- Where
- 6 sites in Canada
- Volunteers
- 56 people
- Sponsor
- McMaster University
Spinal Cord Injury, Bone Loss
Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide
The purpose of this study is to determine if a year of alendronate treatment will maintain or increase bone mass density (BMD) compared to baseline BMD values in people with chronic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT02195895
- Testing
- Alendronate, Calcium, Vitamin D
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwestern University
Healthy
Fasting Study of Alendronate Sodium Tablets (10 mg) and Fosamax Tablets (10 mg)
The objective of this study is to investigate the bioequivalence of Mylan's alendronate sodium 10 mg tablets to Merck's Fosamax 10 mg tablets following a single, oral 40 mg (4 x 10 mg) dose administration under fasting conditions.
- Trial name
- NCT00983996
- Testing
- Alendronate Sodium Tablets, 10 mg, Fosamax Tablets, 10 mg
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Rheumatoid Arthritis, Polymyalgia Rheumatica
Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol.
The purpose of this study is to determine wich treatment is the most effective in prevention of glucocorticoid-induced osteoporosis in patients with rheumatic diseases.
- Conditions
- Rheumatoid Arthritis, Polymyalgia Rheumatica, Giant Cell Arteritis, Polymyositis
- Trial name
- NCT00138983
- Testing
- Alendronate versus alfacalcidol (1-alpha OH vitamin D)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Osteoporosis, Vitamin D Deficiency
A Study to Evaluate the Safety, Tolerability, and Efficacy of an Investigational Drug and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)
The purpose of this study is to test the safety, tolerability and effectiveness of an investigational drug and dietary supplement to reduce the risk of vitamin D insufficiency and deficiency during the treatment of osteoporosis…
- Trial name
- NCT00092066
- Testing
- MK0217A, alendronate sodium (+) cholecalciferol / Duration of Treatment: 15 weeks
- Volunteers
- 717 people
- Sponsor
- Organon and Co
Osteoporosis, Vitamin D Deficiency
A Study of MK0217A and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)
The purpose of this study is to test the safety, tolerability, and effectiveness of an investigational drug and dietary supplement to reduce the risk of vitamin D insufficiency and deficiency during treatment of osteoporosis in…
- Trial name
- NCT00092079
- Testing
- MK0217A, alendronate sodium (+) cholecalciferol / Duration of Treatment: 24 weeks
- Volunteers
- 652 people
- Sponsor
- Merck Sharp & Dohme LLC
Non-Traumatic Osteonecrosis
Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis
To determine the cumulative incidence of total hip replacement, time to event after treatment with Fosamax or placebo during the study peroid
- Trial name
- NCT00265252
- Testing
- Alendronate
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Chronic Periodontitis
1% Alendronate Gel in Treatment of Chronic Periodontitis Among Smokers
Locally delivered Alendronate (ALN) have potent inhibitory effect on bone and increases new bone formation in chronic periodontitis patients Till date no study has reported the effect of local delivery of ALN in chronic…
- Trial name
- NCT02168543
- Testing
- Alendronate
- Volunteers
- 46 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical efficacy of autologous PRF, 1% alendronate (ALN) and 1.2% atorvastatin (ATV) gel placement with open…
- Trial name
- NCT02516111
- Testing
- Open flap debridement (OFD), OFD with PRF, OFD with ALN
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Diabetes Mellitus
BLADE-PCI Trial (BLADE); PHASE IIB LIPOSOMAL ALENDRONATE STUDY
The main objective of this study is to assess the safety, efficacy and dose response of LABR-312 administered intravenously at the time of percutaneous coronary intervention (PCI) with a drug eluting stent in reducing restenosis…
- Trial name
- BLADE (NCT02645799)
- Testing
- LABR-312
- Where
- Israel
- Volunteers
- 270 people
- Sponsor
- BIOrest Ltd.
Post-Menopausal Osteoporosis
A Study of Bonviva (Ibandronate) and Alendronate on Renal Function in Postmenopausal Women With Osteoporosis at High Risk for Renal Disease.
This 3 arm study will evaluate renal safety after administration of an intravenous (iv) injection or infusion of Bonviva, compared to oral alendronate, in patients with postmenopausal osteoporosis, at increased risk of renal…
- Trial name
- NCT00503113
- Testing
- ibandronate [Bonviva/Boniva], Alendronate
- Where
- 44 sites in United States, Argentina and 4 more
- Volunteers
- 801 people
- Sponsor
- Hoffmann-La Roche
Osteoporosis, Cystic Fibrosis
Randomized Study of Alendronate in Adult Patients With Cystic Fibrosis Related Osteoporosis
OBJECTIVES: I. Determine the bioavailability and biologic effect of alendronate on bone metabolism in patients with cystic fibrosis. II.
- Trial name
- NCT00004489
- Testing
- alendronate sodium, calcium carbonate, cholecalciferol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina
Osteopenia, Osteoporosis
Pharmacokinetics of a Single 14C-labeled Dose of Risedronate or Alendronate Followed by Once-a-week Unlabeled Oral Dose
The primary objective of this study is to compare the urinary excretion of 14C-labeled risedronate and alendronate over 28 days.
- Trial name
- NCT00577850
- Testing
- risedronate, alendronate
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Warner Chilcott
Post-Menopausal Osteoporosis
BONCURE Study: A Study of Monthly Bonviva (Ibandronate) in Women With Post-Menopausal Osteoporosis on Bisphosphonate Therapy.
This single arm study will assess participant preference for monthly Bonviva, versus daily or weekly alendronate or risedronate, in the treatment of postmenopausal osteoporosis.
- Trial name
- NCT00545779
- Testing
- Ibandronate
- Where
- 32 sites in Albania, Bosnia and Herzegovina and 4 more
- Volunteers
- 677 people
- Sponsor
- Hoffmann-La Roche
Sickle Cell Disease, Sickle Cell Anemia
Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
A prospective, single-arm, intervention study of oral alendronate in adults with sickle cell disease and osteonecrosis
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Osteonecrosis, Ischemic Necrosis
- Trial name
- NCT06016634
- Testing
- Alendronate Sodium
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Postmenopausal Osteoporosis
A Study of Ibandronate [Bonviva/Boniva] and Alendronate in Female Patients With Post-Menopausal Osteoporosis
This observational study will assess the compliance and persistence of patients, real life efficacy and safety of intravenously quarterly administered 3 mg ibandronate [Bonviva/Boniva] in comparison to oral alendronate generics…
- Trial name
- NCT01128257
- Testing
- alendronate, ibandronate [Bonviva/Boniva]
- Where
- Germany
- Volunteers
- 6,054 people
- Sponsor
- Hoffmann-La Roche
Heart Transplantation, Liver Transplantation
Zoledronic Acid Versus Alendronate for Prevention of Bone Loss After Organ Transplantation
The purpose of this study is to compare the effectiveness and safety of zoledronic acid with alendronate in the prevention of bone loss after organ transplantation. Zoledronic acid is given as a single intravenous infusion.
- Conditions
- Heart Transplantation, Liver Transplantation, Bone Resorption
- Trial name
- CTX (NCT00297830)
- Testing
- Zoledronic acid, Alendronate
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Columbia University