Clinical trials: Sleep Apnea
OSA - Obstructive Sleep Apnea, Dysphagia
Effects of Surgery on Oral Frailty and Dysphagia in Patients With Obstructive Sleep Apnea
Dysphagia is a commonly reported complaint among patients with obstructive sleep apnea (OSA), particularly those who have undergone upper-airway (oropharyngeal) surgery.
- Conditions
- OSA - Obstructive Sleep Apnea, Dysphagia, Oral Frailty
- Trial name
- NCT07880067
- Testing
- Upper airway surgery for OSA, Non-surgical management
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Sun Yat-sen University
Apnea, Sleep Disorders
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Do Not Use a Breathing Machine (PAP) (VESPER-OSA 2)
This study is being done to learn about the safety and effects of a study medicine called berobenatide (bear-oh-BEN-uh-tide). The study will see if berobenatide can help adults with breathing problems during sleep (obstructive…
- Conditions
- Apnea, Sleep Disorders, Overweight and/or Obesity
- Trial name
- VESPER-OSA 2 (NCT07881757)
- Testing
- Berobenatide
- Where
- 2 sites in United States
- Volunteers
- 258 people
- Sponsor
- Pfizer
Sleep Apnea, Obstructive
Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea
The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between…
- Trial name
- NCT04712656
- Testing
- CPAP therapy
- Where
- United States
- Volunteers
- 1,739 people
- Sponsor
- Ohio State University
Sleep Apnea, Obstructive
Virtual Surgery of the Upper Airways
Obstructive sleep apnea (OSA) is a sleep related breathing disorder caused by repetitive collapses of the upper airways resulting in impaired breathing, oxygen desaturation and sleep disturbances.
- Trial name
- VirtuOSA (NCT04829201)
- Testing
- functional septorhinoplasty or oropharyngeal/orthognathic surgery
- Where
- 2 sites in Norway
- Volunteers
- 30 people
- Sponsor
- Norwegian University of Science and Technology
Obstructive Sleep Apnea, Sleep Apnea
The Comfort of Proactive Sleep Apnea Therapy
The goal of this clinical trial is to compare in OSA patients who regularly adhere to CPAP therapy. The main question[s] it aims to answer are: To assess if proactive therapy can effectively treat OSA with lower mean therapy…
- Trial name
- NCT06144892
- Testing
- Proactive Therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- NovaResp Technologies Inc
Obstructive Sleep Apnea
The Adherence of Proactive Sleep Apnea Therapy
The goal of this clinical trial is to compare the adherence to Positive Airway Pressure (PAP) therapy for newly diagnosed Obstructive Sleep Apnea (OSA) patients. The main question(s) it aims to answer are: 1.
- Trial name
- NCT06319482
- Testing
- Proactive CPAP Therapy, Conventional APAP Therapy
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- NovaResp Technologies Inc
Obstructive Sleep Apnea (OSA)
The Effects of Hypoxic Burden on Executive Function (EF) in Preschool Children With Obstructive Sleep Apnea
The goal of this observational study is to study the effect of hypoxic burden on executive function in preschool children aged 2-6 years who have OSA.
- Trial name
- NCT07023458
- Testing
- Brief-P
- Where
- Thailand
- Volunteers
- 72 people
- Sponsor
- Mahidol University
Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Evaluation of the F&P Mask, US, 2026
This clinical investigation is designed to validate and confirm the overall performance, safety, usability, reliability, and acceptability of the F\&P PAP mask in a home environment.
- Trial name
- NCT07826429
- Testing
- F&P Licorice Mask
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Obesity, Obstructive Sleep Apnea
Long-term Effects of Lipoabdominoplasty on Pulmonary Function and Sleep Apnea Risk in Obese Subjects
This study investigates the long-term effects of lipoabdominoplasty on pulmonary function and obstructive sleep apnea (OSA) risk in obese patients.
- Trial name
- NCT07029750
- Testing
- Lipoabdominoplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Atlas University
Comorbid Insomnia and Sleep Apnea, Insomnia
Wearable Voice-Guided BBTi for Comorbid Insomnia and Sleep Apnea (COMISA)
This study investigates the efficacy of a wearable voice-guided Brief Behavioral Therapy for Insomnia (BBTi) combined with a smart eye-mask device for individuals with Comorbid Insomnia and Sleep Apnea (COMISA).
- Conditions
- Comorbid Insomnia and Sleep Apnea, Insomnia, Obstructive Sleep Apnea
- Trial name
- BBTi-COMISA (NCT07521319)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTi), Smart Eye-Mask with Voice-Guided Modules
- Where
- Taiwan
- Volunteers
- 361 people
- Sponsor
- National Sun Yat-sen University
Obstructive Sleep Apnea
Follow-up of Apneic Patients by Visio-consultation
Prospective multicenter open-label randomized clinical trial comparing videoconsultation to a face-to-face consultation during the follow-up of apneic patients treated by continuous positive pressure (CPAP) .
- Trial name
- VISIOSAS (NCT04547543)
- Testing
- Videoconsultation
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
DISE: Phenotyping Obstruction Patterns
Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and…
- Trial name
- DISE-PhOP (NCT05050383)
- Testing
- Pharyngeal Manometry
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- University of Pennsylvania
Sleep Disordered Breathing, Able Bodied
Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment
Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive…
- Trial name
- CSA-HF (NCT07210606)
- Testing
- Trazodone + positive airway pressure (PAP) therapy, Oxygen + positive airway pressure (PAP) therapy
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Apnea, Obstructive, Exercise Addiction
Development and Investigation of the ApneaTheraPlay
Obstructive Sleep Apnea Syndrome (OSAS) is commonly treated with CPAP devices, but adherence rates are low. Exercise has been shown to strengthen respiratory muscles, improve upper airway function, and enhance sleep quality.
- Conditions
- Apnea, Obstructive, Exercise Addiction, Physiotherapy and Rehabilitation
- Trial name
- NCT07214636
- Testing
- Structured Pre-Sleep Exercise, ApneaTheraPlay (ATP)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Medipol University
Obstructive Sleep Apnea (OSA)
DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea.
The goal of this randomized, double-blind, multi-dose crossover clinical trial is to determine the safety and efficacy of IHL-42X in subjects with obstructive sleep apnea.
- Trial name
- DReAMzz (NCT07635563)
- Testing
- IHL-42X: 2.5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 7.5 mg dronabinol + 125 mg acetazolamide
- Where
- 13 sites in United States
- Volunteers
- 120 people
- Sponsor
- Incannex Healthcare Ltd
Apnea, Sleep Disorders
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1)
This study is being done to learn about the safety and effects of a study medicine called berobenatide (bear-oh-BEN-uh-tide). The study will see if berobenatide can help adults with breathing problems during sleep (obstructive…
- Conditions
- Apnea, Sleep Disorders, Overweight and/or Obesity
- Trial name
- NCT07823608
- Testing
- Berobenatide
- Where
- 6 sites in United States
- Volunteers
- 258 people
- Sponsor
- Pfizer
PCOS, PCOS (Polycystic Ovary Syndrome)
PMOS in OSA Pilot Study
The goal of this study is to obtain pilot data investigating the effects of sleep apnea on mitochondrial function and cellular metabolism in Polyendocrine Metabolic Ovarian Syndrome (PMOS) patients.
- Conditions
- PCOS, PCOS (Polycystic Ovary Syndrome), OSA, OSA - Obstructive Sleep Apnea
- Trial name
- NCT07871149
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis
MASLD in Type 2 Diabetes in Primary Care - a Follow-up Study
The goal of this observational study is to understand how metabolic dysfunction-associated steatotic liver disease (MASLD) changes over time in individuals with type 2 diabetes who previously participated in the EPSONIP study.
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis, Advanced Fibrosis, Sarcopenia
- Trial name
- EPSOMIP2 (NCT07312136)
- Where
- Sweden
- Volunteers
- 317 people
- Sponsor
- Linkoeping University
Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Evaluation of F&P Mask, US, 2026
This clinical investigation is designed to validate and confirm the overall performance, safety, usability, reliability, and acceptability of the F\&P mask in a home environment.
- Trial name
- NCT07847814
- Testing
- F&P Mask
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Down Syndrome, Obstructive Sleep Apnea
Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome
The purpose of this research study is to develop a way of predicting with computers how surgery on the airway will affect night time breathing called Obstructive Sleep Apnea (OSA) in children with Down Syndrome.
- Trial name
- DYMOSA (NCT01902407)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati