Clinical trials: Sleep Apnea
Obstructive Sleep Apnea of Child
Single Cell Sequencing of Tonsillar Tissue in Children With OSA
Obstructive sleep apnoea (OSA) in children is a prevalent sleep disorder, and is characterised by repetitive complete or partial upper airway obstruction during sleep.
- Trial name
- NCT05115968
- Testing
- Tonsillectomy
- Where
- Hong Kong
- Volunteers
- 16 people
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Mucosal Inflammation in Children With OSA
Objectives: Variability of clinical phenotypes in childhood obstructive sleep apnoea (OSA) has prompted research for biomarkers to identify patients at risk of developing OSA-related complications.
- Trial name
- NCT06452979
- Where
- Hong Kong
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Complementary Exercise-Based Therapy for Obstructive Sleep Apnea
This randomized interventional study evaluates a complementary exercise-based therapy in adults with moderate-to-severe obstructive sleep apnea who are receiving continuous positive airway pressure (CPAP) therapy.
- Trial name
- NCT07891247
- Testing
- Multimodal Exercise, Respiratory and Cervical-Postural Rehabilitation Program, Continuous Positive Airway Pressure (CPAP)
- Where
- Romania
- Volunteers
- 24 people
- Sponsor
- bioROne
Obstructive Sleep Apnea
Effect of Transcutaneous Electrical Stimulation on Polysomnographic Parameters in Patients With Obstructive Sleep Apnea
The aim of this study is to assess the impact of transcutaneous electrical stimulation on polysomnographic findings in obstructive sleep apnea patients.
- Trial name
- NCT07891702
- Testing
- Transcutaneous Electrical Stimulation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Obstructive Sleep Apnea, Sleep Quality
Physical Activity, Sleep Quality, and Respiratory Function in Obstructive Sleep Apnea
Although exercise and physical activity have shown beneficial effects in individuals with obstructive sleep apnea (OSA), evidence regarding the effects of daily physical activity habits on sleep quality and respiratory parameters…
- Conditions
- Obstructive Sleep Apnea, Sleep Quality, Respiratory Function
- Trial name
- NCT07889154
- Testing
- Physical Activity Education
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medipol University
Obstructive Sleep Apnea
Prevalence of Sleep Apnoea in Adolescents
Obstructive sleep apnoea (OSA) is associated with a variety of important complications, namely cardiovascular, neurocognitive and metabolic disturbances. The prevalence of OSA is well studied in children and adults.
- Trial name
- NCT03895775
- Where
- Hong Kong
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Morbid Obesity, Metabolic Syndrome
Impact GLP-1 Agonists Following Bariatric
Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic…
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes Mellitus, Hypertension
- Trial name
- NCT06132477
- Testing
- GLP-1 receptor agonist
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Missouri-Columbia
Obstructive Sleep Apnea
Microbiome and Metabolomics Profiling in Children With OSA
Objectives: Obstructive sleep apnoea (OSA) exhibits variable susceptibility to end-organ morbidities. Previous studies suggest that physiological sequelae in individuals with OSA promote changes in microbiome, which also interact…
- Trial name
- NCT06452992
- Where
- Hong Kong
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Positional Therapy for Childhood Obstructive Sleep Apnoea
Obstructive sleep apnoea (OSA) in children is a prevalent sleep disorder associated with a wide spectrum of morbidities, including neurobehavioural, cardiovascular, and metabolic complications.
- Trial name
- NCT06453018
- Testing
- Positional device, Rematee Bumper Belt or Night Shift
- Where
- Hong Kong
- Volunteers
- 5 people
- Sponsor
- Chinese University of Hong Kong
Sleep Apnea
Janus II Feasibility
The objectives of this study are to evaluate the feasibility of the remedē® Dual Channel System at implant and overnight sleep studies and to assess chronic safety.
- Trial name
- NCT06556693
- Testing
- Dual Channel Stimulation
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Zoll Medical Corporation
Obstructive Sleep Apnea (OSA)
Myofunctional Therapy for Children With OSA
Myofunctional therapy (MFT) has been proposed as an adjunctive therapy for obstructive sleep apnoea (OSA) in children. Some studies have reported improved sleep parameters and reduced oral breathing after MFT.
- Trial name
- NCT07249944
- Testing
- Myofunctional therapy
- Where
- Hong Kong
- Volunteers
- 174 people
- Sponsor
- Chinese University of Hong Kong
Obesity & Overweight, Diabetes Mellitus, Type 2
Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks
This is a nationwide, multi-center, long-term follow-up study of overweight and obese adults in China. The study aims to recruit approximately 26,000 participants across 39 hospitals to better understand how body weight affects…
- Conditions
- Obesity & Overweight, Diabetes Mellitus, Type 2, Hypertension, Non-alcoholic Fatty Liver Disease (MASLD)
- Trial name
- NCT07884903
- Testing
- No intervention; observational assessment only
- Where
- China
- Volunteers
- 25,974 people
- Sponsor
- Shanxi Bethune Hospital
Hereditary Hemorrhagic Telangiectasia (HHT), Obstructive Sleep Apnea (OSA)
Prevalence of Obstructive Sleep Apnea in HHT and HHT-specific Challenges in OSA-therapy - a Retrospective Cohort Study
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder (prevalence approx. 1:5,000-1:8,000) characterized by recurrent epistaxis, mucocutaneous telangiectasias and visceral vascular malformations.
- Trial name
- NCT07886632
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Essen
Sleep Apnea, Obstructive, Fatty Liver
Prevalence of Non-alcoholic Fatty Liver Disease Among Non-obese Obstructive Sleep Apnea by Using Transient Elastography
Obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) are both common diseases related to metabolic diseases with potential cardiovascular consequences and liver complications respectively.
- Trial name
- NCT05351515
- Where
- Hong Kong
- Volunteers
- 861 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Sleep Apnea
Personalized Obstructive Sleep Apnea Treatment and Effects on Alzheimer's Disease Biomarkers and Cognition Among Blacks
The purpose of this research is to see how effective the Personalized obstructive sleep apnea (OSA) Treatment Adherence Model called PRAISE is in helping the patient stick to the physician recommended OSA treatment plan Positive…
- Trial name
- PRAISE (NCT06089161)
- Testing
- Standard of Care, Personalized OSA Treatment
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of Miami
Obstructive Sleep Apnea
Myofunctional Therapy for Obstructive Sleep Apnea
The purpose of this study is to explore a new way to examine the function of the muscles using a technique called high-resolution manometry.
- Trial name
- NCT07301125
- Testing
- Myofunctional Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Hypopnea Syndrome, Apnea, Obstructive Sleep
Impact of Continuous Positive Airway Pressure Therapy on Bilateral Local Hippocampal Gray Matter Volume in Elderly Patients With Obstructive Sleep Apnea - Study BBBSAS
This study evaluates whether treating severe obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) for approximately 6 months modifies local hippocampal and frontal cortex gray matter volume and…
- Trial name
- BBBSAS (NCT07882433)
- Testing
- Continuous Positive Airway Pressure (CPAP) therapy, Multimodal brain MRI with Gadolinium injection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Post Traumatic Stress Disorder, Obstructive Sleep Apnea
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Conditions
- Post Traumatic Stress Disorder, Obstructive Sleep Apnea, Substance Use Disorder, Residential Treatment Program
- Trial name
- NCT05156112
- Testing
- Positive Airway Pressure Device
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea (OSA)
A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults
Researchers want to identify which treatments for obstructive sleep apnea (OSA) work best and are easiest for patients to use consistently.
- Trial name
- ADAPT-OSA (NCT07679282)
- Testing
- Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin
- Where
- 4 sites in United States
- Volunteers
- 2,400 people
- Sponsor
- Sairam Parthasarathy
Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline
Respiratory Progression in Adults With Duchenne Muscular Dystrophy.
This is a multicenter, longitudinal observational study aimed at characterizing the natural history of respiratory progression in adults with genetically confirmed Duchenne muscular dystrophy (DMD).
- Conditions
- Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline, Restrictive Lung Disease, Respiratory Failure
- Trial name
- GUP24005 (NCT07879989)
- Where
- 13 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Giannina Gaslini