Clinical trials: Sedation Strategies
Bronchoscopy
Three Different Oxygenation Strategies in Bronchoscopy Procedures Under Sedation
The purpose of study aims to determine which of the three different oxygenation strategies, including nasal cannula, modified nasopharyngeal cannula, and HFNO groups, is safer in patients undergoing bronchoscopy under sedation.
- Trial name
- NCT05912985
- Testing
- different oxygenation methods
- Where
- Turkey (Türkiye)
- Volunteers
- 252 people
- Sponsor
- Ankara City Hospital Bilkent
Respiratory Insufficiency
Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation
Most patients in ICU are treated with a combination of analgesics and sedatives in most cases. Due to the different mechanism of different sedative and analgesic drugs, different antagonistic or synergistic effects may occur when…
- Trial name
- NCT05024799
- Testing
- Fentanyl, propofol, fentanyl and dexmedetomindine, Butorphanol and propofol
- Volunteers
- 300 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Critical Illness
Development and Evaluation of Strategies to Improve Sedation Quality in InTensive Care
Intensive Care Units (ICUs) across Scotland are working with the Scottish Patient Safety Programme (SPSP) to reduce healthcare associated infections (HAls). This is being done through implementation of "care bundles".
- Trial name
- DESIST (NCT01634451)
- Testing
- Bespoke on-line sedation education package, Sedation specific outcome process feedback, Responsiveness monitoring; novel sedation monitor
- Where
- United Kingdom
- Volunteers
- 1,637 people
- Sponsor
- University of Edinburgh
Critical Illness
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol.
The purpose of this study is to determine whether the use of both a nurse-driven sedation protocol and daily sedative interruption, compared with a sedation protocol alone, result in better outcomes for mechanically ventilated…
- Trial name
- SLEAP (NCT00675363)
- Testing
- Protocolized Sedation, Protocolized sedation, with daily interruption
- Where
- 16 sites in United States, Canada
- Volunteers
- 410 people
- Sponsor
- Mount Sinai Hospital, Canada
Transcatheter Aortic Valve Replacement (TAVR), Aortic Valve Stenosis
Patient Quality of Recovery After TAVR With Different Sedation Regimens
The goal of this clinical trial is to learn whether the type of sedation medication used during a transcatheter aortic valve replacement (TAVR) affects how people recover after the procedure.
- Trial name
- NCT07556523
- Testing
- Propofol, Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- David Lyubashevsky
Prevention of Delirium
Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation
The objective of the study is to determine the impact on the frequency of occurrence of delirium of an early inhaled sedation strategy (from induction in rapid sequence if intubation in intensive care, or from admission if…
- Trial name
- INASED (NCT04341350)
- Testing
- Propofol + analgesic drug, Isoflurane + analgesic drug
- Where
- 12 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Surgery, Critical Illness
Sedation Optimisation Strategy (S.O.S.) Ventilation
Use of sedatives and analgesics is common in mechanically ventilated patients hospitalized in Intensive Care Unit (ICU). That is called " sedation " and aimed to reduce both pain and anxiety and also to allow an effective and…
- Conditions
- Surgery, Critical Illness, Mechanical Ventilation Complication, Organ Dysfunction Syndrome
- Trial name
- NCT01486121
- Testing
- Therapy strategy
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Montpellier
Ischemic Stroke, Anterior Cerebral Circulation
Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2
The goal of this clinical trial is to learn what is the best anesthetic management in participants with severe stroke that require a medical intervention called mechanical thrombectomy (MT) done to open the occluded brain vessel.
- Conditions
- Ischemic Stroke, Anterior Cerebral Circulation, General Anesthesia, Procedural Sedation
- Trial name
- AMETIS 2 (NCT07235514)
- Testing
- General Anesthesia, Procedural sedation
- Where
- 16 sites in France
- Volunteers
- 958 people
- Sponsor
- University Hospital, Clermont-Ferrand
Bronchoscopy, Sedation
Sedation Strategies for Therapeutic Bronchoscopy 2
Therapeutic bronchoscopy is a common procedure to treat respiratory diseases. The procedure includes stent implantation, bronchus dilation, electronic incision, laser therapy, and so on.
- Trial name
- NCT03983915
- Testing
- Dexmedetomidine, Remifentanil, Laryngeal mask
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Changhai Hospital
Dental Anxiety
Flumazenil Reversal of Oral Triazolam
An increase in the utilization of anesthesia and sedation medications by non-anesthesiologists, including dentists, has grown dramatically.
- Trial name
- NCT00695630
- Testing
- Flumazenil
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Washington
Craniotomy, Neurosurgical Patients
an Analgesia-first Strategy Without Hypnotic Sedatives in Adult Patients Admitted to the Intensive Care Unit After Neurosurgical Craniotomy
Analgesia and sedation are core components of intensive care unit (ICU) care. They are used to relieve pain and anxiety, prevent harmful physiological stress responses, improve tolerance of invasive devices and mechanical…
- Trial name
- NCT06727435
- Testing
- analgesia-first strategy without hypnotic sedatives
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Beijing Tiantan Hospital
Intellectual Disability, Perceptual Disorders
Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood
The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes.
- Conditions
- Intellectual Disability, Perceptual Disorders, Memory Disorders
- Trial name
- RESTORE-cog (NCT02225041)
- Where
- 31 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Major Depressive Disorder (MDD)
Sedation and Guided Education for Depression Study
The goal of this clinical trial is to understand how patient education surrounding a one-time, consciousness-altering medical intervention impacts the antidepressant response to the intervention in adults with major depressive…
- Trial name
- SAGE (NCT06705270)
- Testing
- Response-focused education, Diagnosis-focused education, IV naloxone
- Volunteers
- 40 people
- Sponsor
- Stanford University
Respiratory Failure, Mechanical Ventilation Complication
Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery
There is a direct relationship between the sedative agent and the duration of ventilation.
- Conditions
- Respiratory Failure, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- NCT05451121
- Testing
- Propofol, Dexmedetomidine, Propofol and dexmedetomidine
- Where
- Ukraine
- Volunteers
- 356 people
- Sponsor
- Anesthesia Research Group UA
Critical Illness, Mechanical Ventilation
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol
All critically ill, mechanically ventilated patients in the Intensive Care Unit receive medications to relieve pain and anxiety.
- Trial name
- NCT00298493
- Testing
- Sedation management strategy
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Mount Sinai Hospital, Canada
Intensive Care Unit, Postoperative Care
Pharmacokinetics-pharmacodynamics and Safety of Dexmedetomidine in Children
This study evaluates pharmacokinetics and pharmacodynamics of dexmedetomidine for children under sedation at intensive care unit after surgery.
- Trial name
- NCT04027829
- Testing
- Dexmedetomidine Hydrochloride
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Seoul National University Hospital
Mechanical Ventilation, Sedation and Analgesia
Fentanyl Versus Hydromorphone in Patients on Mechanical Ventilation
Patients with respiratory failure who require mechanical ventilation are not only at risk of death, but also of complications of prolonged ICU stay.
- Conditions
- Mechanical Ventilation, Sedation and Analgesia, Critical Care, Intensive Care
- Trial name
- FenHydro (NCT07224620)
- Testing
- fentanyl, Hydromorphone
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Beth Israel Deaconess Medical Center
Bronchoscopy, Sedation
Sedation Strategies for Diagnostic Bronchoscopy 2
Diagnostic bronchoscopy is an invasive procedure performed to diagnose respiratory diseases. But pain has been complained by most of the patients receiving such procedures.
- Trial name
- NCT03983889
- Testing
- Midazolam, Fentanyl, Dexmedetomidine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Acute Respiratory Failure
Pilot Study on Pairing Sedation Strategies and Weaning
A three-arm, randomized, pilot study, to assess the feasibility for the analgesia-first sedation (AFS) study arm/intervention (Fentanyl push first).
- Trial name
- NCT02219659
- Testing
- Sedation Protocol with Daily Interruption, Sedation Protocol Without Daily Interruption, Fentanyl Push First
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- MemorialCare Health System
Sedation Complication
Influence of Sedation Strategies on Hospital LOS and ICU LOS in Patients Cardiac Surgery
Preoperative, intraoperative and postoperative management of the patient are some of the main stages that can affect the hospital LOS and ICU LOS.
- Trial name
- LOS (NCT05809518)
- Testing
- Propofol injection, Dexmedetomidine injection, Dexmedetomidine and Propofol
- Where
- Ukraine
- Volunteers
- 194 people
- Sponsor
- Anesthesia Research Group UA