Clinical trials: Saliva Altered
Saliva Altered, Taste, Altered
Astringency and Oral Health
The perception of astringency is thought to involve the interaction between tannins and salivary proteins. However, the mechanisms underlying this interaction are poorly understood.
- Trial name
- NCT05819073
- Testing
- Plain water, CPE
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Dental Plaque, Saliva Altered
Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables
The purpose of this study is to determine the effect of three times a day mastication, during a follow-up period of 4 weeks, of two sugar-substituted chewing gums on various factors associated with dental caries and gingivitis.
- Conditions
- Dental Plaque, Saliva Altered, Gingivitis
- Trial name
- NCT01578603
- Testing
- xylitol, casein phosphopeptide amorphous calcium phosphate complex
- Where
- Colombia
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Pregnancy Related, Dental Caries
The Effects of Pregnancy on Oral Health
The aim of this study was to evaluate the effects of pregnancy on salivary pH, flow rate, caries experience and periodontal status.
- Conditions
- Pregnancy Related, Dental Caries, Periodontal Diseases, Saliva Altered
- Trial name
- NCT06343337
- Testing
- Evaluation of DMFT index, CPI scores, salivary pH and flow rate in pregnant and non-pregnant woman
- Where
- Turkey (Türkiye)
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Periodontal Diseases, Saliva Altered
The Role of Periodontal Diseases and Stimulation of Saliva Secretion in the Acute Phase of Ischemic Stroke
Methods: 100 consecutive patients with their first ever ischemic stroke were enrolled in the study. 56 randomly selected patients were subjected to stimulation of salivation, the remaining patients were not stimulated.
- Conditions
- Periodontal Diseases, Saliva Altered, Stroke
- Trial name
- NCT05394090
- Testing
- saliva stimulation
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Attention Deficit Hyperactivity Disorders, Caries, Dental
Salivary Bacteria and Oral Health Status in Children With ADHD
Attention deficit and hyperactivity (ADHD) affect 6% of school-aged children. Few studies reported higher prevalence of caries and restorations among children with ADHD. Methylphenidate is the drug of choice to treat ADHD.
- Conditions
- Attention Deficit Hyperactivity Disorders, Caries, Dental, Xerostomia
- Trial name
- ADHD (NCT00966394)
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Alzheimer Disease, Neurodegenerative Diseases
Yogic Breathing Changes Salivary Components
Our aim is to analyze two ancient Tamil practices (chanting and breathing exercise) if they are capable of stimulating saliva containing agents that can be beneficial to the nervous system.
- Conditions
- Alzheimer Disease, Neurodegenerative Diseases, Cancer
- Trial name
- NCT02108769
- Testing
- Yogic Breathing, Attention Control
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Bone Marrow Disease
Busulfan Concentration in Saliva and Plasma, and Its Relationship With Salivary Changes and Mucositis in the Digestive Tract of Patients Submitted to Hematopoietic Stem Cell Transplantation
Busulfan (Bu) has been widely used for the treatment of neoplastic and non-neoplastic hematological disturbances, with satisfactory results in terms of successful hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT03492749
- Testing
- Saliva monitoring
- Volunteers
- 80 people
- Sponsor
- Hospital Israelita Albert Einstein
Saliva Altered
Salivary Flow Promoted by Sugar-Free Chewing Gum
This was a double-blind, single center in vivo salivary flow rate study. The objective was to compare a marketed sugar-free chewing gum to a clinically-tested sugar-free reference chewing gum, with regards to their ability to…
- Trial name
- NCT05447104
- Testing
- Mastication
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mars Wrigley
Obesity, Dental Erosion
Salivary Function and Dental Changes During GLP-1 Therapy
People who use glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide and tirzepatide, may experience changes in their oral health.
- Conditions
- Obesity, Dental Erosion, Saliva Collection, Saliva Altered
- Trial name
- NCT07720466
- Testing
- Unstimulated Whole Saliva Collection, Salivary Analysis, Oral Examination and BEWE Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Electrolyte Disturbance, Saliva Altered
Effects of Cardamom and Fennel on Salivary pH and Anti Microbial Activity
Dental caries is the most prevalent infectious disease related to oral health.. Although significant advances have been made on a global front to prevent caries, studies show its incidence is on the rise making it one of the…
- Trial name
- NCT05245019
- Testing
- cardamom, fennel
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Saliva Altered, Oral Hygiene
Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Carbonated Drink
The diurnal variation in the flow of saliva and hence the composition of saliva is an established fact. Consumption of acidic and sweetened food and beverage is known to reduce the salivary pH and some of them reduce it to…
- Conditions
- Saliva Altered, Oral Hygiene, pH, Tooth Structure; Disorder
- Trial name
- SALPH-C (NCT03526770)
- Testing
- Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr Meru S
Periodontitis
Evaluation of Biomarker Levels in Blood, Saliva and Gingival Fluid in Periodontitis
The aim of this study was to compare IMA, MDA, CAT, GSH and ADA levels in gingival crevicular fluid, serum and saliva of periodontally hopeless, periodontitis and gingivitis teeth with healthy control groups.
- Trial name
- NCT04647123
- Testing
- No intervention was applied to the groups the samples will be collected in terms of the diagnosis (hopeless, periodontitis, gingivitis, healthy)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yuzuncu Yil University
Orthodontic Appliances, Removable, Orthodontic Appliances, Fixed
Microbiome and Immunogenity of Saliva During Orthodontic Therapy
There are two essential ways of treatment in the field of orthodontics. The fixed appliance treatment with self-ligating or conventional brackets and treatment with aligners.
- Conditions
- Orthodontic Appliances, Removable, Orthodontic Appliances, Fixed, Oral Microbiome, Cell Culture
- Trial name
- NCT04139538
- Testing
- orthodontic treatment
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
HIV Infections
HIV in Specific Parts of the Body of Patients Who Are Changing or Starting Potent Anti-HIV Drugs
The purpose of this study is to gain information on how the type and amount of HIV present in certain places in the body and in the blood are affected when potent (powerful) anti-HIV drugs are given.
- Trial name
- NCT00007488
- Where
- 23 sites in United States
- Volunteers
- 164 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Oral Cavity Squamous Cell Carcinoma, Saliva Altered
Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients
According to the World Health Organization, oral cancer (OC) is the eighth most common cancer in the world with a five year survival rate of 50%.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Saliva Altered, Precancerous Lesions
- Trial name
- OCSALTM (NCT03529604)
- Testing
- Saliva sampling, ELISA, HPLC
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Saliva Altered, Oral Hygiene
Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Fruit Juice
The diurnal variation in the flow of saliva and hence the composition of saliva is an established fact. Consumption of most types of acidic and sweetened foods and beverages are known to reduce the pH of saliva and some of them…
- Conditions
- Saliva Altered, Oral Hygiene, pH, Tooth Structure; Disorder
- Trial name
- SALPH-F (NCT03510962)
- Testing
- Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr Meru S
Streptococcal Infections, Saliva Altered
Efficacy of Propolis Varnish Against Oral Biofilm
This study aims to evaluate the effectiveness of a varnish containing 15% of green propolis on Streptococcus mutans in saliva and biofilm.
- Trial name
- NCT02052973
- Testing
- Propolis varnish
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Head and Neck Cancer
Therapy-Associated Saliva and Taste Change Evaluation (TASTE) in Head & Neck Cancer Patients Undergoing Radiotherapy
One of the main side effects of radiation therapy to the head and neck region is altered taste sensation. This causes significant morbidity and has profound effects on the quality of life (QoL) of patients.
- Trial name
- TASTE (NCT06444776)
- Testing
- Repetitive (semi-)objective and subjective taste, smell, and saliva analysis
- Where
- 3 sites in Switzerland
- Volunteers
- 150 people
- Sponsor
- Sonja Stieb, MD
Chronic Kidney Diseases, Caries,Dental
Assessment of The Oral Health Status of Children With Chronic Kidney Disease
The aim of this study is to compare the oral health findings, salivary parameters and disease-related quality of life of children with different stages of Chronic Kidney Disease(CKD), those undergoing dialysis and…
- Conditions
- Chronic Kidney Diseases, Caries,Dental, Quality of Life, Saliva Altered
- Trial name
- NCT06578832
- Testing
- physical and chemical methods, biochemical methods, biochemical tests
- Where
- Turkey (Türkiye)
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Marmara University
Oral Health
Molecular and Organizational Changes in the Human Oral Mucosa During Aging
The objective of this interventional with mucosa et saliva samples, monocentric, transversal and pilot study is to extract vibrational, thermal and dielectric markers obtained by Differential Scanning Calorimetry…
- Trial name
- MMOBUCC (NCT04178668)
- Testing
- Oral mucosa and saliva samples
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Toulouse