Clinical trials: Risk Factor
Cardiometabolic Risk Factors, Mental Health
A Natural History of Cardiometabolic Disease Among US Bhutanese: Developing the Cross-Sectional Bhutanese Community of Central Ohio Health Study to Understand Acculturation as Synergizing Socioenvironmental and Biobehavioral Risk Factors Propagating ...
Background: As of 2021, almost 45 million people in the United States were foreign-born immigrants. South Asians, including people from Bhutan, are the fastest-growing immigrant subgroup in the US.
- Trial name
- NCT06991751
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Mortality in Sickle Cell, Sickle Cell Cardiopulmonary Complications
Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies
Background: People with sickle cell disease (SCD) have problems with their heart, brain, kidneys, liver, and lungs as they age. These problems may improve after transplant. Researchers want to learn how and why this happens.
- Conditions
- Mortality in Sickle Cell, Sickle Cell Cardiopulmonary Complications, Sickle Cell Organ Damage, Sickle Cell Life Expectancy and Risk Factors for Early Death
- Trial name
- NCT05213572
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Risk Factor
Primary Prevention of Cardiovascular Disease Among Female Hospital Employees: The Heart Smart for Women Intervention
This study aims to show that a 6-week program designed specifically for women can lead to sustainable behavior change and improvement in heart disease risk factors over one year among a cohort of 46 female employees recruited…
- Trial name
- Heart Smart (NCT04166097)
- Testing
- Heart Smart Interventional Program
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Northwell Health
Endothelial Dysfunction, Acute Myocardial Infarction (AMI)
Validation of Cor-IS Impedance Spectroscopy Against Ultrasound Flow-Mediated Dilation
This prospective observational study evaluated the Cor-IS bioelectrical impedance spectroscopy technique for the assessment of endothelial function by comparison with ultrasound-based brachial artery flow-mediated dilation (FMD).
- Conditions
- Endothelial Dysfunction, Acute Myocardial Infarction (AMI), Cardiovascular Risk Factors (e.g., Hypertension), Flow Mediated Dilation
- Trial name
- NCT07882550
- Testing
- Cor-IS FMD, Ultrasound FMD
- Where
- Greece
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Cardiac Risk Factors, Healthy
Imaging Techniques in MRI
Background: Magnetic resonance imaging (MRI) scans must be performed according to specified sets of parameters that provide optimal images of each organ and each area of the body.
- Conditions
- Cardiac Risk Factors, Healthy, Healthy Volunteers
- Trial name
- NCT01130545
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Inflammation Biomarkers, Oxidative Stress
Effect of a Ginger-Based Beverage on Inflammation, Oxidative Stress, and Endothelial Function
Randomized, double-blind, parallel, placebo-controlled clinical trial designed and conducted to evaluate the effect of daily consumption of ginger, on parameters related to inflammation, oxidative stress, and endothelial damage…
- Conditions
- Inflammation Biomarkers, Oxidative Stress, Cardiometabolic Risk Factors
- Trial name
- NCT07433998
- Testing
- Functional beverage enriched with ginger, Control beverage without ginger
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Javier Marhuenda
Cardiovascular Diseases, Cardiovascular Risk Factor
Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia (NADI-MyHeartRisk)
This is a pragmatic, risk-stratified, individually randomized controlled trial testing whether personalised WhatsApp-based digital behavioural nudges can improve completion of cardiovascular preventive actions after community…
- Trial name
- NADI-MHR (NCT07879144)
- Testing
- Personalised Digital Behavioural Nudges (NADI-MyHeartRisk Enhanced Pathway)
- Where
- 2 sites in Malaysia
- Volunteers
- 6,588 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Advancement and Research Excellence Institute
Exposome, Non-communicable Diseases (NCD)
Analysis of the Influence of the Exposome in Patients With Non-communicable Diseases
It is well documented that factors such as obesity, a sedentary lifestyle, and comorbidities-including hypertension, diabetes, and dyslipidemia-increase the risk of developing non-communicable diseases (NCDs).
- Conditions
- Exposome, Non-communicable Diseases (NCD), Non-communicable Disease Risk Factors
- Trial name
- EXPOSOME (NCT07879378)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Cardiovascular Risk Factor
South Asian Healthy Lifestyle Initiative (SAHELI)
Research show that South Asians (SA) have a high burden of Cardiovascular Disease (CVD) risk factors of which, poor diet and physical inactivity remain the major lifestyle risk factors in SA.
- Trial name
- SAHELI (NCT03336255)
- Testing
- South Asian Healthy Lifestyle Initiative (SAHELI)
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cardiovascular Risk Factors, Cardiovascular Diseases
Cardiovascular Risk Factors in Mexican Women
Cardiovascular disease is a major cause of morbidity and mortality among women. Cardiovascular risk in women is influenced not only by traditional risk factors, but also by sex-specific factors and social determinants of health.
- Trial name
- REFARCAM Mx (NCT07863674)
- Where
- 3 sites in Mexico
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Medicaweb, S.A.C.V.
Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression
PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis
Heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups in the United States. This clinical trial will test if screening and early treatment of mild heart disease works.
- Conditions
- Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression, Prevention & Control, Premature Atherosclerosis
- Trial name
- PRE-EMPT (NCT07232069)
- Testing
- Rosuvastatin 20 Mg Oral Tablet, Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- 23 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Duke University
Psychosocial Risk Factors
PSYCHosocial Risk Factors of AThletes, Evaluation of a Questionnaire Constructed by CHATGPT
The goal of this observational study was to assess themes generated by ChatGPT to help organize psychosocial risk factors in professional sport.
- Trial name
- PsyChAt (NCT07862855)
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Alcohol Drinking, Drinking Behavior
Reducing Cardiovascular Risks: The Role of Alcohol Use
The purpose of this study is to learn whether avoiding alcohol can improve heart and blood vessel health in adults who regularly drink alcohol and have high blood pressure.
- Conditions
- Alcohol Drinking, Drinking Behavior, At-risk Drinking, Cardiovascular Risk Factor
- Trial name
- NCT07783061
- Testing
- Alcohol Abstinence, Control arm
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- The University of Texas at Arlington
Pre-Eclampsia, Cardiovascular Diseases
Pre-eclampsia and Future Cardiovascular Health: An Underused Opportunity to Improve Family Health
Background: PE (pre-eclampsia) is a common pregnancy-specific vascular hypertensive disease affecting 3-5% of pregnancies. PE independently increases the risk for premature cardiovascular disease (CVD) in mothers and their…
- Conditions
- Pre-Eclampsia, Cardiovascular Diseases, Cardiovascular Risk Factor, Gestational Hypertension
- Trial name
- FINNCARE (NCT04676295)
- Testing
- Face-to-face and web-based lifestyle intervention
- Where
- Finland
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Health Behaviors, Risk Factors
Targeted Health Dialogues in Primary Care
The County Council of Region Skåne, Sweden, has recently initiated Targeted Health Dialogues in primary care. The prevention program includes health dialogues provided by specially trained personnel, collection of clinical and…
- Conditions
- Health Behaviors, Risk Factors, Cardiovascular Diseases, Cancer
- Trial name
- NCT04912739
- Testing
- Targeted health dialogues
- Where
- Sweden
- Volunteers
- 18,000 people
- Sponsor
- Region Skane
Obesity & Overweight, Cardiovascular Risk Factors
Augmenting Primary Care-Based Obesity Management With the Nutu™ Digital Health Platform
This study evaluates the acceptability and clinical effectiveness of integrating the Nutu™ digital health platform into a comprehensive primary care-based behavioral obesity treatment program using a Zelen randomized controlled…
- Trial name
- NCT07404189
- Testing
- FLOW Program, Nutu™ Offer
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Risk Factor, Blood Pressure
Diurnal BP Patterns in Those at Increased Risk of CVD
In health, blood pressure (BP) falls at night by >10% compared with day-time values. This natural dipping pattern is important as without it there is an increased risk of cardiovascular disease (CVD).
- Conditions
- Cardiovascular Risk Factor, Blood Pressure, Arterial Stiffness, Chronic Kidney Diseases
- Trial name
- NCT04522765
- Testing
- Assessment of 24 hour blood pressure and arterial stiffness
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Chronic Pancreatitis, Complication
The Natural History of Chronic Pancreatitis
Chronic pancreatitis (CP) is a disease characterized by inflammation and their replacement by fibrotic tissue. The destruction of pancreatic function and structure are the main complications.
- Conditions
- Chronic Pancreatitis, Complication, Risk Factors
- Trial name
- NCT03324698
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Changhai Hospital
Heart Disease Risk Factors, Healthy Lifestyle
Healthy Communities: A Healthy City Preventive Program on Cardiovascular Health and Well-being (HC)
Healthy Communities is a multidisciplinary health-promotion initiative. The objective of the present study is to determine whether such an intervention will be efficacious to improve cardiovascular health compared to the current…
- Conditions
- Heart Disease Risk Factors, Healthy Lifestyle, Health Behavior
- Trial name
- HC (NCT05974826)
- Testing
- the SI! Program for Secondary Schools (NCT03504059), the Fifty-Fifty Program (NCT02367963)
- Where
- Spain
- Volunteers
- 2,000 people
- Sponsor
- Foundation for Science, Health and Education, Spain
Osteoradionecrosis, Radiotherapy
Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-Radiotherapy
Osteoradionecrosis (ORN) of the jaw is a serious complication that can occur after radiation therapy for head and neck cancers, including oral cavity cancer (OCC).
- Conditions
- Osteoradionecrosis, Radiotherapy, Risk Factors, Oral Cancer
- Trial name
- AOITC (NCT07836829)
- Volunteers
- 1,000 people
- Sponsor
- AO Innovation Translation Center