Clinical trials: Rheumatic Valve Disease
Tricuspid (Valve) Insufficiency (Rheumatic)
PROphylactic triCuspID Annuloplasty in Patients With Dilated Tricuspid Annulus
Patients elected to undergo mitral valve surgery (either repair or replacement) with less equal than moderate (≤+2) tricuspid regurgitation and dilated tricuspid annulus (>21mm/m2) at preoperative echocardiography will be…
- Trial name
- PROCIDA (NCT03129737)
- Testing
- Mitral valve surgery, Tricuspid valve annuloplasty
- Where
- 8 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Ettore Sansavini Health Science Foundation
Rheumatic Heart Disease, Mitral Stenosis
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients
Objective propose: to investigate the effect of Ramipril in suppressing ST2 (suppression of tumorigenicity 2) in the cardiac mitral valve in patients with Rheumatic Heart Disease.
- Conditions
- Rheumatic Heart Disease, Mitral Stenosis, Rheumatic Mitral Stenosis, Fibrosis; Heart
- Trial name
- NCT03991910
- Testing
- Ramipril 5Mg Oral Capsule
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Universitas Indonesia
Mitral Valve Stenosis
Mitral Valve Area Assessment: Comparison With Transthoracic Echocardiography and Magnetic Resonance Imaging
To compare mitral valve area in rheumatic mitral valve stenosis with cardiac magnetic resonance imaging and conventional transthoracic echocardiography.
- Trial name
- NCT00654472
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Florence Nightingale Hospital, Istanbul
Mitral Regurgitation
Left Chamber Function in Mitral Regurgitation and Predicting Outcome After Replacement and Targeting for Early Surgery
The study aims to analyze the role of left ventricular and left atrial functional parameters by speckle tracking echocardiography in predicting outcome after mitral valve replacement and targeting for early intervention compared…
- Trial name
- NCT03870516
- Testing
- Mitral valve replacement, Speckle tracking echocardiography
- Volunteers
- 100 people
- Sponsor
- Assiut University
Heart Valve Diseases, Aortic Valve Stenosis
Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice
Valvular heart disease (VHD) is a growing public health concern globally, with increasing disease burden and rising interest in advanced treatment strategies such as transcatheter interventions.
- Conditions
- Heart Valve Diseases, Aortic Valve Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- NCT07068633
- Where
- 2 sites in South Korea
- Volunteers
- 30,000 people
- Sponsor
- Yonsei University
Rheumatic Heart Disease, Mitral Stenosis
Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region
The purpose of this study is to investigate whether there are genetic differences between patients with rheumatic heart disease and members of the general population.
- Trial name
- NCT02188862
- Where
- 3 sites in Fiji, New Caledonia and 1 more
- Volunteers
- 2,372 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Rheumatic Valve Disease
Clinical Trial of Electro-Acupuncture Preconditioning in Patients Underwent Heart Valve Replacement Surgery
The purpose of this study is to investigate the protective effect of electro-acupuncture preconditioning in patients underwent cardiac surgery.
- Trial name
- NCT00732459
- Testing
- Electro-acupuncture preconditioning
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Atrial Fibrillation, Rheumatic Mitral Stenosis
Rate Control Efficacy in Atrial Fibrillation With Rheumatic Mitral Stenosis: Lenient vs Strict Rate Control Strategies
The goal of this clinical trial is to learn if different types of heart rate control work to improve the clinical outcomes of patients with atrial fibrillation related to rheumatic mitral stenosis in terms of reducing…
- Conditions
- Atrial Fibrillation, Rheumatic Mitral Stenosis, Arrhythmias, Cardiac
- Trial name
- RACE-MS (NCT06409533)
- Testing
- Rate control
- Where
- 3 sites in Indonesia
- Volunteers
- 100 people
- Sponsor
- University of Brawijaya
Mitral Annulus Calcification, Rheumatic Heart Disease
Treating Severe Mitral Valve Annular or Valvular Calcification Using Shockwave Balloon SMARTWAVE
Mitral stenosis (MS) is a heavily symptomatic valvular heart disease. Common causes of MS included chronic rheumatic heart disease (CRHD) and mitral annular calcification (MAC).
- Trial name
- SMARTMAC (NCT06952374)
- Testing
- SmartWave Lithotripsy balloon
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Cheyne-Stokes Respiration, Heart Valve Disease
Effect of Heart Valve Replacement on Cheyne-Stokes Respiration
Sleep disordered breathing, especially central sleep apnea, is common in patients with chronic heart failure. Heart valve replacement could have some effect on central sleep apnea.
- Conditions
- Cheyne-Stokes Respiration, Heart Valve Disease, Central Sleep Apnea
- Trial name
- CSR (NCT01426776)
- Testing
- heart valve replacement
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Nanjing Medical University
Rheumatic Heart Disease
Vitamin K Antagonist in Rheumatic Heart Disease Patients With Mechanical Heart Valves: Our Current Status
VKA in RHD patients with MHV: our current status
- Trial name
- VKA and RHD (NCT07146282)
- Volunteers
- 165 people
- Sponsor
- Ahmed Hassan Rostom Ibrahim
Rheumatic Valve Disease, Atrial Fibrillation
Efficiency of Radiofrequency Ablation for Surgical Treatment of Chronic Atrial Fibrillation With Rheumatic Valve Disease
The purpose of this study is to determine whether concomitant radiofrequency Maze procedure for surgical treatment of chronic atrial fibrillation with rheumatic valve disease could provide better sinus rhythm control, improved…
- Trial name
- NCT01013688
- Testing
- Cardioblate® Surgical Ablation System
- Where
- China
- Volunteers
- 150 people
- Sponsor
- China National Center for Cardiovascular Diseases
Diseases of Mitral Valves, Abnormality of Mitral Valve Annulus (Disorder)
Outcome of Preserved Mitral Valve Apparatus During Mitral Valve Replacement
Are there differences in outcome of mitral valve replacement with preservation of mitral apparatus among rheumatic and/or ischemic mitral lesions?.
- Conditions
- Diseases of Mitral Valves, Abnormality of Mitral Valve Annulus (Disorder), Mitral Valve Replacement
- Trial name
- EarlyOutcome (NCT05438433)
- Testing
- St.Jude bi leaflet prosthetic mitral valve to replace the diseased valve with preservation of both leaflets
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Suez Canal University
Rheumatic Fever, Valvular Heart Diseases
Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria
Background: Nigeria, among other Low and Middle-income countries, bears one of the highest burdens of RHD in Africa, affecting young to middle-aged adults within their productive years.
- Conditions
- Rheumatic Fever, Valvular Heart Diseases, Valvular Cardiomyopathy
- Trial name
- IMPACT-RHD (NCT07625228)
- Testing
- Benzathine Penicillin, Azithromycin (Azithro)
- Volunteers
- 474 people
- Sponsor
- Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Persistent Atrial Fibrillation
Bi-atrial Versus Left Atrial Ablation for Patients With Rheumatic Mitral Valve Disease and Non-paroxysmal Atrial Fibrillation
This study is aimed to compare the efficacy of bi-atrial ablation with left atrial ablation for atrial fibrillation during mitral valve surgery in patients with rheumatic mitral valve disease.
- Trial name
- NCT05021601
- Testing
- Bi-atrial ablation, Left atrial ablation
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- China National Center for Cardiovascular Diseases
Rheumatic Heart Disease, Acute Rheumatic Fever
Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren
Rheumatic heart disease remains a major challenge in low and middle income countries. Early detection of clinically silent valvular lesions by screening echocardiography allows timely implementation of secondary antibiotic…
- Trial name
- NCT02353663
- Testing
- Echocardiography
- Where
- 2 sites in Peru, Switzerland
- Volunteers
- 1,023 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Valve Diseases
Effect of Remote Ischemia Preconditioning on Myocardial Injury in Patients Undergoing Heart Valve Surgery
Remote ischaemic preconditioning has shown its cardiac protective effect during heart surgery including coronary artery bypass graft surgery, congenital heart disease and aneurysm.
- Trial name
- NCT01175681
- Testing
- remote ischaemic preconditioning
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Sun Yat-sen University
Valvular Heart Disease, Rheumatic Heart Disease
Echocardiographic Screening of Pregnant Women During Antenatal Care
Non-obstetrical drivers of adverse pregnancy outcomes are underappreciated. Latent structural heart disease may account for a substantial proportion of adverse pregnancy outcomes in low-resource settings.
- Conditions
- Valvular Heart Disease, Rheumatic Heart Disease, Pregnancy Complications
- Trial name
- NCT04936815
- Testing
- Transthoracic echocardiography
- Where
- 2 sites in Nepal, Switzerland
- Volunteers
- 9,000 people
- Sponsor
- Thomas Pilgrim
Rheumatic Heart Disease, Heart Failure
Gliflozins on HF in Regurgitant Rheumatic Heart
The objective of this trial is to detect impact of Gliflozin on patients with heart failure due to reurgitant rheumatic valve disease
- Trial name
- NCT06097585
- Testing
- SGLT2 inhibitor
- Volunteers
- 150 people
- Sponsor
- Assiut University
Atrial Fibrillation, Rheumatic Heart Disease
Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement
This study evaluates the safety and efficiency of surgical prevention of atrial fibrillation in patients with valvular heart disease and left atrium enlargement
- Trial name
- NCT02474108
- Testing
- surgical prevention of atrial fibrillation, cardiomonitor
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation