Clinical trials: Respiratory Infection, active
Respiratory Recurrent Papillomatosis (RRP), Human Papillomavirus (HPV)
Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP)
Background: Recurrent respiratory papillomatosis (RRP) is a rare disease that causes wart-like growths called papillomas to grow in the airway, most often in the voice box, windpipe, or lungs.
- Conditions
- Respiratory Recurrent Papillomatosis (RRP), Human Papillomavirus (HPV), Papillomavirus Infection, Laryngeal Diseases
- Trial name
- NCT07756840
- Testing
- PRGN-2012, Bevacizumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Lower Respiratory Tract Infection
A Clinical Trial of V175 and V175A in Healthy Adults
Researchers are looking for new vaccines to prevent lower respiratory tract infections. A lower respiratory tract infection is an infection in the lower part of the airways and/or the lungs.
- Trial name
- NCT07855510
- Testing
- V175, V175A, Control Vaccine
- Where
- 2 sites in Australia
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Acute Respiratory Infection
Expanded Diagnostic Strategy in Older Adults Hospitalized With Community-Acquired Acute Respiratory Infection
This study will evaluate whether an expanded diagnostic strategy can reduce antibiotic use in patients aged 65 years or older who are hospitalized with community-acquired acute respiratory infection, without negatively affecting…
- Trial name
- NeuBluMul (NCT07883902)
- Testing
- Expanded Diagnostic Strategy, Conventional Diagnostic Strategy
- Where
- Spain
- Volunteers
- 406 people
- Sponsor
- Santiago Lopez Gil
Acute Upper Respiratory Tract Infections, Nasal Obstruction
Influence of Patient Positioning During Nasal Lavage
Acute upper respiratory tract infections are the primary cause of pediatric visits and hospitalizations in young children. Nasal congestion and mucus accumulation often cause discomfort, feeding difficulties, and respiratory…
- Conditions
- Acute Upper Respiratory Tract Infections, Nasal Obstruction, Bronchiolitis
- Trial name
- nasal lavage (NCT07921680)
- Testing
- Supine position nasal lavage, Semi-sitting position nasal lavage
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Hospital Universitario La Paz
Respiratory Syncytial Virus Infections
A Study on the Immune Response and Safety of Vaccine Against Respiratory Syncytial Virus Given to Chinese Adults 18 to 59 Years of Age at Increased Risk of Respiratory Syncytial Virus Disease
The study will evaluate the immune response of the RSVPreF3 OA investigational vaccine in Chinese adults 18 to 59 years of age (YOA) who are at increased risk of respiratory syncytial virus (RSV) disease, in comparison with the…
- Trial name
- NCT07220109
- Testing
- RSVPreF3 OA vaccine
- Where
- 15 sites in China
- Volunteers
- 750 people
- Sponsor
- GlaxoSmithKline
Respiratory Tract Infections (RTI), Lung Ultrasound
Ultrasound Findings in a Pediatric Population
The purpose of this study is to investigate whether focused ultrasound of the chest can be used in a practical way in children with respiratory symptoms.
- Trial name
- NCT07919613
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- Odense University Hospital
Respiratory Tract Diseases, Influenza (Pandemic)
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of hospitalised…
- Conditions
- Respiratory Tract Diseases, Influenza (Pandemic), Influenza, Community Acquired Pneumonia
- Trial name
- REMAP-CAP (NCT02735707)
- Testing
- Ceftriaxone + Macrolide, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam + Macrolide
- Where
- 408 sites in United States, Australia and 27 more
- Volunteers
- 20,000 people
- Sponsor
- UMC Utrecht
Lower Respiratory Tract Infection
The Impact of MeMed BV® on Management of Patients With Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) ("JUPITER" TRIAL)
This is a Prospective, multi-center study enrolling adults subjects presented to the ED/Urgent care, with symptoms consistent with lower respiratory infection (LRTI).
- Trial name
- NCT05762302
- Testing
- MeMed BV test
- Where
- 10 sites in United States, Israel
- Volunteers
- 1,316 people
- Sponsor
- MeMed Diagnostics Ltd.
Respiratory Tract Diseases, Neoplasms
Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP)
Background: Recurrent respiratory papillomatosis (RRP) is a rare disease that causes wart-like growths in the airways. These growths come back when removed; some people may need 2 or more surgeries per year to keep their airways…
- Conditions
- Respiratory Tract Diseases, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Glandular and Epithelial
- Trial name
- NCT05797246
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Bronchitis, Acute, Community-acquired Pneumonia
Multimodal Stewardship Programme to Improve Antibiotic Prescribing for Children With Lower Respiratory Tract Infections
Children with lower respiratory tract infection (LRTI) are still often prescribed antibiotics in ways that depart from national guidelines.
- Conditions
- Bronchitis, Acute, Community-acquired Pneumonia, Respiratory Tract Infections
- Trial name
- PRACTICE-LRTI (NCT07893834)
- Testing
- PRACTICE-LRTI multimodal antimicrobial stewardship programme
- Where
- Finland
- Volunteers
- 50,000 people
- Sponsor
- Tampere University
Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus (RSV) Infection
A Study to Evaluate Efficacy, Immunogenicity and Safety of a Recombinant Respiratory Syncytial Virus Vaccine in Older Adults Aged 60 Years and Older
This is a randomized, observer-blinded, placebo-controlled Phase III clinical trial to evaluate efficacy, immunogenicity and safety of the Respiratory Syncytial Virus (RSV) Vaccine, LYB005 in participants aged 60 years and older.
- Conditions
- Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus (RSV) Infection, RSV Vaccine
- Trial name
- NCT07908654
- Testing
- LYB005
- Where
- China
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Patronus Biotech Co., Ltd.
COVID -19, COVID - 19
Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study
CIRV2 is a Phase IV randomized, open-label, trial of FDA-approved COVID-19 and/or influenza vaccines (no more than minimal risk) with longitudinal follow-up.
- Conditions
- COVID -19, COVID - 19, COVID 19, Influenza
- Trial name
- CIRV2 (NCT07287137)
- Testing
- Pfizer-BioNTech mRNA COVID-19 vaccine, Novavax recombinant protein vaccine
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Acute Respiratory Tract Infection
HAIQU (Hospital AIr QUality)
The purpose of this research is to assess whether integration of an aerosol biosensor and air quality risk assessment software that integrates into a building management system will improve indoor air quality metrics in hospital…
- Trial name
- HAIQU (NCT07670117)
- Testing
- Self-swab test
- Where
- 3 sites in United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Respiratory Illness, Viral Respiratory Infection
Vocxi Breath Analyzer Study in Pediatric Respiratory Infection
This pilot study will evaluate whether the MBP® Breath Analyzer can collect measurable volatile organic compound signals from pediatric participants with acute respiratory illness and from healthy pediatric controls.
- Trial name
- NCT07902115
- Testing
- MBP® Breath Analyzer
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Upper Respiratory Tract Infections
Probiotic Trial for URTI Prevention in Healthy Adults
This randomized, double-blind, placebo-controlled clinical trial in generally healthy adults aged 18-65 years will compare the incidence of upper respiratory tract infections (URTIs) over 16 weeks between probiotic supplement and…
- Trial name
- NCT07908797
- Testing
- Probiotic Formula
- Where
- Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Viral Lung Infection and Acute Respiratory Failure
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
- Trial name
- TILIA (NCT05624450)
- Testing
- Tozorakimab
- Where
- 473 sites in United States, Argentina and 37 more
- Volunteers
- 3,527 people
- Sponsor
- AstraZeneca
Anogenital Herpes, COVID-19
Viral Infections in Healthy and Immunocompromised Hosts
Background: Viral infections are an important cause of illness and death in hospitalized patients as well as outpatients. New strains of viruses may appear and infect both healthy people and those with weak immune systems.
- Conditions
- Anogenital Herpes, COVID-19, Herpes Labialis
- Trial name
- NCT01306084
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
RSV Infection, Children, Only
RSV Burden in Outpatient and Hospital Settings
Strengthening outpatient low respiratory tract infection surveillance to document the burden of Respiratory Syncytial Virus (RSV)
- Conditions
- RSV Infection, Children, Only, Outpatient, Otitis
- Trial name
- Oursyn (NCT04743609)
- Testing
- nasopharyngeal samples
- Where
- France
- Volunteers
- 1,900 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Acute Respiratory Infection, Acute Respiratory Tract Infection
POS-ARI-ER Observational Study of Acute Respiratory Infections
Acute respiratory infections (ARI) are one of the most frequent reasons for hospital admission and antibiotic use, and can be caused by a broad range of pathogens, including respiratory viruses with proven epidemic potential…
- Trial name
- POS-ARI-ER (NCT05814237)
- Testing
- Data collection
- Where
- 27 sites in Belgium, Croatia and 8 more
- Volunteers
- 11,750 people
- Sponsor
- European Clinical Research Alliance for Infectious Diseases (ECRAID)
Respiratory Syncytial Virus Infection
SPECIAL INVESTIGATION FOR ABRYSVO IN INDIVIDUALS AGED 60 YEARS OR OLDER
This post-marketing study is a multicenter cohort study in individuals aged 60 years or older vaccinated with Abrysvo (RSV vaccine）designed to confirm the safety in individuals aged 60 years or older under actual clinical…
- Trial name
- NCT06546800
- Testing
- RSVpreF vaccine
- Where
- Japan
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Pfizer