Clinical trials: Respiration, Artificial, open to volunteers
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Obstructive Sleep Apnea (OSA)
Evaluation of the Diagnostic Capacity of a Smart Mattress Versus Conventional Polysomnography
This project aims to develop and evaluate an innovative, non-invasive diagnostic system based on a smart mattress for detecting obstructive sleep apnea (OSA), as well as assessing overall sleep quality and identifying periodic…
- Trial name
- NCT07432919
- Testing
- Integrated polysomnographic assessment with smart mattress.
- Where
- 2 sites in Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospital San Pedro de Logroño
Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock
Artificial Intelligence-driven Virtual Standardized Pediatric Patients Trial
Background: China's healthcare system for children faces significant challenges, particularly due to the limited pediatric service capacity of primary healthcare institutions.
- Conditions
- Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock, Hand-foot-and-mouth Disease, Acute Appendicitis
- Trial name
- NCT06699433
- Testing
- Virtual standardized patients (VSPs), Case teaching manuals, Case teaching videos
- Where
- 3 sites in China
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- Southern Medical University, China
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Chest Pain, Stroke Acute
Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).
Improving Telephone Triage in Emergency Calls with AI The Coordinating Centre for Urgencies and Emergencies in Andalusia (CCUE) handles thousands of calls every day.
- Conditions
- Chest Pain, Stroke Acute, Respiratory Failure, Cardiac Arrest (CA)
- Trial name
- TrIAje Project (NCT07247669)
- Where
- Spain
- Volunteers
- 5,000,000 people
- Sponsor
- Centro de Emergencias Sanitarias 061 Andalucía
Chronic Obstructive Pulmonary Disease (COPD)
Monitoring Coughs for the Early Detection of Worsening COPD
This study is for adults with COPD. Flare-ups of COPD, also known as exacerbations, can be serious and lead to hospital stays. The purpose of this research is to see if continuously and automatically monitoring a person's coughs…
- Trial name
- Hyfe-EPOC (NCT07212439)
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Respiration, Artificial, Weaning
Optimal Timing for Spontaneous Breathing Trials
This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU.
- Trial name
- NCT06561295
- Testing
- Later Morning Timing of Spontaneous Breathing Trials
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- Rush University Medical Center
Lung Cancer Diagnosis
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
The PROACT LUNG study is a prospective multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine…
- Trial name
- PROACT-LUNG (NCT06122077)
- Testing
- blood draw
- Where
- 36 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- Freenome Holdings Inc.
Respiration, Artificial, Positive-Pressure Respiration
VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU
Patients undergoing major non-cardiac surgery may require postoperative mechanical ventilation and transfer from the operating room to the intensive care unit (ICU).
- Conditions
- Respiration, Artificial, Positive-Pressure Respiration, Postoperative Complications (Cardiopulmonary), Postoperative Complications
- Trial name
- VENTICRIT (NCT07646249)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva
PEEP, Occult
Evaluation of AI Models in Determining the Optimal PEEP
his study is designed as a prospective observational clinical trial. Patients over 18 years old who are hemodynamically stable and require mechanical ventilation in the Intensive Care Unit (ICU) will be included.
- Trial name
- NCT06844916
- Testing
- AI-Assisted PEEP Optimization
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Mechanical Ventilation, Intensive Care Medicine
Intelligent Lung Support in the Intensive Care Unit
The aim of this observational study is to test the IntelliLung decision support system based on artificial intelligence. This system is intended to help to set the ventilator.
- Trial name
- IntelliLung (NCT06595602)
- Testing
- Artificial intelligence based decision support system (AI-DSS); software
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 530 people
- Sponsor
- Technische Universität Dresden
Mechanical Ventilation, Critical Care, Intensive Care
Use of Connected Glasses to Help the Communication of Non Temporarily Speaking Patients in Intensive Care Unit : a Pilot Study
Hospitalization in an intensive care unit (ICU) is accompanied by major physical and emotional stress for patients, a source of discomfort and a risk factor for post-resuscitation syndrome.
- Conditions
- Mechanical Ventilation, Critical Care, Intensive Care, Artificial Respiration, Communication Aids
- Trial name
- CASTOR-REA (NCT07776795)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome, Barotrauma
Imaging Biomarkers to Stratify the Risk of Barotrauma in ARDS
The high incidence of barotrauma in patients with COVID-19-related acute respiratory distress syndrome (ARDS) (16.1%, with a mortality rate >60%) provides rationale for considering COVID-19 ARDS a paradigm for lung frailty.
- Trial name
- FRAIL ARDS (NCT05816954)
- Testing
- Chest Computed Tomography Scan per normal clinical practice
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Università Vita-Salute San Raffaele
ARDS (Acute Respiratory Distress Syndrome)
Influence of Lung Recruitment Potential on Positive End-Expiratory Pressure (PEEP) Titration Strategies in Acute Respiratory Distress Syndrome (ARDS) Patients.
Acute Respiratory Distress Syndrome (ARDS) is characterized by severe hypoxemia and diffuse alveolar collapse, often requiring invasive mechanical ventilation.
- Trial name
- RECRUIT-PEEP (NCT07603310)
- Testing
- Positive End-Expiratory Pressure (PEEP) Titration guided by Static Compliance, Positive End-Expiratory Pressure (PEEP) Titration guided by Transpulmonary Pressure
- Where
- Chile
- Volunteers
- 52 people
- Sponsor
- Hospital Dr. Franco Ravera Zunino
ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Development and Prospective Validation of the AutoEIT Foundation Model for ARDS
Acute Respiratory Distress Syndrome (ARDS) is a highly heterogeneous condition, making precision mechanical ventilation challenging.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure, Mechanical Ventilation, Ventilator-induced Lung Injury (VILI)
- Trial name
- NCT07898319
- Testing
- AutoEIT Model Training, AutoEIT Blinded Validation
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Ruijin Hospital
Ventilator Weaning, Respiration, Artificial
A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score
Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability…
- Conditions
- Ventilator Weaning, Respiration, Artificial, Respiratory Failure, Extubation Readiness
- Trial name
- REXs (NCT07098611)
- Where
- 7 sites in Chile, Egypt and 4 more
- Volunteers
- 470 people
- Sponsor
- Medipol University
Postmenopausal Period, Postmenopausal Women
AI-Assisted Relaxation and Breathing Training in Postmenopausal Women
This study aims to evaluate the effectiveness of relaxation and breathing training delivered by a physiotherapist and by an artificial intelligence-assisted system in postmenopausal women with non-specific chronic musculoskeletal…
- Trial name
- NCT07302750
- Testing
- Physiotherapist-Guided Relaxation and Breathing Training, Artificial Intelligence-Assisted Relaxation and Breathing Training, Control Group - No Structured Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Baskent University
Chest Pain, Dyspnea
ER-VISION-AI Study
Prospective, multicenter, randomized, open-label, blinded-endpoint (PROBE-like) clinical trial evaluating whether physician-supervised Generative Pre-trained Transformer (GPT)-assisted multimodal diagnostic support improves…
- Conditions
- Chest Pain, Dyspnea, Acute Cardiopulmonary Disease, Emergency Department Patients
- Trial name
- ER-VISION-AI (NCT07727590)
- Testing
- Generative Pre-trained Transformer (GPT)-assisted multimodal visual language model (VLM) diagnostic support, Conventional emergency department diagnostic evaluation
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Respiratory Failure (Pediatric Patients), Pneumonia
AI-Assisted Bronchoscopy Navigation and Diagnostic System for Severe Pneumonia: A Multicenter Prospective Study
This study will evaluate an embodied-intelligence-assisted bronchoscopy navigation and diagnostic system for patients with severe pneumonia who require clinically indicated bronchoscopy.
- Trial name
- EIBRONCH (NCT07230431)
- Testing
- Embodied-Intelligence-Assisted Bronchoscopy Navigation and Diagnostic System (EIBRONCH), Conventional Bronchoscopy (Standard of Care)
- Volunteers
- 100 people
- Sponsor
- Chinese Medical Association
Nursing Care, Pain
Effect of AI-Assisted Respiratory Training on Pain, Fatigue and Respiratory Parameters in Patients After Open Heart Surgery
This randomized controlled study aims to evaluate the effect of artificial intelligence (AI)-assisted respiratory training on fatigue, pain, and respiratory parameters in patients after open heart surgery.
- Conditions
- Nursing Care, Pain, Breathing Exercises, Fatigue Recovery
- Trial name
- NCT07665593
- Testing
- Rhythmic Breathing Group, Range of Motion-Deep Breathing (ROM-DN) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Kocaeli University