Clinical trials: Resistant Arterial Hypertension
Metabolic Cardiovascular Syndrome
Health Improvement After Pregnancy (HIP) Program Randomized Control Trial
Recent Canadian studies, public opinion polls and the Canadian Heart Health Strategy and Action Plan state that women's heart health is a key national priority; it should be addressed through improving heart health awareness and…
- Trial name
- HIP (NCT02077179)
- Testing
- HIP Program
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Queen's University
Obesity, Food Addiction
Impact of a Phone-based Cognitive and Behavioral Therapy on Food Addiction in Patients With Severe or Morbid Obesity
Morbid or severe obesity is a chronic pathology of multifactorial etiology that affects 4.3% of the French population. In these patients, eating disorders are frequent and must be managed as they are considered risk factors with…
- Trial name
- ADALOB (NCT04626570)
- Testing
- Cognitive and Behavioral Therapy
- Where
- 9 sites in France
- Volunteers
- 154 people
- Sponsor
- University Hospital, Tours
Metabolic Syndrome, Hypertension
Study to Determine if Olmesartan Medoxomil Has the Potential to Benefit the Cardiovascular System in Terms of Arterial Protection
This study will analyse the dose-dependent effect of olmesartan medoxomil on the change in arterial stiffness in subjects with hypertension and metabolic syndrome
- Trial name
- ArtStiff (NCT00676845)
- Testing
- olmesartan medoxomil
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 133 people
- Sponsor
- Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Obstructive Sleep Apnea Syndrome, Resistant Hypertension
Efficacy of CPAP Treatment on Blood Pressure of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome
The aim is to evaluate the effect of treatment with Continuous Positive Airway Pressure (CPAP) device on clinic and ambulatory blood pressures (BP) of 200 resistant hypertensive patients with moderate-severe obstructive sleep…
- Trial name
- NCT01508754
- Testing
- Continuous positive airway pressure treatment
- Where
- Brazil
- Volunteers
- 125 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Hypertension, Resistant to Conventional Therapy
Distal Renal Denervation
Objective of this study is to evaluate whether a distal mode of endovascular renal denervation with the treatment performed primarily in segmental branches of renal artery is more effective than conventional mode of the…
- Trial name
- NCT02667912
- Testing
- Distal renal denervation, Conventional renal denervation
- Where
- Russia
- Volunteers
- 55 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Hypertension, Resistant Hypertension
Effects of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects
The aim of this intervention study is to evaluate the acute and chronic effects of different intensity (mild, moderate and high intensity) of aerobic exercise on blood pressure levels of subjects classified as resistant…
- Trial name
- NCT02670681
- Testing
- Aerobic Exercise Training
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of Paraíba
Metabolic Syndrome
The Effect of Allopurinol on Insulin Resistance and Blood Pressure
Studies in animals have found that allopurinol can markedly improve fructose induced metabolic syndrome. In this study we test the hypothesis that allopurinol may lower BP, reduce triglycerides, and improve metabolic parameters…
- Trial name
- NCT00639756
- Testing
- Allopurinol
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Mateo Orfila
Uncontrolled Hypertension
Netrod-Pilot Study of Renal Denervation With NetrodTM Sixelectrode Radiofrequency RDN System
This single-arm, non-randomized, open-label investigation aims to collect safety and efficacy data of the CE-Marked Netrod™ RDN System in treating European patients with primary hypertension in the absence of anti-hypertensive…
- Trial name
- NCT07061054
- Testing
- Netrod™ six-electrode radiofrequency renal denervation system
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Hypertension, Cardiovascular Diseases
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance.
- Trial name
- NCT04715022
- Testing
- Ascorbic acid solution (American Regent Laboratories Inc.), Saline
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Kansas Medical Center
Cardiovascular Diseases, Heart Diseases
Lipoprotein Metabolism in Hypertensive African-Americans
To study relationships among lipoprotein metabolism, hypertension, and hyperinsulinemia-insulin resistance in African American males and females.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hyperinsulinism, Hypertension
- Trial name
- NCT00005709
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Surgery
Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management…
- Conditions
- Cardiovascular Diseases, Surgery, Hypotension, Hypotension on Induction
- Trial name
- PRAM-in-HYPO (NCT05960604)
- Testing
- Passive leg raising
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 660 people
- Sponsor
- Recep Tayyip Erdogan University
Blood Pressure Management, Blood Pressure Monitoring, Ambulatory
Impact of Resistance Training Intensity on Blood Pressure
The goal of the clinical trial is to understand the effect of two resistance training protocols employing different loading intensities (% of 1 repetition maximum; 1-RM), but with standardized effort intensity (2 repetitions in…
- Conditions
- Blood Pressure Management, Blood Pressure Monitoring, Ambulatory, Blood Pressure, High, Blood Pressure
- Trial name
- HEART (NCT06845514)
- Testing
- Condition LL-RE, Control, Condition HL-RE
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Hypertension
Renal Sympathectomy in Treatment Resistant Essential Hypertension, a Sham Controlled Randomized Trial
The purpose of this double blind, randomized and sham controlled study is to determine whether renal denervation in terms of catheter based ablation in the renal arteries is effective in lowering blood pressure in patients with…
- Trial name
- ReSET (NCT01459900)
- Testing
- Renal artery ablation, Renal angiography
- Where
- Denmark
- Volunteers
- 69 people
- Sponsor
- Aarhus University Hospital Skejby
Hypertension, Renal Function
The Vascular and Metabolic Effects of Sunitinib in Patients With Metastatic Renal Cell Carcinoma
Rationale: The introduction of angiogenesis inhibitors, like sunitinib and bevacizumab, has improved the outcome of patients with several types of cancer remarkably.
- Conditions
- Hypertension, Renal Function, Insulin Sensitivity, Renal Cell Carcinoma
- Trial name
- NCT01227213
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Hypertension Secondary to Renal Disease
Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy
The study is designed to investigate the efficacy of renal nerve denervation in treating drug-resistant hypertension in patients with end stage renal disease.
- Trial name
- TreatDialRDN (NCT01881035)
- Testing
- Renal nerve denervation
- Where
- Finland
- Volunteers
- 6 people
- Sponsor
- Turku University Hospital
Essential Hypertension, Metabolic Syndrome
A Clinical Trial to Evaluate the Blood Pressure Control of Telmisartan or Losartan in Essential Hypertensive Patients With Metabolic Syndrome
This is a multi-center, randomized, open-label, active comparator-controlled, phase 4 clinical trial to evaluate the blood pressure control of Telmisartan or Losartan in essential hypertensive patients with metabolic syndrome
- Trial name
- PRISTINE (NCT05843162)
- Testing
- Telmisartan, Losartan
- Volunteers
- 116 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Pulmonary Arterial Hypertension, Insulin Resistance
Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)
The purpose of this study is to investigate the extent to which diet and exercise may improve PAH through the modulation of insulin sensitivity.
- Trial name
- NCT03288025
- Testing
- Nutrition and Exercise
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The Cleveland Clinic
Hypertension, Diabetes
Aliskiren vs Hydrochlorothiazide in Hypertensive Type II Diabetic Patients on Resistance Arteries
This study will be performed only at the Jewish General Hospital. It will investigate the effect of treatment with aliskiren, an inhibitor of renin, a substance produced by the kidney that constricts arteries and raises blood…
- Trial name
- NCT01480791
- Testing
- Aliskiren vs. hydrochlorothiazide, Hydrochlorothiazide
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Metabolic Syndrome
Genetic Assessment of the Patients With Metabolic Syndrome
Metabolic syndrome is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. The exact mechanisms of the complex pathways of metabolic syndrome are not yet completely known.
- Trial name
- GENMetS (NCT01268696)
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Hypertension, Renal
RENABLATE Feasibility Study CS156 (EC12-02) Study of Catheter Based Renal Denervation to Treat Resistant Hypertension
The RENABLATE feasibility study is a prospective, multi-center, non-randomized feasibility study to evaluate the safety and effectiveness of the investigational multi-electrode ablation catheter and integrated ablation system to…
- Trial name
- NCT01756300
- Testing
- Celsius® ThermoCool® RD
- Volunteers
- 35 people
- Sponsor
- Biosense Webster, Inc.