Clinical trials: Repetition Failure
Systolic Heart Failure
Study of Dapansutrile Capsules in Heart Failure
This is a Phase 1b randomized, double-blinded, single-center safety and pharmacodynamics study of sequential cohort, dose-escalating, repeat-dosing of dapansutrile or placebo (4:1 ratio) in subjects with stable systolic heart…
- Trial name
- NCT03534297
- Testing
- dapansutrile capsules
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Olatec Therapeutics, Inc.
Endometrial Injury
Molecular Evaluation of Endometrium After Endometrial Injury
Repeated implantation failure (RIF) is determined when failure of implantation occurred during at least three consecutive IVF attempts while at least one high-grade embryo was transferred in each cycle.
- Trial name
- NCT02480127
- Testing
- PIPELLE Endometrial injury
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Royan Institute
End-Stage Renal Disease
Views on Information Resources for Kidney Transplantation Patients
The goal of this pilot study is to find out whether educational videos can help patients better understand, and remember, important information regarding the benefits and risks of having a kidney transplant.
- Trial name
- NCT07017556
- Testing
- Views on Information Resources for Kidney Transplantation Patients
- Where
- New Zealand
- Volunteers
- 60 people
- Sponsor
- University of Auckland, New Zealand
Metastatic Breast Cancer, Advanced Breast Cancer
Phase II Study With the Trifunctional Antibody Ertumaxomab to Treat Metastatic Breast Cancer Progressing After Endocrine Treatment
The purpose of the study is to demonstrate clinical efficacy of the investigational trifunctional bispecific antibody ertumaxomab for treatment of patients with HER-2/neu 1+ or 2+ (FISH-) expressing advanced or metastatic breast…
- Trial name
- NCT00452140
- Testing
- ertumaxomab
- Where
- 5 sites in Austria, France and 3 more
- Volunteers
- 40 people
- Sponsor
- Neovii Biotech
Heart Failure, Myocardial Infarction
Impact of Intracoronary Injection of Autologous BMMC for LV Contractility and Remodeling in Patients With STEMI
This is multicentre, randomised open-label, controlled, parallel-group phase III study. Its aim is to demonstrate that a triple intracoronary infusion of autologous bone marrow-derived mononuclear cells in addition to state of…
- Trial name
- RACE-STEMI (NCT02323620)
- Testing
- Intracoronary infusion of BM-MC
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- American Heart of Poland
Miscarriage, Early Pregnancy Loss
Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors
About 1 to 3% of women of childbearing age suffer repeated early spontaneous miscarriages (RCF) defined by at least 3 fetal losses before 14 weeks of gestation.
- Trial name
- FALCO (NCT05557201)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure
Repeated Measures Trial of Temporary Automated Manual Ventilation Versus Noninvasive Oxygenation or Conventional Vent
The COVID-19 pandemic has led to a potential shortage of life-saving mechanical ventilators. The purpose of this study is to determine whether a novel simpler to device, the automated bag-valve-mask (BVM) compressor, can be used…
- Trial name
- NCT04369274
- Testing
- Mechanical ventilation with the automated BVM compressor
- Sponsor
- Massachusetts General Hospital
Renal Failure
A Pharmacokinetics and Safety Study of Naproxcinod in Subjects With Impaired Renal Function
To study the pharmacokinetics and safety of naproxcinod in patients with impaired renal function
- Trial name
- HCT3012-X-106 (NCT00674856)
- Testing
- naproxcinod
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NicOx
Infertility
Successful Pregnancy and Delivery After AOA
Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates
- Trial name
- NCT01595815
- Testing
- Calcium ionophore, Strontium chloride (SrCl2)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Maria Fertility Hospital
Repeated Implantation Failure, Normal Fertile
Uterine Microbiome in Women with Repeated Implantation Failure and Normal Fertile Women
Characterization of the uterine microbiome in women with repeated implantation failure as well as in normal fertile women.
- Trial name
- NCT03405883
- Testing
- Vaginal swab + endometrial biopsy
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Heart Failure
Compare the Effects of Single Versus Repeated Intracoronary Application of Autologous Bone Marrow-derived Mononuclear Cells on Mortality in Patients With Chronic Post-infarction Heart Failure
Single or repeated application of autologous bone marrow-derived stem cells to treat chronic post-infarction heart failure
- Trial name
- REPEAT (NCT01693042)
- Testing
- intracoronary infusion of autologous bone marrow-derived cells
- Where
- 6 sites in Germany
- Volunteers
- 81 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Infertility
Effect of Intrauterine Injection of HCG on Pregnancy Outcome in Repeated Implantation Failure Patients
Repeated implantation failure（RIF） is a insurmountable bottleneck in assisted reproductive technology, many studies have considered that the cause of two-thirds of implant failure is the decreased endometrial receptivity.
- Trial name
- NCT02870855
- Testing
- intrauterine injection of HCG
- Where
- China
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Repeated IVF Failure
A Multi-Center Study To Evaluate Multiple Doses of NT100 Following IVF In Women With Repeated IVF Failures (Thrive-IVF)
The purpose of this study is to evaluate the efficacy, safety and tolerability of multiple doses of subcutaneous NT100 vs placebo following in vitro fertilization (IVF) in women with a history of repeated IVF failures.
- Trial name
- Thrive-IVF (NCT01864356)
- Testing
- NT100
- Where
- 21 sites in United States
- Volunteers
- 157 people
- Sponsor
- Nora Therapeutics, Inc.
Osteoarthritis, Knee
Experimental Study of Strength Training to Activate the Quadriceps Muscle After Total Knee Arthroplasty
Background: Progressive strength training is a training modality used in rehabilitation after total knee arthroplasty (TKA). Strength deficits up to 80% in the quadriceps muscle is shown to be present in the operated leg after…
- Trial name
- NCT01713140
- Testing
- 1 strength training set performed until contraction failure
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Conscious Sedation Failure During Procedure
Ketamine Tolerance in Children After Repeated Administrations During Radiotherapy Sessions
Ketamine provides a safety zone for sedated but spontaneously ventilated children especially in remote conditions such as radiotherapy units where sedation is an essential practice for children to keep calm and motionless In this…
- Trial name
- NCT02512055
- Testing
- Ketamine
- Volunteers
- 33 people
- Sponsor
- Baskent University
Repeated Implantation Failure
Follicular Versus Luteal Pipelle in Repeated Implantation Failure Patients
Pipelle was found to increase pregnancy and implantation rates in women undergoing IVF treatment in general, and in particular in repeated implantation failure (RIF).
- Trial name
- NCT01933893
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Assisted Reproduction
Predictive Value of Th1, Th2 and Th17 Cytokines on the Success of Embryo Implantation (ImmuNoFertilité)
Infertility affects approximately 10-15% of the population. The number of assisted reproduction procedures has increased by a factor of 3 to 5.3 worldwide over the last 20 years.
- Trial name
- NCT05783349
- Testing
- Unique blod sample
- Where
- France
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Abortion, Missed, Infertility Unexplained
Autologous Decidual-like Natural Killer Cells Therapy for Reproductive Failure
The aim of this study is to verify the efficacy of in vitro induction of autologous decidual-like NK cells therapy for reproductive failure associated with uterine NK cells abnormalities.
- Conditions
- Abortion, Missed, Infertility Unexplained, Reproductive Disorder
- Trial name
- NCT07230574
- Testing
- NK cell perfusion group
- Volunteers
- 159 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Repeated Implantation Failure
The Study of the Relationship Between TWEAK/Fn14, JAK/STAT3 and IDO in the Immune Microenvironment of Endometrium in Repeated Implantation Failure
The purpose of this study is to find out the possible relationship among TWEAK/Fn14, JAK/STAT3 and IDO as well as their roles in the dysfunction of immune micro-environment of endometrium in people diagnosed as repeated…
- Trial name
- NCT02967419
- Testing
- No Intervention
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ZhangTao
Abortion, Habitual, Infertility Unexplained
Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History
The aim of this study is preliminary exploration of the effectiveness and duration of autologous decidual-like NK cells therapy in improving uterine NK cells dysfunction.
- Conditions
- Abortion, Habitual, Infertility Unexplained, Embryo Implantation, Pre-Eclampsia
- Trial name
- NCT06821685
- Testing
- autologous decidual-like NK cells
- Where
- China
- Volunteers
- 14 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School