Clinical trials: Renal Transplant Patient, active
Kidney Transplant Access, Obese Patients
Access to Kidney Transplant of Obese Patients Beginning Dialysis
Obesity is in constant increase all over the world and affects 35% of the global population according to the World Health Organisation.
- Conditions
- Kidney Transplant Access, Obese Patients, Dialysis, Comorbidities
- Trial name
- Transplantob (NCT04748770)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
End-Stage Renal Disease
Views on Information Resources for Kidney Transplantation Patients
The goal of this pilot study is to find out whether educational videos can help patients better understand, and remember, important information regarding the benefits and risks of having a kidney transplant.
- Trial name
- NCT07017556
- Testing
- Views on Information Resources for Kidney Transplantation Patients
- Where
- New Zealand
- Volunteers
- 60 people
- Sponsor
- University of Auckland, New Zealand
Highly Sensitized Patients Awaiting Kidney Transplant
CAR-T Therapy Targeting CD19 and BCMA in Highly Sensitized Kidney Transplant Participants
The purpose of this study is to assess the safety, tolerability, and efficacy of AZD0120 in highly sensitized adult participants with ESKD awaiting kidney transplant-who, as assessed by investigators, are improbable…
- Trial name
- NCT07350837
- Testing
- AZD0120
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Tongji Hospital
Kidney Transplant Infection
Effectiveness of an Immune-guided Cytomegalovirus Infection Preventive Strategy Compared to a Universal Prophylactic Strategy in Renal Transplant Patients
Cytomegalovirus (CMV) establishes a chronic infection in 60% of the general population. In renal transplant recipients, it is responsible for morbidities occurring mainly in the first 6 months after transplantation.
- Trial name
- CYTOPREV (NCT05708508)
- Testing
- ROVALCYTE
- Where
- France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Rouen
Neuroblastoma, Rhabdomyosarcoma
Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors
Hematopoietic stem cell transplantation can cure patients with blood cancer and other underlying diseases. αβ-T cell and B cell depletion has been introduced to decrease GVHD and PTLD and has demonstrated effectiveness for…
- Conditions
- Neuroblastoma, Rhabdomyosarcoma, Synovial Sarcoma, Peripheral Nerve Sheath Tumors
- Trial name
- NCT06625190
- Testing
- Miltenyi CliniMACS Prodigy ® system, Zoledronic acid
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Florida
Graft Rejection, Kidney Transplantation
TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Response to Extracorporeal Photo-aphereSiS
With this project, the research team aims to identify the molecular pathways associated with the response to extracorporeal photonchemioapheresis (ECP) in kidney or lung transplant patients suffering from chronic rejection, by…
- Conditions
- Graft Rejection, Kidney Transplantation, Lung Transplantation, Antibody-Mediated Rejection
- Trial name
- TRACKLESS (NCT07316829)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Kidney Stones, Urinary Stone Disease / Nephrolithiasis
Fecal Microbiota Transplantation in Kidney Stone Patients
This open-label pilot study evaluates whether oral microbial transplant therapy can change urine factors associated with recurrent calcium-oxalate kidney stones.
- Conditions
- Kidney Stones, Urinary Stone Disease / Nephrolithiasis, Recurrent Calcium-oxalate Kidney Stones
- Trial name
- FMT IND (NCT05516472)
- Testing
- Microbial Transplant Therapy (FMT CAPSULE DE / FMPCapDE / MTP-CP101), Vancomycin and neomycin antibiotic pretreatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Joshua Stern
Kidney Transplant Failure and Rejection
Treatment of Early Borderline Lesions in Low Immunological Risk Kidney Transplant Patients (TRAINING)
Background: Subclinical inflammation, including borderline lesions (BL), is very common (30-40%) after kidney transplantation (KT), even in low immunological risk patients, and can lead to interstitial fibrosis/tubular atrophy…
- Trial name
- NCT04936282
- Testing
- Grafalon, Normal Treatment
- Where
- 4 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Fundación Canaria Instituto de Investigación Sanitaria de Canarias
Kidney Transplantation in Highly Sensitized Patients
Imlifidase Prior to Kidney Transplant in Highly Sensitised Children
The goal of this clinical trial is to learn about the efficacy and safety of imlifidase in highly sensitized paediatric patients, 1-17 years old, with end stage renal disease (ESRD).
- Trial name
- DINKY (NCT05753930)
- Testing
- Imlifidase
- Where
- 6 sites in Finland, France and 3 more
- Volunteers
- 10 people
- Sponsor
- Hansa Biopharma AB
Kidney Transplantation, Physical Function
Online Exercise Program for Transplant Patients: A Pilot Study
Kidney transplant recipients frequently experience reduced physical function, muscle weakness, low levels of physical activity, and an increased risk of cardiovascular and metabolic complications, despite improvements in survival…
- Conditions
- Kidney Transplantation, Physical Function, Muscle Weakness Condition, Physical Activity
- Trial name
- TrasplanCEU (NCT07923188)
- Testing
- Online Therapeutic Exercise Programme, Usual Care Control Group
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Cardenal Herrera University
Kidney Transplantation in Highly Sensitized Patients
Survival and Dialysis Independency in Highly Sensitized Patients After Desensitization With Imlifidase and Tx of Kidneys
The goal of this follow-up study is to learn about long-term patient survival and graft function in highly sensitized patients who have received desensitization treatment with imlifidase or standard of care (SoC) in order to…
- Trial name
- ConfIdeSLTFU (NCT05714514)
- Testing
- Imlifidase administered in the ConfIdeS study, Best available treatment administered in the ConfIdeS study
- Where
- 14 sites in United States
- Volunteers
- 64 people
- Sponsor
- Hansa Biopharma AB
Kidney Transplant, Kidney Failure
Preventing Delayed Graft Function in Kidney Transplant Patients
The health and quality of life benefits of kidney transplantation are reduced by delayed graft function (DGF). There are a number of modifiable risk factors associated with DGF, such as intraoperative hypotension, the type of…
- Conditions
- Kidney Transplant, Kidney Failure, Kidney Injury
- Trial name
- PDF (NCT06724211)
- Testing
- Treatment bundle of care, Control Group
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Kidney Transplant Failure and Rejection
Efficiency of Everolimus for the Treatment of Kidney Transplanted Patients Presenting a Missing Self-induced NK-mediated Rejection
Background: Long-term success of organ transplantation is limited by the inexorable loss of graft function due to rejection. Prevalent dogma defends that allograft rejection is exclusively mediated by the adaptive immune system…
- Trial name
- STARR (NCT03955172)
- Testing
- Everolimus
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Hypogonadism, Male, End Stage Renal Disease (ESRD)
TRT as an Adjunctive ERAS Therapy in ESRD Patients Undergoing Kidney Transplantation
This prospective study aims to evaluate the safety and efficacy of testosterone replacement therapy (TRT) as an adjunct to an enhanced recover after surgery (ERAS) protocol in men with end-stage renal disease (ESRD) undergoing…
- Conditions
- Hypogonadism, Male, End Stage Renal Disease (ESRD), Kidney Transplant
- Trial name
- NCT07287800
- Testing
- Testosterone Replacement Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Los Angeles
Pulmonary Hypertension, Kidney Transplantation
Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation
The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.
- Conditions
- Pulmonary Hypertension, Kidney Transplantation, Haemodialysis
- Trial name
- NCT04842591
- Testing
- exercise echocardiography
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Graz
Diabete Type 1, Chronic Kidney Disease
Breakthrough - T1DM and Chronic Kidney Disease
Single arm- subject treated with Tegoprubart and everolimus. The purpose of this research is to gather information on the safety and effectiveness of investigational regimen containing 2 experimental components: An…
- Trial name
- NCT07592000
- Testing
- Tegoprubart, Islet Cell Transplant
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Kidney Disease, Chronic, Renal Transplant Failure
The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD
Rationale: Sodium glucose co transporter 2 (SGLT2) inhibitors are a relatively new class of agents, originally developed as oral antihyperglycemic drugs.
- Conditions
- Kidney Disease, Chronic, Renal Transplant Failure, Heart Failure, Kidney Failure
- Trial name
- NCT05374291
- Testing
- Dapagliflozin 10 mg/day (oral)
- Where
- 101 sites in Australia, Belgium and 4 more
- Volunteers
- 1,750 people
- Sponsor
- University Medical Center Groningen
Long Term Efficacy and Safety
A Long-term Follow-up Trial of Patients Previously Treated With Imlifidase Prior to Kidney Transplantation and a Non-comparative Transplanted Patient Group
A prospective, post-authorisation long-term follow-up trial of patients previously treated with imlifidase prior to kidney transplantation, including a non-comparative concurrent reference cohort.
- Trial name
- PAES-LTFU (NCT05937750)
- Testing
- Imlifidase administered in the 20-HMedIdeS-19 (PAES) study, Best available treatment administered in the 20-HMedIdeS-19 (PAES) study
- Where
- 14 sites in Austria, Czechia and 5 more
- Volunteers
- 150 people
- Sponsor
- Hansa Biopharma AB
Kidney Transplant Immunosuppression
Use of DNA Testing and Gene Expression Profiling to Help Transition Kidney Transplant Recipients to Belatacept-only Immunosuppression
The purpose of the study is to provide immunosuppression weaning and/or monitoring for an additional 12-months to evaluate the safety and efficacy of belatacept monotherapy in patients previously enrolled in the clinical trial…
- Trial name
- NCT06336863
- Testing
- Allosure and TruGraf, Immunosuppression Taper
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Kidney Injury, Kidney Transplant
MEMRI and Kidney Disease
Acute kidney injury (AKI) is common and costly.1 Although patients who suffer an episode of AKI may recover, many will go on to develop cardiovascular disease and chronic kidney disease (CKD).
- Conditions
- Acute Kidney Injury, Kidney Transplant, Vasculitis, Chronic Kidney Disease(CKD)
- Trial name
- NCT06698614
- Testing
- MRI, Blood tests, Urine tests
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Edinburgh