Clinical trials: Refractive Errors
Astigmatism, Ametropia
Optimization for Toric Contact Lenses
The aim of this study is to evaluate the agreement between subjective and objective toric lens prescriptions.
- Trial name
- NCT07557030
- Testing
- Lens 1 ( stenfilcon A ), Lens 2 ( comfilcon A )
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- CooperVision International Limited (CVIL)
Refractive Errors
Consistency of an Automated Subjective Refraction Program Between Personnel With Diverse Professional Backgrounds and Senior Optometrists
This study aims to evaluate the performance of automated subjective refraction performed by operators with different professional backgrounds.
- Trial name
- NCT07891884
- Testing
- Nurse-Operated Automated Subjective Refraction, Village Doctor-Operated Automated Subjective Refraction, Lay Personnel-Operated Automated Subjective Refraction
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Refractive Errors
Evaluation of the Agreement Between Automated Program-Operated Phoropter Subjective Refraction and Optometrist-Performed Subjective Refraction
This study aims to evaluate the performance of an automated subjective refraction system that operates a digital phoropter. By comparing its results with those obtained through conventional subjective refraction performed by an…
- Trial name
- NCT07891897
- Testing
- Automated Program-Controlled Subjective Refraction, Optometrist-Performed Subjective Refraction
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia, Amblyopia
Access to EyeGlasses for School-aged Children
Uncorrected refractive error is a leading cause of visual impairment in children and can impact vision, quality of life, and academic performance.
- Conditions
- Myopia, Amblyopia, Hyperopia, Refractive Errors
- Trial name
- ATEG (NCT05588362)
- Testing
- Fitz Frames 3-D Printed Glasses
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Presbyopia, Ametropia
Clinical Trial With Artiflex Presbyopic (Artiplus)
The purpose of this clinical trial is to evaluate the effectiveness and safety of the multifocal Artiflex Presbyopic (Artiplus) intraocular lens.
- Conditions
- Presbyopia, Ametropia, Refractive Errors, Myopia
- Trial name
- NCT04632784
- Testing
- Artiflex Presbyopic (Artiplus) implantation
- Where
- 7 sites in South Korea, Spain
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ophtec BV
Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression.
This is a mono-centre, prospective, one-arm, unmask clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation compared to a single vision spectacle lens from…
- Trial name
- NCT05534022
- Testing
- Test myopia control lenses (BSL)
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Essilor International
Presbyopia, Near Vision
Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of Presbyopia
Phase 3 Efficacy Study to evaluate the Safety and Efficacy of LNZ100 \& LNZ101 for the Treatment of Presbyopia
- Conditions
- Presbyopia, Near Vision, Refractive Error, Eye Diseases
- Trial name
- CLARITY 2 (NCT05728944)
- Testing
- Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle
- Where
- 17 sites in United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Myopia, Refractive Errors
Dual-Action Lenses for Slowing Myopia in Children and Teens: A Randomized, Double-Blind Trial
This is a single-center, randomized, double-blind, controlled study to test whether a new type of eyeglass lens - a "dual-action" lens that combines two technologies (multiple defocus zones and dot diffusion) - can slow the…
- Trial name
- NCT07854457
- Testing
- Dual-Action Myopia-Control Spectacle Lens, Stellest Myopia-Control Spectacle Lens（Highly Aspherical Lenslet Target / HALT Lens）
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Refractive Errors
Treatment of Residual Hypermetropic Refraction on Young Patients After LASIK Using Human Fresh Corneal Lenticule Implantation With ReLEX Smile Surgery
LASIK (laser-assisted in situ keratomileusis) is a type of refractive surgery for correction of myopia, hyperopia and astigmatism.
- Trial name
- Relex-Smile (NCT04793893)
- Testing
- ReLex Smile
- Where
- Kosovo
- Volunteers
- 42 people
- Sponsor
- Eye Hospital Pristina Kosovo
Myopia, Myopia Progression
Comparing Myopia Control Spectacle Lenses and Standard Single Vision Spectacle Lenses in Children With Myopia
The purpose of this clinical trial is to compare a new myopia control spectacle lens with a standard single vision spectacle lens in slowing the progression of myopia (nearsightedness) in healthy children aged 6 to under 11…
- Trial name
- PEARL (NCT07839091)
- Testing
- Investigational Myopia Control Spectacle Lens, Single Vision Spectacle Lens
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Essilor International
Refractive Errors, Cycloplegic Refraction
ML Models Predicting Cycloplegic Refractive Error Based on Non-Cycloplegic Parameters in Myopic Adults
This study presents a machine learning model that predicts cycloplegic refraction in adults with myopia using standard non-cycloplegic eye measurements, aiming to reduce the need for cycloplegic drops while still identifying…
- Conditions
- Refractive Errors, Cycloplegic Refraction, Accommodation
- Trial name
- NCT07690813
- Testing
- Machine learning model for predicting cycloplegic refraction
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Refractive Errors
Correcting Myopia Among Secondary School Children to Increase Academic High School Attendance Rates in Rural Communities
Chinese children are some of the most short-sighted in the world, but only one in five children in poor areas who needs glasses has them.
- Trial name
- SWISH (NCT04077086)
- Testing
- Spectacles
- Where
- 3 sites in China, United Kingdom
- Volunteers
- 10,000 people
- Sponsor
- Queen's University, Belfast
Posterior Capsule Opacification, Pseudophakia
IOL Position and Refractive Change After Nd:YAG Laser Posterior Capsulotomy
After cataract surgery, the thin natural membrane that holds the artificial lens in place can slowly turn cloudy. This is called posterior capsule opacification. It makes vision blurry and can cause glare.
- Conditions
- Posterior Capsule Opacification, Pseudophakia, Refractive Errors
- Trial name
- YAG-IOL-POS (NCT07802145)
- Testing
- Nd:YAG laser posterior capsulotomy, Anterior segment swept-source OCT, Swept-source optical biometry
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Vienna Hospital Association
Refractive Errors
Clinical Validation Study Protocol for SmartEyes Smart Optometry Measurement Device (Medical Device Clinical Validation Study)
This study aims to evaluate the SmartEyes smart refraction measurement device in two phases under real outpatient optometry room visits at Wuhan Children's Hospital.
- Trial name
- CVSP-SOMD (NCT07803094)
- Testing
- SmartEyes smart refraction measuring device, Topcon KR800, Subjective refraction
- Volunteers
- 200 people
- Sponsor
- The Hong Kong Polytechnic University
Tomography, Visual Acuity
Keratoconus - Screening in Patients With Downs Syndrome
The initial purpose of the study is to determine the true tomographic based age-specific prevalence of keratoconus among Danish patients with Downs Syndrome.
- Conditions
- Tomography, Visual Acuity, Refraction Error
- Trial name
- NCT07800975
- Where
- Denmark
- Volunteers
- 137 people
- Sponsor
- University of Aarhus
Optical Coherence Tomography, Refractive Errors
To Study the Effects of Refractive Surgery on OCT Measurements in the Eye
Corrective eye surgeries, such as Lasik, are widely used to correct focusing problems such as myopia, or nearsightedness. Often these patients develop other conditions like myopic maculopathy or glaucoma which require monitoring…
- Conditions
- Optical Coherence Tomography, Refractive Errors, Myopia
- Trial name
- NCT05856786
- Testing
- Optical coherence tomography
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Nebraska
Refractive Errors
Clinical Investigation of a Femtosecond Laser for Corneal Flap Creation
The purpose of this study is to see how safe the WaveLight Ultraviolet Femtosecond Laser, Model 1026 (UV fs-Laser), is for creating corneal flaps during laser-assisted in situ keratomileusis (LASIK) surgery.
- Trial name
- NCT07036835
- Testing
- LASIK Surgery, UV fs-Laser, IR fs-Laser
- Where
- Australia
- Volunteers
- 128 people
- Sponsor
- Alcon Research
Axial Myopia, Refractive Errors
Evaluation of Progression of Myopia in Children Treated With Vitamin B2 and Outdoor Sunlight Exposure
The investigators plan on using riboflavin (a Vitamin that can easily be taken orally each day) and having the children involved in the study play outside (where there is UV light created by the sun) in order to prevent the eye…
- Trial name
- NCT03552016
- Testing
- Oral Riboflavin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Refractive Errors, Myopia
Evaluation of Delefilcon A Contact Lenses
The purpose of the study is to evaluate the lens fit characteristics of delefilcon A contact lenses with different base curves and diameters.
- Trial name
- NCT06884202
- Testing
- Delefilcon A contact lenses with different base curves and diameters, Delefilcon A contact lenses with standard base curves and diameters
- Where
- 16 sites in United States
- Volunteers
- 267 people
- Sponsor
- Alcon Research
Presbyopia
PROductivity Study of Presbyopia Elimination in Rural-dwellers II
The investigators will conduct a randomized-controlled trial. The participants will be textile workers aged 35 years and above with uncorrected presbyopia who are employed by a single Indian garment manufacturer - employed by…
- Trial name
- PROSPERII (NCT04629820)
- Testing
- Spectacles
- Where
- India
- Volunteers
- 682 people
- Sponsor
- Queen's University, Belfast