Clinical trials: Radiculopathy
Lumbosacral Radiculopathy
Efficacy and Safety of VER-01 in the Treatment of Participants With Chronic Painful Lumbosacral Radiculopathy
The aim of the trial is to prove the efficacy and safety of VER-01 compared to placebo in patients with chronic painful lumbosacral radiculopathy (PLSR) for whom drug treatment is indicated and previous optimized treatments with…
- Trial name
- EXPAND (NCT06956014)
- Testing
- VER-01
- Where
- 23 sites in United States
- Volunteers
- 810 people
- Sponsor
- Vertanical GmbH
Lumbosacral Radicular Pain, Sciatic Radiculopathy
Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy
The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline
- Conditions
- Lumbosacral Radicular Pain, Sciatic Radiculopathy, Sciatic Leg Pain, Sciatica
- Trial name
- NCT07264270
- Testing
- C-1101
- Where
- 6 sites in United States, Australia
- Volunteers
- 24 people
- Sponsor
- Consano Bio
Cervical Radiculopathy, Cervical Myelomalacia
Cervical Spinal Cord Signal Abnormalities in Patients With Cervical Radicular Pain
This prospective observational study aims to determine the prevalence of cervical spinal cord signal abnormalities, including myelomalacia, among adult patients presenting to a tertiary pain clinic with cervical radicular pain.
- Trial name
- CSCS (NCT07823426)
- Testing
- Clinical and Cervical MRI Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Ankara City Hospital Bilkent
Lumbar Radiculopathy
Comparative Effect Between Mulligan Leg Raise and Spinal Mobilization With Limb Movement in Lumbar Radiculopathy
This study examines the comparative effects of mulligan leg raise traction and Spinal Mobilization with Leg Movement (SMWLM) on lumbar radiculopathy
- Trial name
- NCT07887685
- Testing
- Mulligan Leg Raise traction, Spinal Mobilization with Limb Movement - SMWLM
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Unilateral S1 Nerve Root Pain
Comparison of Efficacy of Caudal Versus Transforaminal Epidural Steroid Injections in Unilateral S1 Nerve Root Pain: A Randomized Controlled Trial
This study compares caudal and transforaminal epidural steroid injections for treating unilateral S1 nerve root pain. It evaluates pain relief, functional improvement, treatment satisfaction, quality of life, and complications…
- Trial name
- NCT07833553
- Testing
- Caudal Epidural Steroid Injection (CEI), Transforaminal Epidural Steroid Injection (TFI)
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- University of Health Sciences Lahore
Cervical Stenosis, Myelopathy
Assessing Microbiome in Primary Anterior Cervical Fusion Patients
Patients who are about to undergo cervical fusion surgery at Hospital for Special Surgery (HSS) are being asked to take part in this research study.
- Conditions
- Cervical Stenosis, Myelopathy, Cervical Spondylosis With Myelopathy, Degenerative Disc Disease
- Trial name
- NCT07877766
- Testing
- Primary Anterior Cervical Discectomy Procedures
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Hospital for Special Surgery, New York
Chronic Neuropathic Pain, Post-Stroke Pain
Transcranial Magnetic Stimulation for Chronic Neuropathic Pain
Chronic neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system. It is highly prevalent, debilitating, and challenging to treat.
- Conditions
- Chronic Neuropathic Pain, Post-Stroke Pain, Trigeminal Neuralgia, Nerve Injury
- Trial name
- NCT05593237
- Testing
- High Frequency rTMS, Low Frequency rTMS
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Lumbar Radiculopathy
Tecar Therapy in Patients With Lumbar Radiculopathy
Lumbar radiculopathy is a common cause of low back and leg pain, most frequently resulting from lumbar disc herniation and nerve root irritation.
- Trial name
- NCT07480252
- Testing
- Tecar Therapy, Conventional Physical Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Izmir City Hospital
Lumbar Spinal Stenosis With Bilateral Lower Extremity Radiculopathy
Effect of Skin Stretching on Pain Reduction During Local Anesthetic Injections: A Randomized Clinical Study
The purpose of this study is to investigate the potential analgesic effect of skin stretching during local anesthetic injection in patients with chronic lumbar pain and bilateral lower extremity radiculopathy undergoing selective…
- Trial name
- NCT06976580
- Testing
- conventional local anesthetic injection, skin stetching technique for local anesthetic injection
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Yonsei University
Radiculopathy Lumbar
Clinical and MRI Factors Associated With Procedural Difficulty in Lumbar TFESI
The technical difficulty of transforaminal epidural steroid injection (TFESI) may be influenced by patient-related characteristics, the target spinal level, a history of lumbar surgery, the presence of spinal instrumentation, and…
- Trial name
- NCT07870720
- Volunteers
- 190 people
- Sponsor
- Selcuk University
Lumbar Radiculopathy, Lumbar Disc Herniation
Randomized Evaluation of Lumbar Injection Effectiveness and Function
The goal of this clinical trial is to learn whether the Triojection® System is safe and effective for treating symptomatic lumbar radiculopathy (leg pain caused by nerve irritation or compression) resulting from a contained…
- Conditions
- Lumbar Radiculopathy, Lumbar Disc Herniation, Contained Herniated Lumbar Disc
- Trial name
- RELIEF (NCT07856810)
- Testing
- Triojection® System, Selective Nerve Root Block (SNRB)
- Volunteers
- 300 people
- Sponsor
- SpinaFX Medical Inc.
Spinal Stenosis Cervical, Radiculopathy, Cervical Region
Hard Cervical Collar Use Following Posterior Cervical Fusion
Postoperative immobilization with a hard cervical collar following posterior cervical fusion remains common practice despite limited evidence demonstrating improved clinical outcomes.
- Conditions
- Spinal Stenosis Cervical, Radiculopathy, Cervical Region, Posterior Cervical Fusion, Spondylosis, Cervical
- Trial name
- NCT07789288
- Testing
- Hard Cervical Collar
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Georgetown University
Lumbar Radiculopathy
Effect of Transfer of Energy Capacitive and Resistive on Chronic Discogenic Sciatica
The goal of this clinical trial is to evaluate the effect of Transfer of Energy Capacitive and Resistive (TECAR) on pain, functional disability and electrophysiological parameters in adults with chronic discogenic sciatica .
- Trial name
- NCT07841405
- Testing
- Transfer of Energy Capacitive and Resistive (TECAR) therapy, conventional physical therapy program
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Stroke, Spinal Cord Diseases
Use of tDCS Stimulation in Neurological and Gynaecological Conditions
The aim of the study is to test the effect of tDCS stimulation on upper and lower limb function in neurological patients and to reduce pain in gynaecological patients.
- Conditions
- Stroke, Spinal Cord Diseases, Nerve Root Disorder, Endometriosis
- Trial name
- tDCS (NCT06891690)
- Testing
- tDSC stimulation
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Cervical Disc Herniation, Intervertebral Disc Displacement
Gelified Radiopaque Ethanol (Absolute Gel) in Cervical Disc Herniation: an Observational Study in Routine Clinical Practice (GENESIS)
GENESIS is a single-centre, observational, non-interventional, no-profit, investigator-initiated study conducted at Ospedale di Vimercate, ASST Brianza (Italy).
- Conditions
- Cervical Disc Herniation, Intervertebral Disc Displacement, Neck Pain, Chronic Pain
- Trial name
- GENESIS (NCT07832929)
- Testing
- Absolute Gel (radiopaque gelified ethanol)
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Aurel Mengri
Cervical Radiculopathy
Does the Combination of Cervical and Sacroiliac Mobilization Enhance Clinical Outcomes in Cervical Radiculopathy?
This study evaluated whether adding mobilization and myofascial techniques targeting the lumbar and sacroiliac regions to cervical-focused manual therapy provides additional clinical benefits in individuals with cervical…
- Trial name
- NCT07831070
- Testing
- Cervical manual-focused manual therapy, Extended Regional Manual Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
Chronic Neuropathic Pain, Radiculopathy
Hypersound Treatment for Chronic Neuropathic and Radicular Pain
This study will evaluate whether the investigational Hypersound system reduces pain in adults with chronic neuropathic or radicular pain.
- Conditions
- Chronic Neuropathic Pain, Radiculopathy, Sciatica, Peripheral Neuropathic Pain
- Trial name
- NCT07831447
- Testing
- Hypersound RF-PNS system
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Hypersound Medical Inc
Lumbar Radiculopathy, Chronic Pain
Effectiveness and Safety of Pharmacopuncture Therapy for Chronic Lumbar Radiculopathy: A Multicenter, Pragmatic, Randomized, Comparative Clinical Trial
A pragmatic clinical study to compare the effectiveness of pharmacopuncture and physical therapy strategies in patients with chronic lumbar radiculopathy
- Trial name
- NCT07832318
- Testing
- Pharmacopuncture, Physical Therapy
- Where
- 4 sites in South Korea
- Volunteers
- 92 people
- Sponsor
- Jaseng Medical Foundation
Chronic Low Back Pain, Radiculopathy
Effect of Alexithymia on Treatment Response to Transforaminal Epidural Steroid Injections in Chronic Low Back Pain
Low back pain and lumbosakral radiculopathy represent common clinical challenges substantially diminishing health-related quality of life and work productivity.
- Conditions
- Chronic Low Back Pain, Radiculopathy, Alexithymia
- Trial name
- NCT07828132
- Testing
- Psychometric Assessment and Clinical Follow-up Battery
- Volunteers
- 60 people
- Sponsor
- Marmara University
Lumbosacral Radiculopathy
Augmented Posterior Oblique Sling Activation on Lumbopelvic Recruitment Pattern in Lumbosacral Radiculopathy
The current study aims to determine the impact of augmented posterior oblique sling activation on lumbopelvic recruitment pattern and functional outcomes in patients with unilateral lumbosacral radiculopathy.
- Trial name
- NCT06558383
- Testing
- augmented posterior oblique sling activation, selected physical therapy program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University