Cervical RadiculopathyNCT07831070
Does the Combination of Cervical and Sacroiliac Mobilization Enhance Clinical Outcomes in Cervical Radiculopathy?
A study testing Cervical manual-focused manual therapy and Extended Regional Manual Therapy in people with Cervical Radiculopathy, run by Fenerbahce University at 1 site in Turkey (Türkiye).
Trial summary
This study evaluated whether adding mobilization and myofascial techniques targeting the lumbar and sacroiliac regions to cervical-focused manual therapy provides additional clinical benefits in individuals with cervical radiculopathy. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Cervical Radiculopathy
- What is being tested?
- Cervical manual-focused manual therapy and Extended Regional Manual Therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 42 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 20 Jan 2024to 20 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Inclusion Criteria:The diagnosis of cervical radiculopathy was established by a specialist neurosurgeon based on clinical examination and magnetic resonance imaging (MRI) findings. Individuals aged 18-55 years with a confirmed diagnosis of cervical radiculopathy and who were considered clinically appropriate for manual therapy were screened for eligibility -
Exclusion Criteria:criteria were previous cervical spine surgery; rheumatologic, vestibular, neurological, or cardiopulmonary disorders that could interfere with assessment or treatment; limb-length discrepancy; scoliosis; a history of fracture involving the spine, sacroiliac joint (SIJ), or lower extremities; mechanical low back pain; receipt of exercise-based treatment or physical therapy within the preceding 6 months; and pregnancy
-
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Fenerbahce University
Ataşehir, Istanbul, 34758
About this study
This study evaluated whether adding mobilization and myofascial techniques targeting the lumbar and sacroiliac regions to cervical-focused manual therapy provides additional clinical benefits in individuals with cervical radiculopathy. Changes in pain, disability, cervical range of motion, and sacroiliac joint (SIJ) clinical findings were assessed. The study also examined whether changes in SIJ clinical findings were associated with changes in cervical clinical outcomes, thereby exploring the relationship between cervical and lumbopelvic responses to an extended regional manual therapy approach.
- Conditions
- Cervical Radiculopathy
- Being tested
- Cervical manual-focused manual therapy, Extended Regional Manual Therapy
- Keywords
- cervical radiculopathy, manual therapy, sacroiliac
- Medical subject headings
- Radiculopathy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cervical manual-focused manual therapyOther
Manual therapy targeting the cervical region was administered to individuals with cervical radiculopathy. The intervention consisted of cervical-focused manual therapy techniques aimed at addressing pain, mobility limitations, and clinical symptoms associated with cervical radiculopathy. All interventions were delivered by the same clinician with 21 years of clinical experience in manual therapy.
Extended Regional Manual TherapyOther
Additional manual therapy targeting the lumbar and sacroiliac regions was administered in combination with cervical-focused manual therapy. The intervention included mobilization and myofascial techniques directed at the lumbar and sacroiliac regions. This extended regional approach was designed to evaluate whether treatment beyond the cervical region provides additional effects on cervical clinical outcomes and sacroiliac joint clinical findings. All interventions were delivered by the same clinician with 21 years of clinical experience in manual therapy.
| Study group | Role | What they receive |
|---|---|---|
| Cervical-Focused Manual Therapy | Active comparator | Participants received manual therapy interventions targeting the cervical region. Receives: Other: Cervical manual-focused manual therapy |
| Extended Regional Manual Therapy | Experimental | Participants received cervical-focused manual therapy combined with additional mobilization and myofascial techniques targeting the lumbar and sacroiliac regions. Receives: Other: Cervical manual-focused manual therapy; Other: Extended Regional Manual Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cervical Radiculopathy Impact Scale (CRIS)
Cervical Radiculopathy Impact Scale (CRIS)
Measured: Baseline and immediately after the intervention
Neck Disability Index (NDI)
Neck-related disability will be assessed using the Neck Disability Index (NDI), a 10-item self-reported questionnaire. The total score ranges from 0 to 50, with higher scores indicating greater neck-related disability. The validated Turkish version will be used.
Measured: Baseline and immediately after completion of the intervention protocol
Short-Form McGill Pain Questionnaire (SF-MPQ)
Pain will be assessed using the Short-Form McGill Pain Questionnaire (SF-MPQ). The questionnaire includes 15 pain descriptors comprising 11 sensory and 4 affective items. Each descriptor is rated from 0 (none) to 3 (severe), with higher scores indicating greater pain severity. The validated Turkish version will be used.
Measured: Baseline and immediately after completion of the intervention protocol
Active Cervical Flexion Range of Motion
Active cervical flexion range of motion will be measured in degrees using a Baseline® digital goniometer. Participants will actively move through their available cervical flexion range using standardized positioning and anatomical landmarks. Higher values indicate greater cervical flexion range of motion.
Measured: Baseline and immediately after completion of the intervention protocol
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Sep 2026
- Study start20 Jan 2024
- Primary completion20 May 2025
- Study completion20 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cervical RadiculopathyStudies of the same condition, open and under way.
- More trials run by Fenerbahce UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 42 participants (actual)
Sponsor and investigators
- Lead sponsor
- Fenerbahce University
- Sponsor type
- University, hospital or other
- Collaborators
- Istinye University
- Responsible party
- Principal investigator, Duygu Reyhanioğlu, Fenerbahce University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07831070
- Sponsor's protocol ID
- IstinyeUdecision no. 4/2023.K-
- Status last verified
- Sep 2026
- First submitted
- 15 Sep 2026
- Last updated
- 21 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 21 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Does the Combination of Cervical and Sacroiliac Mobilization Enhance Clinical Outcomes in Cervical Radiculopathy?
- ClinicalTrials.gov ID
- NCT07831070
- Acronym / sponsor ID
- IstinyeUdecision no. 4/2023.K-
- Conditions
- Cervical Radiculopathy
- Keywords
- cervical radiculopathy, manual therapy, sacroiliac
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 42 participants (actual)
- Lead sponsor
- Fenerbahce UniversityUniversity, hospital or other
- Collaborators
- Istinye University
- Study start
- 20 Jan 2024 (actual)
- Primary completion
- 20 May 2025 (actual)
- Study completion
- 20 Jun 2025 (actual)
- First posted
- 21 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluated whether adding mobilization and myofascial techniques targeting the lumbar and sacroiliac regions to cervical-focused manual therapy provides additional clinical benefits in individuals with cervical radiculopathy. Changes in pain, disability, cervical range of motion, and sacroiliac joint (SIJ) clinical findings were assessed. The study also examined whether changes in SIJ clinical findings were associated with changes in cervical clinical outcomes, thereby exploring the relationship between cervical and lumbopelvic responses to an extended regional manual therapy approach.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Cervical-Focused Manual Therapy | Active comparator | Other: Cervical manual-focused manual therapyParticipants received manual therapy interventions targeting the cervical region. |
| Extended Regional Manual Therapy | Experimental | Other: Cervical manual-focused manual therapy, Other: Extended Regional Manual TherapyParticipants received cervical-focused manual therapy combined with additional mobilization and myofascial techniques targeting the lumbar and sacroiliac regions. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cervical manual-focused manual therapyManual therapy targeting the cervical region was administered to individuals with cervical radiculopathy. The intervention consisted of cervical-focused manual therapy techniques aimed at addressing pain, mobility limitations, and clinical symptoms associated with cervical radiculopathy. All interventions were delivered by the same clinician with 21 years of clinical experience in manual therapy. | Other | Cervical-Focused Manual Therapy, Extended Regional Manual Therapy |
| Extended Regional Manual TherapyAdditional manual therapy targeting the lumbar and sacroiliac regions was administered in combination with cervical-focused manual therapy. The intervention included mobilization and myofascial techniques directed at the lumbar and sacroiliac regions. This extended regional approach was designed to evaluate whether treatment beyond the cervical region provides additional effects on cervical clinical outcomes and sacroiliac joint clinical findings. All interventions were delivered by the same clinician with 21 years of clinical experience in manual therapy. | Other | Extended Regional Manual Therapy |
Primary outcome
Cervical Radiculopathy Impact Scale (CRIS)
Time frame: Baseline and immediately after the intervention
Cervical Radiculopathy Impact Scale (CRIS)
Neck Disability Index (NDI)
Time frame: Baseline and immediately after completion of the intervention protocol
Neck-related disability will be assessed using the Neck Disability Index (NDI), a 10-item self-reported questionnaire. The total score ranges from 0 to 50, with higher scores indicating greater neck-related disability. The validated Turkish version will be used.
Short-Form McGill Pain Questionnaire (SF-MPQ)
Time frame: Baseline and immediately after completion of the intervention protocol
Pain will be assessed using the Short-Form McGill Pain Questionnaire (SF-MPQ). The questionnaire includes 15 pain descriptors comprising 11 sensory and 4 affective items. Each descriptor is rated from 0 (none) to 3 (severe), with higher scores indicating greater pain severity. The validated Turkish version will be used.
Active Cervical Flexion Range of Motion
Time frame: Baseline and immediately after completion of the intervention protocol
Active cervical flexion range of motion will be measured in degrees using a Baseline® digital goniometer. Participants will actively move through their available cervical flexion range using standardized positioning and anatomical landmarks. Higher values indicate greater cervical flexion range of motion.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Sep 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cervical manual-focused manual therapy and Extended Regional Manual Therapy in people with Cervical Radiculopathy, run by Fenerbahce University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cervical Radiculopathy Impact Scale (CRIS) (time frame: Baseline and immediately after the intervention). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Sep 2026.