Clinical trials: Radiation Therapy
Breast Cancer
Partial Breast Radiation Therapy in Treating Women Undergoing Breast-Conserving Therapy for Early Stage Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. Giving radiation therapy in different ways may kill more tumor cells.
- Trial name
- NCT00527293
- Testing
- adjuvant therapy, 3-dimensional conformal radiation therapy, brachytherapy
- Where
- 4 sites in United States
- Volunteers
- 29 people
- Sponsor
- Case Comprehensive Cancer Center
Recurrent Prostate Cancer
Trial of Ultrahypofractionated Focal Salvage Radiotherapy for Isolated Prostate Bed Recurrence After Radical Prostatectomy
The main objective of the trial is to explore the efficacy and safety of combining short-term androgen deprivation therapy (ADT) over 6 months to focal ultrahypofractionated salvage radiotherapy (SRT) delivered in 5 fractions to…
- Trial name
- HypoFocal SRT (NCT05746806)
- Testing
- Ultrahypofractionated salvage radiotherapy to a local recurrence after radical prostatectomy, Androgen deprivation therapy
- Where
- 5 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Brain Tumor, Head and Neck Tumor
In-Room PET in Proton Radiation Therapy
The investigational part of this study is using a mobile PET/CT scanner to take images of the participants tumor immediately after they are treated with proton radiation.
- Conditions
- Brain Tumor, Head and Neck Tumor, Skull Base Tumor
- Trial name
- NCT01228448
- Testing
- PET scan
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Gemcitabine, Carboplatin or Paclitaxel Plus Radiation Therapy in Treating Patients With Stage IIIA or IIIB Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, carboplatin, and paclitaxel, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00016315
- Testing
- carboplatin, gemcitabine hydrochloride, paclitaxel
- Where
- 19 sites in United States
- Volunteers
- 35 people
- Sponsor
- Radiation Therapy Oncology Group
Soft Tissue Sarcoma (STS)
Preoperative Radiotherapy and Anlotinib With or Without Penpulimab for Soft Tissue Sarcoma
Soft tissue sarcoma is a rare cancer that often requires surgery combined with radiotherapy. Preoperative radiotherapy can improve the chance of complete tumor removal and limb preservation, but some patients still experience…
- Trial name
- SPARE-04 (NCT07612098)
- Testing
- Anlotinib, Penpulimab, Preoperative Radiotherapy
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia
Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer
This clinical trial studies the side effects and best dose of giving fludarabine and total-body irradiation (TBI) together followed by a donor stem cell transplant and cyclosporine and mycophenolate mofetil in treating human…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT00112593
- Testing
- fludarabine phosphate, total-body irradiation, peripheral blood stem cell transplantation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Fred Hutchinson Cancer Center
Myocarditis, Immune Checkpoint Inhibitors
Assessment of Myocardial Injury in Patients Treated With Immune Checkpoint Inhibitors
ICI's have become the first-line treatment for patients with various malignancies. Although case studies represent fulminant myocarditis, there is uncertainty in prevalence of subclinical myocardial injury induced by ICI's.
- Conditions
- Myocarditis, Immune Checkpoint Inhibitors, Cardiotoxicity, Myocardial Injury
- Trial name
- MIICI (NCT05349058)
- Testing
- Immune Checkpoint Inhibitors
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Flinders University
Intracranial Aneurysms
CARE: A Prospective Multicenter Case Study to Assess Radiation Exposure in Patients Treated With the Penumbra Coil 400
The primary objective of this study is to gather data on the radiation exposure in patients treated with the Penumbra Coil 400™ System (PC 400) or conventional coils per their respective indications for use.This is a multicenter…
- Trial name
- CARE (NCT02122133)
- Testing
- PC 400
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Penumbra Inc.
Follicular Lymphoma
Frontline Treatment of Follicular Lymphoma With AtezolizUmab and Obinutuzumab With and Without RadiOtherapy
This single-arm phase II interventional study aims to assess disease response to, and toxicity of, a combination of obinutuzumab and atezolizumab, with or without radiotherapy, in treatment naive Follicular Lymphoma.
- Trial name
- FLUORO (NCT04962126)
- Testing
- Obinutuzumab 25 MG/1 ML Intravenous Solution, Atezolizumab 1200 MG/40mL Intravenous Solution, 4 Gy in 2 fractions
- Where
- 3 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Olivia Newton-John Cancer Research Institute
Thymic Carcinoma
Neoadjuvant Treatment For Locally Advanced Thymic Cancer
The aims of this study are to verify the feasibility, effectiveness, and safety of the combination of enrolizumab and radiotherapy for neoadjuvant treatment for locally advanced thymic carcinoma, and to provide recommendations…
- Trial name
- NCT06019468
- Testing
- Envolizumab combined with radiotherapy
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Rectovaginal Fistula
Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula
A new strategy for treatment of late radiation damage is to develop methods aimed at stimulating the regenerative capabilities of irradiated tissues.
- Trial name
- NCT03643614
- Testing
- Injection of autologous regenerative cells of adipose tissue
- Where
- Russia
- Volunteers
- 16 people
- Sponsor
- South Ural State Medical University
Non-small Cell Lung Cancer Stage III, Non-small Cell Lung Cancer Stage II
Dose-painting Radiation for LA-NSCLC
The study evaluated the effectiveness, safety and immune effects of dose-painting radiation in patients with locally advanced non-small cell lung cancer.
- Trial name
- DPRLC (NCT05031533)
- Testing
- Dose-Painting Radiation
- Where
- 4 sites in China
- Volunteers
- 46 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Prostate Disease
In Vivo Dosimetry During Prostate Cancer Radiotherapy
The goal of this clinical research study is to learn if a rectal balloon with attached radiation detectors can be used to help researchers monitor the dose of external beam radiation that is delivered to the prostate during…
- Trial name
- NCT01307852
- Testing
- Plastic Scintillation Detectors
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- M.D. Anderson Cancer Center
Radiation-Induced Dermatitis
A Study for Assessing the Efficacy and Safety of Tetrahydrobiopterin in Radiation-Induced Skin Injury
This study was a single-center prospective phase I clinical study to evaluate the effectiveness and safety of BH4 in the treatment of radiation-induced skin injury during vulvar cancer radiotherapy.
- Trial name
- NCT05114226
- Testing
- Tetrahydrobiopterin
- Where
- China
- Volunteers
- 45 people
- Sponsor
- West China Second University Hospital
Solitary Bone Plasmacytoma, Plasmacytoma of Bone
Radiation Combined With BCMA/CD3 Bispecific Antibody Therapy for Solitary Bone Plasmacytoma With Mild Bone Marrow Infiltration
This is a prospective, single-arm, single-center clinical trial designed to evaluate the safety and efficacy of radiation combined with a BCMA/CD3 bispecific antibody (CM336) in patients with solitary bone plasmacytoma (SBP) with…
- Conditions
- Solitary Bone Plasmacytoma, Plasmacytoma of Bone, Plasma Cell Disorders
- Trial name
- NCT07115667
- Testing
- BCMA/CD3 bispecific antibody (CM336)
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Bladder Urothelial Carcinoma
A Study of Radiation Therapy and Cemiplimab With or Without Fianlimab In People With Bladder Cancer
The researchers are doing this study to find out whether stereotactic body radiation therapy (SBRT) in combination with immunotherapy (cemiplimab with or without fianlimab) before cystectomy is an effective and safe treatment for…
- Trial name
- NCT07414992
- Testing
- Stereotactic body radiotherapy, Cemiplimab, Cemiplimab and Fianlimab
- Where
- 7 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Renal Pelvis Cancer
Radical Radiotherapy Versus Radical Surgery for UTUC
This study is a prospective cohort study, and the proposed plan is to recruit 30 patients with radical radiotherapy for renal pelvic ureteral cancer, according to the actual clinical situation, enrolling the same period of time…
- Trial name
- NCT06652009
- Testing
- Radical nephroureterectomy, Radical radiotherapy
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Stage IV Adult Soft Tissue Sarcoma, Sarcoma,Soft Tissue
(SBRT) and (ART) for Pulmonary Metastases From Soft Tissue Sarcomas
This is a prospective study to document the local control rates with SBRT specifically for pulmonary metastases from soft tissue sarcoma.
- Trial name
- NCT01949506
- Testing
- SBRT
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Medical College of Wisconsin
Spinal Cord Compression, Unspecified Adult Solid Tumor, Protocol Specific
Radiation Therapy in Treating Patients With Metastatic Spinal Cord Compression
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy regimen is more effective in treating metastatic spinal cord compression.
- Trial name
- NCT00727584
- Testing
- radiation therapy
- Where
- 4 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Cancer Research UK
Solid Tumor Malignancies
ALI Post Radiation Therapy in Patients With Lung and Esophageal Canter
The goal of this clinical research study is to learn if giving autologous lymphocyte infusions to patients who are receiving chemotherapy and radiation for non-small cell lung cancer or esophageal cancer is safe and effective.
- Trial name
- NCT04668833
- Testing
- Autologous lymphocyte infusion (ALI)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center