Clinical trials: Protein Energy Wasting
Cardiac Cachexia
Protein-energy Oral Supplementation Enriched With Omega-3 Fatty Acids in Cardiac Cachexia
Cardiac cachexia, the main feature of undernutrition in chronic heart failure, usually defined as a weight loss over 6% over 6 months, is a proven factor of morbidity and mortality in this disease.
- Trial name
- NCT00748332
- Testing
- Fortimel Extra®, Fortimel Care®
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Kidney Diseases
Ghrelin and Obestatin in CKD Children
Protein energy wasting (PEW) is a complex syndrome associated with different underlying illnesses and characterized by loss of muscle, with or without loss of fat.
- Trial name
- NCT03171116
- Testing
- none intervention
- Volunteers
- 154 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Renal Insufficiency, Chronic, Dialysis
Egg White for Phosphorus Control in Haemodialysis Patients
To evaluate the effect on phosphatemia in hemodialysis patients of replacing the meat or fish included in two meals a week with an amount of egg white containing the same quantity of proteins.
- Conditions
- Renal Insufficiency, Chronic, Dialysis, Hyperphosphatemia
- Trial name
- UAUDIPE (NCT03236701)
- Testing
- Egg White replacement
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Federico II University
Chronic Kidney Failure
Multimodal Therapeutic Approach in Undernourished Maintenance Hemodialysis Patients (AMERICANO)
The aim of the study is to evaluate a 3 months integrated multimodal therapeutic approach including exercise training program with ergocycle during dialysis sessions, oral nutritional supplementation, omega 3 and androgen, on…
- Trial name
- AMERICANO (NCT02418065)
- Testing
- training on ergonomic bicycle, Testosterone, Oral nutritional supplementation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Protein-energy; Imbalance
Serum Level of Myokines and Protein Energy Wasting, Inflammation and Atherosclerosis in Hemodialysis Patients
The aim is to test if serum level of myokines are associated with protein energy wasting, inflammation and atherosclerotic vascular disease among Taiwanese dialysis patients.
- Trial name
- NCT02718586
- Volunteers
- 170 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Hypoalbuminemia, Protein-energy Malnutrition
Anit-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
Study of efficiency and safety of oral nutritional supplements with anti-inflammatory and antioxidative properties combined with an appetite stimulant with anti-inflammatory properties (pentoxiphylline) in treatment of…
- Conditions
- Hypoalbuminemia, Protein-energy Malnutrition, Inflammation, Oxidative Stress
- Trial name
- AIONID (NCT00561093)
- Testing
- pentoxiphylline, Nepro, anti-inflammatory module (similar to Oxepa)
- Where
- 2 sites in United States
- Volunteers
- 93 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Protein-Energy Wasting, Kidney Failure
Effects of Homemade Oral Nutrition Supplements for Patients on Hemodialysis With Protein-energy Wasting
The goal of this clinical trial is to learn if homemade oral nutrition supplements works to treat protein energy wasting in patients on hemodialysis.
- Conditions
- Protein-Energy Wasting, Kidney Failure, Hemodialysis
- Trial name
- HOMES-HD (NCT06569732)
- Testing
- Homemade oral nutrition supplements, Commercial oral nutrition supplements
- Volunteers
- 40 people
- Sponsor
- Universiti Malaysia Sabah
End Stage Renal Disease, Hemodialysis
Study of a Dialysate Without Acetate on Protein Energy Wasting Syndrome in Chronic Hemodialysis Patient (EASY)
This work aims to study the effect of an acetate-free dialysate on protein-energy wasting syndrome in patients with chronic hemodialysis renal failure, in comparison to a conventional dialysate with acetate.
- Trial name
- EASY (NCT04824885)
- Testing
- Chlorhydric acid based acid concentrate for bicarbonate hemodialysis (medical device)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Kidney Disease (CKD), End-Stage Renal Disease (ESRD)
Malnutrition, Diet and Racial Disparities in Chronic Kidney Disease (CKD)
In the United States, African Americans are 3.6 time and Hispanics 1.5 times more likely to suffer from chronic kidney disease and need dialysis treatment for life, when compared to the non-Hispanic Whites.
- Trial name
- MADRAD (NCT01415570)
- Where
- United States
- Volunteers
- 1,050 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Muscle Wasting, End Stage Renal Disease on Dialysis
Muscle Status to Oral Nutritional Supplementation in Hemodialysis Patients With Protein Energy Wasting
This multi-centred randomized, open label-controlled trial consists of hemodialysis (HD) patients identified with protein energy wasting (PEW) using the International Society of Renal Nutrition and Metabolism criteria.
- Trial name
- NCT04789031
- Testing
- Oral nutritional supplementation (ONS)
- Volunteers
- 54 people
- Sponsor
- Taylor's University
End-Stage Renal Disease
Fosrenol for Enhancing Dietary Protein Intake in Hypoalbuminemic Dialysis Patients (FrEDI) Study
Protein-energy wasting, as reflected by a serum albumin <4.0 g/dL, is very common in maintenance hemodialysis (MHD) patients and associated with poor clinical outcomes including high death rates.
- Trial name
- FrEDI (NCT01116947)
- Testing
- Meals during hemodialysis accompanied by lanthanum carbonate to control phosphorus
- Volunteers
- 108 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Anemia, Iron-Deficiency, Deficiency, Vitamin A
Newly Formulated, Extruded Fortified-blended Foods for Food Aid: the MFFAPP Tanzania Efficacy Study
Corn-soy vitamin and mineral fortified blended foods (FBFs) are primarily used for food aid, although sorghum and cowpea may be suitable alternative FBF commodities.
- Trial name
- NCT02847962
- Testing
- Corn Soy Blend Plus (CSB+), Corn Soy Blend 14 (CSB14), White Sorghum Cowpea Blend Variety 1
- Volunteers
- 2,179 people
- Sponsor
- Kansas State University
Nephrotic Syndrome
Ketoanalogues for Muscle Mass Loss in Nephrotic Syndrome
The goal of this non-commercial clinical trial is to assess efficacy and safety of ketoanalogues of essential amino acids in the prevention of protein-energy wasting in nephrotic syndrome.
- Trial name
- FORMA (NCT05716880)
- Testing
- Ketosteril, Medium Protein Diet (MPD)
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Military Institute od Medicine National Research Institute
Undernutrition
Microbiota and Protein-energy Wasting (MIDIWA)
Oral supplementation with branched chain amino acids (BCAA) increases the levels of circulating BCAA, stimulates BCAA uptake in muscles, and decreases amino acid release from muscle, eventually promoting muscle anabolism.
- Trial name
- MIDIWA (NCT02962089)
- Testing
- Branched chain amino acids (BCAA)
- Where
- 5 sites in Switzerland
- Volunteers
- 37 people
- Sponsor
- University Hospital, Geneva
Military Operational Stress Reaction, Malnutrition (Calorie)
Physiological Response to Protein and Energy-enhanced Food Products During Winter Military Training
Soldiers commonly lose muscle mass during training and combat operations that produce large energy deficits (i.e., calories burned > calories consumed).
- Conditions
- Military Operational Stress Reaction, Malnutrition (Calorie), Weight Loss, Muscle Wasting
- Trial name
- NCT05210205
- Testing
- EAA, Energy Dense, Control
- Where
- Norway
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Inflammation, Malnutrition
Effect of Anti-inflammatory Diet on Inflammatory, Oxidative and Nutritional Markers in Hemodialysis Patients
The purpose of this study is to evaluate the effect of especial diet therapy "Anti-inflammatory Diet" on inflammatory, oxidative stress, and nutritional markers in the context of protein-energy wasting syndrome(PEW) in…
- Conditions
- Inflammation, Malnutrition, Protein Energy Wasting Syndrome, Oxidative Stress
- Trial name
- NCT01874106
- Testing
- Diet Therapy, Control Group
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Maryam Ekramzadeh, PhD
End Stage Renal Disease, Kidney Disease
Effects of PINTA 745 in End Stage Renal Disease (ESRD) Patients Who Require Hemodialysis and Have Protein Energy Wasting
This is a pilot study to assess the safety, pharmacokinetics and effectiveness of PINTA 745 or placebo in treating protein energy wasting (PEW) in patients receiving maintenance hemodialysis (MHD).
- Conditions
- End Stage Renal Disease, Kidney Disease, Protein Energy Wasting
- Trial name
- NCT01958970
- Testing
- PINTA 745
- Where
- 6 sites in United States
- Volunteers
- 51 people
- Sponsor
- Pinta Biotherapeutics
Oxidative Stress, Protein-Energy Wasting
Effect of Oral Nutritional Supplementation on Oxidative Stress in Protein-energy Wasting Patients With Peritoneal Dialysis
End-stage kidney disease (ESKD) represents a serious public health problem in Mexico. Data from the United States Renal Data System (USRDS) have reported that the region of Jalisco (Mexico) is one of the places with the highest…
- Conditions
- Oxidative Stress, Protein-Energy Wasting, Malnutrition, Protein-Energy Malnutrition
- Trial name
- NCT04628117
- Testing
- Oral nutritional supplementation for kidney disease
- Volunteers
- 22 people
- Sponsor
- Hospital Civil Juan I. Menchaca
Undernutrition, Renal Insufficiency, Chronic
Prevalence of Protein-energy Wasting and Obesity Among Danish Dialysis Patients
The purpose of this study is to determine the prevalence of protein-energy wasting and obesity among Danish dialysis patients.
- Conditions
- Undernutrition, Renal Insufficiency, Chronic, Obesity
- Trial name
- NCT02320552
- Testing
- No intervention
- Volunteers
- 105 people
- Sponsor
- Zealand University Hospital
Chronic Kidney Disease Requiring Chronic Dialysis
The Effect of On-line Hemodiafiltratrion on Nutritional Status and Body Composition
Compared to conventional hemodialysis (HD), on-line hemodiafiltration (OL-HDF) achieves a more efficient removal of uremic toxins and reduces inflammation, which could favourably affect nutritional status.
- Trial name
- NCT03190629
- Testing
- High-flux hemodialysis, On line-hemodiafiltration
- Volunteers
- 33 people
- Sponsor
- Pablo Molina