Clinical trials: Prosthetic Joint Infections of Hip
Prosthetic Joint Infection, Prosthetic Infection
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections
The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patient outcomes and reduce the…
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Hip Prosthesis Infection, Knee Prosthesis Infection
- Trial name
- NCT04488458
- Testing
- MIC or MBEC+MIC based treatment algorithm
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Prosthetic Joint Infection
Abbreviated Protocol for Two-Stage Exchange
Study Type: A multi-site, parallel group, randomized trial. Study Objectives: The objective is to evaluate safety and determine preliminary efficacy of VT-X7 (Vancomycin and Tobramycin Exchanged over 7 Days).
- Trial name
- APEX (NCT04662632)
- Testing
- VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty
- Where
- 17 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Prosthetic Joint Infections of Hip, Bacteriophage Therapy
Bacteriophage Therapy for Staphylococcus Lugdunensis Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Staphylococcus lugdunensis prosthetic joint infection of the hip.
- Trial name
- NCT07461337
- Testing
- Five phage anti-Staphylococcus aureus bacteriophage cocktail
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Prosthetic-joint Infection
A Second Trial of the Abbreviated Protocol Two-Stage Exchange
Apex-2 is a multi-site, parallel group, randomized trial. Patients will be randomly assigned in a 1:1 ratio to the Experimental Arm or the Control Arm.
- Trial name
- Apex-2 (NCT05607030)
- Testing
- VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics
- Where
- 19 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Periprosthetic Joint Infection (PJI)
Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?
This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection.
- Trial name
- NCT05117671
- Testing
- data collection to classify infection status
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 1,554 people
- Sponsor
- University Hospital, Basel, Switzerland
Prosthetic Joint Infection
Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI)
This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.
- Trial name
- ACTIVE2 (NCT05269134)
- Testing
- Bacteriophage
- Where
- 10 sites in United States
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Prosthesis-related Infections
European Prosthetic Joint Infection Cohort Study- Hip, Knee and Shoulder Prosthetic Joint Infection
The purpose of the study is to compare different approaches for the treatment of prosthetic joint revisions and to optimize the outcomes in patients with prosthetic joint infections (PJI) by improving the treatment concept of PJI.
- Trial name
- EPJIC (NCT02424903)
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Pro-Implant Foundation
Prosthetic Joint Infection
Bacteriophage Therapy in Patients With Prosthetic Joint Infections
This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.
- Trial name
- NCT04787250
- Testing
- Phage Therapy, Two-Stage Exchange Arthroplasty
- Where
- United States
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Peri-Prosthetic Joint Infection
IP-coated Revision Hip Implants
The primary aim of the clinical investigation is to demonstrate the efficacy of a silver-based antimicrobial coating on hip implants in the reduction of periprosthetic infections in revision hip arthroplasty due to periprosthetic…
- Trial name
- HIPrevision (NCT06737809)
- Testing
- IP Plasmafit® Revision cup (and stem) system
- Where
- 2 sites in Germany, Poland
- Volunteers
- 268 people
- Sponsor
- Aesculap AG
Infections Joint Prosthetic
Egyptian Arthroplasty Surgeons' Antibiotics Usage Awareness
Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are procedures successfully applied to manage various end-stage chronic hip and knee diseases, such as osteoarthritis, rheumatoid arthritis, and femoral head…
- Trial name
- NCT06451224
- Testing
- Questionnaire
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- South Valley University
Bone Infection, Osteomyelitis
Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections
Because of its prolonged terminal half-life, dalbavancin is an extremely attractive option in treating Gram-positive infections caused by S. aureus including MRSA, and streptococcal species.
- Conditions
- Bone Infection, Osteomyelitis, Septic Arthritis, Joint Infection
- Trial name
- NCT03426761
- Testing
- Dalbavancin, Vancomycin
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Infectious Diseases Physicians, Inc.
Prosthesis Related Infections
Biodistribution and Dosimetry Evaluation of [124I]FIAU
This protocol will evaluate the biodistribution and dosimetry of [124I]FIAU in both healthy volunteers and patients with prosthetic joint infections.
- Trial name
- NCT01337466
- Testing
- [124I]FIAU
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- BioMed Valley Discoveries, Inc
Prosthetic Joint Infection, Debridement With Prosthesis Retention
Antibiotic-coated Braided Suture Study
The purpose of this study is to evaluate whether the use of antibiotic-coated (triclosan) braided sutures is non-inferior or potentially superior to standard monofilament sutures in patients with prosthetic joint infections…
- Conditions
- Prosthetic Joint Infection, Debridement With Prosthesis Retention, Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
- Trial name
- NCT07322289
- Testing
- VICRYL™ Plus (Coated VICRYL™ Plus Antibacterial), Polydioxanone (PDS™ II ) Sterile Synthetic Absorbable Surgical Suture-Monofilament
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Miami
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection
To determine if oral antibiotic treatment with CEM-102 and Rifampin is as effective and safe as the standard of care antibiotic therapy for the treatment of hip and knee prosthetic joint or spacer infections
- Conditions
- Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Infected Spacers
- Trial name
- NCT01756924
- Testing
- CEM-102, IV or Oral standard of care antibiotics, Rifampin
- Where
- 13 sites in United States
- Volunteers
- 14 people
- Sponsor
- Arrevus Inc.
Prosthetic Joint Infection
68Ga-citrate PET/CT for the Diagnosis of Chronic Prosthetic Hip or Knee Infection
Diagnosis of chronic prosthetic joint infection (PJI) can be difficult. 68Ga-citrate Positron Emission Tomography/Computed Tomography (PET/CT) has been recently developed and has many advantages such as high resolution and low…
- Trial name
- Gal-I-TEP (NCT04938193)
- Testing
- 68Ga-citrate PET/CT
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Bordeaux
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
ROADMAP Clinical Trial
Artificial joint infections are treated with different types of antibiotics and surgery. The ROADMAP study aims to find out which treatments currently used work best in regards to surgery, antibiotic choice as well as the time…
- Conditions
- Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Large Joint Prosthetic Joint Infections
- Trial name
- ROADMAP (NCT06771050)
- Testing
- Debridement and Implant Retention (DAIR), Antibiotic Choice, Antibiotic duration Part A - Single stage revision
- Where
- 43 sites in Australia, New Zealand
- Volunteers
- 2,500 people
- Sponsor
- University of Newcastle, Australia
Infection of Total Hip Joint Prosthesis, Infection of Total Knee Joint Prosthesis
Phage Therapy in Prosthetic Joint Infection Due to Staphylococcus Aureus Treated With DAIR.
Pilot non comparative study assessing the clinical control of infection of DAIR + SAT +NaCl and DAIR + SAT + Phages anti-Staphylococcus aureus in patients with Staphylococcus aureus Prosthetic Joint Infection with an indication…
- Trial name
- PhagoDAIRI (NCT05369104)
- Testing
- Anti-Staphylococcus aureus Bacteriophages
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Phagenix
Surgery, Knee Arthropathy
Evaluation of Arthroplasty Treatment
The aim of the study is to examine patients after knee and hip endoprosthesis in the longitudinal section and to evaluate the surgical outcome.
- Conditions
- Surgery, Knee Arthropathy, Hip Arthropathy, Prosthetic-joint Infection
- Trial name
- Endo-GEP (NCT07799818)
- Testing
- Joint replacement
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bonn
Osteoarthritis, Hip, Osteoarthritis, Knee
Total Joint Arthroplasty (TJA) Weight Loss Study
This is a randomized clinical trial (RCT) to assess the efficacy of bariatric surgery vs medical weight loss vs. the "usual standard of care" to optimize a morbidly obese patient with end-stage osteoarthritis of the hip or knee…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Obesity, Morbid
- Trial name
- NCT05156762
- Testing
- Bariatric surgery, Medical weight loss, Patient research surveys
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston Medical Center
Prosthetic-joint Infection, Infection Hip
Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection
In this Dutch multicenter clinical trial, patients with a staphylococcal prosthetic joint infection, will, in the oral antibiotic treatment phase, be randomized between clindamycin monotherapy and rifampicin / levofloxacin…
- Conditions
- Prosthetic-joint Infection, Infection Hip, Infection; Knee, Joint
- Trial name
- RiCOTTA (NCT06172010)
- Testing
- Clindamycin, Rifampicin and levofloxacin
- Where
- 13 sites in Netherlands
- Volunteers
- 316 people
- Sponsor
- Leiden University Medical Center