Clinical trials: Propylene Glycol
Type 2 Diabetes
forREAL: FORXIGA PRESCRIPTION EVENT MONITORING PROGRAM (PEMP)
The study purpose is to assess adverse events in patients with Type 2 diabetes who have newly been prescribed Forxiga for the management of glycemic control
- Trial name
- forREAL (NCT01944618)
- Testing
- Forxiga
- Where
- Australia
- Volunteers
- 5,000 people
- Sponsor
- AstraZeneca
Dry Eye
Patient Satisfaction and Tear Osmolarity With the Use of Blink Tears, Blink Gel Tears and Systane Balance
This is a single center clinical study designed to determine patient satisfaction and the effect of the use of artificial tears on tear osmolarity with time after instillation of three commercially available artifical tear eye…
- Trial name
- NCT01589640
- Testing
- Blink Tears lubricating Eye Drops, Blink Gel Tears Lubricating Eye Drops, Systane Balance Lubricant Eye Drop
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Connecticut
Analgesia
Lorazepam for the Analgosedation of Pediatric Patients in Mechanical Ventilation.
The aim of this study is to better define the pharmacokinetic and pharmacodynamic profile of lorazepam for the analgosedation in pediatric intensive care unit.
- Trial name
- NCT04646135
- Testing
- Lorazepam 4 mg/ml
- Volunteers
- 9 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Multiple Myeloma
Safety & Efficacy Study High Dose Evomela Injection for MA Conditioning in MM Patients With Autologous Transplantation
The purpose of this trial is to confirm the safety and efficacy of high-dose Melphalan HCL for Injection (Propylene Glycol-Free) as a myeloablative conditioning regimen in multiple myeloma patients (MM) undergoing autologous…
- Trial name
- NCT01660633
- Testing
- High-Dose Melphalan HCL for Injection (Propylene Glycol-Free), Autologous Transplantation
- Where
- 6 sites in United States
- Volunteers
- 61 people
- Sponsor
- Acrotech Biopharma Inc.
Hodgkin Disease, Lymphoma, Non-Hodgkin
Study of Melphalan HCl for Injection (Propylene Glycol-free), Carmustine, Etoposide, Cytarabine (BEAM Regimen) and Autologous Stem Cell Transplantation for Lymphoma
Phase II study is being conducted to confirm the safety and efficacy of high-dose Melphalan HCl for Injection (Propylene Glycol-Free) when included in the BEAM regimen for myeloablative conditioning in lymphoma patients…
- Trial name
- NCT01969435
- Testing
- Carmustine, Etoposide phosphate, Cytarabine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Dry Eye
Efficacy of Systane Balance to Stabilize the Tear Film in Dry Eye Subjects
Evaluation of the optical effects of Systane Ultra
- Trial name
- NCT01086774
- Testing
- Systane Ultra Lubricant Eye Drops
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Amyloidosis; Systemic
Propylene Glycol-Free Melphalan Hydrochloride (Evomela) in AL Amyloidosis Patients
This is a single arm, open label study designed to evaluate the safety and efficacy of propylene glycol-free melphalan hydrochloride in patients with AL amyloidosis.
- Trial name
- NCT02994784
- Testing
- Propylene Glycol-Free Melphalan Hydrochloride
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Boston Medical Center
Dry Eye
The Effect of SYSTANE® BALANCE on Tear Film Break Up Time in Dry Eye Subjects
The purpose of this study was to evaluate the ability of SYSTANE® BALANCE dosed 4 times a day for 30 days to increase non-invasive tear film break up time over baseline, compared to a saline control, in dry eye subjects with…
- Trial name
- NCT01718028
- Testing
- Propylene glycol 0.6% ocular emulsion, Sodium chloride 0.9% saline solution
- Where
- Argentina
- Volunteers
- 51 people
- Sponsor
- Alcon Research
Lung Injury
Propylene Glycol/Glycerol Intake and Cardiorespiratory Function
Propylene glycol/Glycerol intake is increasingly popular. The propylene glycol/glycerol intake effects on cardiorespiratory function are unknown.
- Trial name
- PGGICF (NCT03410511)
- Testing
- Nicotine free intake, Nicotine intake, Cessation intake
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Healthy, Pharmacokinetic Profile
A Clinical Trial to Assess the Pharmacokinetic Profile of Propylene Glycol (PG) in Healthy Adults Following PG Exposure
The goal of this clinical trial is to determine the translation of propylene glycol (PG) exposure in beverages to circulating PG levels to better understand the margin of safety in healthy participants.
- Conditions
- Healthy, Pharmacokinetic Profile, Propylene Glycol
- Trial name
- NCT07644169
- Testing
- Propylene glycol
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- American Beverage Association
Dry Eye
Clinical Trial to Compare the Safety and Efficacy of Nanodrop®
Study design: Phase I-II clinical trial, comparative, non-inferiority with active control, parallel groups, double blind with randomisation.
- Trial name
- PRO-176/I (NCT04111965)
- Testing
- Nanodrop®, Systane Balance
- Where
- 6 sites in Mexico
- Volunteers
- 126 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Metabolic Complication
Acute Effects of Propylene Glycol/Glycerol Intake on Blood Parameters
The aim of this study is to evaluate the acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters.
- Trial name
- AEPGGIBP (NCT03404011)
- Testing
- Propylene glycol and Glycerol intake, Mimicking intake
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Hematological Malignancy, Multiple Myeloma
Propylene Glycol-Free Melphalan HCl (EVOMELA®) in Combination With Fludarabine and Total Body Irradiation Based Reduced Intensity Conditioning for Haploidentical Transplantation
This is an open-label, single-arm, phase II study to determine the safety of propylene glycol-free melphalan HCl (EVOMELA®), in combination with fludarabine and total-body irradiation-based reduced-intensity conditioning for…
- Trial name
- NCT03159702
- Testing
- Evomela, Fludarabine, Total Body Irradiation
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Medical College of Wisconsin
Female Pattern Hair Loss
Comparison of Topical Minoxidil 5% in Ethanol Plus Propylene Glycol Versus Minoxidil 5% in Ethanol Alone in Treatment of Women With Female Pattern Hair Loss
The study will be included 60 women with FPHL. The diagnosis of FPHL will be established by clinical (Ludwig classification) and trichoscopic evaluation of frontal and occipital regions of the scalp.
- Trial name
- FPHL (NCT04090801)
- Testing
- Topical minoxidil 5% in 90% ethanol and 5% propylene glycol, Topical minoxidil 5% in pure ethanol alone
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Excipient Exposure, Neonatal
Safe Excipient Exposure in Neonates and Small ChildreN
The purpose of this study is to explore the quantity of excipient exposure in neonatal and young pediatric patients in a Danish Hospital.
- Conditions
- Excipient Exposure, Neonatal, Pediatric
- Trial name
- SEEN (NCT02545712)
- Testing
- Exposure to ethanol, Exposure to propylene glycol, Exposure to benzyl alcohol
- Volunteers
- 630 people
- Sponsor
- Bispebjerg Hospital
Multiple Myeloma
PK Study of Melphalan HCL & Alkeran for Injection of MA Conditioning in MM Patients of Autologous Transplantation
To assess and compare the pharmacokinetics of Melphalan HCL for Injection (Propylene Glycol-Free) versus Alkeran for Injection in multiple myeloma (MM) patients undergoing autologous stem cell transplant (ASCT).
- Trial name
- NCT00925782
- Testing
- Melphalan HCL for Injection (Propylene Glycol-Free)/Alkeran for Injection, Alkeran for Injection/Melphalan HCL for Injection (Propylene Glycol-Free)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Acrotech Biopharma Inc.
Chronic Arsenic Poisoning
Effect of Neem Extract, Propylene Glycol and Salicylic Acid Combination in the Treatment of Arsenical Palmar Keratosis
This study is designed to find out the effectiveness of combination of ethanol extract of neem leaf, propylene glycol (40%) and salicylic acid (10%) in the treatment of palmar arsenical keratosis.
- Trial name
- NCT02352987
- Testing
- Neem plus propylene glycol plus salicylic acid, Salicylic acid
- Where
- Bangladesh
- Volunteers
- 30 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Healthy Subjects
A Pharmacokinetic Study of DW6012 (FDC of Dapagliflozin and Sitagliptin) in Healthy Adult Volunteers
This study is to compare and evaluate the safety and pharmacokinetic characteristics (PK) after administration of DW6012 and each component in healthy adult volunteers.
- Trial name
- NCT05403281
- Testing
- DW6012
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Dong Wha Pharmaceutical Co. Ltd.
Multiple Myeloma
Pharmacokinetic Study of Propylene Glycol-Free Melphalan HCl for Myeloablative Conditioning in Multiple Myeloma Patients Undergoing Autologous Transplantation
This study is a single-center, open-label study of high-dose Melphalan HCl (hydrochloric acid) for injection (propylene glycol-free Melphalan) conducted in 24 patients, who have symptomatic multiple myeloma and qualify for…
- Trial name
- NCT02669615
- Testing
- Melphalan HCl for injection (propylene glycol free)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical College of Wisconsin
Acetaminophen Toxicity
Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing
A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to determine if it prevents the formation of the…
- Trial name
- APAPII (NCT02322879)
- Testing
- First Treatment Period, Washout, Second Treatment Period
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center