Clinical trials: Pre-Lung-Transplantation
Influenza
Influenza Vaccine in Lung Transplant Patients
This 5-year study was designed to investigate how antibody and T cell responses following influenza vaccine compare among lung transplant patients, patients waiting for lung transplantation, and healthy individuals.
- Trial name
- NCT00205270
- Testing
- Influenza vaccine
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Post Intensive Care Syndrome (PICS), PTSD - Post Traumatic Stress Disorder
ICU-VR Prior to ICU Admission
Rationale: A substantial proportion of the Intensive Care Unit (ICU) survivors develop psychological impairments due to their ICU admission.
- Trial name
- NCT06642636
- Testing
- Intensive Care Unit-specific Virtual Reality
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Denzel Drop
Lung Transplant
Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates
To examine the effectiveness of an individual health coaching intervention for lung transplant candidates. This intervention will include up to 12 health coaching sessions via phone call over a 12-16 week period.
- Trial name
- NCT05426200
- Testing
- Health Coaching
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- Mayo Clinic
Influenza
Influenza Vaccine in Lung Transplant Patients - Persistence of Antibodies
This a sub-study of a 5-year study designed to investigate how antibody and T cell responses following influenza vaccine compare among lung transplant patients, patients waiting for lung transplantation, and healthy individuals.
- Trial name
- NCT04531787
- Testing
- Influenza vaccine
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Covid19, Kidney Transplant; Complications
Multicenter CTS Pre-and Post-Transplantation Covid-19 Serum Studies
The Covid-19 Serum Study is a prospective case-control study in 1. kidney or liver transplanted patients being hospitalized due to an infection with Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) after…
- Conditions
- Covid19, Kidney Transplant; Complications, Kidney Transplant Failure and Rejection, Liver Transplant; Complications
- Trial name
- NCT04694573
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Heidelberg University
Pre-Bronchiolitis Obliterans Syndrome
Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant
The goal of this Phase 3 clinical trial is to compare ARINA-1 (a nebulized immunomodulatory agent) plus Standard of Care vs Standard of Care alone.
- Trial name
- NCT05654922
- Testing
- ARINA-1, Standard of care only
- Where
- 22 sites in United States
- Volunteers
- 100 people
- Sponsor
- Renovion, Inc.
Blood And Marrow Transplantation, Leukemia
Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies
The goal of this clinical research study is to learn if it is safe and feasible to transplant changed cord blood for patients with leukemia or lymphoma. Researchers also want to learn if this can help to control the disease.
- Conditions
- Blood And Marrow Transplantation, Leukemia, Lymphoma, Transplantation Infection
- Trial name
- NCT01471067
- Testing
- Melphalan, Fludarabine, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- M.D. Anderson Cancer Center
Thrombocytopenia
Romiplostim in Thoracic Transplantation
The investigators developed a platelet transfusion saving strategy based on thrombopoietin administration in heart or lung transplantation (HLT) patients or assist device implantation in bridge-to-transplantation (BTT) or bridge…
- Trial name
- N-PLATE (NCT03515447)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Transplant-Related Lung Cancer
Non-ablative Oligofractionated Radiation Therapy Before Surgical Transplantation As Radiovaccination
This is a prospective phase I study to determine the safety and feasibility of non-ablative oligofractionated radiation therapy (NORT) before lung transplantation for patients with underlying pulmonary malignancy.
- Trial name
- NORThSTAR (NCT04782752)
- Testing
- Radiation: Varying Doses of RT
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Marc de Perrot
Cytomegalovirus Infections
Cytomegalovirus-Specific Response Measured by QuantiFeron® and Overall Immunologic Response Measured by ImmuKnow® in Lung Transplant Patients CMV-positive
The purpose of this study is to determine the sensitivity and specificity of QuantiFeron® and ImmuKnow® in combination for early detection of patients who will develop CMV infection in lung transplant patients with CMV-positive…
- Trial name
- REIVI (NCT02076971)
- Where
- 7 sites in Spain
- Volunteers
- 92 people
- Sponsor
- Fundacio Catalana de Pneumologia
Aspergillosis, Lung Transplant Infection
The Effect of Early Treatment of PC945 on Aspergillus Fumigatus Lung Infection in Lung Transplant Patients.
This study tests the effects of pre-emptive treatment with an experimental drug PC945 in lung transplant recipients whose lungs are infected by the fungus Aspergillus fumigatus.
- Trial name
- NCT03905447
- Testing
- PC945, Standard of Care
- Where
- 3 sites in United Kingdom
- Volunteers
- 2 people
- Sponsor
- Pulmocide Ltd
COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm
Pharmacokinetics of Sotrovimab as Pre-exposure Prophylaxis for COVID-19 in Hematopoietic Stem Cell Transplant Recipients, COVIDMAB Study
This phase I trial studies the process by which sotrovimab is absorbed, distributed, metabolized, and eliminated by the body (pharmacokinetics) in hematopoietic stem cell transplant recipients.
- Conditions
- COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT05135650
- Testing
- Questionnaire Administration, Sotrovimab, Biospecimen Collection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Fred Hutchinson Cancer Center
Idiopathic Pulmonary Fibrosis
Impact of Pre-transplant Anti-fibrotic Therapy for IPF Upon Lung Transplant Outcomes
Two oral medications, nintedanib and pirfenidone, were approved simultaneously by the FDA in October 2014 for the treatment of this disease.
- Trial name
- IPF-LTOS (NCT04316780)
- Testing
- Retrospective observational study- no intervention to occur.
- Where
- 8 sites in United States
- Volunteers
- 320 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Varicella Zoster Vaccine
Safety and Immunogenicity of Non-live, Recombinant Subunit Herpes Zoster Vaccine Before and After Lung Transplantation
The investigators plan to study the immunogenicity of the vaccine before and after lung transplantation. Patients (at least 50 years old) before and after lung transplantation will be enrolled.
- Trial name
- NCT03493776
- Testing
- VZV subunit vaccine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Deepali Kumar
Lung Diseases
Interest of Learning Self-hypnosis for Patients Awaiting Lung Transplantation
Patients benefitting from a lung transplantation are subject to long-lasting and often severe post-operative pain. Self-hypnosis has been proven effective in the management of acute pain.
- Trial name
- AUTOHYPNOSE-TP (NCT02216539)
- Testing
- Self-hypnosis, Lung transplantation, Standard post-operative pain management
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Hepatitis C, Hepatocellular Carcinoma
Efficacy of Sofosbuvir With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant
The primary objective is to determine if the administration of a combination of sofosbuvir (SOF; GS-7977; PSI-7977) and ribavirin (RBV) to HCV-infected adults with hepatocellular carcinoma (HCC) meeting the MILAN criteria prior…
- Trial name
- NCT01559844
- Testing
- Sofosbuvir, Ribavirin
- Where
- 15 sites in United States, New Zealand and 1 more
- Volunteers
- 61 people
- Sponsor
- Gilead Sciences
Lung Transplantation, Psychosomatic Medicine
Psychosocial Evaluation Prior to Lung Transplantation
In a prospective longitudinal cohort study we aim at investigating the extent to which pre-transplant psychosocial levels of functioning predict the medical and psychosocial outcomes of lung transplantation.
- Trial name
- EVALUT (NCT02799810)
- Volunteers
- 200 people
- Sponsor
- Hannover Medical School
Solid Organ Transplant Recipients
TIXAGEVIMAB/CILGAVIMAB Protection of Covid-19 in Transplanted Patients
Covid-19 has a very bad prognosis in solid organ transplant recipients with a 60 days-mortality exceeding 20%. For this reason, transplant patients were prioritized to receive Covid-19 vaccination since December 2020 in France.
- Trial name
- TIXCI-TRANS (NCT05234398)
- Testing
- Blood and saliva samplings
- Where
- 2 sites in France
- Sponsor
- Hospices Civils de Lyon
Cystic Fibrosis
The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
Gastro-oesophageal reflux (GOR) has been found to be prevalent in children with cystic fibrosis (CF)and may further worsen lung damage via reflex bronchospasm or pulmonary aspiration.
- Trial name
- NCT00164021
- Testing
- Physiotherapy, exercise, percutaneous gastrostomy feeds, Anti-reflux pharmacotherapy
- Where
- Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Lung Transplant; Complications, Ventilator-Induced Lung Injury
Inspiratory Work of Breathing Before and After Extubation
Critically ill patients who (1) are not able to maintain their airway, (2) cannot breathe on their own, or (3) both, are ones who often require tracheal intubation and support from a breathing machine (mechanical ventilator).
- Conditions
- Lung Transplant; Complications, Ventilator-Induced Lung Injury, Ventilator Associated Pneumonia
- Trial name
- INTEGRATION (NCT07017608)
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- University Health Network, Toronto