Clinical trials: Population
Atrial Fibrillation
GISSI-AF - Use of Valsartan an Angiotensin II AT1-Receptor Blocker in the Prevention of Atrial Fibrillation Recurrence
Study purpose The purpose of the study is to show that the addition of valsartan on top of established therapies can reduce the recurrence of atrial fibrillation in patients with a history of recent atrial fibrillation associated…
- Trial name
- NCT00376272
- Testing
- Valsartan
- Where
- 114 sites in Italy, Switzerland
- Volunteers
- 1,442 people
- Sponsor
- Gruppo di Ricerca GISSI
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in participants with chronic rhinosinusitis and nasal polyps treated with intranasal corticosteroids. The study will last about 18 months.
- Trial name
- NCT06338995
- Testing
- LY3650150, Standard therapy for INCS
- Where
- 202 sites in United States, Argentina and 18 more
- Volunteers
- 510 people
- Sponsor
- Eli Lilly and Company
Pregnancy Related, Remote Monitoring
Feasibility of Remote eCTG Monitoring Home@Hospital in Complicated Pregnancies
The objective of this single center, interventional cohort study is to evaluate the feasibility of remote electrophysiological cardiotocography (eCTG) monitoring in complicated pregnancies in a home@hospital setting.
- Conditions
- Pregnancy Related, Remote Monitoring, Feasibility
- Trial name
- HASTA (NCT06859177)
- Testing
- Remote eCTG
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Asthma
Intermittent and Daily Dosing for Episodic (Periodic) Asthma (0476-302)(COMPLETED)
This is a year-long study evaluating the efficacy of both daily and intermittent treatment of asthma in children who experience symptoms episodically (i.e., seasonally, usually in the context of upper respiratory tract infection).
- Trial name
- NCT00337675
- Testing
- montelukast sodium
- Volunteers
- 1,771 people
- Sponsor
- Organon and Co
Postherpetic Neuralgia
Efficacy and Safety of LX9211 in Participants With Postherpetic Neuralgia
Evaluation of the efficacy of LX9211 compared to placebo in reducing pain related to postherpetic neuralgia over an 11 week assessment period.
- Trial name
- RELIEF-PHN1 (NCT04662281)
- Testing
- LX9211
- Where
- 32 sites in United States, Czechia and 1 more
- Volunteers
- 79 people
- Sponsor
- Lexicon Pharmaceuticals
Gastric Cancer, Gastric Intestinal Metaplasia
Chemoprevention of Gastric Carcinogenesis
A clinical study of the efficacy of oral alpha-difluoromethylornithine (eflornithine or DFMO) in male and female subjects ages 30-60 with gastric premalignant lesions in two high risk regions of Latin America.
- Trial name
- NCT02794428
- Testing
- Eflornithine
- Where
- 2 sites in Honduras, Puerto Rico
- Volunteers
- 91 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Adult Caregivers of Individuals With TSC, Tuberous Sclerosis Complex (TSC)
TANDem-2: Closing the Gap to Interventions for TAND
The goal of this pilot study is to determine the feasibility, acceptability and impact of a brief behavioral intervention - the "Well-Beans for Caregivers" program, for adult caregivers of individuals with tuberous sclerosis…
- Trial name
- TANDem-2 (NCT06879665)
- Testing
- Well-Beans for Caregivers Program
- Where
- 2 sites in United States, Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Huntington's Disease
A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease
The primary purpose of this study is to assess the effect of food upon the pharmacokinetics (PK) of SEN0014196 in subjects with Huntington disease (HD).
- Trial name
- NCT01485965
- Testing
- SEN0014196
- Where
- 7 sites in United States
- Volunteers
- 26 people
- Sponsor
- Siena Biotech S.p.A.
Head and Neck Cancer
Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) 2.0
Head and neck cancer (HNC) survivors with body image-related distress (BID) will be randomized to 5-weeks of tablet-based BRIGHT or tablet-based active control (AC; electronic information about HNC recovery).
- Trial name
- BRIGHT (NCT03831100)
- Testing
- BRIGHT, Active Control
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Medical University of South Carolina
Burned Children, Ceftazidime Treatment
Ceftazidime in Burn Children
Concentrations and effects of Ceftazidime in critically ill burn children are unpredictable and the risk of under-exposure may be associated with poor clinical outcomes.
- Trial name
- CEFTAZOPTIM (NCT03881800)
- Testing
- titration- blood sample
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoporosis
Artificial Intelligence-Guided Diagnosis for High-Risk Osteoporosis Populations: A Pragmatic Randomized Clinical Trial
Project Summary I. Project Objectives With the rapid advancement of medical technology, smart medical devices have become one of the key components of modern healthcare.
- Trial name
- NCT07620834
- Testing
- VeriOsteo OP
- Where
- 3 sites in Taiwan
- Volunteers
- 1,180 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Diabetes Mellitus, Type 2
Compare Two Dosing Algorithms in Insulin-Naive Patients With Type 2 Diabetes Mellitus
This randomized, multicenter, open-label, active-comparator, 2-arm, parallel-group, 6 month study with approximately 360 patients will compare the efficacy of two treatment regimens (Algorithm A versus Algorithm B) in…
- Trial name
- NCT00391209
- Testing
- simplified diabetes regimen starting with a fixed dose of Human Insulin Inhalation Powder, intensive diabetes management starting with an adjusted dose of Human Insulin Inhalation Powder
- Where
- 42 sites in United States, Argentina and 7 more
- Volunteers
- 379 people
- Sponsor
- Eli Lilly and Company
Lumbosacral Radiculopathy
Efficacy and Safety of ETX-018810 in Subjects With Lumbosacral Radicular Pain
Efficacy and Safety of ETX 018810 in Subjects with Lumbosacral Radicular Pain
- Trial name
- NCT04778592
- Testing
- ETX-018810
- Where
- 24 sites in United States
- Volunteers
- 149 people
- Sponsor
- Eliem Therapeutics (UK) Ltd.
Health Behavior
"HASCV-R" Health Programme
The goal of this randomized controlled trial: is to determine the effect of " HASCV-R " health programme on the health promoting and protective behaviours of the Turkish-Greek Population Exchange migrant women.
- Trial name
- HASCV-R (NCT06177145)
- Testing
- HASCV-R program
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Bozok University
Hypercholesterolemia
Study of Efficacy and Safety of Inclisiran in Asian Participants With Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD High Risk and Elevated Low Density Lipoprotein Cholesterol (LDL-C)
A multicenter study to evaluate safety and efficacy of inclisiran in Asian patients with ASCVD or ASCVD high risk and elevated LDL-C
- Trial name
- NCT04765657
- Testing
- inclisiran sodium
- Where
- 45 sites in China, Singapore and 2 more
- Volunteers
- 345 people
- Sponsor
- Novartis Pharmaceuticals
Necrotizing Soft Tissue Infections, Necrotizing Fasciitis
Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections
The purpose of this study is to determine whether AB103 is safe and effective in the treatment of patients with necrotizing soft tissue infections (NSTI) receiving standard of care therapy.
- Conditions
- Necrotizing Soft Tissue Infections, Necrotizing Fasciitis, Fournier's Gangrene
- Trial name
- ACCUTE (NCT02469857)
- Testing
- AB103 0.5 mg/kg, NaCl 0.9%
- Where
- 71 sites in United States, France
- Volunteers
- 290 people
- Sponsor
- Atox Bio Ltd
Balance, Cerebellum
Association Between Balance and the Integrity of Cerebellar White Matter Tracts in a Healthy Population
The cerebellum is involved in regulating balance and walking and plays a crucial role in the locomotor adaptation and learning processes.
- Trial name
- NCT04934319
- Testing
- Balance and Proprioceptive Training
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Community Members
Evaluation of Tak Community Advisory Board
A popular form of community engagement is for the researchers to interact with a Community Advisory Board. The Shoklo Malaria Research Unit has been working on the Thai-Burmese border for many years and has been informally…
- Trial name
- NCT01719965
- Testing
- Interviews and Focus Group Discussions
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Acute Severe Colitis
Prognostic Role of Bowel Ultrasound Scan in Children Affected by Acute Severe Colitis
ASC is a life-threatening medical emergency. The lack of a timely intervention has shown to be associated with a mortality rate higher than 20% in adults, whereas a prompt targeted therapy has displayed a decrease of the…
- Trial name
- NCT06324500
- Where
- 4 sites in Italy, Spain
- Volunteers
- 120 people
- Sponsor
- Meyer Children's Hospital IRCCS
Healthy Participants
A Comparative Study to Evaluate the Effects and Mechanism of Action of Dysport®, Botox® and Xeomin® in the Extensor Digitorum Brevis Model in Healthy Adult Male Participants
Study aimed at comparing the pharmacodynamic profile (including duration of action) of three commercialized toxins by measuring the action potential of the injected muscle (extensor digitorum brevis)
- Trial name
- NCT04970407
- Testing
- Botulinum toxin type A
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ipsen