Clinical trials: Polypharmacy
Polypharmacy (Individuals Treated With 4 or More Medications)
THE EFFECTS OF MULTIPLE DRUG USE ON BALANCE, FALL RISK, AND COGNITIVE STATUS
This study aims to evaluate the effects of polypharmacy on balance, fall risk, cognitive status, vestibular function, and hearing among individuals living in nursing homes.
- Trial name
- NCT07816276
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Polypharmacy, Alzheimer's Disease and Related Dementias
ALIGN: Aligning Medications With What Matters Most (Demonstration)
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners.
- Conditions
- Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment
- Trial name
- NCT06335953
- Testing
- Pharmacist-led deprescribing intervention
- Where
- United States
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Polypharmacy, Alzheimer Disease and Related Dementias
Aligning Medications With What Matters Most
The Aligning Medications with What Matters Most (ALIGN) study will assess the feasibility and preliminary efficacy of a deprescribing intervention to reduce medication regimen complexity and treatment burden for people living…
- Trial name
- ALIGN (NCT04938648)
- Testing
- Pharmacist-led deprescribing intervention
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Risk Factors, Polypharmacy
Telecommunication Technology-based Online Survey
The aim of this study is to identify and assess new health-associated risk factors, including clinical-pharmacological risk factors. The cohort is built using telecommunication approaches.
- Conditions
- Risk Factors, Polypharmacy, Drug Interactions, Self Medication
- Trial name
- NCT06159699
- Testing
- Online Survey, Genetic Testing
- Where
- Russia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Polypharmacy, Deprescribing
Effect of Medication Management at Home Via Pharmacy Home Televisits
Older Veterans, particularly those with multiple chronic conditions requiring complex medication regimens, are more susceptible to adverse effects of medications.
- Conditions
- Polypharmacy, Deprescribing, Telemedicine
- Trial name
- NCT04340570
- Testing
- Medication management via televisit to home
- Where
- 2 sites in United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Polypharmacy, Dementia
Adapting the Shed-MEDS Deprescribing Intervention to Dementia Care in Assisted Living
This single-arm pilot study will evaluate the effects of an intervention to reduce exposure to unnecessary or potentially harmful medications among residents with dementia living in an assisted living facility.
- Conditions
- Polypharmacy, Dementia, Quality of Life
- Trial name
- NCT05956665
- Testing
- Shed-MEDS deprescribing intervention
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Caregivers of Multi-pathological and Polypharmacy Adults
Safe Use of Medication at Home by Caregivers. Experimental Study
Experimental study to test the effectiveness of a psychoeducational intervention using virtual reality, aimed at caregivers of multi-pathological and polypharmacy persons to promote safer medication use at home.
- Trial name
- NCT05247801
- Testing
- Psychoeducational intervention for safe medication use at home + Medication dosing device, Medication dosing device
- Where
- Spain
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Cognitive Decline, Sarcopenia
Holistic Integration for Healthy Longevity and Aging in Place
Background: Taiwan is experiencing rapid population aging, with a growing prevalence of chronic diseases and functional impairments among older adults.
- Conditions
- Cognitive Decline, Sarcopenia, Depression Disorders, Nutrition Disorder
- Trial name
- HIHOPE (NCT06882434)
- Testing
- Local intervention program, Referral Process, Telehealth Education & Digital Integration
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Polypharmacy, Dementia
Shared Decision Making About Medication Use for People With Multiple Health Problems
The Shared Decision Making about Medication Use for People with Multiple Health Problems study will assess the feasibility and acceptability of a deprescribing educational intervention in primary care for patients with mild…
- Conditions
- Polypharmacy, Dementia, Multiple Chronic Conditions, Deprescribing
- Trial name
- NCT05156073
- Testing
- Educational Materials
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Polypharmacy, Multiple Chronic Conditions
Protocol for a Multi-site Pilot Study of the OptiMed Clinical Trial
Background: Optimal medication management is one of the essential preconditions for polymedicated home-dwelling older adults with multiple chronic conditions to remain at home and preserve their quality of life and autonomy.
- Trial name
- OptiMed (NCT06688591)
- Testing
- Intervention programme to optimise medication management and prevent MRPs
- Volunteers
- healthy volunteers welcome
- Sponsor
- HES-SO Valais-Wallis
Polypharmacy
Bundled Hyperpolypharmacy Deprescribing
Older patients using many prescription drugs (hyperpolypharmacy) may be at increased risk of adverse drug effects. This randomized controlled trial tested the effectiveness and safety of a quality intervention intended to reduce…
- Trial name
- NCT05616689
- Testing
- Bundled hyperpolypharmacy
- Where
- United States
- Volunteers
- 2,471 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Inappropriate Prescribing, Primary Health Care
Deprescribing in Primary Health Care
Medications can help older adults but can also harm them. Frail older adults tend to have many health problems that require treatment, but are also at risk of harm from the medications prescribed.
- Conditions
- Inappropriate Prescribing, Primary Health Care, Polypharmacy
- Trial name
- NCT03903484
- Testing
- Deprescribing toolbox and intervention
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Fall, Fall Injury
A Clinical Decision Support System and Patient Portal for Preventing Medication-related Falls in Older Patients
Falls in older adults represents a growing public health challenge. The use of certain medication is recognized as an important modifiable risk factor for falls.
- Conditions
- Fall, Fall Injury, Fall Patients, Accidental Fall
- Trial name
- ADFICE_IT (NCT05449470)
- Testing
- CDSS, Patient Portal
- Where
- 10 sites in Netherlands
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Polypharmacy
Measuring the Impact of an Interdisciplinary Polypharmacy Clinic Within a Patient-centered Medical Home
Title: Measuring the impact of an interdisciplinary polypharmacy clinic within a patient-centered medical home Objectives: The primary objective of this project will be to track the types of interventions made in an…
- Trial name
- NCT02077725
- Testing
- interdisciplinary polypharmacy clinic visit
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Polypharmacy, Aging
Psychological and Clinical Factors That Predict Intent to Deprescribe Medications Among Older Adults
The investigators are conducting two experimental surveys to explore clinical and psychological factors that influence older adults' willingness to stop medications in the face of polypharmacy.
- Trial name
- NCT04676282
- Testing
- Hypothetical Scenario
- Where
- United States
- Volunteers
- 10,184 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Polypharmacy
Appropriate Polypharmacy in Older People in Primary Care
In the past, prescribing many medicines (polypharmacy) was seen in a negative light. However, because people are living longer and have several medical conditions at the same time, views on polypharmacy have changed.
- Trial name
- PolyPrime (NCT04181879)
- Testing
- Intervention
- Where
- 2 sites in Ireland, United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Comorbidity, Medication Therapy Management
Effectiveness of a Medication Wallet Card
This study evaluates whether or not the use of a medication wallet card in patients over 70 taking 5 or more medications promotes self-efficacy with regards to coping with illness, understanding medications, and staying healthy.
- Conditions
- Comorbidity, Medication Therapy Management, Polypharmacy
- Trial name
- NCT02820129
- Testing
- Medication Wallet Card, Reminder Card
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Polypharmacy, Inappropriate Prescribing
Opportunities and Limits to Deprescribing in Nursing Homes:Quality Circle Deprescribing Module
Older people residing in nursing homes (NH) are frequently polymedicated and often prescribed potentially inappropriate medications.
- Trial name
- OLD-NH-QC-DeMo (NCT03688542)
- Testing
- Quality Circle Deprescribing Module
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Anne Niquille
Polypharmacy
Structured Polypharmacy Management Before Elective Non-cardiac Surgery in Frail and Elderly People
The older segment of the population is growing faster than any other segment. Older people have surgery more often than any other age group, and these older patients often take multiple medications, including medications that may…
- Trial name
- NCT03445767
- Testing
- MedSafer
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Aging, Polypharmacy
Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.
In this study, the investigators will investigate and characterize acute medical patients in order to optimize patient courses in the acute care departments, especially with regard to polypharmacy and undernourishment.
- Conditions
- Aging, Polypharmacy, Malnutrition, Inflammation
- Trial name
- FAM-CPH (NCT03052192)
- Where
- Denmark
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital