Clinical trials: Polypharmacy
Medication Review, Polypharmacy
Medication Review in Chronic Complex or Polymedicated Patients After Hospital Discharge.
The goal of this prospective multicentre clustered randomized controlled trial is to evaluate the effect on new hospitalization episodes of a multidisciplinary medication review in primary care patients with polypharmacy or…
- Conditions
- Medication Review, Polypharmacy, Disease, Chronic
- Trial name
- NCT05799430
- Testing
- Multidisciplinary medication review, Control group
- Where
- Spain
- Volunteers
- 372 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Adverse Drug Reaction (ADR), Polypharmacy Patients
IPGx PILOT Whole Genome Sequencing Extension Cohort
The investigator's primary aim is to evaluate polypharmacy-associated adverse drug reactions (ADR) in a pilot study of at-risk patients using state-of-the-art pharmacogenomic technology and to use this information to make…
- Trial name
- NCT06766071
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Texas A&M University
Polypharmacy
Medication Minimization for Long-term Care Residents
The purpose of this experiment is to test the effect of medication minimization on mortality and hospitalization in long-term care residents.
- Trial name
- WiseMed (NCT01932632)
- Testing
- Medication Minimization
- Where
- 6 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
Polypharmacy Patients
Assessment of a Novel Algorithm System for Polypharmacy Patient Medication Safety and Consultation
The aim of this study is to determine if insights based on the analysis of historical data of multidrug patients' electronic health records, by a novel system and algorithm, is noninferior to a clinical pharmacist analysis and…
- Trial name
- NCT05589870
- Testing
- Multi-drug analysis of polypharmacy treatment
- Where
- Israel
- Volunteers
- 91 people
- Sponsor
- MDI Health
Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction (HFrEF and HFmrEF)
Polypharmacy, Safety, and Medication Adherence in Patients With Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction
This prospective registry study (FARAON) aims to assess the prevalence, structure, safety profile, and dynamics of polypharmacy, as well as its association with medication adherence, quality of life, and clinical outcomes in…
- Trial name
- FARAON (NCT07640854)
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Polypharmacy, Incontinence
An Intervention Study to Reduce the Use and Impact of Potentially Inappropriate Medications Among Older Adults
An educational intervention targeting community-dwelling older adults will lead to a reduction in potentially inappropriate prescriptions (e.g. benzodiazepines, oxybutynin).
- Conditions
- Polypharmacy, Incontinence, Insomnia, Anxiety
- Trial name
- NCT01148186
- Testing
- knowledge transfer tool
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Poly Pharmacy, Frail Elderly
Applying a Multidisciplinary Intervention for Drug Adequacy in an Intermediate Care Hospital (AMIDA-ICH)
The goal of this clinical trial is to learn if a multi-professional (conducted by geriatricians, clinical pharmacists, nurses) medication revision, centered on patients' goals and characteristics, can improve treatment adequacy…
- Trial name
- AMIDA-ICH (NCT07015112)
- Testing
- Patient-centered multidisciplinary treatment review
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Parc Sanitari Pere Virgili
Hypertension
Reduction Of Dietary Salt Intake To Control Systolic Blood Pressure In Hypertensive Older Patients
REPRESS is an open label, pragmatic, multicenter, randomized controlled phase III trial with blinded endpoint with 1:1 (intervention to control arm) allocation ratio.
- Trial name
- REPRESS (NCT05976477)
- Testing
- educational intervention
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Adverse Drug Event
Improving Wisely - Polypharmacy
This is a randomized controlled trial that uses an audit and feedback intervention to alert primary care physicians who are outliers in one or more metrics related to high risk prescribing of participants' outlier status.
- Trial name
- NCT03857100
- Testing
- Audit and feedback - letter and report
- Where
- United States
- Volunteers
- 11,000 people
- Sponsor
- Johns Hopkins University
Neurologic Disorder, Chronic Disease
Parent-Reported Symptom Assessments in Children Taking Multiple Medications
This study plans to learn about how to measure symptoms (like tiredness or rash) in children with special healthcare needs who take 5 or more medications. Sometimes symptoms change in severity over time or new symptoms develop.
- Conditions
- Neurologic Disorder, Chronic Disease, Pediatric Disorder
- Trial name
- PRSA (NCT03849066)
- Testing
- Parent-Reported Symptom Assessment
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Colorado, Denver
Polypharmacy, Drug-drug Interactions
Epidemiology of Polipharmacy and Potential Drug-Drug Interactions in Elderly Cardiac Outpatients
As the proportion of elderly population increasing over the last years, polypharmacy and drug-drug interactions (DDI) has been a common health care problem.
- Trial name
- EPIC (NCT03370523)
- Testing
- No intervention is planned in our study
- Where
- Turkey (Türkiye)
- Volunteers
- 5,000 people
- Sponsor
- Muğla Sıtkı Koçman University
Age 65 and Older, Polypharmacy
Effect of Longitudinal Care in Primary Health Care: An Analysis From the Patient's Perspective
Objective To explore and describe the opinions of Primary Health Care chronically ill users regarding being cared for over time by the same reference professional.
- Conditions
- Age 65 and Older, Polypharmacy, Cronic Lung Disease, Mental Disorder
- Trial name
- CUALIPRIM (NCT07320053)
- Where
- 2 sites in Spain
- Volunteers
- 26 people
- Sponsor
- IBS Granada
Polypharmacy
Deprescribing in a Long Term Care Facility
This study will develop, implement and evaluate a deprescribing initiative at a Canadian Long Term Care (LTC) Facility. Residents currently undergo an annual medication review as part of the clinical pharmacy services provided in…
- Trial name
- NCT03091153
- Testing
- Medication Review
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Memorial University of Newfoundland
Schizophrenia, Schizoaffective Disorder
Polypharmacy in Clozapine-resistant Schizophrenia
The aim of this randomized, double-blind study is to verify the hypothesis that clozapine monotherapy is as efficient as a combination of clozapine and olanzapine therapy in treatment-resistant schizophrenia.
- Trial name
- CLOZANS (NCT00918021)
- Testing
- olanzapine
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Niuvanniemi Hospital
Multi-morbidity, Medication Therapy Management
Team Approach to Polypharmacy Evaluation and Reduction
In an aging population, most seniors suffer from multiple chronic conditions. When the number of medications taken is ≥5 (polypharmacy), the burden of taking multiple concurrent medications can do more harm than good.
- Conditions
- Multi-morbidity, Medication Therapy Management, Polypharmacy
- Trial name
- TAPER-RCT (NCT02942927)
- Testing
- Medication reduction
- Where
- Canada
- Volunteers
- 345 people
- Sponsor
- McMaster University
Polypharmacy, General Surgery
Polypharmacy and Associated Risk Factors and Clinical Outcomes for Surgical Patients Discharged From Hospital
The World Health Organisation Patient Safety Challenge: Medication Without Harm has brought our attention to the importance of medication-related harm as a global public health issue.
- Trial name
- NCT04805151
- Testing
- No intervention
- Where
- Iceland
- Volunteers
- 56,000 people
- Sponsor
- University of Iceland
Polypharmacy, Multimorbidity
Reduction of Polypharmacy in Elderly People With Multiple Diseases
Elderly GP patients are often treated with five or more medications and therefore prone to adverse drug reactions (ADR). Potentially inappropriate prescriptions (PIPs) lead to increased adverse events like falls, hospitalizations…
- Trial name
- RED (NCT05526963)
- Testing
- Medication plan review, Adherence support
- Where
- Germany
- Volunteers
- 1,146 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Multi-morbidity, Medication Therapy Management
Team Approach to Polypharmacy Evaluation and Reduction (Pharmacy)
In an aging population, most seniors suffer from multiple chronic conditions. When the number of medications taken is ≥5 (polypharmacy), the burden of taking multiple concurrent medications can do more harm than good.
- Conditions
- Multi-morbidity, Medication Therapy Management, Polypharmacy
- Trial name
- NCT03557944
- Testing
- Medication reduction
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Elderly Internal Medicine Patients
Intervention to Improve Prescribing in Elderly Patients
This study tested the efficacy of an easy-to-use checklist aimed at supporting the therapeutic reasoning of physicians in order to reduce inappropriate prescribing and polypharmacy in elderly adults admitted to an internal…
- Trial name
- NCT02712268
- Testing
- Checklist
- Volunteers
- 450 people
- Sponsor
- University Hospital, Basel, Switzerland