Clinical trials: Pneumoperitoneum, active
Respiratory Mechanics, Hemodynamics
vNOTES vs Laparoscopy: Respiratory Mechanics and Hemodynamics
Pneumoperitoneum and Trendelenburg position are unavoidable in laparoscopic surgery and are known to have adverse effects on intraoperative respiratory mechanics and hemodynamics.
- Trial name
- NCT07667907
- Testing
- vNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery, Laparoscopic Gynecological Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Airway Edema, Postoperative Complications
Effect of Prophylactic Dexamethasone vs Placebo on Airway Dimensions Assessed by Ultrasonography in Patients Undergoing Laparoscopic Cholecystectomy
During laparoscopic surgery, the abdomen is inflated with carbon dioxide gas (pneumoperitoneum), which alters venous return and fluid distribution, potentially leading to swelling in the tissues of the upper airway.
- Conditions
- Airway Edema, Postoperative Complications, Cholecystolithiasis
- Trial name
- NCT07918495
- Testing
- Dexamethasone
- Volunteers
- 80 people
- Sponsor
- Assiut University
Vnotes, Respiratory Mechanics
Effects of Trendelenburg Position and Pneumoperitoneum on Mechanical Power and Respiratory Mechanics During V-NOTES Surgery
The purpose of this observational study is to evaluate the effects of Trendelenburg positioning and pneumoperitoneum on mechanical power and respiratory mechanics in adult women undergoing vaginal natural orifice transluminal…
- Trial name
- NCT07885111
- Volunteers
- 14 people
- Sponsor
- Burcu Ayvazoğlu
Postoperative Atelectasis, Postoperative Pulmonary Complications
HFNC for Postoperative Atelectasis After Laparoscopic Surgery
Pneumoperitoneum and Trendelenburg positioning during laparoscopic surgery promote atelectasis development, which has been reported in up to 90% of patients under general anesthesia and increases the risk of postoperative…
- Trial name
- NCT07676760
- Testing
- High-Flow Nasal Cannula (HFNC), Conventional Oxygen Therapy
- Volunteers
- 90 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Robotic Surgery, Urologic Surgical Procedures
Timing of Recruitment Maneuver in Robotic Prostate Surgery
Robotic prostate surgery is commonly performed under general anesthesia with carbon dioxide pneumoperitoneum and steep Trendelenburg positioning.
- Conditions
- Robotic Surgery, Urologic Surgical Procedures, Postoperative Pulmonary Complications (PPCs), Pulmonary Atelectasis
- Trial name
- ROBPROREC1 (NCT07662642)
- Testing
- Recruitment maneuver after insufflation and Trendelenburg positioning, Recruitment maneuver in the supine position
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Ankara University
Postoperative Delirium (POD), Prostate Cancer
Preoperative Breathing Exercise Training and Postoperative Delirium After Robotic Radical Prostatectomy
Postoperative delirium is an acute and fluctuating disturbance in attention, awareness, and thinking that may occur after major surgery.
- Trial name
- NCT07766603
- Testing
- Preoperative Deep Breathing Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- ALİ DEMİRTAŞ
Malignant or Benign Pathology
Low Impact Laparoscopic in Colorectal Resection - PAROS2
To improve post-operative recovery, the concept of Low Impact Laparoscopy was developed in colo-rectal surgery with associating low-pressure pneumoperitoneum and microlaparoscopic surgery.
- Trial name
- PAROS2 (NCT04742881)
- Testing
- Low pressure + microsurgical instruments, Low pressure + standard instruments
- Where
- 3 sites in France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Bordeaux
Appendectomy, Laparoscopic, Intra Abdominal Pressure
Laparoscopic Appendectomy: Outcomes of 10 mmHg Versus 15 mmHg Intra-abdominal Pressure
This prospective, randomized controlled trial aims to compare the clinical outcomes of laparoscopic appendectomy performed under two standard pneumoperitoneum pressures (10 mmHg and 15 mmHg).
- Trial name
- NCT07727499
- Testing
- Laparoscopic appendectomy with 10 mmHg pneumoperitoneum, Laparoscopic appendectomy with 15 mmHg pneumoperitoneum
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ankara Etlik City Hospital
Obesity, Morbid
Low Impact Laparoscopy In Bariatric Surgery
The goal of this clinical trial is to learn if low pressure pneumoperitoneum and small incisions (low impact laparoscopy, LIL) works to reduce pain and improve pulmonary function in patients underwent to bariatric surgery.
- Trial name
- LILYBET (NCT07119437)
- Testing
- low pneumoperitoneum laparoscopy with microsurgery, standard laparoscopy
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Laparoscopic Surgery, Neuromuscular Blocking Agents
Study of the Relationship Between Curarization and Pneumoperitoneum in Laparoscopic Surgery
The number of surgical procedures is increasing worldwide (1). Laparoscopic surgery is one of the surgical techniques that has become indispensable. Laparoscopic surgery is less invasive than laparotomy.
- Conditions
- Laparoscopic Surgery, Neuromuscular Blocking Agents, Pneumoperitoneum
- Trial name
- PneumandTOF (NCT07005518)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 200 people
- Sponsor
- Poitiers University Hospital
Shoulder Pain
Pneumoperitoneum Management With SurgiQuest AirSeal® at Low vs. Higher Pressure
A prospective, randomized, controlled single-center clinical Study designed to evaluate Physician Preference related to the use of the SurgiQuest AirSeal® Insufflation System (AIS) at low vs.
- Trial name
- PRESSURE (NCT02837601)
- Testing
- AirSeal® Insufflation System (AIS)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Akron Children's Hospital
Acute Kidney Injury, Subclinical Acute Kidney Injury
Early Kidney Injury Biomarkers in Gynecologic Laparoscopic Surgery
This prospective observational study aims to evaluate early subclinical acute kidney injury associated with pneumoperitoneum and Trendelenburg positioning during gynecological laparoscopic surgery.
- Trial name
- NCT07704242
- Testing
- Pneumoperitoneum and Trendelenburg Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Medipol University
Trendelenburg Position, Pneumoperitoneum
Predictors of Postoperative Complications in Surgery With Pneumoperitoneum in the Trendelenburg Position
Evaluate early postoperative complications after surgery in Trendelenburg position with increased intraabdominal pressure (surgery with pneumoperitoneum).
- Trial name
- NCT06685159
- Testing
- Laparoscopic Surgery
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Reuven Pizov
Endometrial Cancer
Low-Residue Diet Versus Rectal Enema Before Laparoscopic Surgery for Endometrial Cancer
The goal of this clinical trial is to compare a standardized 3-day bowel preparation protocol with a rectal enema before laparoscopic surgery for endometrial cancer.
- Trial name
- NCT07702799
- Testing
- Low-Residue Diet, Sodium Phosphate Rectal Enema
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Mahmut Yassa
Laparoscopy, Pneumoperitoneum
The Turbine-based CO2 Insufflator Pediatric Feasibility Study
A novel CO2 insufflator, the Turbine-based insufflator, has been developed to improve minimally invasive surgery. Turbine technology permits accurate pressure control resulting in an intra-abdominal volume that is dynamically…
- Trial name
- TuBa (NCT07715968)
- Testing
- Turbine-based insufflator
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Erasmus Medical Center
Atelectasis, Perioperative Oxygenation
Individualized vs Standard PEEP and Oxygen Reserve Index in Laparoscopic Hernia Surgery
During laparoscopic surgery under general anesthesia, lung function can be affected by increased abdominal pressure and patient positioning.
- Conditions
- Atelectasis, Perioperative Oxygenation, Laparoscopic Inguinal Hernia Repair, Mechanical Ventilation
- Trial name
- NCT07775573
- Testing
- Standard PEEP Ventilation, Individualized PEEP Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Anesthesia, Mechanical Ventilation
VC-AF vs FCV in Obese Patients Undergoing Laparoscopic Surgery
Obesity adversely affects respiratory physiology by reducing lung volumes and compliance and increasing airway resistance and alveolar collapse.
- Conditions
- Anesthesia, Mechanical Ventilation, Obesity
- Trial name
- NCT07875530
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Robotic Surgery, Pneumoperitoneum
Low Gas Pressure vs Standard Gas Pressure in Robotic Surgery
During surgery that is done using a robot, the surgeon needs to put carbon dioxide gas into the belly to lift the belly wall. This is done so the surgeon can adequately see all the body organs and operate safely.
- Trial name
- NCT07710352
- Testing
- AirSeal Robotic Solution, Standard-pressure pneumoperitoneum (15 mmHg)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Weill Medical College of Cornell University
Postoperative Delirium (POD), Intracranial Hypertension
Low Pneumoperitoneum Pressure for Delirium Prevention in Elderly Laparoscopy
A randomized, double-blind trial comparing low (8-10 mmHg) versus standard (14 mmHg) intraabdominal pressure during laparoscopic pelvic surgery in patients aged 60 and older.
- Trial name
- NCT07906444
- Testing
- Low Intraabdominal Pressure Pneumoperitoneum, Standard Intraabdominal Pressure Pneumoperitoneum
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Benha University
Thyroid Cancer
Clinical Study on the Efficacy of Laparoscopic Assisted Open Surgery Through Subclavian Approach for Unilateral Thyroid Cancer
This study compares the clinical efficacy of non inflatable subclavian endoscopic surgery and open surgery for unilateral thyroid cancer, aiming to compare the differences in lymph node dissection rate, complication rate…
- Trial name
- NCT07654322
- Volunteers
- 400 people
- Sponsor
- Xijing Hospital