Clinical trials: Physiology
Normal Physiology
Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction
Background: Abusing alcohol, drugs, and other substances can cause serious health problems. These substances also can affect brain function.
- Trial name
- NCT02535702
- Testing
- In vivo MRS, fMRI, EEG/EOG
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Normal Physiology
Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making
Background: People with substance use disorder (SUD) often have changes in brain function that can make it difficult to control drug-seeking behavior.
- Trial name
- NCT06561828
- Testing
- continuous Theta Burst Stimulation (cTBS), intermittent Theta Burst Stimulation (iTBS)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Normal Physiology
Causal Mechanisms of Odor-Guided Behavior in Humans
Background: Little is known about how different regions of the brain responsible for the human sense of smell guide behaviors. In this study, researchers use a technique called transcranial ultrasound stimulation (TUS) to learn…
- Trial name
- NCT07099092
- Testing
- TUS PirC, TUS Amy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Dehydrated, Water-Electrolyte Imbalance, Malnutrition, Dehydration (Physiology)
Effects of Increased Water Intake on Hormonal Response, Hydration Status, and Physical Function in Low-drinking Older Adults
DrinkAge is a randomized controlled trial investigating whether increasing daily water intake can improve hydration and health-related outcomes in adults aged 60 years or older who habitually drink relatively little water.
- Trial name
- DrinkAge (NCT07892742)
- Testing
- Water
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Polytechnic University of Santarém
Obesity, Puberty
Investigating the Impact of Obesity on Pubertal Development in Girls
Background: Studies suggest that overweight girls may be developing breast tissue, and therefore starting puberty, earlier than normal weight girls. However, it is hard to distinguish breast tissue from fatty tissue.
- Conditions
- Obesity, Puberty, Normal Physiology
- Trial name
- NCT02583646
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Normal Physiology
Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array
Background: Brain activity produces magnetic fields. These fields can be measured outside the head. Existing technology, called MEG, measures these fields. Researchers are testing a new type of magnetic field sensor called OPM.
- Trial name
- NCT04950309
- Testing
- SQUID MEG, OPM MEG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cardiovascular Physiology
Effects of Tart Cherry and Aronia Extract Supplementation on Selected Physiological Parameters in Endurance-Trained Men
This study will evaluate the effects of four weeks of oral supplementation with a double-standardized tart cherry (Prunus cerasus) and aronia (Aronia melanocarpa) extract on cardiovascular regulation and exercise performance in…
- Trial name
- NCT07885098
- Testing
- Standardized Tart Cherry and Aronia Extract
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Cell Physiology Education
RGE-Based Cell Physiology Education for International Medical Students
This study evaluated an integrated active-learning approach for teaching cell physiology to international medical students at Tehran University of Medical Sciences.
- Trial name
- NCT07885553
- Testing
- RGE-Based Cell Physiology Education
- Where
- Iran
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Pain, Normal Physiology
Neural and Psychological Mechanisms of Pain Perception
Background: Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain.
- Conditions
- Pain, Normal Physiology, Healthy Volunteers
- Trial name
- NCT02446262
- Testing
- Instructions, Attention, Thermal Pain
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Normal Physiology, Healthy Volunteers
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain.
- Conditions
- Normal Physiology, Healthy Volunteers, Pain
- Trial name
- NCT03258580
- Testing
- Medoc thermal stimulator, Electric shock stimulator, Cold water bath
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Normal Physiology, Alcohol Use Disorder
Addictions Neuroclinical Assessment (ANA)
Background: Alcohol use disorder (AUD) is a major public health problem. In the U.S., 16 to 18 million adults have an AUD. Researchers want to test an assessment tool called the ANA.
- Trial name
- NCT04946851
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Normal Physiology
Perception, Sensation, Cognition and Action in Humans
Background: When people see and hear, the brain changes signals from the eyes and ears into perceptions and thoughts. No one fully understands how this happens.
- Trial name
- NCT03407066
- Where
- 2 sites in United States
- Volunteers
- 10,200 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Stress Physiology, Stress Reaction
The Human Stress Response in a Simulated ED Setting
Stress is important for health. As emergency departments (EDs) are often stressful places, a better understanding of the human stress response is important for understanding how and why patients respond as they do when they come…
- Conditions
- Stress Physiology, Stress Reaction, Substance Use Disorders, Methamphetamine-dependence
- Trial name
- NCT04317482
- Testing
- Standard social stress task, Stressful experience in the ED
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Normal Physiology
Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex
Background: Training in a new motor skill often involves periods of active practice and periods of rest. During early motor skill learning, improvements in performance usually happen during the short rest periods between practice…
- Trial name
- NCT04431011
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Normal Physiology
Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects
Background: Magnetic resonance imaging (MRI), which uses strong magnets to get images of structures inside the body, is a valuable tool in modern medicine. But researchers are always looking for ways to improve this technology.
- Trial name
- NCT05604534
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Schizophrenia, Normal Physiology
Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers
The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers.
- Trial name
- NCT00004571
- Where
- United States
- Volunteers
- 3,273 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Normal Physiology
MRS Measurement of Glutamate and GABA Metabolism in Brain
This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of [13]C as it is naturally metabolized from glucose to specific chemical transmitters.
- Trial name
- NCT00109174
- Testing
- 3T and 7T device
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Normal Physiology
Development of 3T Magnetic Resonance Research Methods for NIA Studies
Background: Magnetic resonance imaging (MRI) studies provide important information on the structure and function of various body systems, including the brain, muscles, joints, heart, and blood vessels.
- Trial name
- NCT01324206
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Normal Physiology, Pain
Clinical and Scientific Assessment of Pain and Painful Disorders
Background: Researchers want to better understand pain by studying people with and without different kinds of pain. To do this, researchers will expose people to pleasant and unpleasant sensations.
- Trial name
- NCT02707029
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Exercise Physiology, Muscle Strength and Oxygenation
Effects of Squat Variations on Quadriceps Muscle Thickness and Strength
The study was conducted using a randomized controlled trial design. This randomized controlled trial investigated the effects of traditional and heel-elevated squat training on quadriceps muscle thickness and knee extensor…
- Trial name
- NCT07700641
- Testing
- Tradional Squat Group, Heel-Elevated Squat Group
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Uskudar University