Clinical trials: Persistent Depressive Disorder
Traumatic Brain Injury
Neurofeedback Technology (GZNT) for Persistent Post-Concussive Symptoms in Soldiers
A new technology called Global Z-Score Neurofeedback Technology (GZNT) has been identified that can overcome an existing barrier to the use of neurofeedback as a treatment technique in a military setting.
- Trial name
- GZNT (NCT02509689)
- Testing
- Global Z-Score Neurofeedback Training
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- The Defense and Veterans Brain Injury Center
Anxiety Depression (Mild or Not Persistent)
Implementation and Evaluation of an Internet-Based Stress Management Program for Health Students in the Sfax Region
The objective of this experimental study (randomized controlled trial) is to evaluate the effectiveness of an internet-based stress management program, inspired by the French program "Je gère mon stress," among healthcare…
- Trial name
- NCT07123311
- Testing
- Online Stress Management Program
- Where
- Tunisia
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Major Depressive Disorder, Depression Moderate
Exercise Recovery From Persistent Depression: A Thematic Analysis
Depression is a leading cause of disability worldwide and poses a large economic burden in the UK. There is evidence that exercise is beneficial in the management of depression and NICE now recommends group exercise programs as a…
- Conditions
- Major Depressive Disorder, Depression Moderate, Depression Severe
- Trial name
- NCT05539495
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Delirium, Postoperative Cognitive Dysfunction
Dexmedetomidine to Reduce the Incidence of POCD After Open Cardiac Surgery
Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated.
- Conditions
- Delirium, Postoperative Cognitive Dysfunction, Dexmedetomidine, Cognitive Impairment
- Trial name
- NCT03480061
- Testing
- Dexmedetomidine Hydrochloride Group
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Sunnybrook Health Sciences Centre
Anxiety Depression (Mild or Not Persistent)
Clinical Trials to Evaluate Neurophysiological and Neuropsychological Effects of a Mindfulness-based Intervention
Depression and anxiety are conditions with a high prevalence in the world population and youth are no exception. In developing countries it is reported that given the conditions of social disadvantage, anxiety and depression are…
- Trial name
- PRESENTE-IA (NCT06618339)
- Testing
- Mindfulness-based intervention
- Where
- Mexico
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Mental Illness, Schizophrenia
Cognitive Training to Enhance VA Work Program Outcomes
The purpose of this study is to determine whether augmenting work services with cognitive remediation can improve vocational outcomes for psychiatrically disabled participants in VA work services.
- Conditions
- Mental Illness, Schizophrenia, Depression, PTSD
- Trial name
- NCT00829400
- Testing
- Cognitive Remediation, Nintendo Brain Age
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- VA Connecticut Healthcare System
Persistent Depressive Disorder
Effects of Mindfulness on Brain Functioning in Depressed Patients
Depression is a common disorder that often takes a recurrent or chronic course. Recent research has indicated that such courses are associated with significant changes in brain functioning including changes in strength of…
- Trial name
- NCT05650177
- Testing
- blended Mindfulness-Based Intervention (bMBI)
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- University of Surrey
Stress Disorders, Stress
Measuring the Effectiveness of Forest Therapy to Alleviate Stress Among International Students
International students often face high levels of stress, leading to mental health conditions, from factors including cultural and social change, educational system, financial insecurity and family responsibilities.
- Conditions
- Stress Disorders, Stress, Anxiety, Anxiety Depression (Mild or Not Persistent)
- Trial name
- FTIS-2024 (NCT06792656)
- Testing
- standardized Forest Therapy session (120 min)
- Where
- Australia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- International Nature and Forest Therapy Alliance
Major Depressive Disorder, Persistent Depressive Disorder
Imagery Rescripting as Treatment for Depression
The goal of this multiple baseline case series study is to test Imagery Rescripting in depression. The main question[s] it aims to answer are: does Imagery Rescripting lead to a reduction of depression and of believability of…
- Trial name
- NCT05976945
- Testing
- Imagery Rescripting
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University of Amsterdam
Depressive Disorder
Telephone-administered Relapse Prevention for Depression
This study determines the effectiveness of telephone-delivered cognitive-behavioral continuation therapy (T-CT) in comparison to usual care in people with recurrent or chronic depression.
- Trial name
- NaTel (NCT03219879)
- Testing
- Telephone-administered continuation therapy, Usual care
- Where
- 11 sites in Germany, Switzerland
- Volunteers
- 201 people
- Sponsor
- University of Zurich
Major Depressive Disorder, Persistent Depressive Disorder
Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective psychotherapy for individuals with depressive and anxiety disorders.
- Conditions
- Major Depressive Disorder, Persistent Depressive Disorder, Posttraumatic Stress Disorder, Panic Disorder
- Trial name
- TBT-RCT (NCT01947647)
- Testing
- Transdiagnostic Behavior Therapy, Behavioral Activation Therapy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- VA Office of Research and Development
Breast Cancer, Chronic Pain
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
Pre-existing pain and severe postoperative pain are predictors of persistent pain after surgery, but a complete understanding on the development of persistent pain is still lacking.
- Conditions
- Breast Cancer, Chronic Pain, Acute Pain, Depression, Anxiety
- Trial name
- B-CAPP (NCT03408717)
- Testing
- Questionnaires, Mechanical Temporal Summation assessment, Pain threshold assessment
- Where
- 2 sites in United States, Singapore
- Volunteers
- 220 people
- Sponsor
- KK Women's and Children's Hospital
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Chronic Pain, Persistent Pain
Physiotherapy Intervention Program for Chronic Pain Associated With Depressive Disorder
This prospective longitudinal pre-post intervention study aims to evaluate the effects of an 8-week physiotherapy program combining face-to-face and asynchronous tele-rehabilitation sessions in individuals with chronic persistent…
- Conditions
- Chronic Pain, Persistent Pain, Depressive Disorder
- Trial name
- NCT07764848
- Testing
- Hybrid Physiotherapy Program
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Chronic Depression, Persistent Depressive Disorder
Intensive Psychotherapy for Chronic Depression
The study evaluates whether Intensive psychotherapy show superior effect on chronic depression over TAU
- Conditions
- Chronic Depression, Persistent Depressive Disorder, Recurrent Major Depression
- Trial name
- NCT05221567
- Testing
- Psychotherapy
- Volunteers
- 280 people
- Sponsor
- Modum Bad
Rheumatoid Arthritis, Depressive Symptoms
MBSR in Rheumatoid Arthritis Patients With Controlled Disease But Persistent Depressive Symptoms
Despite their efficacy at controlling joint inflammation, current treatments of rheumatoid arthritis (RA) leave up to 40% of patients into non-remission.
- Trial name
- PARIS-D (NCT03514355)
- Testing
- Mindfulness-Based Stress Reduction
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Université de Sherbrooke
Depression, Comorbid Personality Disorders
Effects of Vagus Nerve Stimulation (VNS) as a Treatment of Persistent Depression With Comorbid Personality Disorders (Impulse-VNS
In this monocentre two-armed double blind randomised placebo-controlled study - in which the control group obtains the VNS therapy within a defined space of time after 12 weeks - the impact of vagus nerve stimulation on…
- Trial name
- Impuls-V (NCT01119053)
- Testing
- VNS Pulse Model 102
- Where
- Germany
- Sponsor
- University Medical Center Goettingen
Major Depressive Disorder, Persistent Depressive Disorder
Personalized, Predictive, Precise & Preventive Medicine for Major Depression
Depressive disorders are among the most common psychiatric disorders. However, this disorder is multifaceted, as are its etiological factors, and is not yet fully understood.
- Trial name
- P4D (NCT06027177)
- Volunteers
- 1,000 people
- Sponsor
- Hannover Medical School
Pain, Function
Preventing Persistent Post-Surgical Pain and Dysfunction
Primary Aim: To examine the superior efficacy of ACT versus Attention Control (AC) on postoperative pain intensity and functioning in at-risk Veterans undergoing TKA.
- Conditions
- Pain, Function, Anxiety, Depression
- Trial name
- PrePARE (NCT03965897)
- Testing
- Acceptance and Commitment Therapy (ACT), Attention Control (AC)
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- University of Iowa
Mild-moderate Unipolar Depression; Persistent Negative Affect
Dismantling Mindfulness: Contributions of Attention vs. Acceptance
This study addresses NCCAM's request for research that investigates the neuropsychological mechanisms underlying mind-body therapies, and for precise criteria and better delineation of meditation practices.
- Trial name
- NCT01831362
- Testing
- Mindfulness-Based Cognitive Therapy, Focused Attention (FA), Open- Monitoring
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Brown University