Clinical trials: Periodontitis, Chronic
Chronic Periodontitis
Adjunctive Photodynamic Therapy in the Treatment of Chronic Periodontitis
The aim of this randomized clinical trial is to clinically evaluate the effectiveness of the adjunctive use of photodynamic therapy (PDT) with an light-emitting diode (LED) light source in the treatment of chronic periodontitis.
- Trial name
- NCT01330082
- Testing
- Adjunctive Photodynamic Therapy, Light-emitting diod Irradiation, applying Photosensitizer
- Where
- Iran
- Volunteers
- 16 people
- Sponsor
- Tehran University of Medical Sciences
Periodontitis, Adult, Prediabetes / Type 2 Diabetes
HbA1c Screening in Dental Care and Primary Care Referral in Patients With Advanced Periodontitis
This study will evaluate whether HbA1c screening can be performed in dental care to detect elevated blood glucose in patients with advanced periodontitis and support referral to primary care.
- Trial name
- DENT-PC (NCT07688278)
- Testing
- Point-of-care HbA1c screening, Conditional standardized primary care referral
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Skane
Chronic Periodontitis
Perio. Maint. With Diode LBR
The primary aim of this pilot study is to determine whether the test methods described feasibly achieve the goal defined for a future clinical study.
- Trial name
- NCT05276817
- Testing
- Epic Diode, HP
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Biolase Inc
Chronic Periodontitis, Type 2 Diabetes Mellitus
Chronic Periodontitis Microbiota in Type 2 Diabetes Mellitus Patients
This study is a retrospective comparative evaluation of six main periodontal pathogens and total bacterial load in chronic periodontitis patients affected or not by type 2 diabetes mellitus by polymerase chain reaction analysis.
- Trial name
- NCT03786133
- Testing
- Analysis of microbiological tests
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Bologna
Intrabony Defects in Chronic Periodontitis
Study of Two Different Putty Bone Grafts in Treatment of Intrabony Defects with the Aid of Intramarrow Penetration Technique
to evaluate and compare efficacy of two different putty forms for both Demineralized Bone Matrix allograft (DBM) and nanocrystalline hydroxyapatite (NCHA) in treatment of intrabony defects with the aid of intramarrow penetration…
- Trial name
- NCT06699043
- Testing
- nanocrystalline hydroxyapatite in putty form, Demineralized Bone Matrix allograft putty
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Afaf Mansour Dao Abdelslam
Periodontal Disease, Chronic Periodontitis (Disorder)
Salivary Mitofusin-1 Levels in Periodontitis: Associations With Disease Severity, Smoking, and Treatment Response
Periodontitis (gum inflammation) is a common disease worldwide. This study aims to investigate a novel biomarker, a protein called Mitofusin-1 (Mfn1), in saliva that may be associated with the severity of periodontitis and…
- Trial name
- NCT07262606
- Testing
- Non-surgical Periodontal Therapy (Scaling and Root Planing), Saliva Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Ömer Faruk Okumuş
Aggressive Periodontitis
Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis
Approaches and objectives related to the treatment of patients with aggressive periodontitis are not markedly different compared patients with the chronic form.
- Trial name
- NCT03025204
- Testing
- Enamel Matrix Proteins, Open Flap Debridement
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Campinas, Brazil
Chronic Periodontitis, Coronary Artery Disease
Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease
The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further.
- Conditions
- Chronic Periodontitis, Coronary Artery Disease, miRNA
- Trial name
- NCT04583085
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Polycystic Ovary Syndrome, Chronic Periodontitis
Chronic Periodontitis and Polycystic Ovary Syndrome
Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic…
- Trial name
- NCT02954120
- Testing
- no intervention provided
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Dental Implantation, Missing Teeth
The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness
Scientists do research to answer important questions which might help change or improve the way we do things in the future. The investigators know that using Enamel Matrix Derivatives results in thicker gum tissues around teeth.
- Conditions
- Dental Implantation, Missing Teeth, Periodontitis, Adult, Mucositis
- Trial name
- NCT07053969
- Testing
- Enamel Matrix Derivative
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes Mellitus, Periodontitis
Effect of Antioxidant Intake on Resistin Levels In Patients With Gum Disease and Diabetes
To evaluate the effectiveness of non surgical periodontal therapy in addition to antioxidant(ALA) on resistin levels in patients with type 2 diabetes and periodontal disease
- Trial name
- EARGD (NCT02775266)
- Testing
- Alpha lipoic acid, Scaling and Root planing
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Chronic Periodontitis, Aggressive Periodontitis
Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease
Subjects were selected from the outpatient clinic, Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Cairo University.
- Trial name
- NCT03128502
- Volunteers
- 40 people
- Sponsor
- Cairo University
Treatment, Periodontitis, Apical
Treatment of Young Permanent Teeth With Different Adjuvant Approaches
To determine microbiology assessment of infected root canal in young permanent teeth, as well as antimicrobial efficiency of different adjuvant treatment modalities including photodynamic therapy (PDT), high-power diode laser…
- Conditions
- Treatment, Periodontitis, Apical, Necrotic Pulp
- Trial name
- NCT05291195
- Testing
- Laser-device group, Essential Oil, Sodium hypochlorite group
- Where
- Serbia
- Volunteers
- 40 people
- Sponsor
- University of Belgrade
Periodontitis
The Safety and Tolerability of Initial Periodontal Therapy Combined With Human Dental Pulp Stem Cell Injection in the Treatment of Chronic Periodontitis
The principal objective of this trial is to investigate the safety and tolerability of human dental pulp stem cells injection in the treatment of chronic periodontitis.
- Trial name
- NCT04983225
- Testing
- Human Dental Pulp Stem Cells, Saline solution
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Peking University Third Hospital
Chronic Periodontitis
1% Alendronate Gel in Treatment of Chronic Periodontitis Among Smokers
Locally delivered Alendronate (ALN) have potent inhibitory effect on bone and increases new bone formation in chronic periodontitis patients Till date no study has reported the effect of local delivery of ALN in chronic…
- Trial name
- NCT02168543
- Testing
- Alendronate
- Volunteers
- 46 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Chronic Periodontitis
Locally Delivered Atorvastatin & Rosuvastatin for Treatment of Furcation Defects in Chronic Periodontitis
Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for cholesterol…
- Trial name
- NCT02800902
- Testing
- Rosuvastatin, Atorvastatin
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Dental Implants, Aggressive Periodontitis
Impact of Periodontitis Grading on Peri-Implant Clinical and Bone Health: A 60-Month Prospective Study
This prospective cohort study evaluated the effect of periodontitis grading on peri-implant clinical and radiographic outcomes over a 60-month follow-up.
- Conditions
- Dental Implants, Aggressive Periodontitis, Chronic Periodontitis, Staging
- Trial name
- NCT07671456
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Chronic Periodontitis
Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing
It is common practice to carry out the therapy of periodontal diseases in two phases. In a first, non-surgical phase, bacterial deposits on tooth surfaces (plaque and calculus) are removed using a cleaning method called "scaling…
- Trial name
- GAR (NCT02197260)
- Testing
- 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Geneva, Switzerland
Periodontitis
Gingiva Mesenchymal Stem Cells Treatment of Chronic Periodontitis
This study is to evaluate the safety and efficacy of Gingiva Mesenchymal Stem Cell Therapy for Chronic Adult Periodontitis.
- Trial name
- NCT03137979
- Testing
- GMSCs and collagen scaffolds, Collagen scaffolds, Open flap debridement
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hebei Medical University