Clinical trials: Pericardial Effusion
Lung Cancer, Small Cell Lung Cancer
QUILT-2.013: First-Line Treatment for Extensive Stage Small Cell Lung Cancer
This trial is titled "A Phase 1b/2 trial of AMG 479 or AMG 102 with Platinum-Based Chemotherapy as First-Line Treatment for Extensive Stage Small-Cell Lung Cancer (SCLC)." Part 1, the phase 1b portion of this study, is a…
- Conditions
- Lung Cancer, Small Cell Lung Cancer, Solid Tumors, Extensive-stage Small Cell Lung Cancer
- Trial name
- SCLC (NCT00791154)
- Testing
- AMG 479, Etoposide, AMG 102
- Volunteers
- 213 people
- Sponsor
- NantCell, Inc.
Pericardial Effusion, Inflammatory Response After Surgery
Anesthesia Management, Inflammatory Response and Recovery After Non-intubated VATS Pericardial Window
Non-intubated video-assisted thoracoscopic surgery (NIVATS) is performed under spontaneous ventilation and avoids tracheal intubation and one-lung mechanical ventilation.
- Conditions
- Pericardial Effusion, Inflammatory Response After Surgery, Postoperative Complications, Procedural Sedation and Analgesia
- Trial name
- RNIVATS (NCT07800767)
- Testing
- Systemic opioid-based analgesia during NIVATS, Thoracic regional analgesia during NIVATS
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Pericardial Effusion Malignant
Primary Percutaneous Pericardiotomy for Malignant Pericardial Effusion (PMAP)
Pericardial effusion is a common complication in patients with metastatic malignancy. While pericardiocentesis provide effective relieve from life-threatening situation such as cardiac tamponade, recurrence of pericardial…
- Trial name
- PMAP (NCT04472468)
- Testing
- Percutaneous Balloon Pericardiotomy
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Pericardial Effusion
Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion
The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.
- Trial name
- NCT02260206
- Testing
- Colchicine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yong Seog Oh
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Acute Pericarditis, Pericardial Effusion
Pericardial Fluid Analysis in Recurrent Pericarditis
This clinical trial aims to examine the biochemical and cytological features of pericardial effusion during acute and recurrent pericarditis and to understand the molecular factors responsible for pathogenesis.
- Conditions
- Acute Pericarditis, Pericardial Effusion, Pericardial Disease, Pericardial Fluid Exudate
- Trial name
- PEFLANA (NCT06293924)
- Testing
- Pericardiocentesis, Pericardiotomy, Cytofluorometry and Gene expression analysis
- Where
- Italy
- Volunteers
- 432 people
- Sponsor
- ASST Fatebenefratelli Sacco
Pericardial Effusion, Late Cardiac Tamponade
Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery
The incidence of pericardial effusion and late cardiac tamponade after aortic and valvular surgery is higher than after other cardiac surgical procedures.
- Conditions
- Pericardial Effusion, Late Cardiac Tamponade, Surgical Reintervention
- Trial name
- Blake (NCT00684125)
- Testing
- Blake Drains (Blake drain, Ethicon USA), Standard mediastinal drainage
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Montreal Heart Institute
Deep Vein Thrombosis, Abdominal Aortic Aneurism
Point-of-care Ultrasound in Finland
This study has two aims. 1. Deep venous thrombosis (DVT) is a common suspected medical condition. If it cannot be excluded clinically and using D-dimer, ultrasound examination is required.
- Conditions
- Deep Vein Thrombosis, Abdominal Aortic Aneurism, Pneumothorax, Gallbladder Diseases
- Trial name
- NCT03327688
- Testing
- Point-of-care ultrasound
- Where
- 4 sites in Finland
- Volunteers
- 220 people
- Sponsor
- Ossi Hannula
Pericardial Effusion
Surgical Options for Management of Pericardial Effusion
This is a retrospective descriptive study which will be conducted at Sohag university Hospital, Sohag, Egypt at emergency and cardiothoracic department .
- Trial name
- NCT05061914
- Testing
- pericardial effusion drainage
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Awake Thoracoscope, Pericardial Effusion
Safety and Efficacy of Awake Uniportal Video Assisted Thoracoscopic Modified Pericardial Window in Recurrent Pericardial Effusion at Mid Term Result
this study compare two surgical techniues at the same time two methods of anathesia with assisstance of thoracoscope for cases of repeated collection of fluid in pericardial sac and observation the result of the two techniques on…
- Conditions
- Awake Thoracoscope, Pericardial Effusion, Pericadiopleural Window
- Trial name
- NCT06972836
- Testing
- modified pericardial window, traditional pericardial window
- Where
- 2 sites in Egypt
- Volunteers
- 36 people
- Sponsor
- Zagazig University
Atrial Fibrillation (AF), Cardiac Events
Prevention of Atrial Fibrillation After Cardiac Surgery by Pericardiotomy
PRINCE-CH is a multicentre, randomized controlled trial which evaluates the effectiveness and safety of posterior pericardiotomy in preventing POAF after cardiac surgery in Chinese population.
- Conditions
- Atrial Fibrillation (AF), Cardiac Events, Pericardial Effusion
- Trial name
- PRINCE-CH (NCT06728826)
- Testing
- Posterior pericardiotomy
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Changhai Hospital
Effusion Pleural, Ascites
Cell Block Immunohistochemistry in Effusion Cytology
Cytology is usually the first step in investigating serous effusions, to either detect or exclude an underlying malignancy. This study will try to answer the need for improved diagnostic yield of cytologic examination by cell…
- Conditions
- Effusion Pleural, Ascites, Pericardial Effusion
- Trial name
- NCT04279327
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Heart Disease, Pleural Effusion
Pleural and Pericardial Effusion Following Open Heart Surgery
One of the most common postoperative complications after open cardiac surgery is fluid accumulation between the pleural membranes or in the pericardial sac.
- Conditions
- Heart Disease, Pleural Effusion, Pericardial Effusion
- Trial name
- IMAGING (NCT02045641)
- Testing
- pleuracentesis
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- Aarhus University Hospital Skejby
Lung Cancer
Phase I/II Safety Study of IPI-504 in Relapsed/Refractory Stage IIIb, or Stage IV Non-small Cell Lung Cancer (NSCLC)
The purpose of this study is to determine the safety, tolerability and maximum tolerated dose of IPI-504 in patients with non-small cell lung cancer (NSCLC).
- Trial name
- NCT00431015
- Testing
- IPI-504
- Where
- 11 sites in United States
- Volunteers
- 88 people
- Sponsor
- Infinity Pharmaceuticals, Inc.
Pericardial Effusion
Cochicine Treatment for Post- Operative Pericardial Effusion
Background: The incidence of asymptomatic pericardial effusion is high after cardiac surgery. Objective: To assess whether colchicine is effective in reducing post operative pericardial effusion volume.
- Trial name
- POPE2 (NCT01266694)
- Testing
- Colchicines
- Where
- 10 sites in France
- Volunteers
- 199 people
- Sponsor
- French Cardiology Society
Non-small Cell Lung Cancer, Malignant Pleural Effusion
Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer
Malignant pleural or pericardial effusion is common in lung cancer, and intrapleural drugs injection is important in the treatment.
- Trial name
- NCT02054052
- Testing
- Bevacizumab
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Haihong Yang, MD, Pricipal investigator
Fallopian Tube Cancer, Metastatic Cancer
ILX-295501 in Treating Patients With Stage III or Stage IV Ovarian Cancer That Has Not Responded to Previous Treatment
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of ILX-295501 in treating patients who have stage III or…
- Conditions
- Fallopian Tube Cancer, Metastatic Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00005645
- Testing
- ILX-295501
- Where
- 8 sites in United States
- Sponsor
- Genzyme, a Sanofi Company
Malignant Pericardial Effusion
Trial of Drainage With or Without Bleomycin Instillation for Malignant Pericardial Effusion
The purpose of this study is to evaluate the efficacy of pericardial instillation of bleomycin as a sclerosing agent after pericardial drainage for lung cancer-associated malignant pericardial effusion.
- Trial name
- NCT00132613
- Testing
- Observation alone after pericardial drainage, Pericardial instillation of bleomycin after drainage
- Where
- 31 sites in Japan
- Volunteers
- 80 people
- Sponsor
- Japan Clinical Oncology Group
Ventricular Dysfunction, Pericardial Effusion
Focused Cardiac Ultrasound
To compare the images from standard cardiac ultrasound with images from a small hand-held device; to find out more about the feasibility and accuracy of a small hand-held ultrasound device.
- Conditions
- Ventricular Dysfunction, Pericardial Effusion, Valvular Disease, Septal Defect
- Trial name
- NCT03887286
- Testing
- Philips EPIQ 7 ultrasound machine, Philips Lumify Broadband sector array transducer
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Miami
Hemorrhage, Atrial Fibrillation, Postoperative
Prevention of Retained-Blood Outcomes With Active Clearance Technology
Postoperative bleeding is a common consequence after heart surgery which can significantly impact outcomes and costs . When bleeding occurs, reliable postoperative blood evacuation of the pleural, mediastinal and pericardial…
- Trial name
- NCT02145858
- Testing
- Blood drainage post cardiac surgery using PleuraFlow System
- Where
- 2 sites in United States
- Volunteers
- 891 people
- Sponsor
- ClearFlow, Inc.