Clinical trials: Pericardial Disease
Coronary Artery Disease, Mitral Valve Regurgitation
Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol
The purpose of the study is to demonstrate the long term safety and effectiveness of the Carpentier-Edwards® PERIMOUNT Magna Mitral Valves in patients undergoing mitral valve replacement with or without concomitant procedures…
- Conditions
- Coronary Artery Disease, Mitral Valve Regurgitation, Mitral Valve Incompetence, Heart Failure
- Trial name
- NCT00853632
- Testing
- CEP MAGNA MITRAL PERICARDIAL BIOPROSTHESES
- Where
- 15 sites in United States, Austria and 2 more
- Volunteers
- 329 people
- Sponsor
- Edwards Lifesciences
Lung Cancer, Small Cell Lung Cancer
QUILT-2.013: First-Line Treatment for Extensive Stage Small Cell Lung Cancer
This trial is titled "A Phase 1b/2 trial of AMG 479 or AMG 102 with Platinum-Based Chemotherapy as First-Line Treatment for Extensive Stage Small-Cell Lung Cancer (SCLC)." Part 1, the phase 1b portion of this study, is a…
- Conditions
- Lung Cancer, Small Cell Lung Cancer, Solid Tumors, Extensive-stage Small Cell Lung Cancer
- Trial name
- SCLC (NCT00791154)
- Testing
- AMG 479, Etoposide, AMG 102
- Volunteers
- 213 people
- Sponsor
- NantCell, Inc.
Pericardial Effusion, Inflammatory Response After Surgery
Anesthesia Management, Inflammatory Response and Recovery After Non-intubated VATS Pericardial Window
Non-intubated video-assisted thoracoscopic surgery (NIVATS) is performed under spontaneous ventilation and avoids tracheal intubation and one-lung mechanical ventilation.
- Conditions
- Pericardial Effusion, Inflammatory Response After Surgery, Postoperative Complications, Procedural Sedation and Analgesia
- Trial name
- RNIVATS (NCT07800767)
- Testing
- Systemic opioid-based analgesia during NIVATS, Thoracic regional analgesia during NIVATS
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Pericardial Effusion Malignant
Primary Percutaneous Pericardiotomy for Malignant Pericardial Effusion (PMAP)
Pericardial effusion is a common complication in patients with metastatic malignancy. While pericardiocentesis provide effective relieve from life-threatening situation such as cardiac tamponade, recurrence of pericardial…
- Trial name
- PMAP (NCT04472468)
- Testing
- Percutaneous Balloon Pericardiotomy
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Aortic Stenosis, Aortic Regurgitation
Mitroflow DL Post Approval Study- North America
Prospective, non-randomized, multicenter post-approval study to collect long term clinical and echographic data on Mitroflow DL patients.
- Conditions
- Aortic Stenosis, Aortic Regurgitation, Aortic Valve Insufficiency, Heart Valve Diseases
- Trial name
- NCT02351726
- Testing
- Mitroflow DL
- Where
- 13 sites in United States
- Volunteers
- 186 people
- Sponsor
- LivaNova
Ventricular Tachycardia, Arrythmia
Rook Epicardial Access Device Study
The purpose of this study is to confirm the efficacy and safety of the Talon Surgical Rook® Epicardial Access Kit as a pericardial access device.
- Trial name
- NCT03427333
- Testing
- The Rook® Epicardial Access Kit
- Where
- Czechia
- Volunteers
- 13 people
- Sponsor
- Talon Surgical
Pericardial Effusion
Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion
The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.
- Trial name
- NCT02260206
- Testing
- Colchicine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yong Seog Oh
Coronary Arterial Disease (CAD), Valve Replacement
Prolonged Chest Tube Treatment to Reduce Rates of Atrial Fibrillation Following Cardiac Surgery
Evacuation of pericardial blood by posterior pericardiotomy or use of a posterior pericardial chest tube lowers postoperative atrial fibrillation (POAF) rates after cardiac surgery by 45-68%.
- Conditions
- Coronary Arterial Disease (CAD), Valve Replacement, Aortic Surgery
- Trial name
- PROPER (NCT06800781)
- Testing
- Prolonged treatment with posterior pericardial chest tube plus standard care
- Where
- Sweden
- Volunteers
- 624 people
- Sponsor
- Region Skane
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Acute Pericarditis, Pericardial Effusion
Pericardial Fluid Analysis in Recurrent Pericarditis
This clinical trial aims to examine the biochemical and cytological features of pericardial effusion during acute and recurrent pericarditis and to understand the molecular factors responsible for pathogenesis.
- Conditions
- Acute Pericarditis, Pericardial Effusion, Pericardial Disease, Pericardial Fluid Exudate
- Trial name
- PEFLANA (NCT06293924)
- Testing
- Pericardiocentesis, Pericardiotomy, Cytofluorometry and Gene expression analysis
- Where
- Italy
- Volunteers
- 432 people
- Sponsor
- ASST Fatebenefratelli Sacco
Pericarditis
Pericardial Imaging Study
The pericardium is a thin, double-layered sac around the heart that helps reduce friction as the heart moves. When this sac gets inflamed, it is called pericarditis, which can cause serious health problems and even be…
- Trial name
- NCT07245849
- Testing
- 18F-FDG PET/CT
- Volunteers
- 44 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Pericardial Effusion, Late Cardiac Tamponade
Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery
The incidence of pericardial effusion and late cardiac tamponade after aortic and valvular surgery is higher than after other cardiac surgical procedures.
- Conditions
- Pericardial Effusion, Late Cardiac Tamponade, Surgical Reintervention
- Trial name
- Blake (NCT00684125)
- Testing
- Blake Drains (Blake drain, Ethicon USA), Standard mediastinal drainage
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Montreal Heart Institute
Heart Failure
Pericardial Resection to Treat Heart Failure
The researchers are doing this study to find out whether there will be less increase in cardiac filling pressure after the surgeon opens the pericardium (the membrane around the heart) than when the pericardium is intact.
- Trial name
- NCT03073668
- Testing
- Anterior pericardiotomy, Saline
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic
Pulmonary Valve Insufficiency, Pulmonary Valve Degeneration
COMMENCE Pulmonary: Clinical Evaluation of Edwards Pericardial Aortic Bioprosthesis (Model 11000A) for Pulmonary Valve Replacement
The objective of this trial is to assess the safety and effectiveness of the Edwards Pericardial Aortic Bioprosthesis Model 11000A, in the pulmonary position in pediatric and adult subjects five years or older requiring…
- Conditions
- Pulmonary Valve Insufficiency, Pulmonary Valve Degeneration, Congenital Pulmonary Valve Abnormality
- Trial name
- COMMENCE-P (NCT02656290)
- Testing
- Edwards Pericardial Aortic Bioprosthesis Model 11000A
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Edwards Lifesciences
Arrythmia
Epicardial Access Study With Rook
The goal of this clinical trial is to test how how effective the Circa Scientific Rook® Epicardial Access Kit is at gaining guidewire access to the outside surface of the heart (epicardium).
- Trial name
- EASY-R (NCT06388629)
- Testing
- Rook Epicardial Access Kit
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Circa Scientific, Inc.
Coronary Disease
Obtain Additional Information on Use of CorMatrix ECM (Extracellular Matrix)
The objective of the study is to actively gather additional information on the use of CorMatrix ECM for pericardial reconstruction.
- Trial name
- RECON (NCT02073331)
- Where
- 43 sites in United States
- Volunteers
- 1,420 people
- Sponsor
- Elutia Inc.
Congenital Hypoplasia of Aortic Arch
Long Term Results in Hypoplastic Aortic Arch Repair in Neonates Using a Glutaraldehyde Treated Autologous Pericardial Patch
Hypoplastic aortic arch is a congenital heart defect that is prejudicial for the growth of newborns. It is often associated to other heart defects.
- Trial name
- Aortoplasty (NCT03588312)
- Testing
- Aortoplasty using autologous pericardial patch
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Queen Fabiola Children's University Hospital
Cardiac Defect, Cardiac Anomaly
Post Market Observational Retrospective Study of Glycar Bovine Pericardial Patch (CIP-003)
The overall purpose of this observational Post Market Clinical Follow Up (PMCF) study is to ensure continued acceptability of the benefit risk ratio by assessment of safety and performance, in patients undergoing cardiovascular…
- Conditions
- Cardiac Defect, Cardiac Anomaly, Pericardial Defect
- Trial name
- NCT06088680
- Testing
- Glycar Pericardial Patch
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- GLYCAR SA (Pty) Ltd
Deep Vein Thrombosis, Abdominal Aortic Aneurism
Point-of-care Ultrasound in Finland
This study has two aims. 1. Deep venous thrombosis (DVT) is a common suspected medical condition. If it cannot be excluded clinically and using D-dimer, ultrasound examination is required.
- Conditions
- Deep Vein Thrombosis, Abdominal Aortic Aneurism, Pneumothorax, Gallbladder Diseases
- Trial name
- NCT03327688
- Testing
- Point-of-care ultrasound
- Where
- 4 sites in Finland
- Volunteers
- 220 people
- Sponsor
- Ossi Hannula
Tricuspid Valve Insufficiency
NHLBI and Cook Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty (TRAIPTA) Early Feasibility Study
Background: Tricuspid valve regurgitation is a disease where one of the heart valves leaks. The leak affects blood flow. People with this disease may feel breathless and lack energy; they may need to stay in the hospital when…
- Trial name
- NCT06479824
- Testing
- TRAIPTA (Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)