Clinical trials: Periapical Healing, active
Periapical Diseases, Bioceramic Sealers
Survival and Success of Two Different Filling Techniques
This randomized clinical study analysed the clinical use of a new bioceramic premixed CaSi-containing sealer in association with a warm carrier-based technique or a traditional epoxy resin based sealer.
- Conditions
- Periapical Diseases, Bioceramic Sealers, Survival Rate, Healing Rate
- Trial name
- ROOTCANAL (NCT06252337)
- Testing
- bioceramic sealer group
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Chronic Apical Periodontitis
Effect of Different Chelation Protocols on the Healing of Periapical Lesions in Teeth With Chronic Apical Periodontitis
The aim of this study is to evaluate the effects of different irrigation protocols using ethylenediaminetetraacetic acid (EDTA) and etidronic acid (HEBP) on periapical lesion healing and postoperative pain in single-rooted…
- Trial name
- NCT07353008
- Testing
- Final irrigation with 2.5% NaOCl and 17% EDTA, Final irrigation with 2.5% NaOCl and 9% HEBP, Irrigation with 2.5% NaOCl-9% HEBP during both preparation and final irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Post Endodontic Pain, Periapical Healing
Comparative Evaluation of Endodontic Instrumentation Kinematics and Cryotherapy on Post-endodontic Pain and Periapical Healing
TITLE : Comparative evaluation of two different endodontic instrumentation kinematics and cryotherapy on post endodontic pain and periapical healing in teeth with asymptomatic apical periodontitis - A double blind, prospective…
- Trial name
- NCT07500870
- Testing
- rotary instrumentation kinematics, reciprocating instrumentation kinematics
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Post Operative Pain
Effect of NeoSEALER FLO and AH Plus Resin Sealer on Postoperative Pain and Healing of Periapical Lesions
Tissue repair is an essential process that reestablishes tissue integrity and regular function. Nevertheless, different therapeutic factors and clinical conditions may interfere in this process of periapical healing.The success…
- Trial name
- NCT07785973
- Testing
- AH plus sealer
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Minia University
Chronic Apical Periodontitis
Effects of Irrigation Activation Methods on Periapical Healing in Chronic Apical Periodontitis
This study aims to evaluate the effects of different irrigation activation methods on periapical healing in teeth with chronic apical periodontitis.
- Trial name
- NCT07850895
- Testing
- Sonic Irrigation Activation, Passive Ultrasonic Irrigation, Laser-Activated Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Recep Tayyip Erdogan University
Periapical Periodontitis, Periradicular Lesion
Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide.
The goal of this clinical trial is to evaluate the surgical accuracy and healing outcomes of endodontic surgery performed with the assistance of a 3D-printed static surgical guide in patients requiring apicoectomy.
- Conditions
- Periapical Periodontitis, Periradicular Lesion, Endodontic Treatment Failure, Postoperative Wound Healing
- Trial name
- NCT07734987
- Testing
- 3D-Printed Static Surgical Guide and Trephine Bur, Ultrasonic Retrograde Preparation and Bioceramic Retrograde Obturation
- Where
- Vietnam
- Volunteers
- 11 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Root Canal Obturation, Apical Periodontitis
Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers
The root canal treatment of volunteers with asymptomatic apical periodontitis will be completed using TotalFill BC and AH Plus root canal sealers, and postoperative pain as well as healing will be comparatively evaluated through…
- Trial name
- NCT07307807
- Testing
- AH Plus and PAI 2-3, AH Plus and PAI 4, TotalFill BC Sealer and PAI 2-3
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ankara Yildirim Beyazıt University
Periapical Lesions
Evaluation of Bone Regeneration After Apical Surgery Using Advanced Platelet-rich Fibrin: Utilization of Ultrasound for the Assessment of Periapical Lesions
The study examines the impact of advanced platelet-rich fibrin (A-PRF) on bone regeneration in apical surgery compared to standard methods.
- Trial name
- EBRAAPUU (NCT06734962)
- Testing
- Apical surgery procedure using A-PRF, Apical surgery without using A-PRF
- Where
- Latvia
- Volunteers
- 44 people
- Sponsor
- Riga Stradins University
Chronic Apical Periodontitis, Pulp Necrosis
Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.
This randomized clinical trial aims to compare regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) with conventional root canal treatment in mature necrotic anterior teeth with chronic apical…
- Trial name
- REGEN-iPRF (NCT07913399)
- Testing
- Conventional Root Canal Treatment, Regenerative Endodontic Treatment with i-PRF, Injectable Platelet-Rich Fibrin (i-PRF)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Periapical Healing
Evaluation of Pulpotomy Techniques (Formocresol, Ferric Sulphate, Mineral Trioxide Aggregate)
The goal of this interventional study is to evaluate the different materials used for pulpotomy procedures in deciduous molars. this will help us find out which medicament is more effective in releving which medicament is more…
- Trial name
- MTA (NCT07853183)
- Testing
- FORMOCRESOL PULPOTOMY MATERIAL
- Volunteers
- 120 people
- Sponsor
- Foundation University Islamabad
Periapical Lesion, Periapical Periodontitis
Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment
This study compares two commonly used intracanal medicaments-Triple Antibiotic Paste and Calcium Hydroxide-in patients with infected single-rooted teeth.
- Trial name
- NCT07239739
- Testing
- Triple Antibiotic Paste, Calcium Hydroxide (Ca(OH)2)
- Volunteers
- 62 people
- Sponsor
- Faiz ur rahman
Apical Periodontitis
N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as…
- Trial name
- NAC (NCT07262554)
- Testing
- Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Periapical Healing
Evaluation of Three Different Intra-canal Medicaments
Periapical lesions are the commonly occurring pathologic lesions that affect the periradicular tissues of the tooth . This lesion can be classified as granuloma, cystic, or abscess .The pathologic changes seen in some…
- Trial name
- NCT07892703
- Testing
- Metapaste Calcium Hydroxide
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Minia University
Periapical Healing, Restoration Survival
Effect of Different Root Canal Preparation Sizes and Remaining Tooth Structure on the Survival of Endodontically Treated Mandibular Molars
Teeth that have undergone endodontic treatment are biomechanically weakened compared to vital teeth due to factors such as extensive carious lesions, previous restorations, loss of marginal ridges and pericervical dentin, and…
- Trial name
- NCT07583004
- Testing
- ProTaper Gold, TruNatomy file system
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Pain Management
Comparing the Effectiveness of Hyalone and Calcium Hydroxide in Reducing Post-operative Pain and Promoting Periapical Healing.
This protocol presents a randomized clinical trial comparing Hyalone (hyaluronic acid) with calcium hydroxide as intracanal medicaments in mandibular first molars with necrotic pulp and symptomatic apical periodontitis.
- Trial name
- HCPH (NCT07821866)
- Testing
- Hyalone, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Apical Periodontitis, Periapical Diseases
Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment
The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment.
- Trial name
- NCT07448571
- Testing
- Non-Surgical Root Canal Retreatment, Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Marmara University
Apical Periodontitis
Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled…
- Trial name
- NCT06545084
- Testing
- Leukocyte and Platelet Rich Fibrin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Apical Periodontitis
To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis
This clinical study aims to evaluate the periapical and clinical healing outcomes of full pulpotomy using MTA in mandibular permanent molars diagnosed with symptomatic irreversible pulpitis.
- Trial name
- NCT07179835
- Testing
- Full pulpotomy in adults ≥18 years with restorable mandibular first or second molars diagnosed with irreversible pulpitis, with or without apical periodontitis.
- Where
- India
- Volunteers
- 128 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
This Study Will be Performed to Evaluate the Efficiency of 810 nm Diode Laser Disinfection on Periapical Healing in Root Canal Retreatment Cases
The Efficiency of 810 nm Diode Laser on Periapical Healing After Root Canal Retreatment
The main cause of endodontic disorders is microbial infection. From the infected root canal, microorganisms can penetrate into the deeper layers of root dentine and propagate a periapical tissue through the apical foramen and…
- Trial name
- Retreatment (NCT07194837)
- Testing
- diode laser, Calcium Hydroxide (Ca(OH)2)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Periapical Lesion, Apical Periodontitis
Effect of Apical Patency on Periapical Lesion Healing
This non-randomized clinical study aims to evaluate the effect of apical patency during root canal treatment on the healing of periapical lesions in maxillary anterior teeth.
- Conditions
- Periapical Lesion, Apical Periodontitis, Dental Pulp Necroses, Mouth Diseases
- Trial name
- NCT07867314
- Testing
- Apical Patency During Root Canal Treatment, Root Canal Treatment Without Apical Patency
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Recep Tayyip Erdogan University