Effects of Irrigation Activation Methods on Periapical Healing in Chronic Apical Periodontitis

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

• Ages 18 years and older
• All sexes
• No healthy volunteers
• Adult, Older adult

Trial locations and contacts

1 site in 1 country.

About this study

Official title: Evaluation of the Effects of Sonic, Ultrasonic, and Laser-Activated Irrigation on Periapical Healing in Teeth With Chronic Apical Periodontitis Using PAI and Fractal Analysis

Conditions

Chronic Apical Periodontitis

Being tested

Sonic Irrigation Activation, Passive Ultrasonic Irrigation, Laser-Activated Irrigation

Keywords

Periapical Healing, Irrigation Activation, Sonic Activation, Passive Ultrasonic Irrigation, Laser-Activated Irrigation, Periapical Index, Fractal Analysis, Root Canal Treatment

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

• Sonic Irrigation ActivationDevice

  Irrigating solutions were activated using a sonic activation device. The activation tip was positioned 2 mm short of the working length, and sonic activation was performed for three 20-second cycles, for a total activation time of 60 seconds.

• Passive Ultrasonic IrrigationDevice

  Irrigating solutions were activated using a passive ultrasonic irrigation device in endodontic mode. The activation tip was positioned 2 mm short of the working length, and ultrasonic activation was performed for three 20-second cycles, for a total activation time of 60 seconds.

• Laser-Activated IrrigationDevice

  Irrigating solutions were activated using an Er:YAG laser with the following parameters: SSP mode (50 μs), 0.3 W, 15 Hz, and 20 mJ. A radial laser tip was positioned in the coronal pulp chamber, and activation was performed for three 20-second cycles, for a total activation time of 60 seconds.

What is being measured

The primary outcome is the main question the study is designed to answer.

1. Change in Periapical Index (PAI)

   Periapical healing will be assessed using the Periapical Index (PAI) on periapical radiographs. PAI scores range from 1 to 5, with lower scores indicating healthier periapical conditions and higher scores indicating greater severity of periapical pathology. Changes in PAI scores between baseline and follow-up radiographs will be evaluated.

   Measured: Baseline and at least 6 months after root canal treatment

2. Change in Fractal Dimension (FD)

   Fractal dimension (FD) will be calculated from standardized regions of interest on periapical radiographs using ImageJ software and the box-counting method. Changes in FD values between baseline and follow-up radiographs will be evaluated to quantitatively assess changes in the trabecular bone structure in the periapical region.

   Measured: Baseline and at least 6 months after root canal treatment

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1. First posted30 Sep 2026
2. Study start6 Mar 2024
3. Primary completionDec 2026 (estimated)
4. Study completionDec 2026 (estimated)

Resources

• Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
• Other trials for Chronic Apical PeriodontitisStudies of the same condition, open and under way.
• What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.