Clinical trials: Pediatric Glaucoma
Childhood Glaucoma
Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma
Objectives: The study will assess the ocular hypotensive effect of latanoprost and dorzolamide in a selected sample of patients affected by primary Pediatric Glaucoma (PG), refractory to surgical procedures.
- Trial name
- NCT01527682
- Testing
- Latanoprost, Dorzolamide
- Where
- 2 sites in Italy
- Volunteers
- 37 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Glaucoma
A Phase 3 Prospective, Randomized, Double-Masked, 12-Week, Parallel Group Study In Pediatric Subjects With Glaucoma.
To assess the effectiveness of latanoprost 0.005% ophthalmic solution dosed once-daily and timolol 0.5% dosed twice-daily in paediatric subjects of 18 years of age or under who are diagnosed with glaucoma.
- Trial name
- NCT00716859
- Testing
- Timolol, latanoprost
- Where
- 48 sites in United States, Belgium and 18 more
- Volunteers
- 139 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Glaucoma
AGV Implantation With Ologen in Pediatric Glaucomas
Ahmed Glaucoma Valve Implantation with Ologen augmentation in secondary pediatric glaucomas: A 2-year randomized controlled trial. Background: Many studies have investigated the clinical benefits of Ologen for trabeculectomy.
- Trial name
- NCT05014386
- Testing
- Ahmed Glaucoma Valve Implantation in secondary pediatric glaucomas., Ahmed Glaucoma Valve Implantation with Ologen augmentation in secondary pediatric glaucomas
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Lens Implantation, Intraocular
Incidence of Glaucoma-related Adverse Events in Pediatric Secondary Intraocular Lens Implantation
To compare the incidence of glaucoma-related adverse events of in-the-bag versus ciliary-sulcus-fixed secondary intraocular lens (IOL) implantation in pediatric aphakia
- Trial name
- NCT05136950
- Testing
- Secondary in-the-bag IOL fixation, Secondary ciliary sulcus IOL fixation
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Congenital Cataract, Aphakic or Pseudophakic Glaucoma
Mechanism of Aphakic and Pseudophakic Glaucoma in Pediatric Patients
In cell cultures, lens epithelial cells and trabecular meshwork cells will be exposed to aqueous humor from pediatric eyes undergoing cataract removal surgery.
- Trial name
- NCT01136473
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Carmel Medical Center
Glaucoma
Paul Glaucoma Implant Versus Ahmed Glaucoma Valve in Childhood Glaucoma
A randomized controlled trial comparing the efficacy and safety of Paul glaucoma implant and Ahmed glaucoma valve in refractory childhood glaucoma patients
- Trial name
- NCT05797350
- Testing
- Glaucoma Drainage Device
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Al Watany Eye Hospital
Glaucoma, Ocular Hypertension
A Phase 1, Open-Label Study of Latanoprost Acid Plasma Concentrations in Pediatric and Adult Glaucoma Patients Treated With Latanoprost.
To evaluate the steady-state systemic plasma concentrations of latanoprost acid following administration of latanoprost 0.005% (1.5 ug) in pediatric and adult subjects with glaucoma or ocular hypertension.
- Trial name
- NCT00638742
- Testing
- latanoprost
- Where
- 13 sites in United States, Denmark and 4 more
- Volunteers
- 47 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Glaucoma
Endoscopic Goniotomy for Infantile Glaucoma
Glaucoma surgery is performed on children less than 3 years old for infantile glaucoma which untreated can cause blindness. Glaucoma is an uncontrolled high eye pressure in these children often due to incomplete development of…
- Trial name
- NCT00338533
- Testing
- endoscopic goniotomy
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University
Anesthesia, Intraocular Pressure
Establishment of an Anaesthetic Protocol for Examinations for Children With Glaucoma or Suspected Glaucoma
Correct measurement of the intraocular pressure of children with glaucoma or suspected glaucoma is essential for diagnosis and therapy.
- Conditions
- Anesthesia, Intraocular Pressure, Glaucoma, Suspect, Pediatric Glaucoma
- Trial name
- eyeBIS (NCT03972852)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Pediatric Glaucoma, Elevated IOP in Pediatric Patients
Study of Travoprost Ophthalmic Solution, 0.004% Compared to Timolol (0.5% or 0.25%) in Pediatric Glaucoma Patients
The purpose of this study is to evaluate the intraocular pressure (IOP)-lowering efficacy of Travoprost 0.004% POLYQUAD (PQ) ophthalmic solution compared to Timolol ophthalmic solution (0.5% or 0.25%) in pediatric glaucoma…
- Conditions
- Pediatric Glaucoma, Elevated IOP in Pediatric Patients, Ocular Hypertension in Pediatric Patients
- Trial name
- NCT01652664
- Testing
- Travoprost 0.004% PQ ophthalmic solution, Timolol, 0.5% or 0.25% ophthalmic solution, Travoprost Vehicle
- Volunteers
- 184 people
- Sponsor
- Alcon Research
Glaucoma, Ocular Hypertension
Pharmacokinetic and Safety Study of Travoprost 0.004% in Pediatric Glaucoma Patients
The purpose of this study was to assess the safety and describe the steady-state plasma pharmacokinetic (PK) profiles of Travoprost ophthalmic solution, 0.004% (new formulation) following a once daily administration for 7 days in…
- Trial name
- NCT01658839
- Testing
- Travoprost ophthalmic solution, 0.004% (new formulation)
- Volunteers
- 25 people
- Sponsor
- Alcon Research
Glaucoma Following Pediatric Cataract Surgery
Outcome of Gonioscopy-Assisted Transluminal Trabeculotomy in Pediatric Glaucoma Following Cataract Surgery.
This prospective case series evaluated the 12-month outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in children with glaucoma following cataract surgery (GFCS).
- Trial name
- (GATT in GFCS) (NCT07542522)
- Testing
- gonioscopy assissted transluminal trabeculotomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Pediatric Glaucoma
Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma
The purpose of this study is to compare the success rates and complications of two models of Ahmed glaucoma implants (FP7 and FP8) in patients with pediatric glaucoma.
- Trial name
- NCT01494974
- Testing
- FP7 Ahmed Glaucoma Drainage Implant, FP8 Glaucoma Drainage Implant
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Pediatric Glaucoma
Assessing Combined Bevacizumab-Mitomycin C Use During Ahmed Valve Revision in Recurrent Pediatric Glaucoma
To asess the efficacy and safety of combining subconjunctival bevacizumab with mitomycin C (MMC) during AGV revision surgery in pediatric patients with recurrent glaucoma.
- Trial name
- MMC glaucoma (NCT06983704)
- Testing
- AGV plate, bevacizumab injection
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Glaucoma Congenital
Viscotrabeculotomy in Pediatric Glaucoma Following Cataract Surgery
Long term Surgical Outcomes of Viscotrabeculotomy in Pediatric Glaucoma Following Cataract Surgery. Purpose: This study aims to compare outcomes of single-site rigid probe viscotrabeculotomy (VT) to two-site VT in pediatric…
- Trial name
- NCT05011747
- Testing
- single-site rigid probe viscotrabeculotomy (VT), two-site rigid probe viscotrabeculotomy (VT)
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Pediatric Glaucoma
Combined Phacoaspiration and Angle Surgery Versus Phacoaspiration in Pediatric Cataract
The aim of this study is to report the effectiveness of phacoaspiration when combined with angle surgery in preventing postoperative glaucoma following pediatric cataract surgery
- Trial name
- NCT05401760
- Testing
- Group A :combined phacoaspiration and angle surgery, Group B : phacoaspiration only
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Eye Diseases, Retinal Disease
Advancing Pediatric Retinal Imaging With Auto-aligned OCT
The goal of the current study is to conduct a pilot study to test a new version of the handheld OCT device capable of auto-alignment to image the retina in adult volunteers, and adult and pediatric patients in clinic.
- Conditions
- Eye Diseases, Retinal Disease, Glaucoma, Optic Nerve Diseases
- Trial name
- NCT06841575
- Testing
- Auto-aligned OCT
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Glaucoma, Ocular Hypertension
Safety and Efficacy Study of BETOPTIC S 0.25% and Timolol Gel-forming Solution 0.25% and 0.5% in Pediatric Patients With Glaucoma or Ocular Hypertension
The purpose of this study is to evaluate the safety and efficacy of BETOPTIC S and Timolol Gel-forming solution in pediatric patients. Patients will dose with study drug at 8 am and 8 pm daily for twelve weeks.
- Trial name
- NCT00061542
- Testing
- BETOPTIC S (betaxolol HCl), Timolol Gel-forming Solution (TGFS)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Alcon Research
Amblyopia, Myopia
Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population
Screening of haitian children between the ages of 3 and 6 years old for amblyogenic risk factors with the use of the Spot photoscreener. The photoscreener results will be compared to the complete ophthalmologic evaluation.
- Conditions
- Amblyopia, Myopia, Hyperopia, Astigmatism
- Trial name
- POPH (NCT02655432)
- Testing
- Spot photoscreener, Ophthalmologic evaluation, Cyclopleged refraction
- Where
- 3 sites in Haiti
- Volunteers
- healthy volunteers welcome
- Sponsor
- Université de Montréal
Glaucoma
Supracapsular Ahmed Glaucoma Valve Plate Delivery Technique for Management of Encapsulated Bleb in Pediatric Patients
This study aims to assess the safety and efficacy of supracapsular Ahmed Glaucoma Valve plate delivery for management of encapsulated bleb in pediatric patients with failed Ahmed Glaucoma Valve.
- Trial name
- NCT04931290
- Testing
- Supracapsular Ahmed Glaucoma Valve plate delivery technique
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Mansoura University