Clinical trials: Patient
Prostate Cancer
Patient Preference of Apalutamide Versus Enzalutamide in Patients With Recurrent or Metastatic Hormone-Sensitive Prostate Cancer
This is a prospective, open-label, randomized, controlled, cross-over trial assessing patient preference for apalutamide versus enzalutamide in 146 male patients with recurrent or metastatic hormone-sensitive prostate cancer.
- Trial name
- NCT04409288
- Testing
- Apalutamide, Enzalutamide
- Where
- Hong Kong
- Volunteers
- 74 people
- Sponsor
- Chinese University of Hong Kong
Health Care Utilization, End Stage Disease
ACP Video Intervention for Patients With Life-Limiting Illness
The goal of this research is to increase patients' knowledge about advance care planning (ACP) discussions and hospice care for patients with serious illness receiving home-based care.
- Trial name
- NCT04778761
- Testing
- Home ACP Video
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Dental Implant, Patient Satisfaction
Using Superimposition of Intra-Oral Scan and CBCT in Single Implant Restorations in Aesthetic Zone.
This study will be performed to evaluate patients'satisfaction and aesthetic outcomes of single implant restorations in aesthetic zone by using superimposition of intra-oral scan and CBCT.
- Trial name
- NCT05053958
- Testing
- superimposition of DICOM file from CBCT and STL file of Intraoral scanner
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Cataract, Surgery
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
The current postoperative cataract surgery eye drop regimen used at Zuckerberg San Francisco General Hospital (ZSFG) is a significant burden for its patient population, contributing to high rates of non-adherence and the…
- Conditions
- Cataract, Surgery, Compliance, Patient, Compliance, Medication
- Trial name
- NCT05157113
- Testing
- Dropless Regimen, Standard Regimen
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Serious Games, Transition-age Youth
Aim 3: Pilot Study of a Serious Game to Promote Transition Readiness Skills
This study involves testing a new video game designed to support adolescents with congenital heart disease (CHD) in preparing to manage their health independently.
- Conditions
- Serious Games, Transition-age Youth, Transition to Adult Care, Congenital Heart Defect
- Trial name
- NCT07042334
- Testing
- Serious game for transition readiness
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Resistant Hypertension, Medication Adherence
Heart Rate Variability and Medication Adherence in Resistant Hypertension
This single-center, cross-sectional observational study examines the relationship between adherence to antihypertensive therapy - verified objectively by therapeutic drug monitoring (TDM) - and heart rate variability (HRV) in…
- Conditions
- Resistant Hypertension, Medication Adherence, Autonomic Nervous System
- Trial name
- HRV-HYP-1 (NCT07707583)
- Testing
- Heart rate variability recording (Polar H10) ·, Therapeutic drug monitoring (antihypertensive drug levels), Questionnaires (MARS-CZ, PHQ-9, SF-36, IPAQ)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
ASA III, Elective Prosthetic Surgery
How to Prevent Post-surgery Infections
Evaluation of the effectiveness in reducing the bacterial load on the skin of bedridden opatients through the use of two different cleaning and washing systems (swash bathing gloves vs pre-soaped sponges).
- Conditions
- ASA III, Elective Prosthetic Surgery, Patient Bedridden After Surgery
- Trial name
- Bundle (NCT07848269)
- Testing
- Swab for cleaning, used as first comparator. For this group we want, during these three days and each day, measure skin pH before and after, Coltural exam before and after and time for cleaning
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Malaria
Factors Influencing Adoption of a Novel Malaria Treatment in Côte d'Ivoire, Ghana, and Rwanda
This non-interventional qualitative study will examine factors that influence the adoption of a novel malaria treatment in Côte d'Ivoire, Ghana, and Rwanda.
- Trial name
- NCT07896746
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Mechanically Ventilated Patients, Acute Respiratory Failure (ARF)
Impact of Inspiratory Effort and Patient-Ventilator Interaction During the Transition Phase
The goal of this observational study is to learn whether breathing effort and patient-ventilator asynchrony (PVA) during the transition phase are associated with clinical outcomes in mechanically ventilated adults.The main…
- Trial name
- PV-INTERACT (NCT07896967)
- Testing
- PVA classification software
- Where
- Chile
- Volunteers
- 250 people
- Sponsor
- Pontificia Universidad Catolica de Chile
ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Development and Prospective Validation of the AutoEIT Foundation Model for ARDS
Acute Respiratory Distress Syndrome (ARDS) is a highly heterogeneous condition, making precision mechanical ventilation challenging.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure, Mechanical Ventilation, Ventilator-induced Lung Injury (VILI)
- Trial name
- NCT07898319
- Testing
- AutoEIT Model Training, AutoEIT Blinded Validation
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Ruijin Hospital
Childhood Cancer, Survivorship
A Multilevel Intervention to Improve Adherence to Childhood Cancer Survivorship
More than 80% of childhood cancer survivors develop serious or life-threatening late effects after cancer therapy, but <20% receive recommended survivorship care offered at cancer center survivorship clinics.
- Conditions
- Childhood Cancer, Survivorship, Health Care Utilization, Health Knowledge, Attitudes, Practice
- Trial name
- BRIDGES (NCT05448560)
- Testing
- Multi-level Intervention of shared model of survivorship care, Comparison Group
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Georgetown University
mERAS Intervention, The ASA (American Society of Anesthesiologists) Score
The Contribution of Accelerated Recovery (mERAS) Approach to Postoperative Recovery in Pediatric Laparoscopic Surgery Cases
Pediatric laparoscopic surgery is a gold standard across all ages, offering benefits like smaller incisions, faster recovery, and better cosmetic outcomes.
- Conditions
- mERAS Intervention, The ASA (American Society of Anesthesiologists) Score, The Patient Must be Between 4 and 12 Years Old
- Trial name
- Accelerated Re (NCT07375511)
- Testing
- mERAS Protocol
- Volunteers
- 60 people
- Sponsor
- Emel Yürük
Critical Illness, Geriatric Patient
Dynamic Inflammatory Changes and Nutritional Risk Scores in ICU Patients Aged 65 Years and Older
"This prospective observational study aims to evaluate the prognostic value of dynamic changes in the serum uric acid-to-albumin ratio (UAR) measured on admission (Day 0) and on Day 3, along with mNUTRIC and PNI scores, regarding…
- Conditions
- Critical Illness, Geriatric Patient, Mortality, Inflamation
- Trial name
- NCT07888010
- Testing
- Uric Acid to Albumin Ratio (UAR) and Nutritional Risk Scores
- Where
- Turkey (Türkiye)
- Volunteers
- 224 people
- Sponsor
- Ankara Etlik City Hospital
Traumatic Brain Injuries, TBI (Traumatic Brain Injury)
Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)
The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI.
- Conditions
- Traumatic Brain Injuries, TBI (Traumatic Brain Injury), MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- ReVIVE (NCT07890337)
- Testing
- Virtual Reality, Standard Psychotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
3D Printing, Oral Habit
3D-Printed Versus Conventional Palatal Cribs in Managing Tongue Thrusting Habit in Children
This randomized controlled clinical trial evaluates and compares the clinical effectiveness of 3D-printed palatal cribs versus conventional soldered palatal cribs in managing the tongue thrusting habit in pediatric patients.
- Conditions
- 3D Printing, Oral Habit, Patient Comfort
- Trial name
- NCT07895121
- Testing
- 3D-Printed Palatal Crib Appliance Therapy (Group I):, Conventional Soldered Palatal Crib Appliance Therapy (Group II)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Colorectal Cancer, Colorectal Neoplasms
Resistance vs Aerobic Prehabilitation Before Colorectal Cancer Surgery
The goal of this clinical trial is to learn which type of exercise before surgery best reduces complications after colorectal surgery in adults with colorectal cancer or precancerous lesions.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Postoperative Complications
- Trial name
- NCT07896174
- Testing
- Resistance Training Prehabilitation, Aerobic Training Prehabilitation, Standard Trimodal Care
- Where
- Hungary
- Volunteers
- 480 people
- Sponsor
- Semmelweis University
Patient Engagement
Virtual and Video Counseling Versus In-Office Counseling for Laparoscopic Hysterectomy
Compare preparedness for total laparoscopic hysterectomies between patients who undergo virtual visits and those who undergo in-office visits for pre-operative counseling.
- Trial name
- NCT05086406
- Testing
- Combination of Video and Virtual Pre-operative Counseling
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
New Patient Use of Teledermatology Mobile App
Direct-to-patient Teledermatology and Computer-assisted Diagnosis
This study will examine access to dermatology care. The operational partner will implement a direct-to-new patient teledermatology clinical care pathway while the research will study the effects of that implementation, use data…
- Trial name
- NCT05128006
- Testing
- New patient teledermatology visit
- Where
- 3 sites in United States
- Volunteers
- 63,200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson's Disease
Telerehabilitation in People With Parkinson's Disease
Although TeleRehabilitation (TR) is widely accepted as an appropriate model for the provision of professional health services in the field of physiotherapy, with already established standards, guidelines and policies, there are…
- Trial name
- TEMPO (NCT05773885)
- Testing
- VRRS Tablet (Khymeia s.r.l., Noventa Padovana, Italy), Conventional rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 58 people
- Sponsor
- IRCCS San Raffaele Roma
Sore Throat, Dysphagia
Chewing Gum and Cold Gargle on Post-Bronchoscopy Symptoms
This study aims to evaluate the effects of chewing gum and gargling with cold water on common post-bronchoscopy symptoms, such as sore throat and difficulty swallowing (dysphagia).
- Conditions
- Sore Throat, Dysphagia, Patient Satisfaction, Bronchoscopy
- Trial name
- NCT07517926
- Testing
- Chewing Gum, Cold Water Gargle
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ankara University