Clinical trials: Parkinson's Syndrome
Parkinson's Disease
The Parkinson's Genetic Research Study
The Parkinson's Genetic Research Study (PaGeR), headed by Dr. Cyrus Zabetian, is searching for genes that increase the risk of developing Parkinson's disease (PD) and related disorders.
- Trial name
- PaGeR (NCT01558479)
- Where
- 5 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dementia With Lewy Bodies, REM Sleep Behavior Disorder
Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD)
This study seeks to evaluate the safety and efficacy of Nelotanserin for the treatment of Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with dementia with Lewy bodies (DLB) or Parkinson's disease dementia…
- Conditions
- Dementia With Lewy Bodies, REM Sleep Behavior Disorder, Parkinson's Disease Dementia
- Trial name
- NCT02708186
- Testing
- Nelotanserin
- Where
- 23 sites in United States
- Volunteers
- 34 people
- Sponsor
- Axovant Sciences Ltd.
Parkinson Disease, Fall
Augmented Reality Treadmill Training in Patients With Parkinson's Disease
Gait disorder is a disabling symptom in Parkinson's disease (PD) affecting all patients during the course. Three methods of treadmill training (TT) will be compared to assess additional augmented reality (AR), or additional dual…
- Trial name
- Falls_in_PD (NCT04108741)
- Testing
- C-Mill augmented reality treadmill training
- Where
- Switzerland
- Volunteers
- 39 people
- Sponsor
- Klinik Valens
Parkinson Disease
Lateral Postural Inclination in Parkinson's Disease : Involvement of the Basal Ganglia ?
The objective of this study is to assess the origins of lateral postural inclination presented by some Parkinson disease's patients. Several mechanisms could cause lateral postural inclination.
- Trial name
- IPOLAP (NCT02704910)
- Testing
- Subthalamic stimulation
- Where
- 2 sites in France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Parkinson Disease
Tai Chi for Enhancing Motor and Cognitive Function in Parkinson's Disease
The purpose of this feasibility study is to preliminarily evaluate the effects of Tai Chi - a mind-body exercise - on motor and cognitive function as well as quality of life in individuals recently diagnosed with Parkinson's…
- Trial name
- NCT02418780
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Harvard University Faculty of Medicine
Parkinson's Disease
Study to Compare Adhesiveness of Two Different Rotigotine Patch Formulations
The primary objective of the study is to compare the adhesiveness of two different patch formulations of rotigotine using patch size 40 cm2, under the assumption that both patch formulations show similar adhesiveness properties.
- Trial name
- NCT01338896
- Testing
- Rotigotine transdermal patch
- Where
- 16 sites in Austria, Germany and 1 more
- Volunteers
- 56 people
- Sponsor
- UCB Pharma
Parkinson's Disease
Follow-up Study to Assess One Boost Immunization With AFFITOPE® PD01A With Regard to Safety and Clinical Activity
This is a follow-up study to assess safety and clinical activity of continued AFFITOPE® PD01A vaccinations in patients with Parkinson's disease.
- Trial name
- AFF008A (NCT02216188)
- Testing
- AFFITOPE® PD01A, Control
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Affiris AG
Parkinson Disease, Physical Activity
Physical Training Induced Plasticity of Motor Control Mechanisms in Parkinson's Disease Patients
There are experimental evidences of the important role of exercise in the PD, that induces similar effects to pharmacotherapy. So far, the mechanisms of the impact of these changes on the brain subcortical and cortical regions…
- Trial name
- NCT03753503
- Testing
- exercise, conventional physical therapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Parkinson Disease
Lenrispodun as Adjunctive Therapy in the Treatment of Patients With Motor Fluctuations Due to Parkinson's Disease
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed-dose study in patients with a diagnosis of Parkinson's Disease consistent with the UK Parkinson's Disease Society (UKPDS) Brain Bank…
- Trial name
- NCT05766813
- Testing
- Lenrispodun
- Where
- 35 sites in United States
- Volunteers
- 79 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Parkinson's Disease
Ancillary Longitudinal CSF Collection Study in the Harvard Biomarker Study - HBS2
The Harvard Biomarker Study is a Harvard-wide, longitudinal case-control study designed for discovering, replicating, and developing biomarkers for Parkinson's disease and Alzheimer's disease.
- Trial name
- HBS2 (NCT01867788)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Parkinson's Disease, Dysphagia
Novel Management of Airway Protection in Parkinson's Disease: A Clinical Trial
Currently, there are no efficacious behavioral treatment approaches to address uncompensated aspiration, or aspiration without appropriate cough response, in Parkinson's disease (PD).
- Conditions
- Parkinson's Disease, Dysphagia, Dystussia
- Trial name
- NCT02927691
- Testing
- EMST, smTAP
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Teachers College, Columbia University
Parkinson Disease
Exploring the Effects of Spinal Cord Stimulation in Parkinson's Disease.
Parkinson Disease (PD) patients experience a variety of motor issues such as walking difficulties, loss of balance, and freezing while walking, which impacts their quality of life.
- Trial name
- SCS for FOG (NCT03526991)
- Testing
- Spinal Cord Stimulator (SCS)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Nora Vanegas
Parkinson Disease
Manual Therapy in Parkinson's Disease
An experimental study will be carried out to examine how a manual therapy protocol can influence a series of parameters related to motor and non-motor symptoms in patients who have Parkinson's disease / Parkinsonism.
- Trial name
- NCT06853262
- Testing
- Manual Therapy Protocol
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of La Laguna
Alzheimer's Disease, Amyotrophic Lateral Sclerosis (ALS)
PRISM Registry: Pseudobulbar Affect Registry Series
PBA is a neurologic condition that is estimated to impact over a million patients and their families in the United States. PBA occurs secondary to an otherwise unrelated neurologic disease or injury, and manifests as involuntary…
- Conditions
- Alzheimer's Disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease
- Trial name
- NCT01366027
- Where
- United States
- Volunteers
- 5,290 people
- Sponsor
- Avanir Pharmaceuticals
Parkinson Disease
Effects of Virtual Reality Versus Motor Imagery Versus Routine Physical Therapy in Patients With Parkinson's Disease.
The aim of this study is to investigate the effects of VR and MI techniques in addition to routine physical therapy on motor skills, balance and ADL in patients with Parkinson's disease.
- Trial name
- NCT04884646
- Testing
- VR with Routine physical therapy and Virtual reality, Motor Imagery with Routine physical therapy, Routine physical therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Idiopathic Parkinson's Disease
Caregivers' and Physicians' Treatment Preference in Parkinson Patients Treated With Neupro® Requiring Caregiver Support
The study objective is to evaluate advantages and disadvantages of Neupro® versus oral anti-Parkinson medication by caregivers and physicians in idiopathic Parkinson's Disease patients requiring caregiver support in nursing home…
- Trial name
- CARE-ACT (NCT01330290)
- Testing
- Neupro®
- Where
- 54 sites in Germany
- Volunteers
- 148 people
- Sponsor
- UCB Pharma
Parkinson Disease
Blood Biomarker in Early Parkinson's Disease
Currently, there are no cures or disease modifying therapies for Parkinson's disease (PD). This is partially due to the inability to detect the disease before it has progressed to a stage where there are clinical manifestations.
- Trial name
- NCT03384797
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Duke University
Parkinson Disease
Asymmetric Targeted DBS for PD With PIGD
The purpose of this study is to compare the effectiveness of the deep brain stimulation of asymmetric targets [subthalamic nucleus (STN) in the right hemisphere while globus pallidus interna (GPi) in the left] versus the…
- Trial name
- ATS-PIGD (NCT05397340)
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Parkinson's Disease (Disorder)
Effect of Deep Brain Stimulation on Neuropsychiatric Fluctuations in Patients With Parkinson's Disease
Retrospective, monocentric, observational study designed to evaluate the effects of Bilateral Subthalamic Nucleus Deep Brain Stimulation (DBS STN) on Neuropsychiatric fluctuations in Patients with Parkinson's Disease (PD)
- Trial name
- PSYCHOSTIM (NCT04608123)
- Testing
- none (observational study)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Grenoble
Parkinson Disease
Effects of Osteopathic Visceral Manipulation on the Autonomic Nervous System, Balance and Gastrointestinal Disturbances in Individuals With Parkinson's Disease
Introduction: Parkinson's disease (PD) is responsible for several changes in the body, such as balance, gastrointestinal and autonomic disorders and are associated with impairments in the clinical prognosis of these individuals.
- Trial name
- NCT05047796
- Testing
- Intervention Protocol
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Instituto Docusse de Osteopatia e Terapia Manual
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