Parkinson's DiseasePaGeRNCT01558479
The Parkinson's Genetic Research Study
An observational study of Parkinson's Disease, run by University of Washington at 5 sites in United States.
Trial summary
The Parkinson's Genetic Research Study (PaGeR), headed by Dr. Cyrus Zabetian, is searching for genes that increase the risk of developing Parkinson's disease (PD) and related disorders. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Parkinson's Disease
- How many people
- 5,000 participants
- Where
- 5 sitesUnited States
- Study dates
- Sep 2009to 31 Oct 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Families in which two or more people have been diagnosed with Parkinson's disease.
Who may be able to join
- Over 18 years of age
- Member of a family in which there are two or more living individuals who have been diagnosed with Parkinson's disease
Who cannot join
- Under 18 years of age
Trial locations and contacts
5 sites in 1 country.
Jennifer Pate contact
5 sites in 1 country
United States5 sites, 5 recruiting
- Recruiting
Emory University/ Wesley Woods Health Center
Atlanta, Georgia, 30329
Barbara Sommerfield, MSN, RN, 404-728-6944, bsommer@emory.edu
- Recruiting
University of Cincinnati
Cincinnati, Ohio, 45267
Jatue Krier, 513-558-0169, katie.krier@uc.edu
- Recruiting
Portland VA Medical Center
Portland, Oregon, 97239
Susan O'Connor, 503-220-8262 ext. 53262
- Recruiting
VA Puget Sound Health Care System
Seattle, Washington, 98108
Jennifer Pate, 855-646-4221
Cyrus Zabetian, MD, MS
- Recruiting
University of Washington
Seattle, Washington, 98118
Jennifer Pate, 855-646-4221
Cyrus Zabetian, MD, MS
About this study
Official title: The Parkinson's Genetic Research Study (PaGeR)
The Parkinson's Genetic Research Study (PaGeR), headed by Dr. Cyrus Zabetian, is searching for genes that increase the risk of developing Parkinson's disease (PD) and related disorders. The study is a joint effort by neurologists and researchers across the United States and is sponsored by the National Institutes of Health. The coordinating center for PaGeR is located at the University of Washington and the VA Puget Sound Health Care System in Seattle.
Read the detailed description
PaGeR is focusing on families in which two or more people have been diagnosed with PD. Past research suggests that such "multiplex" families might hold the key to the discovery of new PD genes.
To take part in PaGeR, participants will be asked to complete a questionnaire and to undergo an interview, a neurological exam, a short memory test, and a blood draw. Enrollment in the study usually takes between one and two hours. There is no cost to participate, and all study information is kept strictly confidential.
There are a number of designated sites across the country where families can enroll. However, for family members who are unable to travel to one of these sites, other arrangements can be made.
- Conditions
- Parkinson's Disease
- Keywords
- Parkinson's Disease, Genetics, Family Research, Hereditary Neurodegenerative Diseases
- Medical subject headings
- Parkinson Disease, Heredodegenerative Disorders, Nervous System
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Case | Has a diagnosis of Parkinson's disease | |
| Control | No diagnosis of Parkinson's disease | |
| Family Member | Has a family history of Parkinson's disease. Can be affected or unaffected with Parkinson's disease |
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Mar 2012 (estimated)
- Study startSep 2009
- Primary completion31 Oct 2026 (estimated)
- Study completion31 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson's DiseaseStudies of the same condition, open and under way.
- More trials run by University of WashingtonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Family based
- Time perspective
- Cross-sectional
- Enrolment
- 5,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Washington
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Cyrus Zabetian, University of Washington
- Investigators
- Cyrus Zabetian, MD, MS, Principal investigator, University of Washington, VA Puget Sound Health Care System
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01558479
- Sponsor's protocol ID
- 36777
- Acronym
- PaGeR
- Status last verified
- May 2024
- First submitted
- 16 Mar 2012
- Last updated
- 14 May 2024
- Results posted
- No
- Data monitoring committee
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 May 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Parkinson's Genetic Research Study (PaGeR)
- ClinicalTrials.gov ID
- NCT01558479
- Acronym / sponsor ID
- PaGeR / 36777
- Conditions
- Parkinson's Disease
- Keywords
- Parkinson's Disease, Genetics, Family Research, Hereditary Neurodegenerative Diseases
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 5,000 participants (estimated)
- Lead sponsor
- University of WashingtonUniversity, hospital or other
- Study start
- Sep 2009 (actual)
- Primary completion
- 31 Oct 2026 (estimated)
- Study completion
- 31 Oct 2026 (estimated)
- First posted
- 20 Mar 2012 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The Parkinson's Genetic Research Study (PaGeR), headed by Dr. Cyrus Zabetian, is searching for genes that increase the risk of developing Parkinson's disease (PD) and related disorders. The study is a joint effort by neurologists and researchers across the United States and is sponsored by the National Institutes of Health. The coordinating center for PaGeR is located at the University of Washington and the VA Puget Sound Health Care System in Seattle.
Detailed description
PaGeR is focusing on families in which two or more people have been diagnosed with PD. Past research suggests that such "multiplex" families might hold the key to the discovery of new PD genes.
To take part in PaGeR, participants will be asked to complete a questionnaire and to undergo an interview, a neurological exam, a short memory test, and a blood draw. Enrollment in the study usually takes between one and two hours. There is no cost to participate, and all study information is kept strictly confidential.
There are a number of designated sites across the country where families can enroll. However, for family members who are unable to travel to one of these sites, other arrangements can be made.
Study design
- Observational model
- Family based
- Time perspective
- Cross-sectional
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Case | – | –Has a diagnosis of Parkinson's disease |
| Control | – | –No diagnosis of Parkinson's disease |
| Family Member | – | –Has a family history of Parkinson's disease. Can be affected or unaffected with Parkinson's disease |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Families in which two or more people have been diagnosed with Parkinson's disease.
Key inclusion criteria (2 listed)
- Over 18 years of age
- Member of a family in which there are two or more living individuals who have been diagnosed with Parkinson's disease
Key exclusion criteria (1 listed)
- Under 18 years of age
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 May 2024.
- Study WebsiteLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jennifer Pate contact
Cyrus Zabetian, MD, MS principal investigator
University of Washington, VA Puget Sound Health Care System
5 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Parkinson's Disease, run by University of Washington at 5 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 14 May 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 5 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Jennifer Pate (1-855-646-4221), or a site near the patient. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 May 2024.