Clinical trials: Paraneoplastic Neurological Syndrome
Paraneoplastic Neurological Syndromes
Liquid Biopsy in Paraneoplastic Neurological Syndromes
The main objective of the study is to assess whether circulating tumor cells (CTCs) can be detected in the peripheral blood of patients with paraneoplastic neurological syndromes (PNS) by diagnostic leukapheresis (DLA) combined…
- Trial name
- LiB-PNS (NCT07491328)
- Testing
- CTC & ctDNA analysis
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis
Metabolic Imaging for Diagnosis and Prognostication of Autoimmune encephalitiS
Autoimmune encephalitis (AE) is a rare neurological disorder mediated by autoimmune antibody response against neuronal cell surface and intraneuronal proteins associated with specific brain areas, resulting in severe inflammation…
- Trial name
- MIDAS (NCT06432803)
- Testing
- PET-Scan analysis
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hospices Civils de Lyon
Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis
Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection
Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms.
- Trial name
- SNP (NCT05198661)
- Testing
- Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.
- Where
- 62 sites in France
- Volunteers
- 3,500 people
- Sponsor
- Hospices Civils de Lyon
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis
Diagnostic Performance of a Commercial Assay for the Detection of Neuronal Antibodies
Detection of autoantibodies targeting neuronal surface or intracellular antigens is a keystone for the diagnosis and the treatment of auto-immune encephalitis and paraneoplastic neurological syndromes.
- Trial name
- IFINEURO (NCT05783947)
- Testing
- Indirect immunofluorescence assay on tissue slides and cell-based assays with CSF and/or sera
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- Hospices Civils de Lyon
Autoimmune Encephalitis, Paraneoplastic Neurological Syndrome
Characterization of Immune-response in Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes
Autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS) are rare neuroimmune syndromes with a wide range of clinical presentation but without pathognomonic clinical sign facilitating the diagnosis.
- Trial name
- Car-Te-Cell (NCT05772611)
- Testing
- Genetic and immunology tests
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis
New Biomarkers in Auto-immune Encephalitis and Neurological Paraneoplastic Syndromes
Autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS) are rare neuroimmune syndromes with a wide range of clinical presentation but without pathognomonic clinical sign facilitating the diagnosis.
- Trial name
- DeNobio (NCT05728931)
- Testing
- Test of biological samples
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Hospices Civils de Lyon
Autoimmune Encephalitis, Paraneoplastic Neurological Syndrome
Epidemiology of Autoimmune Encephalitides and Paraneoplastic Neurological Syndromes in Sweden
Autoimmune encephalitis and paraneoplastic neurological syndromes are rare diseases caused by an abnormal immune response toward the nervous system.
- Trial name
- NCT04708626
- Testing
- Description and analysis
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Uppsala University
Autoimmune Encephalitis, Paraneoplastic Neurological Syndrome
HLA Analysis in Autoimmune Encephalitis and Related Disorders: Part II
Autoimmune encephalitis (AE) are characterized by subacute onset of memory deficits, altered mental status or psychiatric symptoms, frequently associated with seizures, inflammatory cerebrospinal fluid and in cases with prominent…
- Trial name
- ICARE-II (NCT04823728)
- Testing
- Autoimmune encephalitis and paraneoplastic neurological syndromes
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Hospices Civils de Lyon
Paraneoplastic Neurological Syndrome
Methylated DNA Detect in Paraneoplastic Syndrome of Nervous System
The purpose of this study is to verify whether the cell-free DNA of lung cancer in the blood can be used as a biomarker for early diagnosis and prognosis evaluation of patient with paraneoplastic syndrome of the nervous system.
- Trial name
- NCT04454853
- Testing
- Lung cancer, Suspected lung cancer, Positive methylated DNA
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis
Incidence of Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis
This study aims to provide an estimate of the incidence of paraneoplastic neurological syndromes and autoimmune encephalitides in France between the years 2016 and 2018.
- Trial name
- IPNSAE (NCT03957616)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Paraneoplastic Neurological Syndromes
Immunotherapy and Paraneoplastic Neurological Syndromes
Paraneoplastic Neurological Syndromes (PNS) are rare remote effects of cancer, not directly attributed to mass lesions, metastases, infections, ischemia, coagulopathy, metabolic disruptions or tumour treatment.
- Trial name
- IaSON (NCT02343211)
- Testing
- Immunoglobulin
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris