AzTrials
AzTrials

Paraneoplastic Neurological Syndromes or Autoimmune EncephalitisSNPNCT05198661

Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection

A study testing Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma. in people with Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis, run by Hospices Civils de Lyon at 62 sites in France.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms. However, current treatments could be drastically improved by faster and more accurate diagnosis. Read more about this study

Who is it for?
Any age
What is being tested?
Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.
Could I receive a placebo?
No, everyone receives an active treatment
How many people
3,500 participants
Where
62 sitesFrance
Study dates
2 Aug 2022to 2 Aug 2032
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Who may be able to join

  • Patient with consent
  • Patient with well-characterized antibodies in serum or cerebrospinal fluid or not
  • Patient with neurological disorder compatible with PNS or auto-immune encephalitis

Who cannot join

  • Refusal of consent
  • Patient under guardianship

Trial locations and contacts

62 sites in 1 country. Contact the study team or a site near you to ask about taking part.

Jerome HONNORAT, Pr contact

4 72 35 78 06 ext. +33

jerome.honnorat@chu-lyon.fr

Geraldine PICARD contact

4 72 35 58 42 ext. +33

geraldine.picard@chu-lyon.fr

62 sites in 1 country

France62 sites, 62 recruiting

  • Neurology

    Aix-en-Provence, 13616

    Laurent MARTINEZ ALMOYNA, MD, 04 42 33 50 71 ext. +33, lmartinezalmoyna@ch-aix.fr

    Laurent MARTINEZ ALMOYNA, MD

    Not yet recruiting

  • Neurologie

    Amiens, 80000

    Melanie BARBAY, MD, Barbay.melanie@chu-amiens.fr

    Melanie BARBAY, MD

    Not yet recruiting

  • Neurology

    Angers, 49055

    Lila Autier, MD, Lila.Autier@ico.unicancer.fr

    Lila Autier, MD

    Not yet recruiting

  • General neurology

    Annecy, 74370

    Déborah GROSSET JANIN, MD, dgrossetjanin@ch-annecygenevois.fr

    Déborah GROSSET JANIN, MD

    Not yet recruiting

  • Neurology

    Avignon, 84000

    Elodie BICILLI, MD, bicilli.elodie@ch-avignon.fr

    Elodie BICILLI, md

    Not yet recruiting

  • Neurologie

    Bayonne, 64100

    Olivier FLABEAU, MD, oflabeau@ch-cotebasque.fr

    Olivier FLABEAU, MD

    Not yet recruiting

  • Neurology

    Besançon, 25056

    Nathalie Devys Meyer, MD, 0381667391 ext. 33, nmeyer@chu-besancon.fr

    Nathalie Devys Meyer, MD

    Recruiting

  • Neurology

    Bobigny, 93000

    Marie MONGIN, MD

    Marie MONGIN, MD

    Not yet recruiting

  • Neurology

    Bordeaux, 33000

    Frederic VILLEGA, MD, 0556795626, frederic.villega@u-bordeaux.fr

    Frederic VILLEGA, MD

    Not yet recruiting

  • Neurology

    Brest, 29200

    Serge TIMSIT, MD, 02 98 34 76 20 ext. 33, serge.timsit@chu-brest.fr

    Serge TIMSIT, MD

    Not yet recruiting

  • Intensive care medicine

    Cannes, 06400

    Raphaël CHAMBON, MD, r.chambon@ch-cannes.fr

    CHAMBON Raphaël, MD

    Not yet recruiting

  • Neurologie

    Chambéry, 73011

    Marie BARRE, MD, Marie.barre@ch-metropole-savoie.fr

    Marie BARRE, MD

    Not yet recruiting

  • Neurology

    Clermont-Ferrand, 63003

    Eve CHANSON, MD, 0473752200 ext. +33, echanson@chu-clermontferrand.fr

    Eve CHANSON, MD

    Not yet recruiting

  • Neurologie

    Colmar, 68000

    François SELLAL, md, 0389124150 ext. 33, francois.sellal@ch-colmar.fr

    François SELLAL, MD

    Not yet recruiting

  • Neurology

    Créteil, 94010

    Thierry GENDRE, MD, 0149812303 ext. 33, Thierry.gendre@aphp.fr

    Thierry GENDRE, MD

    Not yet recruiting

  • General, Vascular and Degenerative Neurology

    Dijon, 21231

    Yannick BEJOT, MD, 03 80 29 37 53 ext. 33, yannick.bejot@chu-dijon.fr

    Yannick BEJOT, MD

    Not yet recruiting

  • Neurology

    Épinal, 88023

    Arnaud LARDIN, MD, 03.29.68.71.04 ext. 33, arnaud.lardin@ch-ed.fr

    Arnaud LARDIN, MD

    Recruiting

  • Internal and general practitioner

    Gap, 05000

    Thierry WEITTEN, MD, 0492407680 ext. 33

    WEITTEN Thierry, MD

    Not yet recruiting

  • Neurologie

    Grenoble

    Martial MALLARET, MD, mmallaret1@chu-grenoble.fr

    Martial MALLARET, MD

    Recruiting

  • Neurology

    La Roche-sur-Yon, 85925

    Nathalie TESTARD, MD, nathalie.testard@ght85.fr

    Nathalie Testard, MD

    Not yet recruiting

  • Neurology

    Lille, 59000

    Jean Paul NIGUET, MD, 0320874901 ext. 33, niguet.jeanpaul@ghicl.net

    Jean Paul Niguet, MD

    Not yet recruiting

  • Neurology

    Lille

    Tifanie ALBERTO, MD, tifanie.alberto@chu-lille.fr

    Tifanie ALBERTO, MD

    Recruiting

  • Neurology

    Limoges, 87042

    Laurent MAGY, MD, 05 55 05 65 61 ext. 33, Leurent.magy@unilim.fr

    Laurent MAGY, MD

    Not yet recruiting

  • Neurology

    Lisieux, 14100

    Doina CIOCANU, MD, 0231613142 ext. 33, d.ciocanu@ch-lisieux.fr

    Doina Ciocanu, MD

    Not yet recruiting

  • Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites autoimmunes

    Lyon, 69677

    Jerome HONNORAT, Pr, 4 72 35 78 06 ext. +33, jerome.honnorat@chu-lyon.fr

    Jerome HONNORAT, Pr

    Recruiting

  • Neurology

    Mâcon, 71000

    Patricia DEPIERRE, MD, padepierre@ch-macon.fr

    Patricia DEPIERRE, MD

    Not yet recruiting

  • Adult Neurology and Neuropsychology

    Marseille, 13005

    Elsa KAPHAN, MD, elsa.kaphan@ap-hm.fr

    Elsa KAPHAN, MD

    Not yet recruiting

  • Neurologie

    Marseille, 13385

    MAAROUF Adil, MD, 0491385939 ext. +33, Adil.maarouf@ap-hm.fr

    MAAROUF Adil, MD

    Not yet recruiting

  • Neurology

    Marseille

    Hanna BOU ALI, MD

    Hanna BOU ALI, MD

    Not yet recruiting

  • Neurology

    Metz, 57085

    Chrystel CHERAUD BONFORT, MD, c.cheraudbonfort@chr-metz-thioville.fr

    Chrystel CHERAUD BONFORT, MD

    Not yet recruiting

  • Neurology

    Montivilliers, 76290

    Alexandre LECLANCHER, MD, 0686497074 ext. 33, alexandre.leclancher@ch-havre.fr

    Alexandre LECLANCHER, MD

    Not yet recruiting

  • General Neurology

    Montpellier, 34295

    Mahmoud CHARIF, MD, m-charif@chu-montpellier.fr

    Mahmoud CHARIF, MD

    Not yet recruiting

  • General medicine

    Mulhouse, 68070

    Sohrab MOSTOUFIZADEH, md, 0389646186 ext. 33, mostoufizadehs@ghrmsa.fr

    Sohrab MOSTOUFIZADEH, MD

    Not yet recruiting

  • Neurologie

    Nancy, 54035

    Louise TYVAERT, MD, 03 83 85 85 85, l.tyvaert@chru-nancy.fr

    Louise TYVAERT, MD

    Not yet recruiting

  • Neurology

    Nantes, 44093

    Hélène COURTEMANCHE, MD, 02 40 16 52 12 ext. 33, helene.courtemanche@chu-nantes.fr

    Hélène COURTEMANCHE, MD

    Not yet recruiting

  • Neurologie

    Nice, 06000

    BOURG Véronique, MD, 04 92 03 82 80 ext. +33, Bourg.v@chu-nice.fr

    BOURG Véronique, MD

    Not yet recruiting

  • Neurology

    Nîmes, 30029

    Giovanni CASTELNOVO, 466683261 ext. 33

    CASTELNOVO Giovanni, MD

    Not yet recruiting

  • Neurology

    Paris, 75014

    Clément VIALATTE DE PEMILLE, MD, cvialatte@ghpsj.fr

    Clément VIALATTE DE PEMILLE, MD

    Not yet recruiting

  • Neuropediatrics

    Paris, 75015

    Melodie AUBART, MD, melodie.aubart@aphp.fr

    Melodie AUBART, MD

    Not yet recruiting

  • Intensive Care Medicine

    Paris, 75018

    Romain SONNEVILLE, MD, 0140256139 ext. 33, romain.sonneville@aphp.fr

    Romain SONNEVILLE, MD

    Not yet recruiting

  • Neurology

    Paris, 75019

    Marine BOUDOT DE LA MOTTE, MD, 01 48 03 68 52 ext. 33, mboudotdelamotte@for.paris

    Marine BOUDOT DE LA MOTTE, MD

    Not yet recruiting

  • Onco-neurology

    Paris, 75651

    Dimitri PSIMARAS, MD, 0142160435 ext. 33, dimitri.psimaras@aphp.fr

    Dimitri PSIMARAS, MD

    Not yet recruiting

  • Neurology adult

    Paris, 94275

    Céline LABEYRIE, MD, 01 45 21 26 18 ext. 33, celine.labeyrie@aphp.fr

    Céline LABEYRIE, MD

    Not yet recruiting

  • Neurology

    Pointe à Pitre, Guadeloupe, 97159

    Hugo CHAUMONT, MD, 5 90 89 14 30 ext. 590, hugo.chaumont@chu-guadeloupe.fr

    Hugo CHAUMONT, MD

    Not yet recruiting

  • Neurology, neuropsychology and language rehabilitation

    Poitiers

    NEAU Jean-Philippe, MD, 06 08 22 42 31 ext. +33, jph.neau@chu-poitiers.fr

    NEAU Jean-Philippe, MD

    Not yet recruiting

  • Neurology

    Reims, 51100

    Maximilien MOULIN, MD, 03 26 78 71 34 ext. 33, mmoulin@chu-reims.fr

    Maximilien MOULIN, MD

    Not yet recruiting

  • Neurology

    Rennes, 35000

    Anca NICA, MD, anca.nica@chu-rennes.fr

    Anca NICA, MD

    Not yet recruiting

  • Vascular and general neurology

    Rouen, 76038

    Benjamin HEBANT, MD

    Benjamin HEBANT, MD

    Not yet recruiting

  • Neurology

    Saint-Brieuc, 22000

    Olivier VERCRUYSSE, MD

    Olivier VERCRUYSSE, MD

    Not yet recruiting

  • Neurology

    Saint-Denis, 93200

    Mickael BONNAN, MD, 06 27 06 66 86 ext. 33, mickael_bonnan@yahoo.fr

    Mickael BONNAN, MD

    Not yet recruiting

  • Neurology

    Saint-Etienne, 42055

    Jean-Philippe CAMDESSANCHÉ, MD, 0477120559 ext. 33, j.philippe.camdessanche@chu-st-etienne.fr

    Jean-Philippe CAMDESSANCHÉ, MD

    Not yet recruiting

  • Neurologie

    Saint-Nazaire, 44600

    Lucie Metzger, MD, 0272278229 ext. 33, l.metzger@ch-saintnzaire.fr

    Lucie Metzger, MD

    Not yet recruiting

  • Neurology

    St-Malo, 35400

    Alexandre Bonnet, MD, a.bonnet@ch-stmalo.fr

    Alexandre Bonnet, MD

    Not yet recruiting

  • Neurologie

    Strasbourg, 67098

    Christine TRANCHANT, MD, 03 88 12 85 32 ext. +33, Christine.Tranchant@chru-strasbourg.fr

    Christine TRANCHANT, MD

    Not yet recruiting

  • Neurology

    Strasbourg, 67098

    Edouard HIRSCH, MD, 03 88 12 85 62 ext. +33, edouard.hirsch@chru-strasbourg.fr

    Edouard HIRSCH, MD

    Not yet recruiting

  • Neurology

    Suresnes, 92150

    Adrien WANG, MD, 0146257343 ext. 33, a.wang@hopital-foch.com

    Adrien WANG, MD

    Not yet recruiting

  • Neurology

    Toulon, 83100

    Elena-Camelia Rusu, MD, 0616094863 ext. 33, Elena-camelia.rusu@ch-toulon.fr

    Elena-Camelia RUSU, MD

    Not yet recruiting

  • Neurology

    Toulon, 83800

    Anthony FAIVRE, MD, 0483162726 ext. 33, anthonyfa@wanadoo.fr

    Anthony FAIVRE, MD

    Not yet recruiting

  • Neurologie

    Tours, 37000

    Coline DUWICQUET, MD, 06 89 11 48 31 ext. +33, c.duwicquet@chu-tours.fr

    Coline DUWICQUET, MD

    Not yet recruiting

  • Neurology

    Valenciennes, 59300

    Marianne GIROUX, MD, giroux-m@ch-valenciennes.fr

    Marianne GIROUX, MD

    Not yet recruiting

  • Neurology

    Vannes, 56000

    Benoit PEGAT, MD, benoit.pegat@ch-bretagne-atlantique.fr

    Benoit PEGAT, MD

    Not yet recruiting

  • Neurology

    Versailles

    Jérôme SERVAN, MD, 0139639147 ext. 33, jservan@ch-versailles.fr

    Jérôme SERVAN, MD

    Not yet recruiting

Other trials in France

About this study

Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms. However, current treatments could be drastically improved by faster and more accurate diagnosis. The sample collection will benefit to patients with rare neuroimmune syndromes such as Autoimmune Encephalitis (AE) and Paraneoplastic Neurological Syndromes (PNS) leading to a better and early diagnosis, as well as treatment improvement.

Being tested
Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.
Keywords
Paraneoplastic Neurological Syndromes, Autoimmune Encephalitis, biological collection
Medical subject headings
Autoimmune Diseases of the Nervous System

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.Biological

    Blood is collected only one time by blood sample to obtain serum, buffy coat, plasma and PBMC.

    2 *4ml of blood on dry tube 2 *4ml of blood on EDTA tube If possibility of delivery in 48 hours at the Centre of Biological Resources, 7*4ml of blood on heparin tube If cerebrospinal fluid has been drawn for diagnosis, remaining sample available will be stored in the collection

Study groups in NCT05198661
Study groupRoleWhat they receive
Paraneoplastic neurological syndrome patients and autoimmune encephalitis patientOtherpatients with diagnosis of paraneoplastic neurological syndrome or autoimmune encephalitis
Receives: Biological: Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Blood Samples

    Assessment of biocollection of blood samples

    Measured: 10 years

  2. Cerebrospinal fluid biocollection

    Assessment of biocollection of Cerebrospinal fluid

    Measured: 10 years

Secondary outcomes (2)

  1. Scientific collaboration

    Number of project issued from the biocollection

    Measured: 10 years

  2. Scientific

    Number of scientific papers issued from the biocollection

    Measured: 10 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted20 Jan 2022
  2. Study start2 Aug 2022
  3. Primary completion2 Aug 2032 (estimated)
  4. Study completion2 Aug 2032 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Other
Allocation
Not applicable
Intervention model
Single group
Model description
Blood sample
Masking
None (open label)
Enrolment
3,500 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05198661
Sponsor's protocol ID
69HCL21_1271
Acronym
SNP
Status last verified
Feb 2024
First submitted
20 Dec 2021
Last updated
29 Feb 2024
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Questions about this trial

What is this clinical trial studying?

A study testing Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma. in people with Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis, run by Hospices Civils de Lyon at 62 sites in France.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 29 Feb 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 62 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Jerome HONNORAT, Pr (4 72 35 78 06 ext. +33, jerome.honnorat@chu-lyon.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Blood Samples (time frame: 10 years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05198661.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Feb 2024.

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