Clinical trials: POTS - Postural Orthostatic Tachycardia Syndrome
Postural Orthostatic Tachycardia Syndrome (POTS)
Programming Aquatic Therapy for POTS
The goal of this pilot study is to create, implement, and evaluate an aquatic therapy for Postural Orthostatic Tachycardia Syndrome (POTS) program feasibility and ability to improve quality of life as determined by reduced…
- Trial name
- NCT07182578
- Testing
- Aquatic Occupational Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- California State University, Dominguez Hills
Postural Orthostatic Tachycardia Syndrome (POTS)
Beta-3 Enhanced Autonomic Therapy for POTS
The study will test the hypothesis that mirabegron is more effective than a placebo in alleviating postural orthostatic tachycardia (POTS) symptoms.
- Trial name
- BEAT-POTS (NCT07585513)
- Testing
- Mirabegron
- Volunteers
- 36 people
- Sponsor
- Cedars-Sinai Medical Center
Orthostatic Intolerance, Postural Tachycardia Syndrome
Effect of Exercise in OI
The main limitation patients with orthostatic intolerance (OI, or postural tachycardia syndrome, POTS) have to exercise is related to their increase in heart rate when standing.
- Trial name
- NCT00770484
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University
Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome
Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by hyperextensible skin, joint hypermobility and additional connective tissue manifestations.
- Conditions
- Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome, Autonomic Nervous System Disease
- Trial name
- NCT05212129
- Testing
- Percutaneous vagal nerve stimulation (pVNS) device, Acoustic vagal nerve stimulation (aVNS) treatment
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical College of Wisconsin
Pure Autonomic Failure, Amyotrophic Lateral Sclerosis
Anti-Cholinergic Receptors Antibodies, Autonomic Profile and Dysautonomia Symptoms in PAF, ALS and POTS (DISAUT-AB)
Anti alfa-3 and alfa-7 ganglionic cholinergic receptors (anti-AChRs) antibodies (Abs) plasma removal by plasmapheresis (1,2) acutely improved dysautonomia symptoms in case reports with Pure Autonomic Failure (PAF) (3).
- Conditions
- Pure Autonomic Failure, Amyotrophic Lateral Sclerosis, Postural Orthostatic Tachycardia Syndrome, Anti-Cholinergic Receptors Antibodies
- Trial name
- DISAUT-AB (NCT04875949)
- Testing
- Immunoabsorption/plasmapheresis procedure
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Istituto Clinico Humanitas
Postural Tachycardia Syndrome, Orthostatic Intolerance
Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)
We propose to use actigraphy (measured by activity watches) as a tool to quantify sleep disturbances in patients with orthostatic intolerance compared with healthy control subjects.
- Conditions
- Postural Tachycardia Syndrome, Orthostatic Intolerance, Sleep Disorders
- Trial name
- NCT00692471
- Testing
- Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
POTS - Postural Orthostatic Tachycardia Syndrome
The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic…
- Trial name
- POTS (NCT05554107)
- Testing
- Training program
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University
Persistent Physical Symptoms (PPS)
CBT Plus SMC Compared to SMC for Persistent Physical Symptoms in Secondary Care (PRINCE)
Brief Summary: Persistent Physical Symptoms (PPS), also known as medically unexplained symptoms (MUS) is a term used to describe a range of persistent bodily symptoms for which the exact cause is unclear.
- Trial name
- PRINCE (NCT02426788)
- Testing
- Cognitive behavioural therapy (CBT)
- Where
- 7 sites in United Kingdom
- Volunteers
- 324 people
- Sponsor
- King's College London
Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS
POLish Registry of CArdioneuroablation and CArdioneuromodulation
The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus…
- Conditions
- Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV, Postural Orthostatic Tachycardia Syndrome POTS
- Trial name
- POL-CA (NCT07196397)
- Testing
- cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- SABAMED Medical Center Ltd.
Postural Orthostatic Tachycardia Syndrome (POTS), POTS
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
Postural tachycardia syndrome (POTS), is the chronic form of orthostatic intolerance associated with excessive upright tachycardia, and occurs predominantly in young females (>85%).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), POTS, Orthostatic Intolerance
- Trial name
- NCT03261570
- Testing
- Pyridostigmine, Digoxin
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Postural Tachycardia Syndrome
Autonomic Determinants of POTS - Pilot1
Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. It is the cause of significant disability and an impairment in quality of life.
- Trial name
- NCT04050410
- Testing
- Moxonidine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Autonomic Neuropathy, Ehlers-Danlos Syndrome Hypermobility Type
Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry
We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the…
- Conditions
- Autonomic Neuropathy, Ehlers-Danlos Syndrome Hypermobility Type, Small Fiber Neuropathy, Postural Tachycardia Syndrome
- Trial name
- ProANS (NCT04310644)
- Testing
- No intervention planned, but all patients get our standart treatment
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- RWTH Aachen University
Post-COVID Postural Orthostatic Tachycardia Syndrome Postural Orthostatic Tachycardia Syndrome
Open Label Extension of Efgartigimod in Adults With Post-COVID-19 POTS
The OLE study aims to investigate the safety, efficacy, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of efgartigimod in participants with post-COVID-19 postural orthostatic.
- Trial name
- POTS (NCT05918978)
- Testing
- Efgartigimod
- Where
- 9 sites in United States
- Volunteers
- 33 people
- Sponsor
- argenx
Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections.
- Conditions
- Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), Long COVID, SARS CoV 2 Infection
- Trial name
- NCT05421208
- Testing
- Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls, Levels of inflammatory cytokine ( IL-6) in controls, Effect on inflammation after chronic PNS stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Postural Tachycardia Syndrome
The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity
This study is being to see if participating in breathing exercise training and practicing this training will help with Postural tachycardia syndrome (POTS).
- Trial name
- NCT05618067
- Testing
- breathing exercise training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS)
Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS)
Vasovagal syncope (VVS, simple faint) is the most common cause of transient loss of consciousness and represents the acute episodic form of orthostatic intolerance (OI).
- Conditions
- Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS), Fainting
- Trial name
- NCT02558972
- Testing
- Northera (Droxidopa)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Postural Orthostatic Tachycardia Syndrome (POTS)
Tragus Stimulation for POTS Treatment
Postural Tachycardia Syndrome (POTS) is a form of dysautonomia characterized by an abnormal cardiovascular response to orthostatic challenges.
- Trial name
- TREAT-POTS (NCT07163130)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 24 people
- Sponsor
- Aristotle University Of Thessaloniki
Postural Tachycardia Syndrome, Postural Orthostatic Tachycardia Syndrome
Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)
The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease heart rate increases on standing in patients with postural tachycardia syndrome.
- Trial name
- NCT00962728
- Testing
- Inspiratory Threshold Device (Res-Q-Gard ITD)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alfredo Gamboa