Clinical trials: Osteomyelitis
Osteomyelitis
Drug Delivery Devices for Osteomyelitis
Fifty-one patients suffering from chronic post-traumatic or postoperative osteomyelitis of the lower extremities were included in the retrospective investigation.
- Trial name
- NCT02968693
- Testing
- antibiotic-loaded calcium sulfate, antibiotic-loaded polymethyl methacrylate, Vancomycin
- Where
- 2 sites in China
- Volunteers
- 51 people
- Sponsor
- Yulin Orthopedics Hospital of Chinese and Western Medicine
Staphylococcal Infections, Osteomyelitis
Ceftriaxone as Home IV for Staph Infections
Patients who are admitted to hospital with serious infections, such as those in bone, joints or spine, require a long course of intravenous (IV) antibiotics.
- Conditions
- Staphylococcal Infections, Osteomyelitis, CNS Infection, Septic Arthritis
- Trial name
- NCT04141787
- Testing
- Ceftriaxone, Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
- Where
- 2 sites in Canada
- Volunteers
- 310 people
- Sponsor
- Vancouver Island Health Authority
Osteomyelitis, Septic Arthritis
Oral-only Antibiotics for Bone and Joint Infections in Children
A nationwide, multicenter, randomized, non-inferiority trial of children with bone and joint infections. The primary objective is to determine if oral-only antibiotics (experimental arm) is non-inferior to initial intravenous…
- Conditions
- Osteomyelitis, Septic Arthritis, Bone Infection, Joint Infection
- Trial name
- CHILD@HOME_BJI (NCT04563325)
- Testing
- Oral co-amoxiclav or oral dicloxacillin only, IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetic Foot Osteomyelitis
A Feasibility Trial to Investigate the Safety and Between-group Effect Size of STIMULAN VG and Standard of Care (SoC) in Participants With Diabetic Foot Osteomyelitis
The purpose of this trial is to evaluate the safety and between-group effect size of STIMULAN VG compared to SoC treatment in patients with diabetic foot osteomyelitis (DFO).
- Trial name
- BLADE-VG2 (NCT05539963)
- Testing
- STIMULAN VG, Systemic Antibiotics
- Where
- 10 sites in United States
- Volunteers
- 61 people
- Sponsor
- Biocomposites Ltd
Osteomyelitis of Jaw
Management of Medication Related Osteonecrosis of the Jaws With Double Periosteal Flap Closure
20 patients with MRONJ underwent surgical debridement using piezosurgery then closure using double periosteal flap
- Trial name
- NCT07177378
- Testing
- management of medication related osteonecrosis of the jaw
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Sepsis, Bacteraemia
Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity…
- Conditions
- Sepsis, Bacteraemia, Meningitis, Abscess
- Trial name
- ERNIE2 (NCT02024282)
- Testing
- Use of C-reactive protein (CRP) point of care test, Brief intervention and parent leaflet, Finger Pulse Oximeter
- Where
- 2 sites in Belgium
- Volunteers
- 8,962 people
- Sponsor
- KU Leuven
Osteomyelitis, Diabetic Foot
Efficacy of Surgical Treatment of Osteomyelitis in Diabetic Foot Ulcers
Hypothesis:Surgical treatment of osteomyelitis in diabetic foot is more effective that medical treatment through antibiotherapy and leads wound healing in ulcers complicated with bone infection.Material and Methods: Randomized…
- Conditions
- Osteomyelitis, Diabetic Foot, Diabetic Foot Ulcers
- Trial name
- NCT01137903
- Testing
- Conservative surgery, Ciprofloxacin, Amoxicillin-Potassium Clavulanate Combination
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Universidad Complutense de Madrid
Pressure Ulcer, Stage IV, Osteomyelitis
A Randomized Controlled Phase II Trial of STIMULAN VG vs Standard of Care (SoC) for the Treatment of Osteomyelitis Associated With Stage IV Pressure Ulcers.
The purpose of this trial is to assess the safety, tolerability and between-group effect size of STIMULAN VG (with debridement) and a course of systemic antibiotics to standard of care (debridement and systemic antibiotics only)…
- Trial name
- BLADE OPU2 (NCT06283979)
- Testing
- STIMULAN VG, Standard of Care
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Biocomposites Ltd
Stage IV Pressure Ulcer, Diabetic Foot Osteomyelitis
Expanded Access Program (EAP) STIMULAN VG
Individual (single) patient expanded access may be considered.
- Trial name
- EAPSTIMVG (NCT06808568)
- Testing
- STIMULAN VG
- Sponsor
- Biocomposites Ltd
Osteomyelitis
Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis (PCT)
We plan a cohort study of 40 diabetic patients admitted to Parkland hospital with a foot infection. We will enroll a representative cross section of subjects with diabetic foot infection.
- Trial name
- PCT (NCT02308774)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Texas Southwestern Medical Center
Osteomyelitis
Effect of Pulsed Electromagnetic Field Stimulation on Localized Pediatric Osteomyelitis
This study will be applied to evaluate effect of pulsed electromagnetic field on pediatric localized osteomyelitis.
- Trial name
- PEMF (NCT06084754)
- Testing
- pulsed electromagnetic field, Antibiotics
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Osteomyelitis of Jaw
Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial Osteomyelitis
The goal of this clinical trial is compare the efficacy of oral and IV antibiotics in the treatment of orofacial osteomyelitis. The main question it aims to answer is: Are oral antibiotics as effective as IV antibiotics in the…
- Trial name
- NCT05867654
- Testing
- Amoxicillin-clavulanate 875mg/125mg q12hrs, oral clindamycin 300mg q6hrs, Levofloxacin 750mg QID
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Louisville
Bacterial Infections, Bone Diseases, Infectious
Fosfomycin I.v. for Treatment of Severely Infected Patients
The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin…
- Conditions
- Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections
- Trial name
- FORTRESS (NCT02979951)
- Where
- 50 sites in Austria, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Infectopharm Arzneimittel GmbH
Osteomyelitis, Diabetes
The ACHILLS Trial; Application of Cerament in Heel Infection for Lower Limb Salvage
The ACHILLS Trial is a multicentre randomised controlled feasibility study comparing partial calcanectomy with and without the use of an antibiotic-impregnated bone graft substitute (Cerament G) for treating calcaneal…
- Conditions
- Osteomyelitis, Diabetes, Calcanectomy
- Trial name
- ACHILLS (NCT07057817)
- Testing
- Cerament G, Standard Surgical Managment
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Royal College of Surgeons, Ireland
Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute
Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections
The goal of this clinical trial is to learn if trimethoprim-sulfamethoxazole (TMP-SMX) works to treat invasive infections due to methicillin-resistant Staphylococcus aureus (MRSA) in children.
- Conditions
- Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute, Septic Arthritis, Orbital Cellulitis
- Trial name
- NCT06982105
- Testing
- Trimethoprim Sulfamethoxazole
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Osteomyelitis
Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis
This clinical study will be a multi-center, randomized, open-label, active-controlled, parallel-group study comparing dalbavancin to standard of care (SOC) therapy in osteomyelitis.
- Trial name
- NCT03091439
- Testing
- Dalbavancin, Standard of Care
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Allergan
Acute Congestive Heart Failure, Exacerbation of COPD
The RAD-HOME Project: a Pilot Study of Domiciliary Teleradiology
Aim of the study is to assess feasibility and safety of a public territorial radiology service for home hospitalized frail elderly patients whose health conditions discourage the transportation to hospital.
- Conditions
- Acute Congestive Heart Failure, Exacerbation of COPD, Pneumonia, Fractures
- Trial name
- RHP (NCT01098916)
- Testing
- Home X-rays, X-rays in hospital
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Vertebral Osteomyelitis, Spondylodiscitis
Conservative Versus Surgical Treatment of Native Vertebral Osteomyelitis
The optimal treatment of uncomplicated native vertebral osteomyelitis (NVO) is unknown. While some authors recommend surgical treatment (consisting of spinal debridement, decompression and instrumentation using hardware…
- Conditions
- Vertebral Osteomyelitis, Spondylodiscitis, Surgical Procedure, Unspecified
- Trial name
- NCT04436328
- Testing
- Surgical treatment, Antimicrobial treatment
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Osteomyelitis
Don't Treat Ghosts Anti-MRSA Antibiotics in Osteomyelitis Without Identified MRSA
Osteomyelitis is described as infection and inflammation of the long bone or bone marrow, often due to an open wound, operation, or invasive trauma.1 It is invasive and involves hematogenous seeding or contiguous spread of the…
- Trial name
- NCT06096012
- Testing
- Anti-MRSA therapy
- Where
- United States
- Volunteers
- 365 people
- Sponsor
- Methodist Health System
Suppurative Osteomyelitis of Jaw, Potential Abnormality of Glucose Tolerance
Risk Factors Associated With Recurrence and Life-threatening Complications for CSOJ
Clinically, recurrence and life-threatening complications are challenging problems for chronic suppurative osteomyelitis of the jaw.
- Trial name
- NCT01670422
- Where
- China
- Volunteers
- 322 people
- Sponsor
- West China College of Stomatology