Clinical trials: Osteoarthritis Knee Pain
Osteoarthritis
Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.
The Purpose of this trial is to evaluate the use of a cross-over trial design in an osteoarthritis population. We will determine the inter- and intra-subject variability in osteoarthritis (OA) endpoints and evaluate if efficacy…
- Trial name
- NCT00484718
- Testing
- celecoxib, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Pfizer
Postsurgical Pain
Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty
Total knee arthroplasty is a surgical treatment which involves replacing the damaged articular cartilage of the knee joint with an artificial prosthetic in end-stage knee osteoarthritis.
- Trial name
- MP-TKA (NCT06202989)
- Testing
- Multiprofen-CC™ plus standard treatment
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- KAZM Pharmaceuticals Inc.
Knee Osteoarthritis
Effects of Mulligan's Pain Release Phenomenon and Kaltenborn Mobilizations on Knee Osteoarthritis
Knee osteoarthritis is a degenerative condition that is prevalent in older population and is associated with pain, stiffness, decreased range of motion and impaired function.
- Trial name
- NCT07402291
- Testing
- Mulligan's pain release phenomenon, Kaltenborn mobilization with traction
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Osteoarthritis
A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee
To assess the safety and tolerability of orally-administered CR845 in patients with osteoarthritis (OA) of the hip or knee. The study drug is being tested to reduce OA pain, and will be taken twice a day for two weeks, with four…
- Trial name
- NCT02524197
- Testing
- CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Cara Therapeutics, Inc.
Osteoarthritis, Knee
An Acupuncture Functional Magnetic Resonance Imaging (fMRI) Study on Chronic Pain: Response Reliability and Dose Effect
In this proposal, we plan to dynamically investigate brain response to verum acupuncture (of two different "doses") and placebo acupuncture, using a paradigm that approximates clinical acupuncture practice across multiple…
- Trial name
- NCT01079390
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Massachusetts General Hospital
Pes Anserine Bursitis
Comparison of Bracing and Eccentric Loading Exercises on Pain Modulation and Functional Improvement in Acute Pes Anserine Bursitis Patients
This study aims to compare the effects of knee bracing and eccentric loading exercises on pain and functional ability in adults with acute pes anserine bursitis.
- Trial name
- NCT07881913
- Testing
- Medial-Support Knee Brace, Eccentric Loading Exercise
- Where
- 2 sites in Pakistan
- Volunteers
- 32 people
- Sponsor
- Dr Aneeqa Sultan
Osteoarthritis, Knee
Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain
This is a single center randomized controlled trial. Approximately 102 patients will be randomized to one of two treatment groups: cooled radiofrequency or conventional monopolar radiofrequency ablation.
- Trial name
- NCT02260869
- Testing
- Genicular nerve radiofrequency ablation, Pain Management Radiofrequency Kit
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Millennium Pain Center
Knee Osteoarthritis
Immediate Effects of High-intensity Laser Therapy on Knee Joint Position Sense and Knee Muscle Strength in Patients with Knee Osteoarthritis
The goal of this clinical trial is to compare whether HILT versus Sham-HILT is effective to reduce pain, improve knee joint position sense, and knee muscle strength.
- Trial name
- HILT on KOA (NCT06632119)
- Testing
- high-intensity laser therapy
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Mahidol University
Knee Osteoarthritis
Is Pulsed Ultrasound Treatment Effective in Knee Osteoarthritis
Osteoarthritis is a progressive rheumatic disease which is the most common cause of musculoskeletal pain and functional impairment, particularly in the elderly group. The most common form is knee osteoarthritis.
- Trial name
- NCT03705039
- Testing
- Pulsed Ultrasound Treatment, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Dokuz Eylul University
Knee Osteoarthritis
Kinesiophobia, Pain, Functional Status and Self-Efficacy in Patients With Knee Osteoarthritis
Objective: The aim of this study is to examine the relationship between kinesiophobia, pain, functional status and self efficacy in patients with knee osteoarthritis.
- Trial name
- NCT05036551
- Testing
- Kellgren Lawrence classification
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Hacettepe University
Knee Osteoarthritis, Genicular Nerve Block
Phenol Neurolysis Versus Local Anesthetic Plus Steroid Genicular Nerve Block in Knee Osteoarthritis
This study aims to evaluate two different ultrasound-guided procedures for patients with knee osteoarthritis (gonarthrosis) who did not benefit from conservative treatments.
- Trial name
- NCT07267039
- Testing
- Phenol Injection, Bupivacaine + Triamcinolone Acetonide Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Salim Sencar
Osteo Arthritis Knee
High Versus Low Adductor Canal Block
The investigators will be comparing the efficacy of two different techniques for performing an adductor canal block to the saphenous nerve as a part of the multimodal pain control regimen for total knee arthroplasty.
- Trial name
- NCT04155983
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Carilion Clinic
Knee Osteoarthritis
Percutaneous Electrical Stimulation, Education and Exercise Program in Patients With Knee Osteoarthritis
The purpose of this study is to compare the effectiveness of percutaneous electrotherapy treatment with transcutaneous and placebo.
- Trial name
- NCT05955430
- Testing
- Therapeutic exercise, Pain education, Percutaneous electrical stimulation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Josue Fernandez Carnero
Knee Osteoarthritis, Osteoarthritis, Knee
US-Guided Saphenous Block in Knee OA
The purpose of this prospective, randomized, open-label, active-controlled clinical trial is to evaluate the clinical and sonographic effects of ultrasound-guided (US-guided) high-volume saphenous nerve block combined with…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Knee, Gonarthrosis, Knee Pain
- Trial name
- SAPH-KNEE-OA (NCT07868770)
- Testing
- Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, Home-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Knee Osteoarthritis
Bowen Technique and Post Isometric Relaxation in Knee Osteoarthritis Patients
The Hamstring muscles are present at the posterior surface of the thigh. The muscles start in the gluteal region and run back of the thigh and insert into the popliteal fossa.
- Trial name
- NCT05723029
- Testing
- Bowen Technique, Post Isometric Relaxation
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Back Pain, Knee Osteoarthritis
Examination of Foot Posture's Change on Balance in Different Disorders
Foot; It is a terminal joint that opposes external resistance in the lower kinetic chain. It plays a primary role in weight transfer and ground response between the body and the ground.
- Trial name
- NCT05909345
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Istanbul Medipol University Hospital
Knee Pain Chronic, Osteo Arthritis Knee
Individual Patient Expanded Access IND of Autologous HB-adMSCS for the Treatment of Bilateral Knee Pain.
This is an Individual Patient Expanded Access IND of autologous adipose derived Mesenchymal Stem Cells with the primary goal of treating 1 individual with bilateral knee pain who has exhausted all treatment options, his condition…
- Trial name
- NCT04604288
- Testing
- HB-adMSC
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Osteoarthritis of the Knee, Coagulopathy
Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anticoagulants
The purpose of this study is to see if using a topical nonsteroidal antiinflammatory drug (Pennsaid) to treat osteoarthritis knee pain will affect coagulation values in patients who are also taking anticoagulant or antithrombotic…
- Trial name
- ATCCTCP-1 (NCT01511939)
- Testing
- Pennsaid
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Nathan Wei, MD, FACP, FACR:
Osteoarthritis, Knee
The Effect of Therapeutic Methods for Chronic Knee Osteoarthritis Pain
Chronic osteoarthritis (OA) pain of the knee is not effectively abrogated by the available non-pharmacologic or pharmacologic treatments. Radiofrequency (RF) neurotomy is a therapeutic alternative for chronic pain.
- Trial name
- NCT00924677
- Testing
- radiofrequency neurotomy for genicular nerve
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Arthrosis of the Knee
Study on Personalized Total Knee Arthroplasty (TKA) Rehabilitation Using Telemedicine and Psychoeducation
The aim of this clinical study is to evaluate the effectiveness of a telemedicine approach in improving treatment adherence and functional outcomes in patients recently underwent total knee replacement for primary osteoarthritis.
- Trial name
- TKA (NCT07032805)
- Testing
- personalized outpatient rehabilitation treatment after TKA, standard outpatient rehabilitation treatment after TKA
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Laura Belinda Rizzo
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