Clinical trials: Orthopedic Surgery Patients
Neurological Disorders, Orthopedic Disorders
A Model for Continuous Care of Fragile Patients
This observational study aims to monitor functional status and identify potential declines in the functioning of medically fragile patients with neurological and/or orthopedic conditions, representing an added value for ensuring…
- Conditions
- Neurological Disorders, Orthopedic Disorders, Functional Decline, Fragile and More Vulnerable
- Trial name
- AFTER (NCT07299344)
- Testing
- Telemedicine-Based Functional Monitoring
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Sanitaria Locale CN2 Alba-Bra
Cytotoxicity
Biological Evaluation of Orthopedic Materials: An In Vitro Study Using Patient-Derived Human Samples
The anterior cruciate ligament (ACL) is the primary stabilizer of the knee joint, and ACL injuries are highly prevalent, particularly among physically active and athletic individuals.
- Trial name
- RAISE (NCT07671521)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Stefano Zaffagnini
Post Operative Pain, Acute
A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery
Combogesic® 325 contains a combination of ibuprofen and acetaminophen. The purpose of this study is to compare the pain relief effects of Combogesic® 325mg and acetaminophen and to evaluate the safety of Combogesic® 325mg in…
- Trial name
- NCT07225140
- Testing
- Combogesic® tablets, Acetaminophen 500mg
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Pain, Postoperative
An Efficacy and Safety Study to Compare Fentanyl Ionsys and Routine Care With Intravenous (IV) Morphine Patient-controlled Analgesia (PCA) in Participants Who Have Undergone Elective Major Abdominal or Orthopedic Surgery
The purpose of this study is to evaluate the mobilization characteristics, clinical use, safety and Ease of Care (EOC) of a fentanyl Iontophoretic Transdermal Patient Controlled Analgesia (PCA) system (Ionsys) and morphine…
- Trial name
- NCT00766506
- Testing
- Fentanyl IONSYS, Morphine IV PCA
- Where
- 7 sites in United Kingdom
- Volunteers
- 108 people
- Sponsor
- Janssen-Cilag Ltd.
Orthopedic Disorder
Ultrasound-guided FICB for Proximal Femoral Osteotomy in Pediatric Patients
This prospective randomized controlled trial aims to examine the effect of fascia iliaca compartment block on the postoperative pain and opioid consumption in pediatric patients (3y≤ age <18y) who will undergo orthopedics surgery…
- Trial name
- NCT04570891
- Testing
- Ultrasound-guided fascia iliaca compartment block, Control
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Seoul National University Hospital
Guided Imagery
The Effect of Guided Imagery on Activity-Specific Balance Confidence, Pain, and Psychological Well-Being
The aim of this clinical trial is to evaluate the effect of guided imagery on activity-specific balance confidence, pain, and psychological well-being in elderly orthopedic patients.
- Trial name
- NCT06855927
- Testing
- Guided Imagery
- Volunteers
- 78 people
- Sponsor
- Inonu University
Intravenous Drug Usage, Ibuprofen
Postoperative Analgesic Effects of Ibuprofen Versus Ketorolac in Patients Undergoing in Orthopedic Surgery
Objectives: To compare the postoperative analgesic effects of ibuprofen versus ketorolac in patients undergoing orthopedic surgery at Combined Military Hospital, Rawalpindi.
- Conditions
- Intravenous Drug Usage, Ibuprofen, Ketorolac, Knee Arthroscopy
- Trial name
- NCT05695664
- Testing
- Ibuprofen 800 mg, Ketorolac Injection
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Benazir Bhutto Hospital, Rawalpindi
Dysbiosis, Gut -microbiota
Impact of Probiotics on Gut Microbiome During Antibiotic Prophylaxis in Elective Orthopedic Surgery
This study aims to evaluate whether probiotics can help maintain a healthy gut microbiome in patients receiving prophylactic antibiotics during elective orthopedic surgery.
- Conditions
- Dysbiosis, Gut -microbiota, Microbiome Analysis, Probiotic
- Trial name
- NCT06791993
- Testing
- Probiotic with Human Milk Oligosaccharides (HMO)
- Where
- 6 sites in United States, Thailand and 1 more
- Volunteers
- 60 people
- Sponsor
- Acibadem Maslak Hospital
Cognition
Cognition in Postoperative Total Hip Arthroplasty and Total Hip Resurfacing Patients
Transient cognitive changes after surgery may be due to many different factors. It is estimated that between 5-29% of patients undergoing orthopedic surgery experience a transient decline in their cognition.
- Trial name
- NCT01079468
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rothman Institute Orthopaedics
Maxillary Transverse Deficiency
A 6-months Evaluation of Patients' Compliance and Oral Hygiene During Rapid Maxillary Expander (RME) Treatment Using "Ortodontika" Smartphone Application
The aim of this study is to evaluate the clinical use of the smartphone application "Ortodontika" for the compliance of orthodontic patients with Rapid Maxillary Expander (RME).
- Trial name
- NCT05539469
- Testing
- Ortodontika app, Verbal instructions
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Postoperative Delirium, Stroke
Cyclopofol Versus Propofol for Postoperative Delirium in Elderly Patients Having Orthopedic Surgery
Postoperative delirium (POD) is common in elderly patients recovering from surgery and anesthesia. POD has adverse effects on early and long-term prognosis.
- Trial name
- NCT06046638
- Testing
- Cyclopofol, Propofol
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Hypotension
Haemodynamic Response to General Anaesthesia in Healthy Orthopaedic Patients
Continuous cardiovascular monitoring as part of management of high-risk surgical patients is widely practiced, however its role in low-risk surgical patients is unclear.
- Trial name
- HRespToAS (NCT02834000)
- Testing
- LiDCO rapid™ CNAP monitoring
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Total Hip Arthroplasty
The Effects of Cognitive Functioning on Gait Rehabilitation
The present study is designed to investigate whether the behavioral and cognitive functioning might predict the outcome of the rehabilitation of gait related abilities in orthopedic patients submitted to elective surgery (total…
- Trial name
- NCT03624998
- Testing
- Cognitive and physiatric testing
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Fracture Related Infection
Incidence of Fracture-Related Infection Among Adult Trauma Patients Undergoing Operative Fracture Fixation A Prospective Cohort Study at the Orthopaedic and Trauma Surgery Unit, Assiut University Hospital
Fracture-related infection (FRI) is an infection occurring after operative or non-operative management of a fracture, and it represents one of the most serious complications encountered in orthopaedic trauma surgery.
- Trial name
- NCT07853404
- Volunteers
- 375 people
- Sponsor
- Assiut University
Opioid Use
Life Care Specialists (LCS) With a Focus on Patient Pain Management and Prevention of Substance Misuse
The overall hypothesis of this randomized-controlled trial is that the introduction of a Life Care Specialist (LCS) as a novel member of the clinical care team will help reduce opioid utilization, decrease pain scores, and…
- Trial name
- NCT04154384
- Testing
- Life Care Specialist (LCS) Intervention, Clinical Coordination with Referrals, Pilot Study of Pain Management Strategies
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- Emory University
Any Chronic, Non-traumatic Orthopedic Condition
Testing an AI Large Language Model Tool for Cognitive Debiasing in Musculoskeletal Care
The goal of this clinical trial is to find out whether using an artificial intelligence (AI) tool called a Large Language Model (LLM) can help patients think more clearly about their symptoms and improve their trust and…
- Trial name
- NCT07022769
- Testing
- LLM-facilitated cognitive debiasing aid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas at Austin
Osteoarthritis
FORCE-TJR: Improving Orthopedic Outcomes Through a National TJR Registry
Aim 1. Establish a national registry of diverse patients of orthopedic surgeons representing all regions of the country and varied hospital and surgeon practice settings (e.g., urban/rural, low and high volume) to ensure that…
- Trial name
- FORCE-TJR (NCT02566473)
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Orthopedic Disorder
Pupilometric Evaluation of Patients Under Procedural Sedation With Propofol
Procedural sedation involves the administration of sedative medications that allow patients to tolerate painful procedures. Procedural sedation has been formally recommended by experts from the French Society of Emergency…
- Trial name
- ALGISAP 2023 (NCT05750485)
- Testing
- Pupilometric evaluation
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Anemia, Iron Deficiency
Patient Blood Management in the Approach to Prosthetic Surgery [PBM(L4178)]
We have been well guided in the "Good use of blood" during major surgery for many years, reaching a percentage of 4% of patients transfused after elective prosthetic operations.
- Trial name
- PBM(L4178) (NCT05806437)
- Testing
- sideremil vita cp
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Knee Osteoarthritis, Arthritis Knee
How Does the Addition of Adductor Canal Block to Local Infiltration Affect Recovery in Patients Undergoing Total Knee Arthroplasty? A Feasibility Study.
The use of periarticular injection and adductor canal block are well-established techniques used both in combination or in isolation in the management of postoperative pain for patients undergoing total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Arthritis Knee, Knee Disease, Opioid Use
- Trial name
- TRUE KnORTH (NCT04648072)
- Testing
- Adductor Canal Block, Periarticular Injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Health Sciences North Research Institute