Clinical trials: Opioid Use, Unspecified
Post Operative Pain, Acute, Post-Op Complication
Pigtail or Chest Tube Placement After Uniportal Video-assisted Thoracoscopic Surgery
This study aims to figure out how small-bore pigtail catheter or large-bore chest tube for postoperative drainage impact on analgesic efficacy and actually enhance recovery postoperatively.
- Conditions
- Post Operative Pain, Acute, Post-Op Complication, Opioid Use, Unspecified, ERAS
- Trial name
- NCT06050551
- Testing
- uniportal VATS
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Opioid Use, Unspecified, Remifentanil
Anesthesia for Vascular Access Devices
Our aim was to investigate whether remifentanil use in both infusion and bolus techniques could provide sufficient sedation and analgesia without serious adverse effects for central venous access device procedures under monitored…
- Conditions
- Opioid Use, Unspecified, Remifentanil, Sedation Complication, Analgesia
- Trial name
- NCT04749069
- Testing
- Comparison of pain intensity rating scale
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Opioid Use, Unspecified
Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery
The purpose of this study is to determine if methadone improves postoperative pain control in pediatric patient's undergoing cardiac surgery.
- Trial name
- CV_RCT_M_F (NCT02747875)
- Testing
- Methadone, Fentanyl
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Andrew Waberski
Opioid Use, Unspecified
Effect of Opioid Shortage on Drug Selection
This study will look at the effects of fentanyl shortage in laparoscopic cholecystectomy cases. The opioid shortage, specifically hydromorphone and fentanyl, caused a decrease in administration of opioid analgesia for…
- Trial name
- NCT04099030
- Where
- United States
- Volunteers
- 1,668 people
- Sponsor
- Wake Forest University Health Sciences
Opioid Use, Unspecified With Withdrawal, Opioid-Induced Disorders
Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit
The purpose of this study is to determine if administering methadone to mechanically ventilated patients in the medical intensive care unit (ICU) requiring continuous infusions of sedatives and analgesics will decrease the time…
- Conditions
- Opioid Use, Unspecified With Withdrawal, Opioid-Induced Disorders, Delirium
- Trial name
- NCT02025855
- Testing
- Methadone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Henry Ford Health System
Pain, Opioid Use, Unspecified, Uncomplicated
The Effect of Magnesium Sulfate Infusion on the Quality of Recovery of Ambulatory Patients
A national survey has revealed that 80% of patients experienced pain after surgery and 86% of these patients had moderate, severe or extreme pain (1).Postoperative pain can extend recovery room stay after surgery and it is also a…
- Trial name
- NCT01433081
- Testing
- administration of magnesium sulfate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwestern University
Opioid Abuse, Unspecified
Application of Economics & Social Psychology to Improve Opioid Prescribing Safety Trial 1: EHR Nudges
The opioid epidemic has had a tremendous negative impact on the health of persons in the U.S. The objective of the trial 1 of Application of Economics \& Social psychology to improve Opioid Prescribing Safety (AESOPS-T1), is to…
- Trial name
- AESOPS-T1 (NCT04477304)
- Testing
- Opioid Naive, OR, At-risk for long-term use, OR, Long-term opioid recipient
- Where
- United States
- Volunteers
- 555 people
- Sponsor
- University of Southern California
Post-Operative Analgesia, Opioid Use, Unspecified
Comparing Post-Operative Analgesic Effects of PCAM With Dexmedetomidine 1 mcg/ml vs PCAM With Dexmedetomidine 2 mcg/ml
PCA morphine have been a common method in providing excellent analgesia for post-operative period. However, the usage of morphine is not without any side effects such as nausea, vomiting, respiratory depression, and over…
- Conditions
- Post-Operative Analgesia, Opioid Use, Unspecified, Laparotomy Surgery
- Trial name
- NCT05288738
- Testing
- Dexmedetomidine 1 mcg/ml, Dexmedetomidine 2 mcg/ml
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Alcohol Drinking, Opioid Use, Unspecified
Opioid Modulation and Neural Reward Activation in Healthy Adults
This is a double blind study of the effects of opioid antagonism on the brain's reward response. The investigators will recruit participants to undergo two scans, one on active medication and one on placebo.
- Trial name
- NCT04854551
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Opioid Use, Unspecified, Nurse's Role
Nurses' Knowledge and Attitude About Opioids
Opioid analgesics used in moderate or severe pain have potential side effects and addiction. Therefore, nurses have hesitations about opioid administration.This descriptive study aimed to evaluate the attitude and knowledge of…
- Conditions
- Opioid Use, Unspecified, Nurse's Role, Knowledge, Attitudes, Practice
- Trial name
- NCT04252443
- Testing
- Evaluation of nurses' knowledge and attitudes about opioid analgesics working in a university hospital
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- European University of Lefke
Opioid Use, Unspecified
Prescribing Opioid Pain Relievers in the Emergency Department: Understanding and Optimizing the Encounter
The investigators overall study objective is to improve patients knowledge and safe use of opioid pain relievers upon discharge from the Emergency Department.
- Trial name
- NCT02299024
- Testing
- Additional Opioid Information
- Where
- United States
- Volunteers
- 278 people
- Sponsor
- Northwestern University
Post Operative Pain, Opioid Use, Unspecified
Sensory Outcomes in Active Substance Users
The incidence and severity of postoperative pain after spine surgery are notably high, often requiring intensive management and potentially affecting the patient's recovery, satisfaction, and long-term outcomes.
- Trial name
- NCT06639438
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Cardiac Surgery, Opioid Use, Unspecified
Pecto-Intercostal Fascial Plane Block Study
This study is being done to see if bilateral pecto-intercostal fascial plane blocks (PIFB) with a mixture of liposomal and standard bupivacaine decrease pain and opioid requirements in patients undergoing cardiac surgery via…
- Trial name
- NCT04928339
- Testing
- Bupivacaine Injection, Liposomal bupivacaine, Saline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid dronabinol (Marinol) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use, Unspecified
- Trial name
- NCT02901275
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid Use, Unspecified With Other Opioid-induced Disorder
Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients
Assessment of pharmacokinetic parameters of once daily subcutaneously administered methylnaltrexone in 10 evaluable neurointensive care patients.
- Trial name
- RELZH12 (NCT01889290)
- Testing
- Methylnaltrexone
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Opioid Use, Unspecified, S-ketamine
Study on Opioid-free Anesthesia Protocol With S-ketamine and Propofol
The purpose of this study was to observe the effects of opioid-free anesthesia with S-ketamine on postoperative analgesia and perioperative hemodynamics in short surgical operations, and to explore the effects of S-ketamine on…
- Trial name
- NCT05242081
- Testing
- S-ketamine, Sufentanil
- Where
- China
- Volunteers
- 980 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioid Use, Opioid Dependence
Safe Return and Disposal of Unused Opioids
The opioid epidemic in the United States has become a clear health and safety concern for our children and families. Opioids given to our patients for the treatment of pain that go unused after the immediate post operative period…
- Conditions
- Opioid Use, Opioid Dependence, Opioid Abuse, Unspecified
- Trial name
- NCT03352479
- Testing
- Opioid Return
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Opioid Use, Pain, Postoperative
Collaborative Opioid Taper After Trauma: Preventing Opioid Misuse and Opioid Use Disorder
The investigators will enroll 100 participants using a randomized control trial design to implement and evaluate an individualized opioid taper program supporting rural Primary Care Physicians (PCPs) caring for patients with…
- Conditions
- Opioid Use, Pain, Postoperative, Opioid Use, Unspecified, Trauma
- Trial name
- NCT04275258
- Testing
- Provide assistance to subject's rural PCP pertaining to subject/patient pain management goals and opioid taper plan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Opioid Use, Unspecified, Anesthesia
Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception.
This study aims to evaluate esmolol's perfusion impact during induction and maintenance of general anesthesia, using Nociception-Level-guided control of nociception, in adult patients undergoing laparoscopic and lower abdominal…
- Conditions
- Opioid Use, Unspecified, Anesthesia, Nociceptive Pain
- Trial name
- ESMONOL (NCT06291363)
- Testing
- Esmolol Hydrochloride, Saline
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal