Clinical trials: Occlusion, active
Asthma, Atherosclerosis
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Background: Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation.
- Conditions
- Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01143480
- Where
- United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Aortic Stenosis
Videodensitometric Angiographic Assessment of AR in the Cath-lab for Intraprocedural Guidance of TAVI in CHINA
This clinical trial, a prospective, randomized, multicenter study, assigns patients to either videodensitometry-guided TAVI or conventional TTE/TEE-guided TAVI (stand of care), with the primary endpoint being regurgitation…
- Trial name
- NCT06891079
- Testing
- Videodensitometric guided, Stand of care guided
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease
Relation Between Lymphocyte-to-C-Reactive Protein Ratio and Coronary Artery Disease Complexity
Aim(s) of the Research : 1. To assess the relationship between the lymphocyte-to-CRP ratio and CAD complexity as assessed by Syntax score in both emergency (STEMI patients undergoing PPCI) and elective settings (patients…
- Trial name
- NCT06958562
- Testing
- No intervention administered. Standard care will be provided. Blood samples for lymphocyte count and CRP will be collected, and Syntax score will be calculated from angiography.
- Volunteers
- 600 people
- Sponsor
- Assiut University
Congenital Diaphragmatic Hernia
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
The purpose of this research is to gather information on the safety and effectiveness of a procedure called Fetoscopic Endoluminal Tracheal Occlusion (FETO) at Mayo Clinic.
- Trial name
- FETO (NCT05962346)
- Testing
- BALT GOLDBALL 2 detachable latex ballon, BALTACCIBDPE100 Microcatheter, Storz fetoscopic operating sheath and miniature telescope/fetoscope
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mauro H. Schenone
Cardiopulmonary Arrest
REBOA in Nontraumatic OHCA
The investigators propose a multicenter randomized controlled trial in South Korea and Taiwan to observe the clinical effects of REBOA on nontraumatic out-of-hospital-cardiac-arrest (OHCA) patients.
- Trial name
- REBOA (NCT06031623)
- Testing
- REBOA
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Seoul National University Hospital
Primary Prevention of Atherosclerotic Cardiovascular Disease
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
CKJX839D12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 milligram (mg) subcutaneous (s.c.) administered on Day 1, Day 90, and every 6 months thereafter in patients at…
- Trial name
- NCT05739383
- Testing
- Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
- Where
- 983 sites in United States, Argentina and 40 more
- Volunteers
- 14,012 people
- Sponsor
- Novartis Pharmaceuticals
Anesthesia, Postoperative Pain
Lateral QL Block vs Intrathecal Morphine for Cesarean Section
Effective postoperative analgesia after cesarean delivery is essential for maternal recovery, early mobilization, breastfeeding, and maternal-infant bonding.
- Conditions
- Anesthesia, Postoperative Pain, Regional Anesthesia
- Trial name
- NCT07712783
- Testing
- Lateral Quadratus Lumborum Block, ıv morphine PCA, Intrathecal morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Ondokuz Mayıs University
Hemorrhoids
Ultrasound-guided Sacral Erector Spinae Plane Block as a Sole Anesthetic Technique Versus Saddle Block in Hemorrhoidectomy
Study interventions: The patients will be randomized into two equal groups, Group A and Group B. Group A: Patients will receive an Ultrasound guided sacral erector spinae plane block (SESPB) Group B: Patients will receive Saddle…
- Trial name
- NCT06969274
- Testing
- Ultrasound guided sacral erector spinae plane block (SESPB), Saddle block.
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain Management, Abortion
Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement
The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure.
- Conditions
- Pain Management, Abortion, Second Trimester Abortion, Dilation and Evacuation
- Trial name
- PCB-KinD (NCT07487246)
- Testing
- Ketorolac, oral ibuprofen, Lidocaine HCl 1%
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Rush University Medical Center
Cluster Headache
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache
Cluster headache is a primary headache condition characterized by clusters of one-sided, high-intensity pain attacks. The headache may be episodic or chronic. Treatment options are limited and their effects unsatisfactory.
- Trial name
- BASIC (NCT03944876)
- Testing
- Botulinum toxin type A
- Where
- 5 sites in Germany, Italy and 3 more
- Volunteers
- 112 people
- Sponsor
- Norwegian University of Science and Technology
Post Operative Analgesia, Regional Anaesthesia
Comparison Between Paravertebral and Erector Spinal Block Efficacy in Robotic Thoracic Surgeries
The overall goal of this work is to find the preferred continues catheter- based thoracic block for patients who undergoing major ROBOTIC assisted thoracic surgery (Lobectomy, multiple segmental resection and thoracotomy).
- Conditions
- Post Operative Analgesia, Regional Anaesthesia, Pain After Surgery, Opioid Consumption
- Trial name
- TPVB vs ESP (NCT07782073)
- Testing
- Paravertebral Nerve Block, ESP block group
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Soroka University Medical Center
Hemorrhoids, Postoperative Pain
Ultrasound-Guided Versus Landmark-Guided Pudendal Block for Post-Hemorrhoidectomy Pain
Hemorrhoid surgery is often followed by significant pain during the first few days after the operation. Pudendal nerve block is a pain-control technique that can help reduce discomfort after surgery.
- Conditions
- Hemorrhoids, Postoperative Pain, Pudendal Nerve Block
- Trial name
- NCT07889869
- Testing
- Ultrasound-Guided Pudendal Nerve Block, Landmark-Guided Pudendal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya City Hospital
Coronary Artery Disease, Drug Eluting Stent
CREATE Trial, Prospective, Observational Study
Observation of the safety and effectiveness of Cre8 stent, Cre8 evo stent in patients with ischemic heart disease with long coronary lesions
- Trial name
- NCT05658250
- Testing
- CRE8 polymer-free Amphilimus-eluting stent, Cre8 evo stent
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Right Bundle-Branch Block, Heart Failure
His-Bundle Corrective Pacing in Heart Failure
The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs.
- Conditions
- Right Bundle-Branch Block, Heart Failure, His-bundle Pacing, Cardiac Resynchronization Therapy
- Trial name
- HIS-CRT (NCT05265520)
- Testing
- His-CRT implantation, BIV-CRT implantation
- Where
- 14 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Rochester
Analgesia, Hip Arthropathy
Pericapsular Nerve Block Versus Intrathecal Morphine for Analgesia After Primary Hip Arthroplasty
The aim of this clinical trial is to compare the analgesic effect of pericapsular nerve block (PENG) with intrathecal morphine in patients scheduled for total hip replacement surgery.
- Conditions
- Analgesia, Hip Arthropathy, Post Operative Pain
- Trial name
- PENGIT (NCT06317870)
- Testing
- Intrathecal morphine, Pericapsular nerve group block (PENG)
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Atrial Fibrillation (AF)
Prospective Remapping With Concomitant Left Atrial Appendage Occlusion to Ensure Durable Electroporation Study
This is a single-arm, open label, clinical outcome study to research the durability (success) of receiving a pulsed field ablation (PFA) per standard of care for treatment of atrial fibrillation during a subsequent procedure for…
- Trial name
- PRECLUDE (NCT07620262)
- Testing
- Remapping Procedure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Edentulous Alveolar Ridge In Mandible, Complete Edentulism
Compare the Difference in Occlusal Force Distribution and Denture Retention Using 2 Different Denture Base Materials in Implant Retained Overdenture
The global increase in the aging population has led to a rise in total edentulism, which remains a major public health concern. two-implant-retained mandibular overdentures have been regarded as the standard of care, offering…
- Conditions
- Edentulous Alveolar Ridge In Mandible, Complete Edentulism, Dental Implant, Attachments
- Trial name
- NCT07250503
- Testing
- Conventional acrylic resin denture, Flexible resin denture
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Knee Arthroscopy, Spinal Anaesthesia
Investigation of the Effects of Two Different Anaesthesia Methods Applied to Patients Scheduled for Arthroscopic Knee Surgery on the Heart
The study will include 80 patients aged 18-65 years who will undergo elective arthroscopic meniscal surgery. Patients with bleeding disorders, cardiac disease, liver and/or renal failure, arrhythmia and electrolyte imbalance…
- Conditions
- Knee Arthroscopy, Spinal Anaesthesia, Lumbar/Sciatic Block
- Trial name
- NCT07423754
- Testing
- Knee Arthroscopy, Spinal Anaesthesia, Peripheral Nerve Block, Arthroscopic Knee Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Ureteropelvic Junction Obstruction, Renal Functional Recovery
Renal SWE as a Predictor After Pediatric Pyeloplasty for UPJO
Ureteropelvic junction obstruction is an important cause of hydronephrosis and potentially reversible renal functional impairment in children.
- Trial name
- UPJO-SWE (NCT07624019)
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Beni-Suef University
External Oblique Intercostal Plane Block, Subcostal Transverse Abdominis Plane Block
Comparison of the Effects of External Oblique Intercostal Plane Block, Subcostal Transverse Abdominis Plane Block, and Their Combination in the Management of Postoperative Pain in Laparoscopic Cholecystectomy Surgery
This study aims to compare the efficacy of Subcostal Transversus Abdominis Plan Block, External Oblique Intercostal Plan Block and the combination of these two blocks, which are used in anesthesiology practice for postoperative…
- Trial name
- NCT07179731
- Testing
- subcostal transversus abdominis plane block, External Oblique Intercostal Plane Block, external oblique intercostal plane block and subcostal transversus abdominis plane block combination
- Volunteers
- 105 people
- Sponsor
- Istanbul Medeniyet University
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