Clinical trials: Obstructive Sleep Disordered Breathing
Sleep Disordered Breathing, Obstructive Sleep Apnea
The Evaluation of an Alternative Sizing Model in Comparison of a Conventional Sizing Model for Full Face Masks in the Treatment of OSA in Terms of Performance and Comfort
The investigation is a prospective non-blinded and semi-randomized clinical investigation. The investigation is designed to assess the alternative sizing model which the trial mask concept is based on and how it compares to a…
- Trial name
- NCT02851628
- Testing
- Alternative sizing model based trial mask, Prototype Full Face Mask
- Where
- 4 sites in New Zealand
- Volunteers
- 20 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Validation of the ApneaLink Sleep Screener for Obstructive Sleep Apnea (OSA)
The primary endpoints for this study are that the AL validation will 1) achieve a sensitivity of greater than 80% for AHI values greater than or equal to 15, and 2) demonstrate a correlation coefficient of r=0.75 indicating…
- Trial name
- NCT00354614
- Testing
- ApneaLink Sleep Screener
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- ResMed
Mild-Moderate Obstructive Sleep Disordered Breathing
Non-Inferiority Trial of Acute HFT Versus nCPAP
Order randomized crossover non-inferiority study evaluating the acute efficacy of High Flow Therapy (HFT) as compared to nasal Continuous Positive Airway Pressure therapy (CPAP) in the management of apnea / hypopnea index (AHI).
- Trial name
- NCT01860560
- Testing
- High-Flow Therapy, Continuous Positive Airway Pressure
- Where
- United States
- Sponsor
- Vapotherm, Inc.
Obstructive Sleep Apnea
Nexus Compliance Study
Obstructive sleep apnoea (OSA) is characterised by a partial or complete collapse of the upper airway during sleep. The treatment of choice for OSA is Continuous Positive Airway Pressure (CPAP).
- Trial name
- NCT01013207
- Testing
- CPAP Pre Nexus (S9), Nexus (S9), CPAP Post Nexus (S9)
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- ResMed
OSA - Obstructive Sleep Apnea
Effects of Eszopiclone and Lemborexant in People With OSA With a Low Arousal Threshold Who Have Difficulty Sleeping
Insomnia and obstructive sleep apnoea (OSA) are very common conditions, collectively estimated to affect 2 billion people globally, and share many of the same symptoms.
- Trial name
- ELOSA (NCT06928766)
- Testing
- Eszopiclone 3 mg, Lemborexant 10mg
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Flinders University
Sleep-Disordered Breathing, Sleep Architecture
Validation of Belun Ring Gen3 Deep Learning Algorithms With Subxiphoid Body Sensor
Hypothesis: BR's Gen3 DL algorithms, combined with its subxiphoid body sensor, can accurately diagnose OSA, categorize its severity, identify REM OSA and supine OSA, and detect central sleep apnea (CSA).
- Conditions
- Sleep-Disordered Breathing, Sleep Architecture, Arrhythmia
- Trial name
- NCT06255613
- Testing
- Belun Ring, Belun Cor
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- Belun Technology Company Limited
Apnea, Sleep Apnea Syndromes
Comparison of Two Telemonitoring Auto-titrating Modalities in OSA Patients
This study compares the titration pressures achieved through two auto-titrating modalities, a new incremental fixed pressure mode versus routine auto-adjusting pressure mode, in CPAP-naïve obstructive sleep apnea patients.
- Conditions
- Apnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Sleep Disordered Breathing
- Trial name
- NCT03734341
- Testing
- EZ START Titration, APAP Titration
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Basque Health Service
Obstructive Sleep Apnoea (OSA), Hypoventilation Syndrome
Sleep-disordered Breathing Database
The goal of this study is to collect clinical data on patients who have had a sleep study and are given a diagnosis of a sleep related breathing disorder such as obstructive sleep apnoea.
- Trial name
- NCT07402603
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Autism Spectrum Disorder (ASD), Obstructive Sleep Apnea (OSA)
Portable Sleep Monitors in Children With Autism Spectrum Disorder
The goal of this study is to evaluate the ability of a portable sleep monitor to detect obstructive sleep apnea in children with autism spectrum disorder (ASD). The main study objectives are to: 1.
- Trial name
- PrSM (NCT07367022)
- Testing
- Portable sleep monitor (Nox T3s)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Lena Xiao
Pediatric Sleep Disordered Breathing, Obstructive Sleep Apnea
Pediatric/Adolescent WatchPAT 400 Reliability Pilot Study
The goal of this clinical trial is to learn whether a newer sleep-testing device gives results that closely match the standard overnight sleep study, in children and adolescents ages 6-18 who are being evaluated for possible…
- Trial name
- NCT07851402
- Testing
- WatchPAT 400
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Milton S. Hershey Medical Center
Obstructive Sleep Disordered Breathing
Prediction of Tongue Base Obstruction During Sleep
This study investigates the hypothesis that, in children, tongue motor functions can predict both the anatomical site and the degree of upper airway obstruction contributing to obstructive sleep-disordered breathing.
- Trial name
- PTOS (NCT06792045)
- Testing
- Physiotherapist assessment, ENT assessment, Drug-Induced Sleep Endoscopy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
Obstructive Sleep Disordered Breathing
Characterization of the Tongue in Children With Obstructive Sleep-disordered Breathing
The tongue plays a key role in maintaining upper airway patency during sleep, mainly through the genioglossus, the principal pharyngeal dilator muscle.
- Trial name
- NCT07861230
- Testing
- Cross-sectional assessment
- Where
- Belgium
- Volunteers
- 39 people
- Sponsor
- Université Catholique de Louvain
Sleep Apnea, Mixed Central and Obstructive Sleep Apnea
ESS as a Diagnosis Resource Aid of the Syndrome of Obstructive Sleep Apnea
The aim of this study was to analyze the effectiveness of the Epworth's sleepiness scale as a recourse aid in the diagnosis of the syndrome of obstructive sleep apnea.
- Conditions
- Sleep Apnea, Mixed Central and Obstructive Sleep Apnea, Sleep-Disordered Breathing
- Trial name
- NCT00989885
- Testing
- Questionnaire and polysomnography
- Where
- Brazil
- Volunteers
- 475 people
- Sponsor
- Fortaleza University
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Malocclusion
Multi-disciplinary Diagnosis and Treatment Process and Evaluation System for Children With Sleep Disordered Breathing and Malocclusion
The aim of this study is to compare the efficacy and safety of drug therapy, tonsillar adenoidectomy only, orthodontic treatment only and tonsillar adenoidectomy plus orthodontic treatment in children with obstructive sleep apnea…
- Trial name
- NCT03451318
- Testing
- Mometasone Furoate Nasal Spray, tonsillar adenoidectomy, Maxillary expander plus Twin-Block
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Stomotological Hospital
Sleep Disordered Breathing (SDB), Sleep Apnea
Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study
Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent.
- Conditions
- Sleep Disordered Breathing (SDB), Sleep Apnea, Cardiometabolic Diseases, Multimorbidity
- Trial name
- NCT06755840
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Sleep-disordered Breathing, Obstructive Sleep Apnea
Effects of Head Elevation by a Bed on Sleep-disordered Breathing
Sleep is known to be a dynamic state of consciousness that is characterized by rapid fluctuations in autonomic activity as well as changes in body postures.
- Trial name
- NCT01785199
- Testing
- Head elevation by an automatic adjustable bed
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Central Sleep Apnea, Complex Sleep Apnea
Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation
Phase 1: The European ASV Registry (short name) will investigate the use of Adaptive Servo-Ventilation in non-heart failure conditions.
- Conditions
- Central Sleep Apnea, Complex Sleep Apnea, Obstructive Sleep Apnea, Mixed Sleep Apnea
- Trial name
- READ-ASV (NCT03032029)
- Testing
- Adaptive Servo-Ventilation
- Where
- 29 sites in Denmark, France and 4 more
- Volunteers
- 847 people
- Sponsor
- ResMed
Sleep Disorder; Breathing-Related, Snoring
Intranasal Steroid as Medical Therapy For Sleep-Disordered Breathing in Children
MIST+ is studying a nasal spray to see if it will reduce the need for surgery for snoring. Children aged 3-12 are invited to take part.
- Conditions
- Sleep Disorder; Breathing-Related, Snoring, Obstructive Sleep Apnea of Child, Sleep Disorders in Children
- Trial name
- MIST+ (NCT05382494)
- Testing
- Mometasone Furoate 50mcg Nasal Spray, Sodium Chloride 0.9 % Nasal Spray
- Where
- 2 sites in Australia
- Volunteers
- 130 people
- Sponsor
- Murdoch Childrens Research Institute
Myalgia, Apnea, Obstructive Sleep
Temporomandibular Disorder (TMD) Pain in Response to Jaw Advancement in People With TMD and Obstructive Sleep Apnea
The purpose of this study is to characterize the course of temporomandibular disorder (TMD) pain in adults with TMD and obstructive sleep apnea (OSA), all of whom are being treated with mandibular advancement splint (MAS)…
- Trial name
- NCT02685202
- Testing
- Mandibular advancement splint
- Volunteers
- 9 people
- Sponsor
- University of North Carolina, Chapel Hill
Sleep-Disordered Breathing, Sleep Architecture
Screening of OSA in Hospitalized Stroke Patients Using BSP
Obstructive sleep apnea (OSA) is prevalent in patients with stroke and has a negative effect on outcomes by predisposing them to recurrent stroke, increasing mortality, and so forth.
- Conditions
- Sleep-Disordered Breathing, Sleep Architecture, Stroke, Acute
- Trial name
- NCT05466864
- Testing
- Belun Sleep platform
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital