Clinical trials: Obsessive Compulsive Disorders
Depression, Anxiety
Focused Ultrasound for Behavioral Health
This is a double-blind, within-participant crossover, multi-site dose-finding study evaluating the safety, feasibility, and preliminary efficacy of repeated low-intensity focused ultrasound (LIFU) stimulation using the ATTN201…
- Conditions
- Depression, Anxiety, Obsessive Compulsive Disorder (OCD)
- Trial name
- VANTUS (NCT07851038)
- Testing
- ATTN201 head-worn focused ultrasound
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Attune Neurosciences Inc
Obsessive-Compulsive Disorder (OCD), Transcranial Magnetic Stimulation
Continuous Theta-Burst Stimulation for Obsessive-Compulsive Disorder: An Open-Label Study
This single-arm, open-label study evaluates short-term symptom improvement and tolerability of continuous theta-burst stimulation (cTBS), a non-invasive brain stimulation technique, in adults with obsessive-compulsive disorder…
- Conditions
- Obsessive-Compulsive Disorder (OCD), Transcranial Magnetic Stimulation, Electroencephalography
- Trial name
- NCT07896837
- Testing
- Continuous Theta-Burst Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Treatment-refractory Obsessive-compulsive Disorder (trOCD)
Linear Accelerator Radiosurgical Anterior Capsulotomy With Task-based fMRI Identification of PERSonalized and PrEdictiVE Biomarkers of REsponse in Treatment-Refractory Obsessive-Compulsive Disorder (PERSEVERE Trial)
One treatment for treatment-refractory OCD is a procedure called anterior capsulotomy, which modifies a part of the brain called the anterior limb of the internal capsule (ALIC).
- Trial name
- NCT07895706
- Testing
- Radiosurgical anterior capsulotomy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University Hospitals Cleveland Medical Center
Obsessive-Compulsive Disorder
tDCS Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive Disorder
This is a single-center study about patients with severe resistant OCD. Main assumption is that performing 10 tDCS sessions with the anode positioned at the level of the right orbitofrontal cortex, and the cathode at the level of…
- Trial name
- PPSTDCS-TOC (NCT06017713)
- Testing
- tDCS + symptoms provocation
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Henri Laborit
Obsessive - Compulsive Disorder
tDCS and Symptom Provocation in Treatment-Resistant OCD
The goal of this clinical trial is to learn if symptom provocation before transcranial Direct Current Stimulation (tDCS) in Obsessive-Compulsive Disorder (OCD) patients.
- Trial name
- PPS-TDCSTOC (NCT07429500)
- Testing
- tDCS session, symptom provocation
- Where
- 6 sites in France
- Volunteers
- 178 people
- Sponsor
- Centre Hospitalier Henri Laborit
Obsessive - Compulsive Disorder
SONATA Dose Duration LIFU for OCD
This study is testing a new, non-invasive brain stimulation approach for adults with Obsessive Compulsive Disorder (OCD). Researchers are evaluating the safety, tolerability, and target engagement of low-intensity focused…
- Trial name
- NCT07887633
- Testing
- ATTN201 - Low Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Obsessive-Compulsive Disorder
TMS + Exposure Therapy for Pediatric OCD
The goal of this clinical trial is to compare different forms of transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive…
- Trial name
- NExT (NCT05931913)
- Testing
- Transcranial Magnetic Stimulation: intermittent theta burst to dorsolateral prefrontal cortex, Exposure with Response Prevention, Transcranial Magnetic Stimulation: continuous theta burst to pre supplementary motor area
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Bradley Hospital
Obsessive - Compulsive Disorder
The Study is Investigating the Effectiveness of the Traditional Islamically Integrated Psychotherapy Using the Islamic Workbook for Religious Obsessive-Compulsive Disorder in Turkish Adults Who Suffer From Scrupulosity
The goal of the clinical trial is to determine whether the Islamic Workbook of Scrupulosity treats scrupulosity in adults. The main question is whether patients show fewer scrupulosity symptoms after receiving the workbook…
- Trial name
- TIIP (NCT07872462)
- Testing
- Islamically integrated cognitive behavioral intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Ibn Haldun University
Obsessive Compulsive Disorder
Attaining and Maintaining Wellness in Obsessive-compulsive Disorder
The goal of this study is to understand whether patients with obsessive-compulsive disorder (OCD) already on serotonin reuptake inhibitors (SRIs) who then receive a type of Cognitive-behavioral therapy called Exposure and Ritual…
- Trial name
- NCT01686087
- Testing
- Monthly Booster Sessions of EX/RP, Visits with MD and independent evaluators
- Where
- 2 sites in United States
- Volunteers
- 137 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.
This study aims to investigate the effects of oral psilocybin on OCD symptomatology and provide the first evidence of the neural mechanism that may mediate psilocybin's purported therapeutic effects on OCD.
- Trial name
- NCT03356483
- Testing
- Psilocybin (0.25mg/kg), Niacin (250mg)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Yale University
Obsessive Compulsive Disorder (OCD)
Gamified Combined Cognitive Bias Modification in Adults Diagnosed With OCD: Randomized Controlled Trial
This randomized controlled trial examines the effects of a mobile-based gamified combined cognitive bias modification (CBM-C) intervention on obsessive-compulsive symptoms, obsessive beliefs, attentional and interpretation…
- Trial name
- NCT06941155
- Testing
- Gamified-Combined Cognitive Bias Modification, Standard Combined Cognitive Bias Modification
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dokuz Eylul University
Obsessive Compulsive Disorder (OCD)
Artificial Intelligence-Powered Virtual Reality Exposure Therapy for OCD in College Students: A Proof-of-Concept Study
This research study is being conducted to study the use of artificial-intelligence powered virtual reality exposure therapy (AI-VRET) to treat college students with obsessive compulsive disorder (OCD).
- Trial name
- AI-VRET (NCT07877363)
- Testing
- Traditional Exposure and Response Prevention (ERP), Artificial Intelligence-Powered Virtual Reality Exposure Therapy (AI-VRET)
- Volunteers
- 24 people
- Sponsor
- University of California, San Diego
Obsessive-Compulsive Disorder
Cortical Stimulation to Treat Obsessive Compulsive Disorder
The purpose of this study is to identify abnormal brain signals associated with Obsessive Compulsive Disorder (OCD) and psychiatric symptoms and to investigate novel therapeutic stimulation sites.
- Trial name
- NCT04958096
- Testing
- Standard Therapeutic Deep Brain Stimulation, Cortical Stimulation for PFC, Cortical Stimulation for ACC
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Andrew Moses Lee, MD, PhD
Obsessive Compulsive Disorder (OCD)
Low-intensity Ultrasound for Individuals With Obsessive-compulsive Disorder
The goal of this clinical trial is to learn whether low-intensity focused ultrasound (LIFU), a non-invasive form of brain stimulation, can change brain activity and improve thinking and decision-making in adults with…
- Trial name
- LIFU-OCD (NCT07872917)
- Testing
- Low-intensity focused ultrasound (Active)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Obsessive-Compulsive Disorder (OCD)
A Digital Mindfulness-Based Program for OCD
Obsessive-Compulsive Disorder (OCD) is a common long-lasting, and disabling condition, affecting 1 in every 25 people in Portugal.
- Trial name
- MBCT-OCD (NCT07871344)
- Testing
- Mindfulness-based cognitive-behavioral therapy digital program
- Volunteers
- 128 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Obsessive-Compulsive Disorder
Using Personalized Assessments in the Treatment of Childhood OCD
The primary purpose of this study is to learn whether personalized assessment of obsessive-compulsive disorder (OCD) symptoms in childhood OCD using mobile health technology are feasible and acceptable for youth and parents.
- Trial name
- NCT06407648
- Testing
- Personalized Assessments, Standard of Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Obsessive-Compulsive Disorder
Project EMPOWER-OCD
This research study aims to adapt and evaluate the acceptability and effectiveness of Project EMPOWER-OCD for socioeconomically diverse caregivers of patients with OCD. Designed to reduce obstacles (e.g.
- Trial name
- NCT07158801
- Testing
- Project EMPOWER-OCD, Project CARE
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Obsessive - Compulsive Disorder
Efficacy and Underlying Mechanisms of Group-Based Natural Psychotherapy for Anxiety Disorder
This study aims to preliminarily explore the intervention effect and feasibility of group natural psychotherapy (a new Eastern culture-based psychotherapy method) for patients with anxiety disorder through a randomized controlled…
- Trial name
- NCT07518264
- Testing
- Group-based Natural Psychotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing HuiLongGuan Hospital
Obsessive-Compulsive Disorder
Improving Obsessive-compulsive Disorder Treatments: From Lesions to Neuromodulation Targets
While in most cases of obsessive-compulsive disorder (OCD) a cause cannot be identified, this syndrome may develop as a consequence of focal brain lesions.
- Trial name
- ON-TARGET (NCT06490965)
- Testing
- Repetitive Transcranial Magnetic Stimulation, Neuronavigation, Magnetic Resonance Imaging
- Where
- Portugal
- Volunteers
- 32 people
- Sponsor
- Fundacao Champalimaud
ADHD, Obsessive Compulsive Disorder (OCD)
Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
Background: Attention deficit hyperactivity disorder (ADHD) is common in children. It can cause problems with attention and the ability to control actions and impulses.
- Conditions
- ADHD, Obsessive Compulsive Disorder (OCD), Healthy Volunteer
- Trial name
- NCT07566468
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)