Obsessive Compulsive Disorder (OCD)NCT06941155
Gamified Combined Cognitive Bias Modification in Adults Diagnosed With OCD: Randomized Controlled Trial
A study testing Gamified-Combined Cognitive Bias Modification and Standard Combined Cognitive Bias Modification in people with Obsessive Compulsive Disorder (OCD), run by Dokuz Eylul University at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled trial examines the effects of a mobile-based gamified combined cognitive bias modification (CBM-C) intervention on obsessive-compulsive symptoms, obsessive beliefs, attentional and interpretation biases, depressive symptoms, and psychological distress. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Obsessive Compulsive Disorder (OCD)
- What is being tested?
- Gamified-Combined Cognitive Bias Modification and Standard Combined Cognitive Bias Modification
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 90 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 14 May 2025to 2 Apr 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18 years or older
- Primary diagnosis of obsessive-compulsive disorder (OCD), confirmed by a licensed clinician using the Structured Clinical Interview for DSM-5 (SCID-5)
- No current suicidal ideation or psychotic symptoms
- Access to the internet and a mobile phone
- Stable psychiatric medication use for at least one month prior to enrollment, with no changes in dosage during the 4-week intervention period
- No current neurological or medical condition that would interfere with participation
Show all 9Show fewer
- Ability to perceive colored visual stimuli (e.g., no color blindness)
- Not currently enrolled in another intervention-based study
- Not receiving any other form of psychological treatment at the time of participation
Who cannot join
- Presence of active suicidal ideation or psychotic symptoms
- Unstable psychiatric medication use (e.g., recent dose change within the past month or expected change during the intervention period)
- Significant neurological or medical illness that may interfere with participation
- Visual impairments that would prevent accurate perception of colored stimuli (e.g., color blindness)
- Current participation in another clinical trial involving psychological intervention
- Receiving concurrent psychotherapy or other psychological treatments outside of the study
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Dokuz Eylul University Hospital
Izmir, 35340
Sıla Derin, PhD, +905543366293, siladerin@gmail.com
About this study
Official title: A Randomized Controlled Trial on the Effects of Mobile-Based Gamified Combined Cognitive Bias Modification on OCD Symptoms, Obsessive Beliefs, Cognitive Biases, Depressive Symptoms and Distress in Adults Diagnosed With OCD
This randomized controlled trial examines the effects of a mobile-based gamified combined cognitive bias modification (CBM-C) intervention on obsessive-compulsive symptoms, obsessive beliefs, attentional and interpretation biases, depressive symptoms, and psychological distress. The gamified CBM-C condition is compared to a standard mobile-based CBM-C and a placebo control condition. All interventions are delivered via a mobile application. Assessments are conducted at baseline, post-intervention (week 4), and 3-month follow-up.
Read the detailed description
Cognitive Bias Modification (CBM) is a cognitive intervention that experimentally modifies cognitive biases by using a series of disorder-related stimuli designed to manipulate cognitive processes relevant to psychopathology. There are two major forms of CBM interventions: Cognitive Bias Modification-Attention (CBM-A) and Cognitive Bias Modification-Interpretation (CBM-I). CBM is also a promising treatment for Obsessive- Compulsive Disorder (OCD). In recent years, there has been a growing consensus that there may be causal relations among different cognitive biases ("combined cognitive bias hypothesis"). In line with this hypothesis, it is reasonable to suggest that modification in one section will also have an impact on other biases. There are a few studies testing the effect of Combined CBM (CBM-C) programs on anxiety symptoms, depressive symptoms, and OCD symptoms in subclinical samples with promising results.
In recent years, gamification has also been used in order to increase motivation and participation in experimental tasks that constitute the content of both CBM-A and CBM-I interventions. It is possible to see examples of this method in the field of mental health in general and it is stated that it has the potential to be effective as an intervention on reducing the symptoms of psychiatric disorders. However, there is no study to investigate the effect of gamified CBM in individuals with OCD. Based on these new developments and their positive effects, the aim of the study is to investigate the effect of the gamified CBM-C on reducing the severity of OCD symptoms, obsessive beliefs, interpretation and attentional biases, depressive symptoms, and psychological distress, and increasing motivation and participation in experimental tasks.
The study will be conducted on adult participants primarily diagnosed with OCD according to the DSM-5 criteria by a psychiatrist at Dokuz Eylul University Hospital and referred for outpatient treatment at the same hospital. Participants will be randomly assigned to one of three groups: gamified CBM-C, standard CBM-C, or a placebo control condition. The intervention will be delivered via a mobile phone. Data collection will include self-report assessments and behavioral tasks. Attentional bias will be measured using a dot-probe task with eye-tracking, and interpretation bias will be assessed through a recognition scenario task. Measurements will be taken at baseline, post-intervention (week 4), and at 3-month follow-up.
It is expected that participants in the gamified CBM-C condition will demonstrate greater improvements across clinical symptoms, cognitive biases, and motivational outcomes compared to participants in the standard CBM-C and placebo control groups. To the best of current knowledge, this study will be the first to evaluate the effects of a gamified CBM-C intervention in individuals diagnosed with OCD. Its findings are anticipated to contribute to the development of scalable, accessible, and cost-effective digital interventions for clinical populations with elevated dropout and relapse rates.
- Conditions
- Obsessive Compulsive Disorder (OCD)
- Being tested
- Gamified-Combined Cognitive Bias Modification, Standard Combined Cognitive Bias Modification, Placebo
- Medical subject headings
- Obsessive-Compulsive Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Gamified-Combined Cognitive Bias ModificationBehavioural
A gamified version of the combined cognitive bias modification (CBM-C) intervention, which includes both attention and interpretation bias modification tasks. The attention component is a modified dot-probe task, and the interpretation component consists of OCD-related scenarios with word-completion exercises. Gamification elements such as feedback and visual rewards are embedded to enhance motivation and engagement. The presentation order of the two intervention components will be counterbalanced: half of the participants will receive the attention bias task first followed by the interpretation task; the other half will receive the interpretation task first followed by the attention bias task. The intervention is delivered via mobile phone in eight sessions over four weeks (two sessions per week).
Standard Combined Cognitive Bias ModificationBehavioural
A standard version of the combined cognitive bias modification (CBM-C) intervention, consisting of attention and interpretation bias tasks without gamification features. The attention task is a modified dot-probe paradigm, and the interpretation task involves OCD-related scenarios followed by word-completion exercises. The presentation order of the two intervention components will be counterbalanced: half of the participants will receive the attention bias task first followed by the interpretation task; the other half will receive the interpretation task first followed by the attention bias task. The intervention is delivered via mobile phone in eight sessions over four weeks (two sessions per week).
PlaceboBehavioural
A placebo version of the standard CBM-C intervention that retains the same structure and timing but omits all active bias modification elements. The attention task (modified dot-probe) presents probes equally behind threat and neutral stimuli, and the interpretation task includes OCD-related scenarios with word-completion items that lead to neutral outcomes. No manipulations are applied to shift cognitive bias. The presentation order of the two intervention components will be counterbalanced: half of the participants will receive the attention bias task first followed by the interpretation task; the other half will receive the interpretation task first followed by the attention bias task. The intervention is delivered via mobile phone in eight sessions over four weeks (two sessions per week).
| Study group | Role | What they receive |
|---|---|---|
| Gamified-Combined Cognitive Bias Modification | Experimental | Participants in this group will receive the gamified version of the combined cognitive bias modification (CBM-C) intervention, consisting of eight sessions over four weeks (two sessions per week), delivered via mobile phone. The intervention includes both attention and interpretation bias modification tasks enhanced with gamification elements. Receives: Behavioral: Gamified-Combined Cognitive Bias Modification |
| Standart Combined Cognitive Bias Modification | Active comparator | Participants in this group will receive the standard version of the combined cognitive bias modification (CBM-C) intervention, consisting of eight sessions over four weeks (two sessions per week), delivered via mobile phone. The intervention includes both attention and interpretation bias modification tasks, without any gamification features. Receives: Behavioral: Standard Combined Cognitive Bias Modification |
| Placebo Control | Placebo comparator | Participants in this group will receive a placebo version of the standard combined cognitive bias modification (CBM-C) intervention, consisting of eight sessions over four weeks (two sessions per week), delivered via mobile phone. The placebo version retains the structure of the standard intervention but does not include any active bias modification components. Receives: Behavioral: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Yale-Brown Obsessive Compulsive Scale
This clinician-administered measure is used to assess the severity of obsessive-compulsive symptoms. It includes 19 items in total; however, only the first 10 items are used to calculate the total score. Each item is rated on a 0 to 4 scale, resulting in a total score range of 0 to 40. Higher scores indicate greater symptom severity (worse outcome).The measure is conducted through a semi-structured clinical interview.
Measured: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
Obsessive Beliefs Questionnaire-44
This self-report measure is used to assess dysfunctional beliefs commonly associated with obsessive-compulsive symptoms. It consists of 44 items rated on a Likert-type scale ranging from 1 to 7. The total score ranges from 44 to 308. Higher scores indicate that the individual has more maladaptive obsessive-compulsive beliefs (worse outcome).
Measured: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
OC bias index
Measure of interpretation biases. It is a computerized task that requires participants to read and imagine themselves in 10 OC-relevant test scenarios and 10 non-OC-relevant scenarios with a title and missing letter in the final word of the sentence. Participants are then provided with a recognition rating form where they see the title of only the 10 OC-relevant scenarios in which they had previously imagined themselves. Each title corresponds with four different interpretations: target bias (OC-positive and OC-negative), and foil bias (foil-positive and foil-negative). Participants are asked to rate (on a 4-point scale) each sentence independently in terms of how similar each interpretation option is to the meaning of the scenario they had previously read. Target and Foil Bias Index scores are calculated by subtracting ratings for negative items from ratings for positive items. A positive score indicates that the individual has more OC-positive interpretations (better outcome).
Measured: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
Dot-Probe Task with Eye-Tracking
A computerized task measuring attention bias using 48 trials combining probe type, position, and image type (neutral vs. OCD-related). Each trial includes a fixation cross (500 ms), a picture pair (1500 ms), and a directional probe replacing one image. Participants respond via keyboard; bias scores are calculated by subtracting response times for probes replacing OCD-related vs. neutral images. More negative bias scores indicate reduced attention to OCD-related stimuli (better outcome). Eye-tracking (Gazepoint HD 150Hz) measures (a) vigilance: first fixation latency and frequency (including direction bias), (b) disengagement: first fixation duration, and (c) sustained attention: total fixation count and duration. Post-assessment reductions in early, frequent, or prolonged fixations on OCD-related stimuli compared to baseline are interpreted as improved attentional control (better outcome).
Measured: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
Secondary outcomes (2)
Hamilton Depression Rating Scale
This clinician-rated measure is used to assess the severity of depressive symptoms. The version used includes 17 items, each rated on a scale of 0 to 2 or 0 to 4, depending on the item. Total scores range from 0 to 52. Higher scores indicate greater severity of depressive symptoms (worse outcome). The assessment is conducted through a structured clinical interview.
Measured: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
Kessler Psychological Distress Scale
This self-report measure is used to assess general psychological distress based on symptoms of anxiety and depression experienced over the past 30 days. It includes 10 items rated on a 5-point scale from 1 to 5. Total scores range from 10 to 50, with higher scores indicating greater levels of distress (worse outcome).
Measured: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Apr 2025
- Study start14 May 2025
- Primary completion2 Apr 2027 (estimated)
- Study completion2 Apr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Obsessive Compulsive Disorder (OCD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to one of three parallel groups: (1) gamified cognitive bias modification-combined (CBM-C), (2) standard CBM-C, or (3) placebo control. Each group will receive only one type of intervention throughout the study period. Interventions will be delivered independently and simultaneously via mobile phone, and there will be no crossover between conditions.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dokuz Eylul University
- Sponsor type
- University, hospital or other
- Collaborators
- The Scientific and Technological Research Council of Turkey
- Responsible party
- Principal investigator, Sıla Derin, PhD, Dokuz Eylul University
- Investigators
- Sıla Derin, PhD, Principal investigator, Dokuz Eylul University, İzmir, Turkey
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06941155
- Sponsor's protocol ID
- 223S390
- Status last verified
- Oct 2026
- First submitted
- 16 Apr 2025
- Last updated
- 16 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized Controlled Trial on the Effects of Mobile-Based Gamified Combined Cognitive Bias Modification on OCD Symptoms, Obsessive Beliefs, Cognitive Biases, Depressive Symptoms and Distress in Adults Diagnosed With OCD
- ClinicalTrials.gov ID
- NCT06941155
- Acronym / sponsor ID
- 223S390
- Conditions
- Obsessive Compulsive Disorder (OCD)
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- Dokuz Eylul UniversityUniversity, hospital or other
- Collaborators
- The Scientific and Technological Research Council of Turkey
- Study start
- 14 May 2025 (actual)
- Primary completion
- 2 Apr 2027 (estimated)
- Study completion
- 2 Apr 2027 (estimated)
- First posted
- 23 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial examines the effects of a mobile-based gamified combined cognitive bias modification (CBM-C) intervention on obsessive-compulsive symptoms, obsessive beliefs, attentional and interpretation biases, depressive symptoms, and psychological distress. The gamified CBM-C condition is compared to a standard mobile-based CBM-C and a placebo control condition. All interventions are delivered via a mobile application. Assessments are conducted at baseline, post-intervention (week 4), and 3-month follow-up.
Detailed description
Cognitive Bias Modification (CBM) is a cognitive intervention that experimentally modifies cognitive biases by using a series of disorder-related stimuli designed to manipulate cognitive processes relevant to psychopathology. There are two major forms of CBM interventions: Cognitive Bias Modification-Attention (CBM-A) and Cognitive Bias Modification-Interpretation (CBM-I). CBM is also a promising treatment for Obsessive- Compulsive Disorder (OCD). In recent years, there has been a growing consensus that there may be causal relations among different cognitive biases ("combined cognitive bias hypothesis"). In line with this hypothesis, it is reasonable to suggest that modification in one section will also have an impact on other biases. There are a few studies testing the effect of Combined CBM (CBM-C) programs on anxiety symptoms, depressive symptoms, and OCD symptoms in subclinical samples with promising results.
In recent years, gamification has also been used in order to increase motivation and participation in experimental tasks that constitute the content of both CBM-A and CBM-I interventions. It is possible to see examples of this method in the field of mental health in general and it is stated that it has the potential to be effective as an intervention on reducing the symptoms of psychiatric disorders. However, there is no study to investigate the effect of gamified CBM in individuals with OCD. Based on these new developments and their positive effects, the aim of the study is to investigate the effect of the gamified CBM-C on reducing the severity of OCD symptoms, obsessive beliefs, interpretation and attentional biases, depressive symptoms, and psychological distress, and increasing motivation and participation in experimental tasks.
The study will be conducted on adult participants primarily diagnosed with OCD according to the DSM-5 criteria by a psychiatrist at Dokuz Eylul University Hospital and referred for outpatient treatment at the same hospital. Participants will be randomly assigned to one of three groups: gamified CBM-C, standard CBM-C, or a placebo control condition. The intervention will be delivered via a mobile phone. Data collection will include self-report assessments and behavioral tasks. Attentional bias will be measured using a dot-probe task with eye-tracking, and interpretation bias will be assessed through a recognition scenario task. Measurements will be taken at baseline, post-intervention (week 4), and at 3-month follow-up.
It is expected that participants in the gamified CBM-C condition will demonstrate greater improvements across clinical symptoms, cognitive biases, and motivational outcomes compared to participants in the standard CBM-C and placebo control groups. To the best of current knowledge, this study will be the first to evaluate the effects of a gamified CBM-C intervention in individuals diagnosed with OCD. Its findings are anticipated to contribute to the development of scalable, accessible, and cost-effective digital interventions for clinical populations with elevated dropout and relapse rates.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
- Model description
- Participants will be randomly assigned to one of three parallel groups: (1) gamified cognitive bias modification-combined (CBM-C), (2) standard CBM-C, or (3) placebo control. Each group will receive only one type of intervention throughout the study period. Interventions will be delivered independently and simultaneously via mobile phone, and there will be no crossover between conditions.
| Arm | Type | Receives |
|---|---|---|
| Gamified-Combined Cognitive Bias Modification | Experimental | Behavioral: Gamified-Combined Cognitive Bias ModificationParticipants in this group will receive the gamified version of the combined cognitive bias modification (CBM-C) intervention, consisting of eight sessions over four weeks (two sessions per week), delivered via mobile phone. The intervention includes both attention and interpretation bias modification tasks enhanced with gamification elements. |
| Standart Combined Cognitive Bias Modification | Active comparator | Behavioral: Standard Combined Cognitive Bias ModificationParticipants in this group will receive the standard version of the combined cognitive bias modification (CBM-C) intervention, consisting of eight sessions over four weeks (two sessions per week), delivered via mobile phone. The intervention includes both attention and interpretation bias modification tasks, without any gamification features. |
| Placebo Control | Placebo comparator | Behavioral: PlaceboParticipants in this group will receive a placebo version of the standard combined cognitive bias modification (CBM-C) intervention, consisting of eight sessions over four weeks (two sessions per week), delivered via mobile phone. The placebo version retains the structure of the standard intervention but does not include any active bias modification components. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- Age 18 years or older
- Primary diagnosis of obsessive-compulsive disorder (OCD), confirmed by a licensed clinician using the Structured Clinical Interview for DSM-5 (SCID-5)
- No current suicidal ideation or psychotic symptoms
- Access to the internet and a mobile phone
- Stable psychiatric medication use for at least one month prior to enrollment, with no changes in dosage during the 4-week intervention period
Key exclusion criteria (6 listed)
- Presence of active suicidal ideation or psychotic symptoms
- Unstable psychiatric medication use (e.g., recent dose change within the past month or expected change during the intervention period)
- Significant neurological or medical illness that may interfere with participation
- Visual impairments that would prevent accurate perception of colored stimuli (e.g., color blindness)
- Current participation in another clinical trial involving psychological intervention
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Gamified-Combined Cognitive Bias ModificationA gamified version of the combined cognitive bias modification (CBM-C) intervention, which includes both attention and interpretation bias modification tasks. The attention component is a modified dot-probe task, and the interpretation component consists of OCD-related scenarios with word-completion exercises. Gamification elements such as feedback and visual rewards are embedded to enhance motivation and engagement. The presentation order of the two intervention components will be counterbalanced: half of the participants will receive the attention bias task first followed by the interpretation task; the other half will receive the interpretation task first followed by the attention bias task. The intervention is delivered via mobile phone in eight sessions over four weeks (two sessions per week). | Behavioural | Gamified-Combined Cognitive Bias Modification |
| Standard Combined Cognitive Bias ModificationA standard version of the combined cognitive bias modification (CBM-C) intervention, consisting of attention and interpretation bias tasks without gamification features. The attention task is a modified dot-probe paradigm, and the interpretation task involves OCD-related scenarios followed by word-completion exercises. The presentation order of the two intervention components will be counterbalanced: half of the participants will receive the attention bias task first followed by the interpretation task; the other half will receive the interpretation task first followed by the attention bias task. The intervention is delivered via mobile phone in eight sessions over four weeks (two sessions per week). | Behavioural | Standart Combined Cognitive Bias Modification |
| PlaceboA placebo version of the standard CBM-C intervention that retains the same structure and timing but omits all active bias modification elements. The attention task (modified dot-probe) presents probes equally behind threat and neutral stimuli, and the interpretation task includes OCD-related scenarios with word-completion items that lead to neutral outcomes. No manipulations are applied to shift cognitive bias. The presentation order of the two intervention components will be counterbalanced: half of the participants will receive the attention bias task first followed by the interpretation task; the other half will receive the interpretation task first followed by the attention bias task. The intervention is delivered via mobile phone in eight sessions over four weeks (two sessions per week). | Behavioural | Placebo Control |
Primary outcome
Yale-Brown Obsessive Compulsive Scale
Time frame: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
This clinician-administered measure is used to assess the severity of obsessive-compulsive symptoms. It includes 19 items in total; however, only the first 10 items are used to calculate the total score. Each item is rated on a 0 to 4 scale, resulting in a total score range of 0 to 40. Higher scores indicate greater symptom severity (worse outcome).The measure is conducted through a semi-structured clinical interview.
Obsessive Beliefs Questionnaire-44
Time frame: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
This self-report measure is used to assess dysfunctional beliefs commonly associated with obsessive-compulsive symptoms. It consists of 44 items rated on a Likert-type scale ranging from 1 to 7. The total score ranges from 44 to 308. Higher scores indicate that the individual has more maladaptive obsessive-compulsive beliefs (worse outcome).
OC bias index
Time frame: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
Measure of interpretation biases. It is a computerized task that requires participants to read and imagine themselves in 10 OC-relevant test scenarios and 10 non-OC-relevant scenarios with a title and missing letter in the final word of the sentence. Participants are then provided with a recognition rating form where they see the title of only the 10 OC-relevant scenarios in which they had previously imagined themselves. Each title corresponds with four different interpretations: target bias (OC-positive and OC-negative), and foil bias (foil-positive and foil-negative). Participants are asked to rate (on a 4-point scale) each sentence independently in terms of how similar each interpretation option is to the meaning of the scenario they had previously read. Target and Foil Bias Index scores are calculated by subtracting ratings for negative items from ratings for positive items. A positive score indicates that the individual has more OC-positive interpretations (better outcome).
Dot-Probe Task with Eye-Tracking
Time frame: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
A computerized task measuring attention bias using 48 trials combining probe type, position, and image type (neutral vs. OCD-related). Each trial includes a fixation cross (500 ms), a picture pair (1500 ms), and a directional probe replacing one image. Participants respond via keyboard; bias scores are calculated by subtracting response times for probes replacing OCD-related vs. neutral images. More negative bias scores indicate reduced attention to OCD-related stimuli (better outcome). Eye-tracking (Gazepoint HD 150Hz) measures (a) vigilance: first fixation latency and frequency (including direction bias), (b) disengagement: first fixation duration, and (c) sustained attention: total fixation count and duration. Post-assessment reductions in early, frequent, or prolonged fixations on OCD-related stimuli compared to baseline are interpreted as improved attentional control (better outcome).
2 secondary outcomes
Hamilton Depression Rating Scale
Time frame: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
Kessler Psychological Distress Scale
Time frame: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Sıla Derin, PhD principal investigator
Dokuz Eylul University, İzmir, Turkey
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Gamified-Combined Cognitive Bias Modification and Standard Combined Cognitive Bias Modification in people with Obsessive Compulsive Disorder (OCD), run by Dokuz Eylul University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sıla Derin, PhD (+905543366293, siladerin@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Yale-Brown Obsessive Compulsive Scale (time frame: Baseline, Post-Intervention (Week 4), 3-Month Follow-Up). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.