Clinical trials: OSA COPD Overlap Syndrome
Chronic Obstructive Airway Disease
Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea)
Patients with both sleep apnea and COPD have overlap syndrome, but their optimal management is not known. We plan to conduct a randomized trial of of bi-level PAP vs.
- Trial name
- NCT01261377
- Testing
- Bi-level positive airway pressure (BPAP), Oxygen, CPAP
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)
Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD)…
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome
- Trial name
- CRESCENDO-SLP (NCT05237505)
- Testing
- bi-level positive pressure non invasive ventilation, Oxygen gas
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of California, San Diego
Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea
Continuous Positive Airway Pressure Versus Noninvasive Ventilation in Patients With Overlap Syndrome
The purpose of this study is to determine if Bipap should assume a standard-of-care role in the management of overlap syndrome.
- Conditions
- Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, Overlap Syndrome
- Trial name
- OS (NCT01427673)
- Testing
- Bipap procedure
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- United States Air Force
Sleep Apnea, COPD Exacerbation
Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS)
Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) are both frequent respiratory diseases with estimated prevalences between 8 and 15% of the adult population.
- Conditions
- Sleep Apnea, COPD Exacerbation, Overlap Syndrome
- Trial name
- SLEEPOVEA (NCT05958563)
- Testing
- continuous positive airway pressure treatment
- Where
- 15 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Angers
Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea
Monitoring and Peer Support to Improve Treatment Adherence and Outcomes
The O2VERLAP study investigators would like to find out if individuals living with both COPD and OSA would benefit from an online, educational curriculum, coupled with access to peer support (i.e.
- Trial name
- O2VERLAP (NCT03446768)
- Testing
- Peer support, Online platform, Respiratory Therapist support
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- COPD Foundation
Obstructive Sleep Apnea
Diaphragmatic Function and Respiratory Drive in OSA and COPD
This cross-sectional observational study aims to assess the diaphragmatic morphofunction and respiratory drive characteristics among patients with obstructive sleep apnea (OSA), chronic obstructive pulmonary disease (COPD)…
- Trial name
- NCT07003399
- Testing
- Diaphragmatic Ultrasound and EMG Assessment
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Obstructive Sleep Apnea, OSA COPD Overlap Syndrome
Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD
Cognitive dysfunction in the aging Veteran population is a growing health concern in the Veterans Health System. It is not known whether OSA coexisting with COPD will enhance the risk for cognitive dysfunction.
- Trial name
- NCT02703207
- Testing
- Positive airway pressure, NIPPV and /or oxygen
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome
Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise testing in patients with OSA.
- Trial name
- NCT01033266
- Testing
- CPET
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Oklahoma
COPD, OSA
PSG Versus Oxim-capnography to Setup Home NIV
The study aims to compare 2 different strategies used to setup non-invasive ventilation in patients with OCPD-OSA overlap.
- Trial name
- NCT02444806
- Testing
- Full polysomnography, Oximetry-capnography
- Volunteers
- 14 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA
The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in the same patient has been termed overlap syndrome, affecting 1% of the U.S.
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome
- Trial name
- NCT02244957
- Testing
- Bi-level positive airway pressure (BPAP), Nocturnal oxygen
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Diego
Overlap Syndrome
Auto-trilevel Ventilator for Patients With Overlap Syndrome
Obstructive Sleep Apnea Syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that often coexist and are called overlap syndrome(OS).
- Trial name
- NCT01523197
- Testing
- BiPAP ventilation, auto-trilevel ventilation
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Nanjing Medical University
OSA COPD Overlap Syndrome
Comparing Two Types of Breathing Support in People With COPD, High Carbon Dioxide Levels, and Sleep Apnea
This pilot study compares two positive airway pressure strategies for patients with both COPD and obstructive sleep apnea (overlap syndrome) who retain excess carbon dioxide.
- Trial name
- PAVE-OVS (NCT07891962)
- Testing
- high-intensity ventilation strategy, OSA-targeted ventilation strategy
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
COPD, OSA
Efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome
To evaluate efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome
- Conditions
- COPD, OSA, Lung Function Decreased
- Trial name
- NCT05857475
- Testing
- CPAP therapy, Control
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Mahidol University
COPD & OSA
The Effects of Continuous Positive Airway Pressure on Overlap Syndrome
1. The first objective of this study is to determine the differences between, while the airway obstruction severity is the same, and the acute continuous positive airway pressure (CPAP) effect on chronic obstructive pulmonary…
- Trial name
- NCT00914264
- Testing
- continuous positive airway pressure
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Obstructive Sleep Apnea
Pathophysiology of the Upper Airway in Patients With COPD and Concomitant OSA
The purpose of study is to evaluate the physiologic effects of pulmonary tissue/structural changes associated with COPD and upper airway inflammation on upper airway collapsibility.
- Trial name
- NCT02567448
- Testing
- Sleep and pulmonary physiologic measurements
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Sleep Apnea Syndrome, Obstructive Sleep Apnea
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population.
- Conditions
- Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome
- Trial name
- NCT04179981
- Testing
- Positive airway pressure, Conservative care (control arm)
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- VA Office of Research and Development
COPD, OSA
The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA
The term "Overlap Syndrome" (OS) is used to describe the presence of both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in a single patient.
- Trial name
- NCT05254431
- Testing
- Exercise
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
COPD, Overlap Syndrome
Biomarkers of Dementia in Chronic Sleep and Breathing Disorders
Chronic obstructive pulmonary disease (COPD), obstructive sleep apnoea (OSA) and overlap syndrome are associated with obstructions in breathing and disturbed sleep.
- Conditions
- COPD, Overlap Syndrome, OSA
- Trial name
- ORACLE (NCT06377332)
- Testing
- High density electroencephalogram (HdEEG), Functional near infrared spectroscopy (fNIRS), Magnetic resonance imaging (MRI)
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research