Clinical trials: Nosocomial Respiratory Infection
Ventilator-Associated Pneumonia, Nosocomial Pneumonia
Effectiveness of Dental Brushing for Preventing Ventilator-Associated Pneumonia
Poor oral hygiene is associated with respiratory pathogen colonization and secondary lung infection.The possible association between oral care and incidence of VAP, and the role of dental plaque, mouth and tracheal colonization…
- Conditions
- Ventilator-Associated Pneumonia, Nosocomial Pneumonia, Pneumonia
- Trial name
- RASPALL (NCT00842478)
- Testing
- Toothbrushing
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.
Nosocomial Infection, Pneumonia
Pilot Study of the Utility of Empiric Antibiotic Therapy for Suspected ICU-Acquired Infection
Infection developing in the intensive care unit is a common complication of critical illness, but notoriously difficult to diagnose.
- Conditions
- Nosocomial Infection, Pneumonia, Systemic Inflammatory Response Syndrome, Critical Illness
- Trial name
- NCT00438269
- Testing
- Site-specific empiric regimens included: Meropenem, Piperacillin/tazobactam, Ciprofloxacin and cefazolin +/- metronidazole
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Canadian Critical Care Trials Group
Pneumonia, Pneumonia, Ventilator-Associated
Advanced Understanding of Staphylococcus Aureus and Pseudomonas Aeruginosa Infections in EuRopE - ICU
Intensive Care Unit (ICU) acquired pneumonia, including ventilator-associated pneumonia, is a frequently occurring health-care associated infection, which causes considerable morbidity, mortality and health care costs.
- Conditions
- Pneumonia, Pneumonia, Ventilator-Associated, Nosocomial Pneumonia
- Trial name
- ASPIRE-ICU (NCT02413242)
- Testing
- Various observed exposure(s) of interest
- Where
- Netherlands
- Volunteers
- 2,031 people
- Sponsor
- Jan Kluytmans
Pneumonia, Bacterial, Community-Acquired Infections
A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia
The purpose of this study is to evaluate the safety and tolerability of doripenem compared to cefepime in children hospitalized with pneumonia.
- Conditions
- Pneumonia, Bacterial, Community-Acquired Infections, Nosocomial Infection, Pneumonia, Ventilator-Associated
- Trial name
- NCT01110421
- Testing
- Cefepime, Doripenem, Amoxicillin/clavulanate potassium
- Where
- 25 sites in United States, Argentina and 8 more
- Volunteers
- 7 people
- Sponsor
- Janssen Research & Development, LLC
Covid-19, Nosocomial Infection
COG-UK Project Hospital-Onset COVID-19 Infections Study
Hospitals are recognised to be a major risk for the spread of infections despite the availability of protective measures. Under normal circumstances, staff may acquire and transmit infections, but the health impact of within…
- Conditions
- Covid-19, Nosocomial Infection, Coronavirus, Coronavirus Infection
- Trial name
- COG-UK HOCI (NCT04405934)
- Testing
- Use of virus (Covid-19) genome sequence report to inform infection prevention control procedures
- Where
- United Kingdom
- Volunteers
- 2,170 people
- Sponsor
- University College, London
Covid19, Ventilator Associated Pneumonia
Pathogens Involved in Secondary Infections During Severe Forms of Covid-19 Pneumonia:
A Respiratory infection with the SARS-CoV2 virus is associated with a major risk of viral pneumonia that can lead to respiratory distress requiring resuscitation.
- Conditions
- Covid19, Ventilator Associated Pneumonia, Nosocomial Pneumonia
- Trial name
- COVAP (NCT04488510)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Infection, Cross Infection
A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections
The purpose of this study is to assess the safety and efficacy of doripenem in participants with nosocomial pneumonia (inflammation of the lungs in which the lungs become heavy; pneumonia occurring at least 48 hours after…
- Conditions
- Infection, Cross Infection, Bacterial Infections, Pneumonia, Ventilator-Associated
- Trial name
- NCT00965848
- Testing
- Doripenem
- Where
- 8 sites in Thailand
- Volunteers
- 270 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Influenza
Asymptomatic Flu Project
Although clinical presentation of influenza is often symptomatic, asymptomatic cases also occur. The knowledge of the incidence of asymptomatic influenza among healthcare workers is very important because of the risk of…
- Trial name
- AFP (NCT02868658)
- Testing
- Blood sampling, Nasal swab
- Where
- France
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Legionnaires' Disease
Nosocomial and Community Acquired Legionella Pneumophila Pneumonia.
Legionnaire's disease (LD) is a major cause of both community acquired and nosocomial pneumonia, with Legionella pneumophila serogroup A (Lp1) being the most virulent and the greatest cause of disease.
- Trial name
- NCT04106037
- Testing
- Data extraction from medical files
- Where
- 3 sites in Belgium
- Volunteers
- 46 people
- Sponsor
- Dr Philippe CLEVENBERGH
Pathogen Resistance, Pneumococcal Infection
Aerosolized and Intravenous Colistin in Healthy Adults
Colistin is amphipathic, cannot be absorbed from the gastrointestinal tract and is administered intramuscularly, intravenously (IV) or via inhalation.
- Conditions
- Pathogen Resistance, Pneumococcal Infection, Pneumonia
- Trial name
- NCT01863719
- Testing
- Colistimethate sodium
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ventilator Associated Pneumonia, Staphylococcus Aureus
A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2
Clinical trial looking at safety and efficacy of suvratoxumab in prevention of pneumonia caused by Staphylococcus aureus in high-risk patients
- Trial name
- SAATELLITE-2 (NCT05331885)
- Testing
- Suvratoxumab
- Where
- 27 sites in Belgium, France and 4 more
- Volunteers
- 24 people
- Sponsor
- Aridis Pharmaceuticals, Inc.
Infections, Hospital, Ventilator-Associated Pneumonia
Strategies To Prevent Pneumonia 2 (SToPP2)
Ventilator-associated pneumonia (VAP) is a serious complication in mechanically ventilated critically ill patients. The intervention tested in this project (swabbing the mouth with chlorhexidine before the endotracheal tube is…
- Conditions
- Infections, Hospital, Ventilator-Associated Pneumonia, Mechanical Ventilation Complication
- Trial name
- SToPP2 (NCT00893763)
- Testing
- Pre-intubation CHX, Control
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- University of South Florida
Healthcare-associated Pneumonia (HCAP), Hospital Acquired Pneumonia (HAP)
Clinical Study of Cefiderocol (S-649266) for the Treatment of Nosocomial Pneumonia Caused by Gram-negative Pathogens
The primary objective of this study is to compare all-cause mortality at Day 14 in participants receiving cefiderocol with participants receiving the comparator, meropenem, in adults with hospital-acquired bacterial pneumonia…
- Conditions
- Healthcare-associated Pneumonia (HCAP), Hospital Acquired Pneumonia (HAP), Ventilator Associated Pneumonia (VAP)
- Trial name
- APEKS-NP (NCT03032380)
- Testing
- Cefiderocol, Meropenem, Linezolid
- Where
- 119 sites in United States, Belgium and 17 more
- Volunteers
- 300 people
- Sponsor
- Shionogi
Sars-CoV2
Incidence of COVID-19 Test Conversion in Post-surgical Patients
The current Sars-CoV-2 (COVID-19) pandemic has created major changes in how physicians perform routine healthcare for our patients, including elective and non-elective surgical procedures.
- Trial name
- NCT04392323
- Testing
- COVID-19 PCR and Serology
- Where
- 2 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Coronavirus Infectious Disease (COVID-19), Nosocomial Infection
NOSOcomial COVID-19 in ICU (NOSOCOVID)
The current global pandemic at COVID-19 is a major public health issue. Transmission of the virus is primarily through direct and close person-to-person contact.
- Conditions
- Coronavirus Infectious Disease (COVID-19), Nosocomial Infection, Nosocomial COVID-19
- Trial name
- NOSOCOVID (NCT04659356)
- Testing
- Patients admitted in Intensive Care Units
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Nantes University Hospital
Nosocomial Pneumonia, Healthcare-Associated Pneumonia
Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients
Oropharyngeal bacteria play an important role in the pathogenesis of nosocomial pneumonia in critically ill patients. Oral cleansing with chlorhexidine has been shown to decrease incidence of pneumonia in patients undergoing open…
- Conditions
- Nosocomial Pneumonia, Healthcare-Associated Pneumonia, Aspiration Pneumonia, Ventilator-Associated Pneumonia
- Trial name
- NCT00610324
- Testing
- Chlorhexidine gluconate, Potassium permanganate
- Where
- India
- Volunteers
- 512 people
- Sponsor
- King Edward Memorial Hospital
Respiratory Failure
Vitamin D in Ventilated ICU Patients
The increasing rate of hospital-acquired infection and antibiotic resistance are major causes of prolonged ICU stay and death in hospitalized patients.
- Trial name
- R21 HL-110044 (NCT01372995)
- Testing
- Enteral Vitamin D3 50,000 IU, Enteral Vitamin D3 100,000IU, Inactive substance
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Pneumonia
Tedizolid Phosphate (TR-701 FA, MK-1986) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002)
This is a 1:1 ratio, randomized, double-blind, double-dummy, multicenter, global Phase 3 study of tedizolid phosphate (TR-701 FA) 200 mg intravenous (IV) once daily for 7 days versus linezolid (Zyvox®, Zyvoxid®, etc) 600 mg IV…
- Trial name
- NCT02019420
- Testing
- Tedizolid phosphate, Linezolid
- Volunteers
- 726 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Ventilator Associated Pneumonia
GRam Stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) Trial
Background: Optimising the use of antibiotic agents is a pressing challenge to overcoming the rapid emergence and spread of multidrug-resistant pathogens in intensive care units (ICUs).
- Trial name
- NCT03506113
- Testing
- Gram stain-guided antibiotic choice, Guidelines-based antibiotics choice
- Where
- 12 sites in Japan
- Volunteers
- 206 people
- Sponsor
- Osaka General Medical Center
Nosocomial Pneumonia
Optimizing Dosing Regimen of Piperacillin/Tazobactam for Nosocomial Pneumonia
1. To observe clinical and bacteriologic responses of different regimens of piperacillin/tazobactam (4.5g q6h, prolonged or intermittent infusion) for treatment of nosocomial pneumonia. 2.
- Trial name
- NCT01796717
- Testing
- C Group, E Group
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital