Clinical trials: Nicotine Withdrawal
Sedative, Hypnotic, or Anxiolytic Withdrawal, Airway Control
Sedation Compaired With Anesthesia With THRIVE in Endotracheal Intubation With Difficult Airways
To compare the difference in endotracheal intubation in participants with difficult airway between under general anesthesia by Transnasal Humidified Rapid-Insufflation Ventilatory Exchange and under traditional sedation by mask…
- Trial name
- NCT04924621
- Testing
- Respiratory Humidification Treatment Device, AIRVO 2 PT101AZ, Fisher & Paykel Healthcare, Inc., Mask ventilation, Midazolam(T group)
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University
E Cigarette Use
Circuit Breathing Exercise on Smoking Cessation Among Youth E-Cigarette Users
This study aims to investigate the acute effects of a circuit breathing intervention on nicotine withdrawal symptoms and respiratory parameters among youth who use e-cigarettes.
- Trial name
- NCT07886099
- Testing
- Circuit breathing, Diaphragmatic Breathing, Normal Breathing Condition
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
While the prevalence of smoking in the United States general population has declined over the past 50 years, there has been little to no decline among people with mental health conditions.
- Trial name
- NCT04090879
- Testing
- Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Brown University
Tobacco Use, Smoking Cessation
Overcoming Nicotine Dependence to Enable Quitting
Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are…
- Conditions
- Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence
- Trial name
- ON-DEQ (NCT05513872)
- Testing
- Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling
- Where
- United States
- Volunteers
- 780 people
- Sponsor
- Rush University Medical Center
Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder
Effects of Transdermal Nicotine on Smoking, Craving and Withdrawal in People With Schizophrenia
Individuals with schizophrenia are three times as likely to smoke cigarettes as individuals without schizophrenia. While a great deal of research has been focused on smoking cessation programs for healthy individuals, little…
- Conditions
- Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder, Schizophrenia
- Trial name
- NCT00218218
- Testing
- Transdermal Nicotine Patch, 21 mg transdermal nicotine
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation
Efficacy of 2 Probiotics During Nicotine Replacement Therapy on Withdrawal Symptoms Associated With Smoking Cessation
Quitting smoking is a big decision, a decision to achieve better health. Trying to quit smoking can be stressful. The prospect of dealing with withdrawal symptoms, fear or failure to change the routine, can also be sources of…
- Trial name
- NCT02492022
- Testing
- Probiotic L008-1, Probiotic L008-2
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Lallemand Health Solutions
Schizophrenia, Schizoaffective Disorder
The Effects of Nicotine Withdrawal on Reward Responsivity in Schizophrenia
It has been suggested that patients with schizophrenia smoke in order to produce amelioration of dysfunctional dopaminergic pathways allowing them to experience pleasure and satisfaction and overcome anhedonia.
- Trial name
- NCT00373126
- Testing
- transdermal nicotine patch
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Despite marked reductions in cigarette smoking in the general population, smoking among economically disadvantaged women has increased.
- Trial name
- NCT04092387
- Testing
- Varying the nicotine content of cigarettes, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
CBD, Stress
Effects of Cannabidiol on Stress and Nicotine Withdrawal
The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users.
- Conditions
- CBD, Stress, Nicotine Dependence, Tobacco Smoking
- Trial name
- CREWS (NCT07001930)
- Testing
- Epidiolex
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Nicotine Dependence, Smoking
The Effect of Exercise on Acute Nicotine Withdrawal
The primary aim of this project is to test the effect of exercise on acute nicotine withdrawal. Acute nicotine withdrawal is characterized by a complex array of symptoms associated with increased risk of relapse among individuals…
- Conditions
- Nicotine Dependence, Smoking, Sleep Disorders, Intrinsic
- Trial name
- NicEx (NCT01047930)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Smoking Cessation
Assessing Neuropsychiatric Symptoms Including Depression, Anxiety, Irritability, and Suicidal Thoughts or Behavior in Subjects Quitting Smoking on Varenicline Tartrate or Placebo
Study objective is to compare neuropsychiatric adverse events in subjects treated with varenicline or placebo in a controlled setting where both groups are experiencing nicotine withdrawal.
- Trial name
- NCT00749944
- Testing
- varenicline
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Pfizer
Substance Withdrawal Syndrome, Nicotine Dependence
Electronic Cigarettes in Daily Dependent Smokers
The aim of this study is to measure nicotine cue- and withdrawal-induced craving in current smokers under four distinct conditions: after smoking a conventional cigarette, an electronic cigarette (e-Cigarette) containing…
- Trial name
- NCT02108626
- Testing
- Nicotine
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Centre for Addiction and Mental Health
E Cigarette Use, Cessation, Tobacco
Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use
This study aims to improve understanding of how people who use electronic cigarettes (ECIGs or e-cigarettes) respond when they try to stop using them and whether nicotine replacement therapy (NRT) can make that process easier.
- Conditions
- E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
- Trial name
- NCT07786896
- Testing
- Nicotine Replacement Therapies, Brief Behavioral Counseling
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- West Virginia University
Impulse Control Disorders
Restoring Cognitive Control (ReCon) in Acute Nicotine Withdrawal
The purpose of this study is to explore the safety, tolerability and activity of SXC-2023 or placebo when dosed for 5 days in adults with tobacco use disorder who voluntarily abstain from the use of cigarettes.
- Trial name
- NCT03887429
- Testing
- SXC-2023
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Promentis Pharmaceuticals, Inc.
Smoking Cessation
Nicotine Patch Trial in Syrian Primary Care Settings
The study is a two-arm, parallel group, randomized, placebo-controlled, double blind trial, conducted at four primary health care centers in Aleppo, Syria, to test the efficacy of transdermal nicotine patch therapy vs.
- Trial name
- NCT01085032
- Testing
- Transdermal Nicotine
- Where
- Syria
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Tobacco Use Disorder
Tobacco Cessation in Postmenopausal Women (Part II) - 2
The purpose of this study is to evaluate the effects of ERT on appetitive behavior and withdrawal in short-term smoking cessation in postmenopausal females on transdermal nicotine replacement
- Trial name
- NCT00061074
- Testing
- Nicotrol
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Minnesota
Drug Addiction
Effect of Varenicline on Tobacco Addiction and on Abstinence-induced Cognitive Impairment
Background: Varenicline (Chantix ) is a drug that is approved by the Food and Drug Administration (FDA) to help people stop smoking.
- Trial name
- NCT01309685
- Testing
- Varenicline
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, HIV-1-infection
Effects of Metformin During Nicotine Withdrawal
The purpose of this study is to test the effects of a medication called metformin (Glucophage®) on smoking behavior. This medication is FDA-approved for treatment of type-2 diabetes.
- Trial name
- MEP (NCT03593538)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder
Medicinal Nicotine for Preventing Stress Induced Craving and Withdrawal Symptoms
The purpose of this study is to determine the timeframe (relative to a stress task) that is most effective at attenuating the increase in symptoms of tobacco craving and withdrawal that occur when smokers are presented with…
- Trial name
- NCT01522963
- Testing
- Nicotine lozenge
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Minnesota
Tobacco Use Disorder
Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Adults with affective disorders are at increased risk for smoking, nicotine dependence, and using high nicotine yield…
- Trial name
- NCT02232737
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- Brown University