E Cigarette UseNCT07886099
Circuit Breathing Exercise on Smoking Cessation Among Youth E-Cigarette Users
A study testing Circuit breathing, Diaphragmatic Breathing and Normal Breathing Condition in people with E Cigarette Use, run by Chulalongkorn University at 1 site in Thailand.
Trial summary
This study aims to investigate the acute effects of a circuit breathing intervention on nicotine withdrawal symptoms and respiratory parameters among youth who use e-cigarettes. Read more about this study
- Who is it for?
- Ages 15 to 25 yearsHealthy volunteers can take part
- Conditions the study is for
- E Cigarette Use
- What is being tested?
- Circuit breathing, Diaphragmatic Breathing and Normal Breathing Condition
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteThailand
- Study dates
- 15 Aug 2026to 30 Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 25 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Male or female aged 15-25 years.
- Regular e-cigarette use for at least six months and current e-cigarette use, defined as use on at least one day per week or at least 10 puffs per day during the past 30 days.
- Not regularly physically active, defined as exercising fewer than two times per week during the preceding six months.
- Able to understand instructions, communicate effectively, and cooperate with the research procedures.
- No history of cardiovascular disease or respiratory disease, such as asthma or chronic obstructive pulmonary disease.
- No uncontrolled hypertension. Participants with controlled hypertension must have resting blood pressure ≤140/90 mmHg.
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- Able to move independently without assistance or assistive devices.
- Willing to participate and provide informed consent.
- For participants younger than 18 years, consent from a parent or legally authorized representative is required.
Who cannot join
- Development of an illness, injury, or other circumstance that prevents continued participation.
- Withdrawal of consent or unwillingness to continue participation.
- Current use of illicit drugs or other tobacco/nicotine products, including conventional cigarettes, shisha/hookah, roll-your-own tobacco, or other nicotine-containing products.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Thailand1 site, 1 recruiting
- Recruiting
Faculty of Sports Science, Chulalongkorn University
Bangkok, Bangkok, 10330
Dr.Wannaporn Tongtako, 0879823131, wannaporn.t@chula.ac.th
About this study
Official title: Acute Effects of Circuit Breathing Exercise on Smoking Cessation and Respiratory Function Among Youth E-Cigarette Users
This study aims to investigate the acute effects of a circuit breathing intervention on nicotine withdrawal symptoms and respiratory parameters among youth who use e-cigarettes.
Read the detailed description
A randomized crossover study will include 20 male and female e-cigarette users aged 15-25 years. Each participant will undergo three breathing conditions: circuit breathing, diaphragmatic breathing, and normal breathing, with a washout period of at least one week between sessions. The study will evaluate the acute effects of each breathing condition on nicotine withdrawal symptoms, e-cigarette dependence, physiological variables (resting heart rate and blood pressure), peak nasal inspiratory flow (PNIF), and fractional exhaled nitric oxide (FeNO).
- Conditions
- E Cigarette Use
- Being tested
- Circuit breathing, Diaphragmatic Breathing, Normal Breathing Condition
- Keywords
- Circuit breathing, Nicotine withdrawal symptoms, E Cigarette, Fractional exhaled nitric oxide, Respiratory Function
- Medical subject headings
- Vaping, Respiratory Aspiration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Circuit breathingOther
The circuit breathing intervention consists of five stations: paper suction using a straw, blowing a toy pinwheel, incentive spirometry, balloon blowing, and weighted diaphragmatic breathing. Participants will rest for 1 minute between stations.
Diaphragmatic BreathingOther
The diaphragmatic breathing exercise will consist of inhaling through the nose for 4 seconds and exhaling through the nose for 6 seconds, continuously for 10 minutes per set. Participants will rest for 1 minute between sets and complete a total of 3 sets.
Normal Breathing ConditionOther
Participants will breathe normally through the nose without deliberately controlling the rate, rhythm, or depth of breathing. Breathing will remain at each participant's natural pace for approximately 30 minutes.
| Study group | Role | What they receive |
|---|---|---|
| Circuit Breathing | Experimental | Not described Receives: Other: Circuit breathing |
| Diaphragmatic Breathing | Experimental | Not described Receives: Other: Diaphragmatic Breathing |
| Normal Breathing | Experimental | Not described Receives: Other: Normal Breathing Condition |
What is being measured
The primary outcome is the main question the study is designed to answer.
E-cigarette Dependence
E-cigarette dependence will be assessed using the Penn State Electronic Cigarette Dependence Index, adapted by Sornsenee et al. (2025). The questionnaire consists of 10 items, with a maximum total score of 20. Scores are interpreted as follows: 0-3 indicates no e-cigarette dependence, 4-8 indicates low dependence, 9-12 indicates moderate dependence, and 13 or higher indicates high dependence.
Measured: Baseline for demographic data.
Nicotine Withdrawal Symptoms
Nicotine withdrawal symptoms will be assessed using the Thai version of the Minnesota Nicotine Withdrawal Scale-Revised (MNWS) (Hughes \& Hatsukami, 2008), translated by Sirirat Kanokururot and Sunida Preechawong (2010). This self-report questionnaire measures the perceived severity of nicotine withdrawal symptoms. It consists of 9 items rated on a 5-point scale ranging from 0 (no symptoms) to 4 (severe symptoms). The total score ranges from 0 to 36, with a score of 0 indicating no nicotine withdrawal symptoms and a score of 36 indicating the most severe nicotine withdrawal symptoms.
Measured: Immediately before and immediately after each breathing intervention session.
Secondary outcomes (2)
Fractional Exhaled Nitric Oxide (FeNO)
FeNO will be measured using a device equipped with a bacterial filter and mouthpiece. Participants will place their lips around the mouthpiece and exhale into the device for 6 seconds while maintaining the indicator ball within the designated range. Results will be recorded in parts per million (ppm).
Measured: Immediately before and immediately after each breathing intervention session.
Peak Nasal Inspiratory Flow (PNIF)
Peak nasal inspiratory flow will be measured using a peak nasal inspiratory flow meter. Participants will perform the breathing maneuver according to the study procedure, and the measurement will be recorded in liters per second (L/s).
Measured: Immediately before and immediately after each breathing intervention session.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Oct 2026
- Study start15 Aug 2026
- Primary completion15 Oct 2026 (estimated)
- Study completion30 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for E Cigarette UseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Chulalongkorn University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Wannaporn Tongtako, Ph.D., Chulalongkorn University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07886099
- Sponsor's protocol ID
- EX PHYSIO SPSC 14
- Status last verified
- Oct 2026
- First submitted
- 10 Oct 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Circuit Breathing Exercise on Smoking Cessation and Respiratory Function Among Youth E-Cigarette Users
- ClinicalTrials.gov ID
- NCT07886099
- Acronym / sponsor ID
- EX PHYSIO SPSC 14
- Conditions
- E Cigarette Use
- Keywords
- Circuit breathing, Nicotine withdrawal symptoms, E Cigarette, Fractional exhaled nitric oxide, Respiratory Function
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Chulalongkorn UniversityUniversity, hospital or other
- Study start
- 15 Aug 2026 (actual)
- Primary completion
- 15 Oct 2026 (estimated)
- Study completion
- 30 Oct 2026 (estimated)
- First posted
- 21 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate the acute effects of a circuit breathing intervention on nicotine withdrawal symptoms and respiratory parameters among youth who use e-cigarettes.
Detailed description
A randomized crossover study will include 20 male and female e-cigarette users aged 15-25 years. Each participant will undergo three breathing conditions: circuit breathing, diaphragmatic breathing, and normal breathing, with a washout period of at least one week between sessions. The study will evaluate the acute effects of each breathing condition on nicotine withdrawal symptoms, e-cigarette dependence, physiological variables (resting heart rate and blood pressure), peak nasal inspiratory flow (PNIF), and fractional exhaled nitric oxide (FeNO).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Circuit Breathing | Experimental | Other: Circuit breathing |
| Diaphragmatic Breathing | Experimental | Other: Diaphragmatic Breathing |
| Normal Breathing | Experimental | Other: Normal Breathing Condition |
Who may qualify
- Ages
- 15 to 25 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (9 listed)
- Male or female aged 15-25 years.
- Regular e-cigarette use for at least six months and current e-cigarette use, defined as use on at least one day per week or at least 10 puffs per day during the past 30 days.
- Not regularly physically active, defined as exercising fewer than two times per week during the preceding six months.
- Able to understand instructions, communicate effectively, and cooperate with the research procedures.
- No history of cardiovascular disease or respiratory disease, such as asthma or chronic obstructive pulmonary disease.
Key exclusion criteria (3 listed)
- Development of an illness, injury, or other circumstance that prevents continued participation.
- Withdrawal of consent or unwillingness to continue participation.
- Current use of illicit drugs or other tobacco/nicotine products, including conventional cigarettes, shisha/hookah, roll-your-own tobacco, or other nicotine-containing products.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Circuit breathingThe circuit breathing intervention consists of five stations: paper suction using a straw, blowing a toy pinwheel, incentive spirometry, balloon blowing, and weighted diaphragmatic breathing. Participants will rest for 1 minute between stations. | Other | Circuit Breathing |
| Diaphragmatic BreathingThe diaphragmatic breathing exercise will consist of inhaling through the nose for 4 seconds and exhaling through the nose for 6 seconds, continuously for 10 minutes per set. Participants will rest for 1 minute between sets and complete a total of 3 sets. | Other | Diaphragmatic Breathing |
| Normal Breathing ConditionParticipants will breathe normally through the nose without deliberately controlling the rate, rhythm, or depth of breathing. Breathing will remain at each participant's natural pace for approximately 30 minutes. | Other | Normal Breathing |
Primary outcome
E-cigarette Dependence
Time frame: Baseline for demographic data.
E-cigarette dependence will be assessed using the Penn State Electronic Cigarette Dependence Index, adapted by Sornsenee et al. (2025). The questionnaire consists of 10 items, with a maximum total score of 20. Scores are interpreted as follows: 0-3 indicates no e-cigarette dependence, 4-8 indicates low dependence, 9-12 indicates moderate dependence, and 13 or higher indicates high dependence.
Nicotine Withdrawal Symptoms
Time frame: Immediately before and immediately after each breathing intervention session.
Nicotine withdrawal symptoms will be assessed using the Thai version of the Minnesota Nicotine Withdrawal Scale-Revised (MNWS) (Hughes \& Hatsukami, 2008), translated by Sirirat Kanokururot and Sunida Preechawong (2010). This self-report questionnaire measures the perceived severity of nicotine withdrawal symptoms. It consists of 9 items rated on a 5-point scale ranging from 0 (no symptoms) to 4 (severe symptoms). The total score ranges from 0 to 36, with a score of 0 indicating no nicotine withdrawal symptoms and a score of 36 indicating the most severe nicotine withdrawal symptoms.
2 secondary outcomes
Fractional Exhaled Nitric Oxide (FeNO)
Time frame: Immediately before and immediately after each breathing intervention session.
Peak Nasal Inspiratory Flow (PNIF)
Time frame: Immediately before and immediately after each breathing intervention session.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Circuit breathing, Diaphragmatic Breathing and Normal Breathing Condition in people with E Cigarette Use, run by Chulalongkorn University at 1 site in Thailand.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Thailand. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Wannaporn Tongtako, Ph.D. (0879823131, wannaporn.t@chula.ac.th), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
E-cigarette Dependence (time frame: Baseline for demographic data.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026.